Molecular characterization of oxysterol binding to the epstein-barr virus-induced gene 2 (GPR183)

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35470-35483

  Benned Jensen, Tau ^a   Norn, Christoffer ^b   Laurent, Stephane ^c   Madsen, Christian M ^a   Larsen, Hjalte M ^b   Arfelt, Kristine N ^a   Wolf, Romain M ^c   Frimurer, Thomas ^b,d   Sailer, Andreas W ^c   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; CELLULAR PROCESS; DOCKING SIMULATIONS; HYDROPHOBIC INTERACTIONS; KEY RESIDUES; LIGAND BINDING; MOLECULAR CHARACTERIZATION; MUTATIONAL ANALYSIS; OH GROUP; OXYSTEROLS; POSITIVELY CHARGED; RECEPTOR ACTIVATION;

BINDING ENERGY; GENES; LIGANDS; PROTEINS;

VIRUSES;

7ALPHA,25 DIHYDROXYCHOLESTEROL; ARGININE; CHOLESTEROL DERIVATIVE; CYSTEINE; EPSTEIN BARR VIRUS INDUCED GENE 2 PROTEIN; HYDROXYL GROUP; MEMBRANE RECEPTOR; NUCLEOTIDE; OXYSTEROL; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; RECEPTOR BINDING; SIMULATION;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; HEK293 CELLS; HUMANS; HYDROXYCHOLESTEROLS; MOLECULAR DOCKING SIMULATION; MUTATION, MISSENSE; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84867427020     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.387894     Document Type: Article

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