Side-chain oxysterols: From cells to membranes to molecules

Biochimica et Biophysica Acta - Biomembranes

Volumn 1818, Issue 2, 2012, Pages 330-336

  Olsen, Brett N ^a   Schlesinger, Paul H ^b   Ory, Daniel S ^a   Baker, Nathan A ^c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Cholesterol; Homeostasis; Molecular dynamics; Oxysterol; Sterol

Indexed keywords

OXYSTEROL;

BIOPHYSICS; CELL CYCLE; CELL MEMBRANE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; ESTERIFICATION; HOMEOSTASIS; HYDROPHOBICITY; LIPID MEMBRANE; MEMBRANE BIOLOGY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SIMULATION; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANIMALS; CELL MEMBRANE; CHOLESTEROL; HOMEOSTASIS; HUMANS; MODELS, MOLECULAR; STEROLS;

EID: 84855446282     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.06.014     Document Type: Review

References (49)

1. A. Lee How lipids affect the activities of integral membrane proteins Biochim. Biophys. Acta 1666 2004 62 87 (Pubitemid 39425199)
2. M. Houslay Regulation of adenylate cyclase (EC 4.6.1.1) activity by its lipid environment Proc. Nutr. Soc. 44 1985 157 165
3. Q. Yang, R. Alemany, J. Casas, K. Kitajka, S. Lanier, and P. Escribá Influence of the membrane lipid structure on signal processing via G protein-coupled receptors Mol. Pharmacol. 68 2005 210 217 (Pubitemid 41002960)
4. T. McIntosh, and S. Simon Roles of bilayer material properties in function and distribution of membrane proteins Annu. Rev. Biophys. Biomol. Struct. 35 2006 177 198 (Pubitemid 43877375)
5. J.A. Lundbaek, O.S. Andersen, T. Werge, and C. Nielsen Cholesterol-induced protein sorting: an analysis of energetic feasibility Biophys. J. 84 2003 2080 2089 (Pubitemid 36322969)
6. M.P. Czech PIP2 and PIP3: complex roles at the cell surface Cell 100 2000 603 606
7. A. Futerman, and Y. Hannun The complex life of simple sphingolipids EMBO Rep. 5 2004 777 782 (Pubitemid 39199166)
8. Y. Hannun, and L. Obeid Principles of bioactive lipid signalling: lessons from sphingolipids. Nature reviews Mol. Cell Biol. 9 2008 139 150 (Pubitemid 351158911)
9. B. Fadeel, and D. Xue The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease Crit. Rev. Biochem. Mol. Biol. 44 2009 264 277
10. E. Ikonen Cellular cholesterol trafficking and compartmentalization Nat. Rev. Mol. Cell Biol. 9 2008 125 138 (Pubitemid 351158918)
11. A. Ridsdale, M. Denis, P.-Y. Gougeon, J. Ngsee, J. Presley, and X. Zha Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins Mol. Biol. Cell 17 2006 1593 1605 (Pubitemid 44011579)
12. B. Olsen, P. Schlesinger, D. Ory, and N. Baker 25-Hydroxycholesterol increases the availability of cholesterol in phospholipid membranes Biophys. J. 100 2011 948 956
13. H. Ohvo-Rekilä, B. Ramstedt, P. Leppimäki, and P. Slotte Cholesterol interactions with phospholipids in membranes Prog. Lipid Res. 41 2002 66 97 (Pubitemid 32998278)
14. K. Simons, and W. Vaz Model systems, lipid rafts, and cell membranes Annu. Rev. Biophys. Biomol. Struct. 33 2004 269 295 (Pubitemid 38829961)
15. G. Feigenson Phase boundaries and biological membranes Annu. Rev. Biophys. Biomol. Struct. 36 2007 63 77 (Pubitemid 46998110)
16. G. van Meer, D. Voelker, and G. Feigenson Membrane lipids: where they are and how they behave Nat. Rev. Mol. Cell Biol. 9 2008 112 124 (Pubitemid 351158912)
17. J. Horton, J. Goldstein, and M. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131 (Pubitemid 34496588)
18. D. Ory Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? Circ. Res. 95 2004 660 670 (Pubitemid 39331925)
19. J. Chiang Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms J. Hepatol. 40 2004 539 551 (Pubitemid 38230860)
20. M. Norlin, and K. Wikvall Enzymes in the conversion of cholesterol into bile acids Curr. Mol. Med. 7 2007 199 218 (Pubitemid 46488191)
21. Y. Lange, D. Ory, J. Ye, M. Lanier, F.-F. Hsu, and T. Steck Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase J. Biol. Chem. 283 2008 1445 1455
22. A. Frolov, S. Zielinski, J. Crowley, N. Dudley-Rucker, J. Schaffer, and D. Ory NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols J. Biol. Chem. 278 2003 25517 25525 (Pubitemid 36835303)
23. B. Janowski, M. Grogan, S. Jones, B. Wisely, S. Kliewer, E. Corey, and D. Mangelsdorf Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ Proc. Natl. Acad. Sci. 96 1999 266 271 (Pubitemid 29036088)
24. B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731 (Pubitemid 26360651)
25. I. Björkhem Are side-chain oxidized oxysterols regulators also in vivo? J. Lipid Res. 50 2009 S213 S218 Suppl
26. A.R. Tall Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins J. Intern. Med. 263 2008 256 273 (Pubitemid 351207349)
27. J. Goldstein, R. Rawson, and M. Brown Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis Arch. Biochem. Biophys. 397 2002 139 148 (Pubitemid 34852273)
28. G.M. Humphries, and H.M. McConnell Potent immunosuppression by oxidized cholesterol J. Immunol. 122 1979 121 126 (Pubitemid 9078528)
29. M.S. Brown, and J.L. Goldstein The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 1997 331 340 (Pubitemid 27220877)
30. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
31. H. Shimano, J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a J. Clin. Invest. 98 1996 1575 1584 (Pubitemid 26327867)
32. D. Yabe, M. Brown, and J. Goldstein Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proc. Natl. Acad. Sci. U. S. A. 99 2002 12753 12758
33. T. Yang, P. Espenshade, M. Wright, D. Yabe, Y. Gong, R. Aebersold, J. Goldstein, and M. Brown Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 110 2002 489 500 (Pubitemid 35232292)
34. G. Gil, J.R. Faust, D.J. Chin, J.L. Goldstein, and M.S. Brown Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme Cell 41 1985 249 258 (Pubitemid 15068442)
35. P. Kuwabara, and M. Labouesse The sterol-sensing domain: multiple families, a unique role? Trends Genet. 18 2002 193 201 (Pubitemid 34273740)
36. Y. Lange, J. Ye, M. Rigney, and T. Steck Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol J. Lipid Res. 40 1999 2264 2270 (Pubitemid 30017528)
37. T.-Y. Chang, B.-L. Li, C. Chang, and Y. Urano Acyl-coenzyme A: cholesterol acyltransferases Am. J. Physiol. Endocrinol. Metab. 297 2009 E1 E9
38. S. Gale, E. Westover, N. Dudley, K. Krishnan, S. Merlin, D. Scherrer, X. Han, X. Zhai, H. Brockman, R. Brown, D. Covey, J. Schaffer, P. Schlesinger, and D. Ory Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions J. Biol. Chem. 284 2009 1755 1764
39. A. Radhakrishnan, Y. Ikeda, H.J. Kwon, M. Brown, and J. Goldstein Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig Proc. Natl. Acad. Sci. U. S. A. 104 2007 6511 6518 (Pubitemid 47175533)
40. N. Sever, T. Yang, M. Brown, J. Goldstein, and R. DeBose-Boyd Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain Mol. Cell 11 2003 25 33 (Pubitemid 36126588)
41. Y. Lange, and T. Steck Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol Prog. Lipid Res. 47 2008 319 332
42. Y. Lange, J. Ye, and T. Steck How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids Proc. Natl. Acad. Sci. U. S. A. 101 2004 11664 11667 (Pubitemid 39095353)
43. A. Sokolov, and A. Radhakrishnan Accessibility of cholesterol in endoplasmic reticulum membranes and activation of SREBP-2 switch abruptly at a common cholesterol threshold J. Biol. Chem. 285 2010 29480 29490
44. 2+ and other cations Biochim. Biophys. Acta 770 1984 15 21 (Pubitemid 14150327)
45. J.J. Theunissen, R.L. Jackson, H.J. Kempen, and R.A. Demel Membrane properties of oxysterols. Interfacial orientation, influence on membrane permeability and redistribution between membranes, interfacial orientation, influence on membrane permeability and redistribution between membranes Biochim. Biophys. Acta 860 1986 66 74
46. E. Mintzer, G. Charles, and S. Gordon Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes Chem. Phys. Lipids 163 2010 586 593
47. B. Stottrup, and S. Keller Phase behavior of lipid monolayers containing DPPC and cholesterol analogs Biophys. J. 90 2006 3176 3183
48. B. Olsen, P. Schlesinger, and N. Baker Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation J. Am. Chem. Soc. 131 2009 4854 4865
49. M. Edidin The state of lipid rafts: from model membranes to cells Annu. Rev. Biophys. Biomol. Struct. 32 2003 257 283 (Pubitemid 37056230)