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Volumn 17, Issue 1, 2016, Pages 205-220

Complex systems dynamics in aging: new evidence, continuing questions

Author keywords

Aging; Emergent property; Physiological dysregulation; Principal components analysis; Statistical distance; Systems biology

Indexed keywords

ACCURACY; ADAPTATION; AGING; BIOINFORMATICS; HUMAN; LIFESTYLE; NONHUMAN; PHENOTYPE; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; REVIEW; SIMULATION; SYSTEMS BIOLOGY; TEMPERATURE SENSITIVITY; UPREGULATION; BIOLOGICAL MODEL; EVIDENCE BASED MEDICINE; GENE EXPRESSION REGULATION; METABOLOME; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

EID: 84955344859     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-015-9584-x     Document Type: Review
Times cited : (97)

References (80)
  • 1
    • 84883480871 scopus 로고    scopus 로고
    • Maternal and cord-blood thyroid hormone levels and exposure to polybrominated diphenyl ethers and polychlorinated biphenyls during early pregnancy
    • Abdelouahab N, Langlois M-F, Lavoie L, Corbin F, Pasquier J-C, Takser L (2013) Maternal and cord-blood thyroid hormone levels and exposure to polybrominated diphenyl ethers and polychlorinated biphenyls during early pregnancy. Am J Epidemiol. doi:10.1093/aje/kwt140
    • (2013) Am J Epidemiol
    • Abdelouahab, N.1    Langlois, M.-F.2    Lavoie, L.3    Corbin, F.4    Pasquier, J.-C.5    Takser, L.6
  • 2
    • 33745588546 scopus 로고    scopus 로고
    • The limits of reductionism in medicine: could systems biology offer an alternative?
    • PID: 16681415
    • Ahn AC, Tewari M, Poon C-S, Phillips RS (2006) The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med 3:e208. doi:10.1371/journal.pmed.0030208
    • (2006) PLoS Med , vol.3 , pp. e208
    • Ahn, A.C.1    Tewari, M.2    Poon, C.-S.3    Phillips, R.S.4
  • 3
    • 79952740412 scopus 로고    scopus 로고
    • Age trajectories of physiological indices in relation to healthy life course
    • PID: 21262255
    • Arbeev KG et al (2011) Age trajectories of physiological indices in relation to healthy life course. Mech Ageing Dev 132:93–102. doi:10.1016/j.mad.2011.01.001
    • (2011) Mech Ageing Dev , vol.132 , pp. 93-102
    • Arbeev, K.G.1
  • 4
    • 38449123393 scopus 로고    scopus 로고
    • Appearances can be deceiving: phenotypes of knockout mice
    • COI: 1:CAS:528:DC%2BD2sXhtlSqurvK
    • Barbaric I, Miller G, Dear TN (2007) Appearances can be deceiving: phenotypes of knockout mice. Briefings in Functional Genomics & Proteomics 6:91–103. doi:10.1093/bfgp/elm008
    • (2007) Briefings in Functional Genomics & Proteomics , vol.6 , pp. 91-103
    • Barbaric, I.1    Miller, G.2    Dear, T.N.3
  • 5
    • 84906656463 scopus 로고    scopus 로고
    • The mitochondrial free radical theory of aging
    • PID: 25149212
    • Barja G (2014) The mitochondrial free radical theory of aging. Prog Mol Biol Transl Sci 127:1–27
    • (2014) Prog Mol Biol Transl Sci , vol.127 , pp. 1-27
    • Barja, G.1
  • 6
    • 0004224763 scopus 로고
    • The wisdom of the body. W W Norton & Co., New York
    • Cannon WB (1932) The wisdom of the body. W W Norton & Co., New York, NY, 312 pp
    • (1932) NY , pp. 312
    • Cannon, W.B.1
  • 7
    • 0000188718 scopus 로고    scopus 로고
    • Highly optimized tolerance: robustness and design in complex systems
    • COI: 1:CAS:528:DC%2BD3cXhs1Cmsb8%3D, PID: 11018927
    • Carlson JM, Doyle J (2000) Highly optimized tolerance: robustness and design in complex systems. Phys Rev Lett 84:2529
    • (2000) Phys Rev Lett , vol.84 , pp. 2529
    • Carlson, J.M.1    Doyle, J.2
  • 8
    • 0029059325 scopus 로고
    • Antioxidant vitamins affect food animal immunity and health
    • COI: 1:CAS:528:DyaK2MXmt1ahsb8%3D, PID: 7782950
    • Chew BP (1995) Antioxidant vitamins affect food animal immunity and health. J Nutr 125:1804S–1808S
    • (1995) J Nutr , vol.125 , pp. 1804S-1808S
    • Chew, B.P.1
  • 9
    • 0036864468 scopus 로고    scopus 로고
    • Roles of positive and negative feedback in biological systems
    • Cinquin O, Demongeot J (2002) Roles of positive and negative feedback in biological systems. CR Biol 325:1085–1095. doi:10.1016/s1631-0691(02)01533-0
    • (2002) CR Biol , vol.325 , pp. 1085-1095
    • Cinquin, O.1    Demongeot, J.2
  • 10
    • 84955419763 scopus 로고    scopus 로고
    • Cohen AA (Accepted) Taxonomic diversity, complexity, and the evolution of senescence. In: Shefferson R, Salguero-Gómez R, Jones OR (eds) The Evolution of Senescence in the Tree of Life. Cambridge University Press, Cambridge
    • Cohen AA (Accepted) Taxonomic diversity, complexity, and the evolution of senescence. In: Shefferson R, Salguero-Gómez R, Jones OR (eds) The Evolution of Senescence in the Tree of Life. Cambridge University Press, Cambridge
  • 11
    • 77949474959 scopus 로고    scopus 로고
    • The Summary Index of Malaria Surveillance (SIMS): a stable index of malaria within India
    • PID: 20181218
    • Cohen AA, Dhingra N, Jotkar R, Rodriguez P, Sharma V, Jha P (2010) The Summary Index of Malaria Surveillance (SIMS): a stable index of malaria within India. Population Health Metrics 8:1. doi:10.1186/1478-7954-8-1
    • (2010) Population Health Metrics , vol.8 , pp. 1
    • Cohen, A.A.1    Dhingra, N.2    Jotkar, R.3    Rodriguez, P.4    Sharma, V.5    Jha, P.6
  • 13
    • 84875050995 scopus 로고    scopus 로고
    • A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
    • PID: 23376244
    • Cohen AA, Milot E, Yong J, Seplaki CL, Fülöp T, Bandeen-Roche K, Fried LP (2013) A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech Ageing Dev 134:110–117. doi:10.1016/j.mad.2013.01.004
    • (2013) Mech Ageing Dev , vol.134 , pp. 110-117
    • Cohen, A.A.1    Milot, E.2    Yong, J.3    Seplaki, C.L.4    Fülöp, T.5    Bandeen-Roche, K.6    Fried, L.P.7
  • 14
    • 84902687035 scopus 로고    scopus 로고
    • Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
    • PID: 24802990
    • Cohen AA, Milot E, Li Q, Legault V, Fried LP, Ferrucci L (2014) Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Exp Gerontol 57:203–210. doi:10.1016/j.exger.2014.04.016
    • (2014) Exp Gerontol , vol.57 , pp. 203-210
    • Cohen, A.A.1    Milot, E.2    Li, Q.3    Legault, V.4    Fried, L.P.5    Ferrucci, L.6
  • 15
    • 84928795150 scopus 로고    scopus 로고
    • Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
    • PID: 25875923
    • Cohen AA et al (2015a) Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition. PloS One 10:e0122541
    • (2015) PloS One , vol.10 , pp. e0122541
    • Cohen, A.A.1
  • 16
    • 84924347534 scopus 로고    scopus 로고
    • detection of a novel integrative aging process suggests complex physiological integration
    • PID: 25761112
    • Cohen AA et al (2015b) detection of a novel integrative aging process suggests complex physiological integration. PloS One 10:e0116489
    • (2015) PloS One , vol.10 , pp. e0116489
    • Cohen, A.A.1
  • 17
    • 33748636462 scopus 로고    scopus 로고
    • Cellular networks and the aging process
    • COI: 1:CAS:528:DC%2BD2sXhvFGgs7o%3D, PID: 16931447
    • Csermely P, Sőti C (2006) Cellular networks and the aging process. Arch Physiol Biochem 112:60–64. doi:10.1080/13813450600711243
    • (2006) Arch Physiol Biochem , vol.112 , pp. 60-64
    • Csermely, P.1    Sőti, C.2
  • 18
    • 1242315665 scopus 로고    scopus 로고
    • How bioinformatics can help reverse engineer human aging
    • PID: 15177050
    • de Magalhães JP, Toussaint O (2004) How bioinformatics can help reverse engineer human aging. Ageing Res Rev 3:125–141. doi:10.1016/j.arr.2003.08.006
    • (2004) Ageing Res Rev , vol.3 , pp. 125-141
    • de Magalhães, J.P.1    Toussaint, O.2
  • 19
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    • PID: 19189975
    • de Magalhães JP, Curado J, Church GM (2009) Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25:875–881. doi:10.1093/bioinformatics/btp073
    • (2009) Bioinformatics , vol.25 , pp. 875-881
    • de Magalhães, J.P.1    Curado, J.2    Church, G.M.3
  • 20
    • 0036789926 scopus 로고    scopus 로고
    • Food-web structure and network theory: the role of connectance and size
    • COI: 1:CAS:528:DC%2BD38XnvFGht74%3D, PID: 12235364
    • Dunne JA, Williams RJ, Martinez ND (2002) Food-web structure and network theory: the role of connectance and size. Proc Natl Acad Sci 99:12917–12922. doi:10.1073/pnas.192407699
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 12917-12922
    • Dunne, J.A.1    Williams, R.J.2    Martinez, N.D.3
  • 21
    • 84955367191 scopus 로고    scopus 로고
    • Ekström J (2011) Mahalanobis’ Distance Beyond Normal Distributions
    • Ekström J (2011) Mahalanobis’ Distance Beyond Normal Distributions
  • 22
    • 14644416564 scopus 로고    scopus 로고
    • An Exciting Thought
    • Ferrucci L (2005) An Exciting Thought. J Gerontol Ser A 60:56. doi:10.1093/gerona/60.1.56
    • (2005) J Gerontol Ser A , vol.60 , pp. 56
    • Ferrucci, L.1
  • 24
    • 26944445566 scopus 로고    scopus 로고
    • From Bedside to bench: research agenda for frailty
    • Fried LP et al (2005) From Bedside to bench: research agenda for frailty. Sci Aging Knowl Environ. doi:10.1126/sageke.2005.31.pe24
    • (2005) Sci Aging Knowl Environ
    • Fried, L.P.1
  • 25
    • 69949102187 scopus 로고    scopus 로고
    • Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment
    • PID: 19567825
    • Fried LP et al (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64:1049–1057
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 1049-1057
    • Fried, L.P.1
  • 26
    • 84896394642 scopus 로고    scopus 로고
    • A systems analysis of age-related changes in some cardiac aging traits
    • COI: 1:STN:280:DC%2BC2c3msVCqsQ%3D%3D, PID: 24337960
    • Govindaraju D, Pencina K, Raj D, Massaro J, Carnes B, D’Agostino R (2014) A systems analysis of age-related changes in some cardiac aging traits. Biogerontology 15:139–152
    • (2014) Biogerontology , vol.15 , pp. 139-152
    • Govindaraju, D.1    Pencina, K.2    Raj, D.3    Massaro, J.4    Carnes, B.5    D’Agostino, R.6
  • 27
    • 0842277242 scopus 로고    scopus 로고
    • Definition of metabolic syndrome: report of the National Heart Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    • PID: 14744958
    • Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C, Participants ftC (2004) Definition of metabolic syndrome: report of the National Heart Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109:433–438. doi:10.1161/01.cir.0000111245.75752.c6
    • (2004) Circulation , vol.109 , pp. 433-438
    • Grundy, S.M.1    Brewer, H.B.2    Cleeman, J.I.3    Smith, S.C.4    Lenfant, C.5    Participants, C.6
  • 29
    • 84905005772 scopus 로고    scopus 로고
    • Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly Drosophila melanogaster
    • COI: 1:CAS:528:DC%2BC2cXht1aksr%2FN, PID: 24636523
    • Hoffman JM, Soltow QA, Li S, Sidik A, Jones DP, Promislow DE (2014) Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly Drosophila melanogaster. Aging Cell 13:596
    • (2014) Aging Cell , vol.13 , pp. 596
    • Hoffman, J.M.1    Soltow, Q.A.2    Li, S.3    Sidik, A.4    Jones, D.P.5    Promislow, D.E.6
  • 30
    • 0002143544 scopus 로고
    • Complex Adaptive Systems
    • Holland JH (1992) Complex Adaptive Systems. Daedalus 121:17–30. doi:10.2307/20025416
    • (1992) Daedalus , vol.121 , pp. 17-30
    • Holland, J.H.1
  • 31
    • 84908089693 scopus 로고    scopus 로고
    • Standard laboratory tests to identify older adults at increased risk of death
    • PID: 25288274
    • Howlett SE, Rockwood MR, Mitnitski A, Rockwood K (2014) Standard laboratory tests to identify older adults at increased risk of death. BMC Med 12:171. doi:10.1186/s12916-014-0171-9
    • (2014) BMC Med , vol.12 , pp. 171
    • Howlett, S.E.1    Rockwood, M.R.2    Mitnitski, A.3    Rockwood, K.4
  • 32
    • 9944262983 scopus 로고    scopus 로고
    • Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
    • Jüni P, Nartey L, Reichenbach S, Sterchi R, Dieppe PA, Egger M (2004) Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. The Lancet 364:2021–2029. doi:10.1016/S0140-6736(04)17514-4
    • (2004) The Lancet , vol.364 , pp. 2021-2029
    • Jüni, P.1    Nartey, L.2    Reichenbach, S.3    Sterchi, R.4    Dieppe, P.A.5    Egger, M.6
  • 33
    • 0036344567 scopus 로고    scopus 로고
    • Allostatic load as a predictor of functional decline: Macarthur studies of successful aging
    • PID: 12160918
    • Karlamangla AS, Singer BH, McEwen BS, Rowe JW, Seeman TE (2002) Allostatic load as a predictor of functional decline: Macarthur studies of successful aging. J Clin Epidemiol 55:696–710. doi:10.1016/s0895-4356(02)00399-2
    • (2002) J Clin Epidemiol , vol.55 , pp. 696-710
    • Karlamangla, A.S.1    Singer, B.H.2    McEwen, B.S.3    Rowe, J.W.4    Seeman, T.E.5
  • 35
    • 33747225640 scopus 로고    scopus 로고
    • Cellular automata models of complex biochemical systems
    • Biology, and Ecology, Springer, US
    • Kier LB, Witten TM (2005) Cellular automata models of complex biochemical systems. In: Bonchev D, Rouvray DH (eds) Complexity in Chemistry, Biology, and Ecology. Springer, US, pp 237–301
    • (2005) Complexity in Chemistry , pp. 237-301
    • Kier, L.B.1    Witten, T.M.2    Bonchev, D.3    Rouvray, D.H.4
  • 36
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • COI: 1:CAS:528:DC%2BD2MXitVWntbk%3D, PID: 15734677
    • Kirkwood TBL (2005) Understanding the odd science of aging. Cell 120:437–447. doi:10.1016/j.cell.2005.01.027
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.L.1
  • 37
    • 79251471783 scopus 로고    scopus 로고
    • Systems biology of ageing and longevity
    • Kirkwood TBL (2011) Systems biology of ageing and longevity. Philos Trans R Soc B 366:64–70. doi:10.1098/rstb.2010.0275
    • (2011) Philos Trans R Soc B , vol.366 , pp. 64-70
    • Kirkwood, T.B.L.1
  • 38
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: a brief overview
    • COI: 1:CAS:528:DC%2BD38Xhsleitb0%3D, PID: 11872829
    • Kitano H (2002) Systems biology: a brief overview. Science 295:1662–1664. doi:10.1126/science.1069492
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 39
    • 34548825690 scopus 로고    scopus 로고
    • Towards a theory of biological robustness
    • PID: 17882156
    • Kitano H (2007) Towards a theory of biological robustness. Mol Syst Biol 3:137
    • (2007) Mol Syst Biol , vol.3 , pp. 137
    • Kitano, H.1
  • 40
    • 32244445440 scopus 로고    scopus 로고
    • A new approach to the concept and computation of biological age
    • PID: 16318865
    • Klemera P, Doubal S (2006) A new approach to the concept and computation of biological age. Mech Ageing Dev 127:240–248
    • (2006) Mech Ageing Dev , vol.127 , pp. 240-248
    • Klemera, P.1    Doubal, S.2
  • 42
    • 0029890534 scopus 로고    scopus 로고
    • A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
    • COI: 1:CAS:528:DyaK28Xjs1Wrurw%3D
    • Kowald A, Kirkwood TBL (1996) A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutation Research/DNAging 316:209–236. doi:10.1016/S0921-8734(96)90005-3
    • (1996) Mutation Research/DNAging , vol.316 , pp. 209-236
    • Kowald, A.1    Kirkwood, T.B.L.2
  • 43
    • 84876794933 scopus 로고    scopus 로고
    • Robustness and aging—a systems-level perspective
    • PID: 23562399
    • Kriete A (2013) Robustness and aging—a systems-level perspective. Biosystems 112:37–48
    • (2013) Biosystems , vol.112 , pp. 37-48
    • Kriete, A.1
  • 44
    • 77955476576 scopus 로고    scopus 로고
    • Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses
    • PID: 20585546
    • Kriete A, Bosl WJ, Booker G (2010) Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput Biol 6:e1000820
    • (2010) PLoS Comput Biol , vol.6 , pp. e1000820
    • Kriete, A.1    Bosl, W.J.2    Booker, G.3
  • 46
    • 60549111634 scopus 로고    scopus 로고
    • WGCNA: an R package for weighted correlation network analysis
    • Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinform 9:559
    • (2008) BMC Bioinform , vol.9 , pp. 559
    • Langfelder, P.1    Horvath, S.2
  • 47
    • 84878297204 scopus 로고    scopus 로고
    • Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?
    • Levine ME (2013) Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age? J Gerontol Ser A 68:667–674
    • (2013) J Gerontol Ser A , vol.68 , pp. 667-674
    • Levine, M.E.1
  • 48
    • 84955399596 scopus 로고    scopus 로고
    • Li Q, Wang S, Milot E, Bergeron P, Ferrucci L, Fried LP, Cohen AA (in press) Homeostatic dysregulation proceeds in parallel in multiple physiological systems Aging Cell
    • Li Q, Wang S, Milot E, Bergeron P, Ferrucci L, Fried LP, Cohen AA (in press) Homeostatic dysregulation proceeds in parallel in multiple physiological systems Aging Cell
  • 49
    • 2342487417 scopus 로고    scopus 로고
    • Physiological Complexity, Aging, and the Path to Frailty
    • Lipsitz LA (2004) Physiological Complexity, Aging, and the Path to Frailty. Sci Aging Knowl Environ 16:pe16. doi:10.1126/sageke.2004.16.pe16
    • (2004) Sci Aging Knowl Environ , vol.16 , pp. pe16
    • Lipsitz, L.A.1
  • 50
    • 0026534404 scopus 로고
    • Loss of ‘complexity’ and aging: potential applications of fractals and chaos theory to senescence
    • COI: 1:STN:280:DyaK387osF2muw%3D%3D, PID: 1482430
    • Lipsitz LA, Goldberger AL (1992) Loss of ‘complexity’ and aging: potential applications of fractals and chaos theory to senescence. JAMA 267:1806–1809
    • (1992) JAMA , vol.267 , pp. 1806-1809
    • Lipsitz, L.A.1    Goldberger, A.L.2
  • 51
    • 0033147626 scopus 로고    scopus 로고
    • Multivariate analysis by data depth: descriptive statistics, graphics and inference,(with discussion and a rejoinder by Liu and Singh)
    • Liu RY, Parelius JM, Singh K (1999) Multivariate analysis by data depth: descriptive statistics, graphics and inference,(with discussion and a rejoinder by Liu and Singh). Ann Stat 27:783–858
    • (1999) Ann Stat , vol.27 , pp. 783-858
    • Liu, R.Y.1    Parelius, J.M.2    Singh, K.3
  • 52
    • 84902242629 scopus 로고    scopus 로고
    • Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers The
    • COI: 1:CAS:528:DC%2BC2cXhtVaks73N, PID: 24418792
    • Ludlow AT, Spangenburg EE, Chin ER, Cheng W-H, Roth SM (2014) Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers The. J Gerontol A Biol Sci Med Sci 69:821–830
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 821-830
    • Ludlow, A.T.1    Spangenburg, E.E.2    Chin, E.R.3    Cheng, W.-H.4    Roth, S.M.5
  • 54
    • 84880508860 scopus 로고    scopus 로고
    • Physiologic complexity and aging: implications for physical function and rehabilitation
    • PID: 22985940
    • Manor B, Lipsitz LA (2013) Physiologic complexity and aging: implications for physical function and rehabilitation. Prog Neuropsychopharmacol Biol Psychiatry 45:287–293. doi:10.1016/j.pnpbp.2012.08.020
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.45 , pp. 287-293
    • Manor, B.1    Lipsitz, L.A.2
  • 55
    • 80053262092 scopus 로고    scopus 로고
    • Integrator Networks: illuminating the black box linking genotype and phenotype
    • PID: 21705794
    • Martin LB, Liebl AL, Trotter JH, Richards CL, McCoy K, McCoy MW (2011) Integrator Networks: illuminating the black box linking genotype and phenotype. Integr Comp Biol 51:514–527. doi:10.1093/icb/icr049
    • (2011) Integr Comp Biol , vol.51 , pp. 514-527
    • Martin, L.B.1    Liebl, A.L.2    Trotter, J.H.3    Richards, C.L.4    McCoy, K.5    McCoy, M.W.6
  • 56
    • 0032078238 scopus 로고    scopus 로고
    • Stress adaptation, and disease: allostasis and allostatic load
    • COI: 1:STN:280:DyaK1c3pt1ykuw%3D%3D, PID: 9629234
    • McEwen BS (1998) Stress adaptation, and disease: allostasis and allostatic load. Ann N Y Acad Sci 840:33–44
    • (1998) Ann N Y Acad Sci , vol.840 , pp. 33-44
    • McEwen, B.S.1
  • 57
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of ageing
    • COI: 1:STN:280:DyaK3czotFentg%3D%3D, PID: 2205304
    • Medvedev ZA (1990) An attempt at a rational classification of theories of ageing. Biol Rev 65:375–398. doi:10.1111/j.1469-185X.1990.tb01428.x
    • (1990) Biol Rev , vol.65 , pp. 375-398
    • Medvedev, Z.A.1
  • 58
    • 84893960255 scopus 로고    scopus 로고
    • A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
    • Milot E, Cohen AA, Vézina F, Buehler DM, Matson KD, Piersma T (2014a) A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods Ecol Evol 5:146–155. doi:10.1111/2041-210x.12145
    • (2014) Methods Ecol Evol , vol.5 , pp. 146-155
    • Milot, E.1    Cohen, A.A.2    Vézina, F.3    Buehler, D.M.4    Matson, K.D.5    Piersma, T.6
  • 59
    • 84949116267 scopus 로고    scopus 로고
    • Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
    • PID: 25454986
    • Milot E, Morissette-Thomas V, Li Q, Fried LP, Ferrucci L, Cohen AA (2014b) Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech Ageing Dev 141–142:56–63. doi:10.1016/j.mad.2014.10.001
    • (2014) Mech Ageing Dev , vol.141-142 , pp. 56-63
    • Milot, E.1    Morissette-Thomas, V.2    Li, Q.3    Fried, L.P.4    Ferrucci, L.5    Cohen, A.A.6
  • 60
    • 84904746130 scopus 로고    scopus 로고
    • Inflamm-aging does not simply reflect increases in pro-inflammatory markers
    • COI: 1:CAS:528:DC%2BC2cXhtlSqsLjJ, PID: 25011077
    • Morrisette-Thomas V et al (2014) Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev 139:49–57. doi:10.1016/j.mad.2014.06.005
    • (2014) Mech Ageing Dev , vol.139 , pp. 49-57
    • Morrisette-Thomas, V.1
  • 61
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • COI: 1:CAS:528:DC%2BD2cXhtVOjsL3K, PID: 15514116
    • Nemeth E et al (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090–2093. doi:10.1126/science.1104742
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1
  • 62
    • 1342289563 scopus 로고    scopus 로고
    • Bmi1, stem cells, and senescence regulation
    • COI: 1:CAS:528:DC%2BD2cXmsVyrsg%3D%3D, PID: 14722607
    • Park I-K, Morrison SJ, Clarke MF (2004) Bmi1, stem cells, and senescence regulation. J Clin Investig 113:175–179
    • (2004) J Clin Investig , vol.113 , pp. 175-179
    • Park, I.-K.1    Morrison, S.J.2    Clarke, M.F.3
  • 63
    • 84875645464 scopus 로고    scopus 로고
    • Network Class Superposition Analyses
    • COI: 1:CAS:528:DC%2BC3sXmtVeiur8%3D, PID: 23565141
    • Pearson CA, Zeng C, Simha R (2013) Network Class Superposition Analyses. PloS one 8:e59046
    • (2013) PloS one , vol.8 , pp. e59046
    • Pearson, C.A.1    Zeng, C.2    Simha, R.3
  • 64
    • 37749029855 scopus 로고    scopus 로고
    • Hormesis in aging
    • PID: 17964227
    • Rattan SIS (2008) Hormesis in aging. Ageing Res Rev 7:63–78. doi:10.1016/j.arr.2007.03.002
    • (2008) Ageing Res Rev , vol.7 , pp. 63-78
    • Rattan, S.I.S.1
  • 66
    • 84955336025 scopus 로고    scopus 로고
    • Serme YK, Abdelouahab N, Pasquier J-C, Cohen AA, Takser L (Submitted) Maternal polybrominated diphenyl ether levels in early pregnancy do not predict birth weight in the Canadian birth cohort GESTE
    • Serme YK, Abdelouahab N, Pasquier J-C, Cohen AA, Takser L (Submitted) Maternal polybrominated diphenyl ether levels in early pregnancy do not predict birth weight in the Canadian birth cohort GESTE
  • 67
    • 20144377464 scopus 로고    scopus 로고
    • A comparative analysis of measurement approaches for physiological dysregulation in an older population
    • PID: 15919596
    • Seplaki CL, Goldman N, Glei D, Weinstein M (2005) A comparative analysis of measurement approaches for physiological dysregulation in an older population. Exp Gerontol 40:438–449. doi:10.1016/j.exger.2005.03.002
    • (2005) Exp Gerontol , vol.40 , pp. 438-449
    • Seplaki, C.L.1    Goldman, N.2    Glei, D.3    Weinstein, M.4
  • 70
    • 74249118093 scopus 로고    scopus 로고
    • Aging mice show a decreasing correlation of gene expression within genetic modules
    • PID: 20019809
    • Southworth LK, Owen AB, Kim SK (2009) Aging mice show a decreasing correlation of gene expression within genetic modules. PLoS Genet 5:e1000776
    • (2009) PLoS Genet , vol.5 , pp. e1000776
    • Southworth, L.K.1    Owen, A.B.2    Kim, S.K.3
  • 71
    • 51749113333 scopus 로고    scopus 로고
    • Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring
    • PID: 18799892
    • Suvorov A, Girard S, Lachapelle S, Abdelouahab N, Sebire G, Takser L (2008) Perinatal exposure to low-dose BDE-47, an emergent environmental contaminant, causes hyperactivity in rat offspring. Neonatology 95:203–209
    • (2008) Neonatology , vol.95 , pp. 203-209
    • Suvorov, A.1    Girard, S.2    Lachapelle, S.3    Abdelouahab, N.4    Sebire, G.5    Takser, L.6
  • 72
    • 30744467580 scopus 로고    scopus 로고
    • Physiology of Aging
    • Cassel CK, Leipzig RM, Cohen HJ, Larson EB, Meier DE, Capello CF, (eds), Springer, New York
    • Taffett GE (2003) Physiology of Aging. In: Cassel CK, Leipzig RM, Cohen HJ, Larson EB, Meier DE, Capello CF (eds) Geriatric Medicine. Springer, New York, pp 27–35. doi:10.1007/0-387-22621-4_3
    • (2003) Geriatric Medicine , pp. 27-35
    • Taffett, G.E.1
  • 73
    • 0141790263 scopus 로고    scopus 로고
    • Invited review: theories of aging
    • COI: 1:CAS:528:DC%2BD3sXotFyrtrY%3D, PID: 12970376
    • Weinert BT, Timiras PS (2003) Invited review: theories of aging. J Appl Physiol 95:1706–1716
    • (2003) J Appl Physiol , vol.95 , pp. 1706-1716
    • Weinert, B.T.1    Timiras, P.S.2
  • 74
    • 84896725382 scopus 로고    scopus 로고
    • No senescence despite declining selection pressure: Hamilton’s result in broader perspective
    • PID: 24316386
    • Wensink MJ, Wrycza TF, Baudisch A (2014) No senescence despite declining selection pressure: Hamilton’s result in broader perspective. J Theor Biol 347:176–181. doi:10.1016/j.jtbi.2013.11.016
    • (2014) J Theor Biol , vol.347 , pp. 176-181
    • Wensink, M.J.1    Wrycza, T.F.2    Baudisch, A.3
  • 75
    • 64949135371 scopus 로고    scopus 로고
    • Toward a Systems Biology Framework for understanding aging and health span
    • West GB, Bergman A (2009) Toward a Systems Biology Framework for understanding aging and health span. J Gerontol A Biol Sci Med Sci 64A:205–208. doi:10.1093/gerona/gln066
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64A , pp. 205-208
    • West, G.B.1    Bergman, A.2
  • 77
    • 36849004497 scopus 로고    scopus 로고
    • A modular network model of aging
    • PID: 18059442
    • Xue H et al (2007) A modular network model of aging. Mol Syst Biol. doi:10.1038/msb4100189
    • (2007) Mol Syst Biol
    • Xue, H.1
  • 78
    • 84955409251 scopus 로고    scopus 로고
    • Yashin AI et al. (2010) Dynamic determinants of longevity and exceptional health Current Gerontology and Geriatrics Research 2010
    • Yashin AI et al. (2010) Dynamic determinants of longevity and exceptional health Current Gerontology and Geriatrics Research 2010
  • 79
    • 84955330993 scopus 로고    scopus 로고
    • Zhang B, Horvath S (2005) A general framework for weighted gene co-expression network analysis Statistical applications in genetics and molecular biology 4
    • Zhang B, Horvath S (2005) A general framework for weighted gene co-expression network analysis Statistical applications in genetics and molecular biology 4
  • 80
    • 0035035416 scopus 로고    scopus 로고
    • Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats
    • COI: 1:CAS:528:DC%2BD3MXjtV2rs7Y%3D, PID: 11294977
    • Zhou T, Ross DG, DeVito MJ, Crofton KM (2001) Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 61:76–82. doi:10.1093/toxsci/61.1.76
    • (2001) Toxicol Sci , vol.61 , pp. 76-82
    • Zhou, T.1    Ross, D.G.2    DeVito, M.J.3    Crofton, K.M.4


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