Physiologic complexity and aging: Implications for physical function and rehabilitation

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 45, Issue , 2013, Pages 287-293

  Manor, Brad ^a,b,c   Lipsitz, Lewis A ^a,b,c,d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^d Hebrew Senior Life   (United States)

Author keywords

Cardiovascular; Complexity; Multiscale entropy; Nonlinear; Postural control

Indexed keywords

AGING; ARTICLE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; EXERCISE TEST; FORCE; GERIATRIC REHABILITATION; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART RATE; HUMAN; MEASUREMENT ERROR; MENTAL DISEASE; MOTOR CONTROL; MUSCULOSKELETAL SYSTEM; NOISE; PHYSIOLOGY; SOMATOSENSORY DISORDER; STIMULUS; STRESS; TRAUMATIC BRAIN INJURY; VISUAL IMPAIRMENT;

BLOOD-OXYGEN LEVEL DEPENDENT; BOLD; CARDIOVASCULAR; COMPLEXITY; MAGNETIC RESONANCE IMAGING; MAGNETOENCEPHALOGRAPHY; MEG; MRI; MSE; MULTI-SCALE ENTROPY; MULTISCALE ENTROPY; NONLINEAR; POSTURAL CONTROL;

ADAPTATION, PHYSIOLOGICAL; AGING; HUMANS; NONLINEAR DYNAMICS; PHYSIOLOGICAL PROCESSES;

EID: 84880508860     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.08.020     Document Type: Article

References (70)

1. Angelini L., Maestri R., Marinazzo D., Nitti L., Pellicoro M., Pinna G.D., et al. Multiscale analysis of short term heart beat interval, arterial blood pressure, and instantaneous lung volume time series. Artif Intell Med 2007, 41:237-250.
2. Beckers F., Verheyden B., Aubert A.E. Aging and nonlinear heart rate control in a healthy population. Am J Physiol Heart Circ Physiol 2006, 290:H2560-H2570.
3. Bullmore E., Sporns O. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 2009, 10:186-198.
4. Castiglioni P., Parati G., Di R.M., Carabalona R., Cividjian A., Quintin L. Scale exponents of blood pressure and heart rate during autonomic blockade as assessed by detrended fluctuation analysis. J Physiol 2011, 589:355-369.
5. Collins J.J., Priplata A.A., Gravelle D.C., Niemi J., Harry J., Lipsitz L.A. Noise-enhanced human sensorimotor function. IEEE Eng Med Biol Mag 2003, 22:76-83.
6. Costa M., Goldberger A.L., Peng C.K. Multiscale entropy analysis of complex physiologic time series. Phys Rev Lett 2002, 89:068102.
7. Costa M., Priplata A.A., Lipsitz L.A., Wu Z., Huang N.E., Goldberger A.L., et al. Noise and poise: enhancement of postural complexity in the elderly with a stochastic-resonance-based therapy. Europhys Lett 2007, 77:68008.
8. Costa M., Ghiran I., Peng C.K., Nicholson-Weller A., Goldberger A.L. Complex dynamics of human red blood cell flickering: alterations with in vivo aging. Phys Rev E Stat Nonlin Soft Matter Phys 2008, 78:020901.
9. Duarte M., Sternad D. Complexity of human postural control in young and older adults during prolonged standing. Exp Brain Res 2008, 191:265-276.
10. Goldberger A.L., Amaral L.A., Hausdorff J.M., Ivanov P.C., Peng C.K., Stanley H.E. Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci U S A 2002, 99(Suppl. 1):2466-2472.
11. Goldberger A.L., Peng C.K., Lipsitz L.A. What is physiologic complexity and how does it change with aging and disease?. Neurobiol Aging 2002, 23:23-26.
12. Gomez-Garcia J.A., Martinez-Vargas J.D., Castellanos-Dominguez G. Complexity-based analysis for the detection of heart murmurs. Conf Proc IEEE Eng Med Biol Soc 2011, 2011:2728-2731.
13. Grassberger P. Information dynamics 1991, Plenum, New York.
14. Hafstrom A., Fransson P.A., Karlberg M., Ledin T., Magnusson M. Visual influence on postural control, with and without visual motion feedback. Acta Otolaryngol 2002, 122:392-397.
15. Hartman M.L., Pincus S.M., Johnson M.L., Matthews D.H., Faunt L.M., Vance M.L., et al. Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release. J Clin Invest 1994, 94:1277-1288.
16. Hausdorff J.M., Peng C.K., Ladin Z., Wei J.Y., Goldberger A.L. Is walking a random walk? Evidence for long-range correlations in stride interval of human gait. J Appl Physiol 1995, 78:349-358.
17. Hausdorff J.M., Edelberg H.K., Mitchell S.L., Goldberger A.L., Wei J.Y. Increased gait unsteadiness in community-dwelling elderly fallers. Arch Phys Med Rehabil 1997, 78:278-283.
18. Hausdorff J.M., Mitchell S.L., Firtion R., Peng C.K., Cudkowicz M.E., Wei J.Y., et al. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. J Appl Physiol 1997, 82:262-269.
19. Heffernan K.S., Fahs C.A., Shinsako K.K., Jae S.Y., Fernhall B. Heart rate recovery and heart rate complexity following resistance exercise training and detraining in young men. Am J Physiol Heart Circ Physiol 2007, 293:H3180-H3186.
20. Herman T., Giladi N., Gurevich T., Hausdorff J.M. Gait instability and fractal dynamics of older adults with a "cautious" gait: why do certain older adults walk fearfully?. Gait Posture 2005, 21:178-185.
21. Higuchi T. Approach to an irregular time series on the basis of the fractal theory. Physica D 1988, 31:277-283.
22. Ho K.K., Moody G.B., Peng C.K., Mietus J.E., Larson M.G., Levy D., et al. Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics. Circulation 1997, 96:842-848.
23. Ho Y.L., Lin C., Lin Y.H., Lo M.T. The prognostic value of non-linear analysis of heart rate variability in patients with congestive heart failure-a pilot study of multiscale entropy. PLoS One 2011, 6:e18699.
24. Horak F., MacPherson J.M. Postural orientation and equilibrium. Handbook of physiology 1996, 255-292. Oxford University Press, New York. L.B. Rowell, J.T. Shepard (Eds.).
25. Hu K., Scheer F.A., Buijs R.M., Shea S.A. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24hours. J Biol Rhythms 2008, 23:265-273.
26. Iyengar N., Peng C.K., Morin R., Goldberger A.L., Lipsitz L.A. Age-related alterations in the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol 1996, 271:R1078-R1084.
27. Jartti T.T., Kuusela T.A., Kaila T.J., Tahvanainen K.U., Valimaki I.A. The dose-response effects of terbutaline on the variability, approximate entropy and fractal dimension of heart rate and blood pressure. Br J Clin Pharmacol 1998, 45:277-285.
28. Jordan K., Challis J.H., Newell K.M. Long range correlations in the stride interval of running. Gait Posture 2006, 24:120-125.
29. Kanaley J.A., Goulopoulou S., Franklin R.M., Baynard T., Holmstrup M.E., Carhart R., et al. Plasticity of heart rate signalling and complexity with exercise training in obese individuals with and without type 2 diabetes. Int J Obes (Lond) 2009, 33:1198-1206.
30. Kang H.G., Costa M.D., Priplata A.A., Starobinets O.V., Goldberger A.L., Peng C.K., et al. Frailty and the degradation of complex balance dynamics during a dual-task protocol. J Gerontol A Biol Sci Med Sci 2009, 64:1304-1311.
31. Kaplan D.T., Furman M.I., Pincus S.M., Ryan S.M., Lipsitz L.A., Goldberger A.L. Aging and the complexity of cardiovascular dynamics. Biophys J 1991, 59:945-949.
32. Lepoluoto A., Nino J., Tahvanainen K., Ylitalo R., Kuusela T., Kahonen M., et al. Propranolol increases the complexity of heart rate fluctuations-a mode of antiarrhythmic action?. Int J Clin Pharmacol Ther 2005, 43:101-108.
33. Leveille S.G., Kiel D.P., Jones R.N., Roman A., Hannan M.T., Sorond F.A., et al. The MOBILIZE Boston Study: design and methods of a prospective cohort study of novel risk factors for falls in an older population. BMC Geriatr 2008, 8:16.
34. Lipsitz L.A. Age-related changes in the "complexity" of cardiovascular dynamics: a potential marker of vulnerability to disease. Chaos 1995, 5:102-109.
35. Lipsitz L.A. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci 2002, 57:B115-B125.
36. Lipsitz L.A. Physiological complexity, aging, and the path to frailty. Sci Aging Knowledge Environ 2004, 2004:e16.
37. Lipsitz L.A., Goldberger A.L. Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA 1992, 267:1806-1809.
38. Lough M., Manor B., Gagnon M., Iloputaife I., Wayne P., Lipsitz L. Tai Chi training increases the complexity of standing postural control in frail older adults. J Am Geriatr Soc 2012, 60:S102-S103.
39. Maki B.E., McIlroy W.E. Postural control in the older adult. Clin Geriatr Med 1996, 12:635-658.
40. Makikallio T.H., Seppanen T., Airaksinen K.E., Koistinen J., Tulppo M.P., Peng C.K., et al. Dynamic analysis of heart rate may predict subsequent ventricular tachycardia after myocardial infarction. Am J Cardiol 1997, 80:779-783.
41. Makikallio T.H., Koistinen J., Jordaens L., Tulppo M.P., Wood N., Golosarsky B., et al. Heart rate dynamics before spontaneous onset of ventricular fibrillation in patients with healed myocardial infarcts. Am J Cardiol 1999, 83:880-884.
42. Manor B., Costa M.D., Hu K., Newton E., Starobinets O., Kang H.G., et al. Physiological complexity and system adaptability: evidence from postural control dynamics of older adults. J Appl Physiol 2010, 109:1786-1791.
43. Millar P.J., Levy A.S., McGowan C.L., McCartney N., Macdonald M.J. Isometric handgrip training lowers blood pressure and increases heart rate complexity in medicated hypertensive patients. Scand J Med Sci Sports 2012, 10.1111/j.1600-0838.2011.01435.x.
44. Norris P.R., Stein P.K., Morris J.A. Reduced heart rate multiscale entropy predicts death in critical illness: a study of physiologic complexity in 285 trauma patients. J Crit Care 2008, 23:399-405.
45. Peng C.K., Havlin S., Stanley H.E., Goldberger A.L. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos 1995, 5:82-87.
46. Peng C.K., Mietus J.E., Liu Y., Lee C., Hausdorff J.M., Stanley H.E., et al. Quantifying fractal dynamics of human respiration: age and gender effects. Ann Biomed Eng 2002, 30:683-692.
47. Peng C.K., Costa M., Goldberger A.L. Adaptive data analysis of complex fluctuations in physiologic time series. Adv Adapt Data Anal 2009, 1:61-70.
48. Pikkujamsa S.M., Makikallio T.H., Sourander L.B., Raiha I.J., Puukka P., Skytta J., et al. Cardiac interbeat interval dynamics from childhood to senescence: comparison of conventional and new measures based on fractals and chaos theory. Circulation 1999, 100:393-399.
49. Pincus S.M. Approximate entropy as a measure of system complexity. Proc Natl Acad Sci U S A 1991, 88:2297-2301.
50. Priplata A., Niemi J., Salen M., Harry J., Lipsitz L.A., Collins J.J. Noise-enhanced human balance control. Phys Rev Lett 2002, 89:238101.
51. Priplata A.A., Patritti B.L., Niemi J.B., Hughes R., Gravelle D.C., Lipsitz L.A., et al. Noise-enhanced balance control in patients with diabetes and patients with stroke. Ann Neurol 2006, 59:4-12.
52. Raja Beharelle A., Kovacevic N., McIntosh A.R., Levine B. Brain signal variability relates to stability of behavior after recovery from diffuse brain injury. Neuroimage 2012, 60:1528-1537.
53. Riley M.A., Clark S. Recurrence analysis of human postural sway during the sensory organization test. Neurosci Lett 2003, 342:45-48.
54. Sabatini A.M. Analysis of postural sway using entropy measures of signal complexity. Med Biol Eng Comput 2000, 38:617-624.
55. Scafetta N., Marchi D., West B.J. Understanding the complexity of human gait dynamics. Chaos 2009, 19:026108.
56. Seigle B., Ramdani S., Bernard P.L. Dynamical structure of center of pressure fluctuations in elderly people. Gait Posture 2009, 30:223-226.
57. Sosnoff J.J., Newell K.M. Age-related loss of adaptability to fast time scales in motor variability. J Gerontol B Psychol Sci Soc Sci 2008, 63:344-352.
58. Sun J., Tong S., Yang G.Y. Reorganization of brain networks in aging and age-related diseases. Aging Dis 2012, 3:181-193.
59. Takahashi T. Complexity of spontaneous brain activity in mental disorders. Prog Neuropsychopharmacol Biol Psychiatry 2012, 120:476-483.
60. Takahashi T., Cho R.Y., Murata T., Mizuno T., Kikuchi M., Mizukami K., et al. Age-related variation in EEG complexity to photic stimulation: a multiscale entropy analysis. Clin Neurophysiol 2009, 120:476-483.
61. Thurner S., Mittermaier C., Ehrenberger K. Change of complexity patterns in human posture during aging. Audiol Neurootol 2002, 7:240-248.
62. Tulppo M.P., Hughson R.L., Makikallio T.H., Airaksinen K.E., Seppanen T., Huikuri H.V. Effects of exercise and passive head-up tilt on fractal and complexity properties of heart rate dynamics. Am J Physiol Heart Circ Physiol 2001, 280:H1081-H1087.
63. Vaillancourt D.E., Newell K.M. Changing complexity in human behavior and physiology through aging and disease. Neurobiol Aging 2002, 23:1-11.
64. Vaillancourt D.E., Newell K.M. Aging and the time and frequency structure of force output variability. J Appl Physiol 2003, 94:903-912.
65. Vikman S., Makikallio T.H., Yli-Mayry S., Pikkujamsa S., Koivisto A.M., Reinikainen P., et al. Altered complexity and correlation properties of R-R interval dynamics before the spontaneous onset of paroxysmal atrial fibrillation. Circulation 1999, 100:2079-2084.
66. Wayne P.M., Kaptchuk T.J. Challenges inherent to t'ai chi research: part I-t'ai chi as a complex multicomponent intervention. J Altern Complement Med 2008, 14:95-102.
67. Wayne P.M., Kaptchuk T.J. Challenges inherent to t'ai chi research: part II-defining the intervention and optimal study design. J Altern Complement Med 2008, 14:191-197.
68. Webber C.L., Zbilut J.P. Dynamical assessment of physiological systems and states using recurrence plot strategies. J Appl Physiol 1994, 76:965-973.
69. Winter D.A., Patla A.E., Frank J.S. Assessment of balance control in humans. Med Prog Technol 1990, 16:31-51.
70. Yang A.C., Huang C.C., Yeh H.L., Liu M.E., Hong C.J., Tu P.C., et al. Complexity of spontaneous BOLD activity in default mode network is correlated with cognitive function in normal male elderly: a multiscale entropy analysis. Neurobiol Aging 2012, [Epub ahead of print].