Modeling the rate of senescence: Can estimated biological age predict mortality more accurately than chronological age?

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 6, 2013, Pages 667-674

  Levine, Morgan E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Biological age; Biomarkers; Mortality

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; AGING; ALGORITHM; ARTICLE; BIOLOGICAL AGE; BIOMARKERS; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; EPIDEMIOLOGY; FEMALE; FOLLOW UP; HUMAN; LIFE EXPECTANCY; MALE; MIDDLE AGED; MORTALITY; MORTALITY.; REPRODUCIBILITY; THEORETICAL MODEL;

BIOLOGICAL AGE; BIOMARKERS; MORTALITY.;

ADULT; AGED; AGING; ALGORITHMS; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIFE EXPECTANCY; MALE; MIDDLE AGED; MODELS, THEORETICAL; MORTALITY; REPRODUCIBILITY OF RESULTS; SAMPLING STUDIES;

EID: 84878297204     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls233     Document Type: Article

References (35)

1. Yin D, Chen K. The essential mechanisms of aging: Irreparable damage accumulation of biochemical side-reactions. Exp Gerontol. 2005;40:455-465.
2. Hayflick L. Biological aging is no longer an unsolved problem. Ann N Y Acad Sci. 2007;1100:1-13. doi:10.1196/annals.1395.001
3. Yashin AI, Manton KG, Vaupel JW. Mortality and aging in a heterogeneous population: a stochastic process model with observed and unobserved variables. Theor Popul Biol. 1985;27:154-175.
4. Comfort A. Test-battery to measure ageing-rate in man. Lancet. 1969;2:1411-1415.
5. Kirkwood TB. Alex Comfort and the measure of aging. Exp Gerontol. 1998;33:135-140.
6. Johnson TE. Recent results: biomarkers of aging. Exp Gerontol. 2006;41:1243-1246.
7. Sprott RL. Biomarkers of aging and disease: introduction and definitions. Exp Gerontol. 2010;45:2-4.
8. Hollingsworth JW, Hashizume A, Jablon S. Correlations between tests of aging in Hiroshima subjects-An attempt to define "physiologic age". Yale J Biol Med. 1965;38:11-26.
9. Takeda H, Inada H, Inoue M, Yoshikawa H, Abe H. Evaluation of biological age and physical age by multiple regression analysis. Med Inform (Lond). 1982;7:221-227.
10. Krøll J, Saxtrup O. On the use of regression analysis for the estimation of human biological age. Biogerontology. 2000;1:363-368.
11. Bae CY, Kang YG, Kim S, et al. Development of models for predicting biological age (BA) with physical, biochemical, and hormonal parameters. Arch Gerontol Geriatr. 2008;47:253-265.
12. Hofecker G, Skalicky M, Kment A, Niedermüller H. Models of the biological age of the rat. I. A factor model of age parameters. Mech Ageing Dev. 1980;14:345-359.
13. Nakamura E, Miyao K, Ozeki T. Assessment of biological age by principal component analysis. Mech Ageing Dev. 1988;46:1-18.
14. Nakamura E, Miyao K. A method for identifying biomarkers of aging and constructing an index of biological age in humans. J Gerontol A Biol Sci Med Sci. 2007;62:1096-1105.
15. MacDonald SW, Dixon RA, Cohen AL, Hazlitt JE. Biological age and 12-year cognitive change in older adults: findings from the Victoria Longitudinal Study. Gerontology. 2004;50:64-81.
16. Klemera P, Doubal S. A new approach to the concept and computation of biological age. Mech Ageing Dev. 2006;127:240-248.
17. Cho IH, Park KS, Lim CJ. An empirical comparative study on biological age estimation algorithms with an application of Work Ability Index (WAI). Mech Ageing Dev. 2010;131:69-78.
18. Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr. 2002;2:1.
19. Kulminski AM, Ukraintseva SV, Culminskaya IV, et al. Cumulative deficits and physiological indices as predictors of mortality and long life. J Gerontol A Biol Sci Med Sci. 2008;63:1053-1059.
20. Seplaki CL, Goldman N, Glei D, Weinstein M. A comparative analysis of measurement approaches for physiological dysregulation in an older population. Exp Gerontol. 2005;40:438-449.
21. Butler RN, Sprott R, Warner H, et al. Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci. 2004;59: B560-B567.
22. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: CDC. http://www.cdc. gov/nchs/nhanes/nh3data.htm
23. Crimmins E, Vasunilashorn S, Kim JK, Alley D. Biomarkers related to aging in human populations. Adv Clin Chem. 2008;46:161-216.
24. Ingram DK. Key questions in developing biomarkers of aging. Exp Gerontol. 1988;23:429-434.
25. Starr JM, Shiels PG, Harris SE, et al. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mech Ageing Dev. 2008;129: 745-751.
26. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-495.
27. Krishnamurthy J, Torrice C, Ramsey MR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004;114:1299-1307.
28. Martin-Ruiz C, Jagger C, Kingston A, et al. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech Ageing Dev. 2011;132:496-502.
29. Kirkwood TB, Austad SN. Why do we age? Nature. 2000;408: 233-238.
30. Masoro EJ. Caloric restriction and aging: an update. Exp Gerontol. 2000;35:299-305.
31. Kenyon C. A conserved regulatory system for aging. Cell. 2001;105:165-168.
32. Verbeke P, Fonager J, Clark BF, Rattan SI. Heat shock response and ageing: mechanisms and applications. Cell Biol Int. 2001;25: 845-857.
33. McEwen BS. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002;23:921-939.
34. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008; 4:89-96.
35. Karasik D, Demissie S, Cupples LA, Kiel DP. Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures. J Gerontol A Biol Sci Med Sci. 2005;60:574-587.