Cross-clade protective immune responses of NS1-truncated live attenuated H5N1 avian influenza vaccines

Vaccine

Volumn 34, Issue 3, 2016, Pages 350-357

  Shi, Shaohua ^a,b,c   Chen, Sujuan ^a,b   Han, Weizhou ^a,b   Wu, Bai ^a,b   Zhang, Xiaojian ^a,b   Tang, Ying ^a,b   Wang, Xiao ^a,b   Zhu, Yinbiao ^a,b   Peng, Daxin ^a,b   Liu, Xiufan ^a,b  

^a YANGZHOU UNIVERSITY   (China)

^b Jiangsu Research Center of Eng and Technology for the Prevention and Control of Poultry Disease   (China)

^c INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Cross protection; H5N1 avian influenza; Live attenuated vaccine; NS1

Indexed keywords

AVIAN INFLUENZA VACCINE; BETA INTERFERON; LIVE VACCINE; NONSTRUCTURAL PROTEIN 1; RECOMBINANT S HALO NS48 VACCINE; RECOMBINANT S HALO NS70 VACCINE; RECOMBINANT S HALO NS73 VACCINE; RECOMBINANT S HALO NS99 VACCINE; UNCLASSIFIED DRUG; HEMAGGLUTININ, AVIAN INFLUENZA A VIRUS; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; INS1 PROTEIN, INFLUENZA VIRUS; VIRAL PROTEIN; VIRULENCE FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA (H5N1); AVIAN INFLUENZA VIRUS; CHICKEN MODEL; CLADISTICS; CONTROLLED STUDY; CROSS PROTECTION; DRUG EFFICACY; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; CHICKEN; GENE DELETION; GENETICS; IMMUNOLOGY; INFLUENZA A VIRUS (H5N1); ORTHOMYXOVIRIDAE INFECTIONS;

ANIMALS; CHICKENS; CROSS PROTECTION; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; SEQUENCE DELETION; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

EID: 84955340191     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.11.045     Document Type: Article

References (42)

1. Jiang W.M., Liu S., Chen J., Hou G.Y., Li J.P., Cao Y.F., et al. Molecular epidemiological surveys of H5 subtype highly pathogenic avian influenza viruses in poultry in China during 2007-2009. J Gen Virol 2010, 91:2491-2496.
2. Zhao G., Gu X., Lu X., Pan J., Duan Z., Zhao K., et al. Novel reassortant highly pathogenic H5N2 avian influenza viruses in poultry in China. PLoS ONE 2012, 7:e46183.
3. Gu M., Liu W., Cao Y., Peng D., Wang X., Wan H., et al. Novel reassortant highly pathogenic avian influenza (H5N5) viruses in domestic ducks, China. Emerg Infect Dis 2011, 17:1060-1063.
4. Bi Y., Mei K., Shi W., Liu D., Yu X., Gao Z., et al. Two novel reassortants of avian influenza A (H5N6) virus in China. J Gen Virol 2015, 96:975-981.
5. Wu H., Peng X., Xu L., Jin C., Cheng L., Lu X., et al. Novel reassortant influenza A(H5N8) viruses in domestic ducks, eastern China. Emerg Infect Dis 2014, 20:1315-1318.
6. Ellis T.M., Leung C.Y., Chow M.K., Bissett L.A., Wong W., Guan Y., et al. Vaccination of chickens against H5N1 avian influenza in the face of an outbreak interrupts virus transmission. Avian Pathol 2004, 33:405-412.
7. Wareing M.D., Tannock G.A. Live attenuated vaccines against influenza; an historical review. Vaccine 2001, 19:3320-3330.
8. Murphy B.R., Chalhub E.G., Nusinoff S.R., Chanock R.M. Temperature-sensitive mutants of influenza virus II. Attenuation of ts recombinants for man. J Infect Dis 1972, 126:170-178.
9. Song H., Nieto G.R., Perez D.R. A new generation of modified live-attenuated avian influenza viruses using a two-strategy combination as potential vaccine candidates. J Virol 2007, 81:9238-9248.
10. Cai Y., Song H., Ye J., Shao H., Padmanabhan R., Sutton T.C., et al. Improved hatchability and efficient protection after in ovo vaccination with live-attenuated H7N2 and H9N2 avian influenza viruses. Virol J 2011, 8:31.
11. Chen G.L., Lamirande E.W., Jin H., Kemble G., Subbarao K. Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets. Virology 2010, 398:109-114.
12. Palese P., Shaw M.L. Orthomyxoviridae: the viruses and their replication. Fields virology 2006, 1648-1689. Lippencott Williams and Wilkins, Philadelphia, PA. D.M. Knipe, P.M. Howley (Eds.).
13. Garcia-Sastre A., Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 2006, 312:879-882.
14. Kochs G., Garcia-Sastre A., Martinez-Sobrido L. Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol 2007, 81:7011-7021.
15. Mibayashi M., Martinez-Sobrido L., Loo Y.M., Cardenas W.B., Gale M., Garcia-Sastre A. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 2007, 81:514-524.
16. Fernandez-Sesma A., Marukian S., Ebersole B.J., Kaminski D., Park M.S., Yuen T., et al. Influenza virus evades innate and adaptive immunity via the NS1 protein. J Virol 2006, 80:6295-6304.
17. Garcia-Sastre A., Egorov A., Matassov D., Brandt S., Levy D.E., Durbin J.E., et al. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 1998, 252:324-330.
18. Talon J., Salvatore M., O'Neill R.E., Nakaya Y., Zheng H., Muster T., et al. Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proc Natl Acad Sci USA 2000, 97:4309-4314.
19. Hai R., Martinez-Sobrido L., Fraser K.A., Ayllon J., Garcia-Sastre A., Palese P. Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach. J Virol 2008, 82:10580-10590.
20. Richt J.A., Lekcharoensuk P., Lager K.M., Vincent A.L., Loiacono C.M., Janke B.H., et al. Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. J Virol 2006, 80:11009-11018.
21. Solorzano A., Webby R.J., Lager K.M., Janke B.H., Garcia-Sastre A., Richt J.A. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol 2005, 79:7535-7543.
22. Quinlivan M., Zamarin D., Garcia-Sastre A., Cullinane A., Chambers T., Palese P. Attenuation of equine influenza viruses through truncations of the NS1 protein. J Virol 2005, 79:8431-8439.
23. Baskin C.R., Bielefeldt-Ohmann H., Garcia-Sastre A., Tumpey T.M., Van Hoeven N., Carter V.S., et al. Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J Virol 2007, 81:11817-11827.
24. Steel J., Lowen A.C., Pena L., Angel M., Solorzano A., Albrecht R., et al. Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza. J Virol 2009, 83:1742-1753.
25. Wang L., Suarez D.L., Pantin-Jackwood M., Mibayashi M., Garcia-Sastre A., Saif Y.M., et al. Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry. Vaccine 2008, 26:3580-3586.
26. Tang Y., Wu P., Sun Q., Peng D., Zhang W., Li Y., et al. Role of amino acid residues at positions 322 and 329 of hemagglutinin in virulence of H5N1 avian influenza virus. Bing du xue bao 2008, 24:340-344.
27. Zhang W., Xue T., Wu X., Zhang P., Zhao G., Peng D., et al. Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk. Vaccine 2011, 29:8032-8041.
28. Hu J., Hu Z., Mo Y., Wu Q., Cui Z., Duan Z., et al. The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks. J Virol 2013, 87:11063-11075.
29. Cikos S., Bukovska A., Koppel J. Relative quantification of mRNA: comparison of methods currently used for real-time PCR data analysis. BMC Mol Biol 2007, 8:113.
30. Reed L.J., Muench H. A simple method of estimating fifty per cent endpoints. Am J Epidemiol 1938, 27:493-497.
31. http://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.03.04_AI.pdf.
32. Cauthen A.N., Swayne D.E., Sekellick M.J., Marcus P.I., Suarez D.L. Amelioration of influenza virus pathogenesis in chickens attributed to the enhanced interferon-inducing capacity of a virus with a truncated NS1 gene. J Virol 2007, 81:1838-1847.
33. Egorov A., Brandt S., Sereinig S., Romanova J., Ferko B., Katinger D., et al. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J Virol 1998, 72:6437-6441.
34. Hale B.G., Randall R.E., Ortin J., Jackson D. The multifunctional NS1 protein of influenza A viruses. J Gen Virol 2008, 89:2359-2376.
35. Van Hoeven N., Belser J.A., Szretter K.J., Zeng H., Staeheli P., Swayne D.E., et al. Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J Virol 2009, 83:2851-2861.
36. Garcia-Sastre A., Durbin R.K., Zheng H., Palese P., Gertner R., Levy D.E., et al. The role of interferon in influenza virus tissue tropism. J Virol 1998, 72:8550-8558.
37. Szretter K.J., Gangappa S., Belser J.A., Zeng H., Chen H., Matsuoka Y., et al. Early control of H5N1 influenza virus replication by the type I interferon response in mice. J Virol 2009, 83:5825-5834.
38. Kugel D., Kochs G., Obojes K., Roth J., Kobinger G.P., Kobasa D., et al. Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets. J Virol 2009, 83:3843-3851.
39. Qian X.Y., Chien C.Y., Lu Y., Montelione G.T., Krug R.M. An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure. RNA 1995, 1:948-956.
40. Qian X.Y., Alonso-Caplen F., Krug R.M. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA. J Virol 1994, 68:2433-2441.
41. Katz J.M., Lu X., Tumpey T.M., Smith C.B., Shaw M.W., Subbarao K. Molecular correlates of influenza A H5N1 virus pathogenesis in mice. J Virol 2000, 74:10807-10810.
42. Lee L.Y., Ha do L.A., Simmons C., de Jong M.D., Chau N.V., Schumacher R., et al. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest 2008, 118:3478-3490.