Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk

Vaccine

Volumn 29, Issue 45, 2011, Pages 8032-8041

  Zhang, Wenjun ^a   Xue, Tao ^a   Wu, Xiaowei ^a   Zhang, Pinghu ^a,b   Zhao, Guo ^a   Peng, Daxing ^a   Hu, Shunlin ^a   Wang, Xiaoquan ^a   Liu, Xiaowen ^a   Liu, Wenbo ^a   Liu, Xiufan ^a  

^a YANGZHOU UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Avian influenza virus; NA stalk; Vaccines; Viral growth

Indexed keywords

H5N1 VACCINE; INFLUENZA VACCINE; RECOMBINANT VACCINE; SIALIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CELL STRAIN; CHICKEN; DRUG EFFICACY; ENZYME ACTIVITY; GENETIC REASSORTMENT; GENETIC VARIABILITY; HEMAGGLUTINATION INHIBITION TEST; IMMUNIZATION; INFLUENZA A (H5N1); INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H9N2; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PHYLOGENETIC TREE; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; VIRUS REPLICATION; ZYGOTE;

ANIMALS; CHICK EMBRYO; CHINA; DOGS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MUTAGENESIS, INSERTIONAL; NEURAMINIDASE; REASSORTANT VIRUSES; TECHNOLOGY, PHARMACEUTICAL; VACCINES; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 80053620304     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.08.054     Document Type: Article

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