Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice

Molecular Psychiatry

Volumn 20, Issue 11, 2015, Pages 1329-1338

  Chu, J ^a   Li, J G ^a   Giannopoulos, P F ^a   Blass, B E ^b   Childers, W ^b   Abou Gharbia, M ^b   Pratico D ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; BETA SECRETASE 1; GAMMA SECRETASE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; LIPOXYGENASE INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; NICASTRIN; NOOTROPIC AGENT; PD 146176; PLACEBO; TAU PROTEIN; UNCLASSIFIED DRUG; 12-15-LIPOXYGENASE; 6,11-DIHYDRO-5-THIA-11-AZA-BENZO(A)-FLUORENE; ENZYME INHIBITOR; FLUORENE DERIVATIVE; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

3XTG MOUSE; AMNESIA; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; MALE; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; WORKING MEMORY; ALZHEIMER DISEASE; ANIMAL; BRAIN; C57BL MOUSE; COMPLICATION; CONDITIONING; DRUG EFFECTS; FEAR; GENETICS; HUMAN; MAZE TEST; MEMORY DISORDERS; METABOLISM; MUTATION; NEUROBLASTOMA; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BRAIN; CELL LINE, TUMOR; CONDITIONING (PSYCHOLOGY); ENZYME INHIBITORS; FEAR; FLUORENES; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEUROBLASTOMA; PRESENILIN-1; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84946491536     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.170     Document Type: Article

References (30)

1. Li Y, Maher P, Schubert D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron 1997; 19: 453-463.
2. Lebeau A, Terro F, Rostene W, Pelaprat D. Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Cell Death Differ 2004; 11: 875-884.
3. Chinnici C, Yao Y, Funk C, Pratico D. Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice. Am J Pathol 2005; 167: 1371-1377.
4. Pratico D, Zhukareva V, Yao Y, Uryu K, Funk CD, Lawson JA et al. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am J Pathol 2004; 164: 1655-1662
5. Yao Y, Clark CM, Trojanowski JQ, Lee VM, Pratico D. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Ann Neurol 2005; 58: 623-626.
6. Yang H, Zhuo J, Chu J, Chinnici C, Pratico D. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psychiatry 2010; 68: 922-929.
7. Chu J, Zhuo JM, Pratico D. Transcriptional regulation of -secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Ann Neurol 2012; 71: 57-67.
8. Oddo A, Caccamo A, Shepherd JD, Murphy MP, Golde T, Kayed R et al. Triple transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003; 39: 409-421.
9. Succol F, Pratico D. A role for 12/15 lipoxygenase in the amyloid precursor protein metabolism. J Neurochem 2007; 103: 380-387.
10. Joshi YB, Chu J, Pratico D. Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease. J Alzheimers Dis 2012; 31: 167-176.
11. Giannopoulos PF, Chu J, Joshi Y, Sperow M, Kirby LG, Pratico D. Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple transgenic model of Alzheimer's disease. Mol Psychiatry 2014; 19: 511-518.
12. Chu J, Pratico D. 5-Lipoxygenase as an endogenous modulator of amyloid beta formation in vivo. Ann Neurol 2011; 69: 34-46
13. Giannopoulos PF, Joshi YB, Chu J, Pratico D. The 12/15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo. Aging Cell 2013; 12: 1082-1090.
14. Giannopoulos PF, Joshi YB, Pratico D. Novel lipid signaling pathways in Alzheimer disease pathogenesis. Biochem Pharmacol 2014; 88: 560-564.
15. Sendobry SM, Cornicelli JA, Welch K, Bocan T, Tait B, Trivedi BK et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 1997; 120: 1199-1206.
16. Gong CX, Iqbal K. Hyper-phosphorylation of microtubule-associated protein tau: A promising therapeutic target for Alzheimer disease. Curr Med Chem 2008; 15: 2321-2328.
17. Martin L, Latypova X, Terro F. Post-translational modifications of tau protein: implications for Alzheimer's disease. Neurochem Int 2011; 58: 458-471.
18. DeKosky ST, Scheff SW. Synaptic loss in frontal cortex biopsies in Alzheimer's disease correlation with cognitive severity. Ann Neurol 1990; 27: 457-464.
19. Sahara N, Maeda S, Takashima A. Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration. Curr Alzheimer Res 2008; 5: 591-598.
20. Atzori C, Ghetti B, Piva R, Srinivasan AN, Zolo P, Delisle MB et al. Activation of JNK/ p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J Neuropathol Exp Neurol 2001; 60: 1190-1197.
21. Savage MJ, Lin YG, Ciallella JR, Flood DG, Scott RW. Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J Neurosci 2002; 22: 3376-3385.
22. Sun W, Qureshi HY, Cafferty PW, Sobue K, Agarwal-Mawal A, Neufield KD et al. Glycogen synthase kinase-beta is complexed with tau protein in brain microtubules. J Biol Chem 2002; 277: 11933-11940.
23. Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, Netzer WJ et al. Over-activation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 2003; 87: 1333-1344.
24. Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH. Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3. J Neurochem 2000; 74: 1587-1595.
25. Planel E, Miyasaka T, Launey T, Chui D, Tanemura K, Sato S et al. Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J Neurosci 2004; 24: 2401-2411.
26. Ferrer I, Barrachina M, Puig B. Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains. Acta Neuropathol 2002; 104: 658-664.
27. Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H et al. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem 2001; 76: 435-441.
28. Masliah E, Mallory M, Alford M, De Teresa R, Hansen LA, McKeel DW et al. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 2001; 56: 127-129.
29. Joshi YB, Pratico D. Neuroinflammation and Alzheimer's disease: lessons learned from the 5-lipoxygenase. Transl Neurosci 2014; 5: 197-202.
30. Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH et al. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: A mechanistic link between Abeta and tau pathology. J Neurosci 2008; 28: 12163-12175.