Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

Neuropharmacology

Volumn 85, Issue , 2014, Pages 121-130

  Jiang, Teng ^a   Yu, Jin Tai ^a,b   Zhu, Xi Chen ^a   Zhang, Qiao Quan ^c   Cao, Lei ^a   Wang, Hui Fu ^a   Tan, Meng Shan ^b   Gao, Qing ^d   Qin, Hao ^c   Zhang, Ying Dong ^d   Tan, Lan ^a,b  

^a QINGDAO UNIVERSITY   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; GSK 3 ; Spatial cognitive deficits; Tauopathy; Temsirolimus

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; OKADAIC ACID; TAU PROTEIN; TEMSIROLIMUS; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MAPT PROTEIN, HUMAN; MAPT PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPATIAL LEARNING; TAUOPATHY; TRANSGENIC MOUSE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; MEMORY DISORDERS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SPATIAL MEMORY; TAUOPATHIES; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; BRAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MEMORY DISORDERS; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; OKADAIC ACID; PHOSPHORYLATION; SIROLIMUS; SPATIAL LEARNING; SPATIAL MEMORY; TAU PROTEINS; TAUOPATHIES;

EID: 84902273908     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.05.032     Document Type: Article

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