Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke

Journal of Neuroscience

Volumn 35, Issue 8, 2015, Pages 3384-3396

  Kawabori, Masahito ^a   Kacimi, Rachid ^a,b   Kauppinen, Tiina ^c   Calosing, Cyrus ^a   Kim, Jong Youl ^a   Hsieh, Christine L ^a,b   Nakamura, Mary C ^a   Yenari, Midori A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Kleysen Institute for Advanced Medicine   (Canada)

Author keywords

Ischemia; Neuroprotection; Permanent ischemia; Phagocytosis; Stroke; Triggering receptor expressed on myeloid cells 2

Indexed keywords

GENOMIC DNA; LENTIVIRUS VECTOR; MEMBRANE RECEPTOR; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, MOUSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEDERSON SCORE; BRAIN ISCHEMIA; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISEASE ASSESSMENT; EMBRYO; FLUORESCENCE MICROSCOPY; GENE EXPRESSION ASSAY; GENE SILENCING; HEMISPHERE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LASER DOPPLER FLOWMETRY; MALE; MICROGLIA; MOUSE; NERVE CELL; NICK END LABELING; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VALIDATION PROCESS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL HYPOXIA; CEREBRAL ARTERY DISEASE; DEFICIENCY; FOAM CELL; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL HYPOXIA; CELLS, CULTURED; FOAM CELLS; INFARCTION, MIDDLE CEREBRAL ARTERY; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC;

EID: 84923346682     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2620-14.2015     Document Type: Article

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