A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class

Angewandte Chemie - International Edition

Volumn 54, Issue 50, 2015, Pages 15128-15133

  Košutic, Marija ^a   Neuner, Sandro ^a   Ren, Aiming ^b   Flür, Sara ^a   Wunderlich, Christoph ^a   Mairhofer, Elisabeth ^a   Vušurovic, Nikola ^a   Seikowski, Jan ^c   Breuker, Kathrin ^a   Höbartner, Claudia ^c   Patel, Dinshaw J ^b   Kreutz, Christoph ^a   Micura, Ronald ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

metal ion rescue; nucleoside modifications; oligoribonucleotides; perturbed pKa; solid phase synthesis

Indexed keywords

ATOMS; ESTERS; MANGANESE; METAL IONS; METALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUBSTRATES; SYNTHESIS (CHEMICAL);

CATALYTIC MECHANISMS; METAL ION BINDING; NON-BRIDGING OXYGEN ATOMS; NUCLEOSIDE MODIFICATIONS; OLIGORIBONUCLEOTIDES; PERTURBED PKA; PHOSPHOROTHIOATES; SOLID PHASE SYNTHESIS;

CADMIUM COMPOUNDS;

ADENINE; CADMIUM; CATION; MANGANESE; ORGANOPHOSPHATE; RIBOZYME;

BIOCATALYSIS; CHEMISTRY; CLASSIFICATION; METABOLISM; MOLECULAR MODEL;

ADENINE; BIOCATALYSIS; CADMIUM; CATIONS; MANGANESE; MODELS, MOLECULAR; ORGANOPHOSPHATES; RNA, CATALYTIC;

EID: 84955198007     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201506601     Document Type: Article

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