메뉴 건너뛰기




Volumn 14, Issue 2, 2010, Pages 269-275

Controlling ribozyme activity by metal ions

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE EARTH METAL; BARIUM ION; CADMIUM; CALCIUM; COBALT; COPPER ION; GROUP II INTRON RIBOZYME; HAMMERHEAD RIBOZYME; HEPATITIS DELTA VIRUS RIBOZYME; IRON; LIGAND; LITHIUM ION; MAGNESIUM ION; MANGANESE; METAL ION; NICKEL; PHOSPHATE; RIBOZYME; SODIUM ION; STRONTIUM; UNCLASSIFIED DRUG; ZINC ION;

EID: 77949905333     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2009.11.024     Document Type: Review
Times cited : (95)

References (50)
  • 1
    • 33846887629 scopus 로고    scopus 로고
    • Alternative roles for metal ions in enzyme catalysis and the implication for ribozyme chemistry
    • A review that transfers the knowledge on metalloproteins to ribozymes showing that metal ions can exert their influence on catalysis also from distance.
    • Sigel R.K.O., and Pyle A.M. Alternative roles for metal ions in enzyme catalysis and the implication for ribozyme chemistry. Chem Rev 107 (2007) 97-113. A review that transfers the knowledge on metalloproteins to ribozymes showing that metal ions can exert their influence on catalysis also from distance.
    • (2007) Chem Rev , vol.107 , pp. 97-113
    • Sigel, R.K.O.1    Pyle, A.M.2
  • 2
    • 12844260994 scopus 로고    scopus 로고
    • Probing counterion modulated repulsion and attraction between nucleic acid duplexes in solution
    • Bai Y., Das R., Millett I.S., Herschlag D., and Doniach S. Probing counterion modulated repulsion and attraction between nucleic acid duplexes in solution. Proc Natl Acad Sci U S A 102 (2005) 1035-1040
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1035-1040
    • Bai, Y.1    Das, R.2    Millett, I.S.3    Herschlag, D.4    Doniach, S.5
  • 3
    • 57649130782 scopus 로고    scopus 로고
    • A repulsive field: advances in the electrostatics of the ion atmosphere
    • Chu V.B., Bai Y., Lipfert J., Herschlag D., and Doniach S. A repulsive field: advances in the electrostatics of the ion atmosphere. Curr Opin Chem Biol 12 (2008) 619-625
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 619-625
    • Chu, V.B.1    Bai, Y.2    Lipfert, J.3    Herschlag, D.4    Doniach, S.5
  • 4
    • 58749105663 scopus 로고    scopus 로고
    • RNA folding: thermodynamic and molecular descriptions of the roles of ions
    • Draper D.E. RNA folding: thermodynamic and molecular descriptions of the roles of ions. Biophys J 95 (2008) 5489-5495
    • (2008) Biophys J , vol.95 , pp. 5489-5495
    • Draper, D.E.1
  • 5
    • 34250613522 scopus 로고    scopus 로고
    • From nucleotides to ribozymes - a comparison of their metal ion binding properties
    • Freisinger E., and Sigel R.K.O. From nucleotides to ribozymes - a comparison of their metal ion binding properties. Coord Chem Rev 251 (2007) 1834-1851
    • (2007) Coord Chem Rev , vol.251 , pp. 1834-1851
    • Freisinger, E.1    Sigel, R.K.O.2
  • 6
    • 0038054299 scopus 로고    scopus 로고
    • Crystallographic characterization of an exocyclic DNA adduct: 3,N4-etheno-2′-deoxycytidine in the dodecamer 5′-CGCGAATTεCGCG-3′
    • Freisinger E., Fernandes A., Grollman A.P., and Kisker C. Crystallographic characterization of an exocyclic DNA adduct: 3,N4-etheno-2′-deoxycytidine in the dodecamer 5′-CGCGAATTεCGCG-3′. J Mol Biol 329 (2003) 685-697
    • (2003) J Mol Biol , vol.329 , pp. 685-697
    • Freisinger, E.1    Fernandes, A.2    Grollman, A.P.3    Kisker, C.4
  • 7
    • 34250349882 scopus 로고    scopus 로고
    • A second divalent metal ion in the group II intron reaction center
    • Identification of a second metal ion required for nucleophile activation in the step of exon ligation. Comparison with similar experiments using group I introns suggests a two-metal ion mechanism as a paradigm for large ribozymes.
    • Gordon P.M., Fong R., and Piccirilli J.A. A second divalent metal ion in the group II intron reaction center. Chem Biol 14 (2007) 607-612. Identification of a second metal ion required for nucleophile activation in the step of exon ligation. Comparison with similar experiments using group I introns suggests a two-metal ion mechanism as a paradigm for large ribozymes.
    • (2007) Chem Biol , vol.14 , pp. 607-612
    • Gordon, P.M.1    Fong, R.2    Piccirilli, J.A.3
  • 8
    • 24944569654 scopus 로고    scopus 로고
    • Functional identification of catalytic metal ion binding sites within RNA
    • Hougland J.L., Kravchuk A.V., Herschlag D., and Piccirilli J.A. Functional identification of catalytic metal ion binding sites within RNA. PLoS Biol 3 (2005) 1536-1548
    • (2005) PLoS Biol , vol.3 , pp. 1536-1548
    • Hougland, J.L.1    Kravchuk, A.V.2    Herschlag, D.3    Piccirilli, J.A.4
  • 9
    • 0032404048 scopus 로고    scopus 로고
    • Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: a NAIM analysis
    • Boudvillain M., and Pyle A.M. Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: a NAIM analysis. EMBO J 17 (1998) 7091-7104
    • (1998) EMBO J , vol.17 , pp. 7091-7104
    • Boudvillain, M.1    Pyle, A.M.2
  • 10
    • 70449416220 scopus 로고    scopus 로고
    • The identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme
    • A study indicating that results from nucleotide modifications have to be interpreted with care as the change in local environment might alter the general mechanism.
    • Osborne E.M., Ward W.L., Ruehle M.Z., and DeRose V.J. The identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme. Biochemistry 48 (2009) 10654-10664. A study indicating that results from nucleotide modifications have to be interpreted with care as the change in local environment might alter the general mechanism.
    • (2009) Biochemistry , vol.48 , pp. 10654-10664
    • Osborne, E.M.1    Ward, W.L.2    Ruehle, M.Z.3    DeRose, V.J.4
  • 11
    • 47649130326 scopus 로고    scopus 로고
    • The different role of high-affinity and low-affinity metal ions in cleavage by a tertiary stabilized cis hammerhead ribozyme from tobacco ringspot virus
    • Kisseleva N., Khvorova A., Westhof E., Schiemann O., and Wolfson A.D. The different role of high-affinity and low-affinity metal ions in cleavage by a tertiary stabilized cis hammerhead ribozyme from tobacco ringspot virus. Oligonucleotides 18 (2008) 101-110
    • (2008) Oligonucleotides , vol.18 , pp. 101-110
    • Kisseleva, N.1    Khvorova, A.2    Westhof, E.3    Schiemann, O.4    Wolfson, A.D.5
  • 12
    • 85013257546 scopus 로고    scopus 로고
    • Characterizing multiple metal ion binding sites within a ribozyme by cadmium-induced EPR silencing
    • Kisseleva N., Kraut S., Jaschke A., and Schiemann O. Characterizing multiple metal ion binding sites within a ribozyme by cadmium-induced EPR silencing. HFSP J 1 (2007) 127-136
    • (2007) HFSP J , vol.1 , pp. 127-136
    • Kisseleva, N.1    Kraut, S.2    Jaschke, A.3    Schiemann, O.4
  • 13
    • 0037028557 scopus 로고    scopus 로고
    • Structural analysis of metal ion ligation to nucleotides and nucleic acids using pulsed EPR spectroscopy
    • Hoogstraten C.G., Grant C.V., Horton T.E., DeRose V.J., and Britt R.D. Structural analysis of metal ion ligation to nucleotides and nucleic acids using pulsed EPR spectroscopy. J Am Chem Soc 124 (2002) 834-842
    • (2002) J Am Chem Soc , vol.124 , pp. 834-842
    • Hoogstraten, C.G.1    Grant, C.V.2    Horton, T.E.3    DeRose, V.J.4    Britt, R.D.5
  • 14
    • 0025998488 scopus 로고
    • Role of divalent metal ions in the hammerhead RNA cleavage reaction
    • Dahm S.C., and Uhlenbeck O.C. Role of divalent metal ions in the hammerhead RNA cleavage reaction. Biochemistry 30 (1991) 9464-9469
    • (1991) Biochemistry , vol.30 , pp. 9464-9469
    • Dahm, S.C.1    Uhlenbeck, O.C.2
  • 15
    • 33749267488 scopus 로고    scopus 로고
    • Extraordinary rates of transition metal ion-mediated ribozyme catalysis
    • Roychowdhury-Saha M., and Burke D.H. Extraordinary rates of transition metal ion-mediated ribozyme catalysis. RNA 12 (2006) 1846-1852
    • (2006) RNA , vol.12 , pp. 1846-1852
    • Roychowdhury-Saha, M.1    Burke, D.H.2
  • 16
    • 0001101248 scopus 로고
    • Hydrolysis of nucleoside phosphates. 8. General considerations on transphosphorylations - mechanism of the metal ion-facilitated dephosphorylation of nucleoside 5′-triphosphates, including promotion of ATP dephosphorylation by addition of adenosine 5′-monophosphate
    • Sigel H., Hofstetter F., Martin R.B., Milburn R.M., Scheller-Krattiger V., and Scheller K.H. Hydrolysis of nucleoside phosphates. 8. General considerations on transphosphorylations - mechanism of the metal ion-facilitated dephosphorylation of nucleoside 5′-triphosphates, including promotion of ATP dephosphorylation by addition of adenosine 5′-monophosphate. J Am Chem Soc 106 (1984) 7935-7946
    • (1984) J Am Chem Soc , vol.106 , pp. 7935-7946
    • Sigel, H.1    Hofstetter, F.2    Martin, R.B.3    Milburn, R.M.4    Scheller-Krattiger, V.5    Scheller, K.H.6
  • 17
    • 0001340347 scopus 로고
    • Mechanistic aspects of the metal ion promoted hydrolysis of nucleoside 5′-triphosphates (NTPs)
    • Sigel H. Mechanistic aspects of the metal ion promoted hydrolysis of nucleoside 5′-triphosphates (NTPs). Coord Chem Rev 100 (1990) 453-539
    • (1990) Coord Chem Rev , vol.100 , pp. 453-539
    • Sigel, H.1
  • 18
    • 41749109563 scopus 로고    scopus 로고
    • Crystal structure of a self-spliced group II intron
    • First crystal structure of a complete group II intron ribozyme. Two metal ions are found in the catalytic core being indicative of a two-metal ion mechanism.
    • Toor N., Keating K.S., Taylor S.D., and Pyle A.M. Crystal structure of a self-spliced group II intron. Science 320 (2008) 77-82. First crystal structure of a complete group II intron ribozyme. Two metal ions are found in the catalytic core being indicative of a two-metal ion mechanism.
    • (2008) Science , vol.320 , pp. 77-82
    • Toor, N.1    Keating, K.S.2    Taylor, S.D.3    Pyle, A.M.4
  • 19
    • 67349123194 scopus 로고    scopus 로고
    • Comparative enzymology and structural biology of RNA self-cleavage
    • Fedor M.J. Comparative enzymology and structural biology of RNA self-cleavage. Ann Rev Biophys 38 (2009) 271-299
    • (2009) Ann Rev Biophys , vol.38 , pp. 271-299
    • Fedor, M.J.1
  • 21
    • 0001940219 scopus 로고
    • Have ATP and related purine nucleotides played a role in early evolution? ATP, its own 'enzyme' in metal ion facilitated hydrolysis
    • Sigel H. Have ATP and related purine nucleotides played a role in early evolution? ATP, its own 'enzyme' in metal ion facilitated hydrolysis. Inorg Chim Acta 198-200 (1992) 1-11
    • (1992) Inorg Chim Acta , vol.198-200 , pp. 1-11
    • Sigel, H.1
  • 22
    • 63649098099 scopus 로고    scopus 로고
    • Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation
    • Lee T.-S., Giambasu G.M., Sosa C.P., Martick M., Scott W.G., and York D.M. Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation. J Mol Biol 388 (2009) 195-206
    • (2009) J Mol Biol , vol.388 , pp. 195-206
    • Lee, T.-S.1    Giambasu, G.M.2    Sosa, C.P.3    Martick, M.4    Scott, W.G.5    York, D.M.6
  • 23
    • 33745700326 scopus 로고    scopus 로고
    • Cations and hydration in catalytic RNA: molecular dynamics of the hepatitis delta virus ribozyme
    • Krasovska M.V., Sefcikova J., Reblova K., Schneider B., Walter N.G., and Sponer J. Cations and hydration in catalytic RNA: molecular dynamics of the hepatitis delta virus ribozyme. Biophys J 91 (2006) 626-638
    • (2006) Biophys J , vol.91 , pp. 626-638
    • Krasovska, M.V.1    Sefcikova, J.2    Reblova, K.3    Schneider, B.4    Walter, N.G.5    Sponer, J.6
  • 24
    • 52949104434 scopus 로고    scopus 로고
    • Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozyme
    • Detailed FRET investigation of the effect of different metal ions on the folding and catalytic cleavage reaction of the tertiary stabilized Schistosoma hammerhead ribozyme, operating the effect on folding and cleavage.
    • Boots J.L., Canny M.D., Azimi E., and Pardi A. Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozyme. RNA 14 (2008) 2212-2222. Detailed FRET investigation of the effect of different metal ions on the folding and catalytic cleavage reaction of the tertiary stabilized Schistosoma hammerhead ribozyme, operating the effect on folding and cleavage.
    • (2008) RNA , vol.14 , pp. 2212-2222
    • Boots, J.L.1    Canny, M.D.2    Azimi, E.3    Pardi, A.4
  • 25
    • 33749016245 scopus 로고    scopus 로고
    • HDV ribozyme activity in monovalent cations
    • Perrotta A.T., and Been M.D. HDV ribozyme activity in monovalent cations. Biochemistry 45 (2006) 11357-11365
    • (2006) Biochemistry , vol.45 , pp. 11357-11365
    • Perrotta, A.T.1    Been, M.D.2
  • 26
    • 33847691104 scopus 로고    scopus 로고
    • Structural roles of monovalent cations in the HDV ribozyme
    • Ke A., Ding F., Batchelor J.D., and Doudna J.A. Structural roles of monovalent cations in the HDV ribozyme. Structure 15 (2007) 281-287
    • (2007) Structure , vol.15 , pp. 281-287
    • Ke, A.1    Ding, F.2    Batchelor, J.D.3    Doudna, J.A.4
  • 27
    • 34247560640 scopus 로고    scopus 로고
    • A single nucleotide linked to a switch in metal ion reactivity preference in the HDV ribozymes
    • 2+ in catalysis.
    • 2+ in catalysis.
    • (2007) Biochemistry , vol.46 , pp. 5124-5130
    • Perrotta, A.T.1    Been, M.D.2
  • 28
    • 41949138497 scopus 로고    scopus 로고
    • Solvent structure and hammerhead ribozyme catalysis
    • Martick M., Lee T.-S., York D.M., and Scott W.G. Solvent structure and hammerhead ribozyme catalysis. Chem Biol 15 (2008) 332-342
    • (2008) Chem Biol , vol.15 , pp. 332-342
    • Martick, M.1    Lee, T.-S.2    York, D.M.3    Scott, W.G.4
  • 29
    • 0043009734 scopus 로고    scopus 로고
    • Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
    • Khvorova A., Lescoute A., Westhof E., and Jayasena S.D. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity. Nat Struct Biol 10 (2003) 708-712
    • (2003) Nat Struct Biol , vol.10 , pp. 708-712
    • Khvorova, A.1    Lescoute, A.2    Westhof, E.3    Jayasena, S.D.4
  • 30
    • 0142105383 scopus 로고    scopus 로고
    • Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity
    • De la Pena M., Gago S., and Flores R. Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity. EMBO J 22 (2003) 5561-5570
    • (2003) EMBO J , vol.22 , pp. 5561-5570
    • De la Pena, M.1    Gago, S.2    Flores, R.3
  • 31
    • 21244480925 scopus 로고    scopus 로고
    • Group II intron ribozymes and metal ions - a delicate relationship
    • Sigel R.K.O. Group II intron ribozymes and metal ions - a delicate relationship. Eur J Inorg Chem 12 (2005) 2281-2292
    • (2005) Eur J Inorg Chem , vol.12 , pp. 2281-2292
    • Sigel, R.K.O.1
  • 32
    • 34250631912 scopus 로고    scopus 로고
    • Group II introns: structure, folding and splicing mechanism
    • Fedorova O., and Zingler N. Group II introns: structure, folding and splicing mechanism. Biol Chem 388 (2007) 665-678
    • (2007) Biol Chem , vol.388 , pp. 665-678
    • Fedorova, O.1    Zingler, N.2
  • 33
    • 48149099082 scopus 로고    scopus 로고
    • Divalent metal ions tune the self-splicing reaction of the yeast mitochondrial group II intron Sc.ai5γ
    • 2+ binding sites within the active structure.
    • 2+ binding sites within the active structure.
    • (2008) J Biol Inorg Chem , vol.13 , pp. 1025-1036
    • Erat, M.C.1    Sigel, R.K.O.2
  • 35
    • 71949084158 scopus 로고    scopus 로고
    • 2+ on single molecule folding of a group II intron ribozyme
    • 2+, the intron folds into two distinct subpopulations that do not interchange.
    • 2+, the intron folds into two distinct subpopulations that do not interchange.
    • (2009) Angew Chem Int Ed , vol.48 , pp. 9739-9742
    • Steiner, M.1    Rueda, D.2    Sigel RKO3
  • 36
    • 0030476765 scopus 로고    scopus 로고
    • Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme
    • Scott W.G., Murray J.B., Arnold J.R.P., Stoddard B.L., and Klug A. Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme. Science 274 (1996) 2065-2069
    • (1996) Science , vol.274 , pp. 2065-2069
    • Scott, W.G.1    Murray, J.B.2    Arnold, J.R.P.3    Stoddard, B.L.4    Klug, A.5
  • 37
    • 0033860560 scopus 로고    scopus 로고
    • Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction
    • Murray J.B., Szoke H., Szoke A., and Scott W.G. Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction. Mol Cell 5 (2000) 279-287
    • (2000) Mol Cell , vol.5 , pp. 279-287
    • Murray, J.B.1    Szoke, H.2    Szoke, A.3    Scott, W.G.4
  • 38
    • 58149280561 scopus 로고    scopus 로고
    • a shifts through metals: potential relevance to ribozyme chemistry
    • a shifts in model systems and transferring it to ribozymes.
    • a shifts in model systems and transferring it to ribozymes.
    • (2008) Chem Biodivers , vol.5 , pp. 1455-1474
    • Lippert, B.1
  • 39
    • 50649098884 scopus 로고    scopus 로고
    • a
    • a into the physiological pH range with the electrostatic effects of different metal ions on the VS ribozyme.
    • a into the physiological pH range with the electrostatic effects of different metal ions on the VS ribozyme.
    • (2008) RNA , vol.14 , pp. 1942-1949
    • Smith, M.D.1    Mehdizadeh, R.2    Olive, J.E.3    Collins, R.A.4
  • 40
    • 4544273058 scopus 로고    scopus 로고
    • Two metal ions coordinated to a purine residue tolerate each other well!
    • Knobloch B., Sigel R.K.O., Lippert B., and Sigel H. Two metal ions coordinated to a purine residue tolerate each other well!. Angew Chem Int Ed 43 (2004) 3793-3795
    • (2004) Angew Chem Int Ed , vol.43 , pp. 3793-3795
    • Knobloch, B.1    Sigel, R.K.O.2    Lippert, B.3    Sigel, H.4
  • 41
    • 55549085243 scopus 로고    scopus 로고
    • Mechanistic characterization of the HDV genomic ribozyme: solvent isotope effects and proton inventories in the absence of divalent metal ions support C75 as the general acid
    • A thorough and detailed study on proton transfers taking part in the catalytic steps of the HDV genomic ribozyme.
    • Cerrone-Szakal A.L., Siegfried N.A., and Bevilacqua P.C. Mechanistic characterization of the HDV genomic ribozyme: solvent isotope effects and proton inventories in the absence of divalent metal ions support C75 as the general acid. J Am Chem Soc 130 (2008) 14504-14520. A thorough and detailed study on proton transfers taking part in the catalytic steps of the HDV genomic ribozyme.
    • (2008) J Am Chem Soc , vol.130 , pp. 14504-14520
    • Cerrone-Szakal, A.L.1    Siegfried, N.A.2    Bevilacqua, P.C.3
  • 42
    • 26944448948 scopus 로고    scopus 로고
    • Nucleoside 5′-triphosphates: self-association, acid-base, and metal ion-binding properties in solution
    • Sigel H., and Griesser R. Nucleoside 5′-triphosphates: self-association, acid-base, and metal ion-binding properties in solution. Chem Soc Rev 34 (2005) 875-900
    • (2005) Chem Soc Rev , vol.34 , pp. 875-900
    • Sigel, H.1    Griesser, R.2
  • 43
    • 84899742655 scopus 로고    scopus 로고
    • Complex formation of Nickel(II) and related metal ions with sugar residues, nucleobases, phosphates, nucleotides, and nucleic acids
    • Sigel R.K.O., and Sigel H. Complex formation of Nickel(II) and related metal ions with sugar residues, nucleobases, phosphates, nucleotides, and nucleic acids. Met Ions Life Sci 2 (2007) 109-180
    • (2007) Met Ions Life Sci , vol.2 , pp. 109-180
    • Sigel, R.K.O.1    Sigel, H.2
  • 44
    • 0001056524 scopus 로고    scopus 로고
    • Solution structures of nucleotide-metal ion complexes. Isomeric equilibria
    • Sigel H., and Song B. Solution structures of nucleotide-metal ion complexes. Isomeric equilibria. Met Ions Biol Syst 32 (1996) 135-206
    • (1996) Met Ions Biol Syst , vol.32 , pp. 135-206
    • Sigel, H.1    Song, B.2
  • 45
    • 38149014107 scopus 로고    scopus 로고
    • 2+ ions coordinated to domain 6 of a group II intron ribozyme
    • 2+ ions coordinated to domain 6 of a group II intron ribozyme. Inorg Chem 46 (2007) 11224-11234
    • (2007) Inorg Chem , vol.46 , pp. 11224-11234
    • Erat, M.C.1    Sigel, R.K.O.2
  • 46
    • 34250647750 scopus 로고    scopus 로고
    • 2+ binding site is located close to the stacked branch adenosine
    • 2+ binding site is located close to the stacked branch adenosine. ChemBioChem 8 (2007) 306-314
    • (2007) ChemBioChem , vol.8 , pp. 306-314
    • Erat, M.C.1    Zerbe, O.2    Fox, T.3    Sigel, R.K.O.4
  • 47
    • 54749153656 scopus 로고    scopus 로고
    • Capturing hammerhead ribozyme structures in action by modulating general base catalysis
    • Chi Y.-I., Martick M., Lares M., Kim R., Scott W.G., and Kim S.-H. Capturing hammerhead ribozyme structures in action by modulating general base catalysis. PLoS Biol 6 (2008) e234-e1234
    • (2008) PLoS Biol , vol.6
    • Chi, Y.-I.1    Martick, M.2    Lares, M.3    Kim, R.4    Scott, W.G.5    Kim, S.-H.6
  • 48
    • 33947296922 scopus 로고
    • On the discriminating behavior of metal ions and ligands with regard to their biological significance
    • Sigel H., and McCormick D.B. On the discriminating behavior of metal ions and ligands with regard to their biological significance. Acc Chem Res 3 (1970) 201-208
    • (1970) Acc Chem Res , vol.3 , pp. 201-208
    • Sigel, H.1    McCormick, D.B.2
  • 49
    • 19744375331 scopus 로고    scopus 로고
    • Metal ion-binding properties of (N3)-deprotonated uridine, thymidine, and related pyrimidine nucleosides in aqueous solution
    • Knobloch B., Linert W., and Sigel H. Metal ion-binding properties of (N3)-deprotonated uridine, thymidine, and related pyrimidine nucleosides in aqueous solution. Proc Natl Acad Sci U S A 102 (2005) 7459-7464
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7459-7464
    • Knobloch, B.1    Linert, W.2    Sigel, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.