A tale in molecular recognition: The hammerhead ribozyme

Journal of Molecular Recognition

Volumn 20, Issue 1, 2007, Pages 1-3

  Westhof, Eric ^a,b  

^a CNRS   (France)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Hammerhead; Ribozyme; RNA

Indexed keywords

HAMMERHEAD RIBOZYME; RIBOZYME;

ANIMAL; CATALYSIS; CHEMISTRY; CONFORMATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REVIEW; SCHISTOSOMA MANSONI;

ANIMALS; BASE SEQUENCE; CATALYSIS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, CATALYTIC; SCHISTOSOMA MANSONI;

EID: 33846502132     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.806     Document Type: Review

References (25)

1. Buzayan JM, Gerlach WL, Bruening G. 1986. Satellite tobacco ringspot virus RNA: a subset of the rna sequence is sufficient for autolytic processing. Proc Natl Acad Sci USA. 83: 8859-8862.
2. De La Pena M, Gago S, Flores R. 2003. Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity. Embo J. 22: 5561-5570.
3. Doudna JA, Cech TR. 2002. The chemical repertoire of natural ribozymes. Nature. 418: 222-228.
4. Forster AC, Symons RH. 1987. Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites. Cell. 49: 211-220.
5. Grabowski PJ, Zaug AJ, Cech TR. 1981. The intervening sequence of the ribosomal rna precursor is converted to a circular RNA in isolated nuclei of tetrahymena. Cell. 23: 467-476.
6. Guerrier-Takada C, Gardiner K, Marsh T, Pace N, Altman S. 1983. The rna moiety of ribonuclease p is the catalytic subunit of the enzyme. Cell. 35: 849-857.
7. Hammann C, Lilley DM. 2002. Folding and activity of the hammerhead ribozyme. Chembiochem. 3: 690-700.
8. Haseloff J, Gerlach WL. 1989. Sequences required for self-catalysed cleavage of the satellite RNA of tobacco ringspot virus. Gene. 82: 43-52.
9. Khvorova A, Lescoute A, Westhof E, Jayasena SD. 2003. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity. Nat Struct Biol. 10: 708-712.
10. Leontis NB, Westhof E. 2001. Geometric nomenclature and classification of RNA base pairs. Rna. 7: 499-512.
11. Lilley DM. 2005. Structure, folding and mechanisms of ribozymes. Curr Opin Struct Biol. 15: 313-323.
12. Martick M, Scott WG. 2006. Tertiary contacts distant from the active site prime a ribozyme for catalysis. Cell. 126: 309-320.
13. McKay DB. 1996. Structure and function of the hammerhead ribozyme: an unfinished story. Rna. 2: 395-403.
14. Nelson JA, Uhlenbeck OC. 2006. When to believe what you see. Mol Cell. 23: 447-450.
15. Pley HW, Flaherty KM, McKay DB. 1994. Three-dimensional structure of a hammerhead ribozyme. Nature. 372: 68-74.
16. Przybilski R, Graf S, Lescoute A, Nellen W, Westhof E, Steger G, Hammann C. 2005. Functional hammerhead ribozymes naturally encoded in the genome of arabidopsis thaliana. Plant Cell. 17: 1877-1885.
17. Scott WG. 1999. Biophysical and biochemical investigations of RNA catalysis in the hammerhead ribozyme. Q Rev Biophys. 32: 241-284.
18. Scott WG, Finch JT, Klug A. 1995. The crystal structure of an all-rna hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell. 81: 991-1002.
19. Slim G, Gait MJ. 1991. Configurationally defined phosphorothioate- containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes. Nucleic Acids Res. 19: 1183-1188.
20. Symons RH. 1997. Plant pathogenic RNAs and RNA catalysis. Nucleic Acids Res. 25: 2683-2689.
21. Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F. 1994. A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements. Science. 266: 785-789.
22. Uhlenbeck OC. 1987. A small catalytic oligoribonucleotide. Nature. 328: 596-600.
23. Uhlenbeck OC. 2003. Less isn't always more. RNA. 9: 1415-1417.
24. Wang S, Karbstein K, Peracchi A, Beigelman L, Herschlag D. 1999. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate. Biochemistry. 38: 14363-14378.
25. Wedekind JE, McKay DB. 1998. Crystallographic structures of the hammerhead ribozyme: relationship to ribozyme folding and catalysis. Annu Rev Biophys Biomol Struct. 27: 475-502.