Protonation-Dependent Base Flipping at Neutral pH in the Catalytic Triad of a Self-Splicing Bacterial Group II Intron

Angewandte Chemie - International Edition

Volumn 54, Issue 33, 2015, Pages 9687-9690

  Pechlaner, Maria ^a   Donghi, Daniela ^a   Zelenay, Veronika ^a   Sigel, Roland K O ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

group II introns; NMR spectroscopy; ribozymes; RNA; structure function relationships

Indexed keywords

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA;

BASE FLIPPING; CATALYTIC DOMAINS; CATALYTIC TRIAD; CONFORMATIONAL CHANGE; GROUP II INTRONS; LINKER REGION; RIBOZYMES; STRUCTURE-FUNCTION RELATIONSHIP;

PROTONATION;

ADENINE; PROTON; RIBOZYME;

AZOTOBACTER VINELANDII; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; ENZYMOLOGY; INTRON; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PH; RNA SPLICING;

ADENINE; AZOTOBACTER VINELANDII; BASE SEQUENCE; CATALYTIC DOMAIN; HYDROGEN-ION CONCENTRATION; INTRONS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; PROTONS; RNA SPLICING; RNA, CATALYTIC;

EID: 84938418312     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201504014     Document Type: Article

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