Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in p. Aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways

Drug Design, Development and Therapy

Volumn 10, Issue , 2016, Pages 183-203

  Luo, Jing ^a   Kong, Jin Liang ^a   Dong, Bi Ying ^a   Huang, Hong ^a   Wang, Ke ^a   Wu, Li Hong ^a   Hou, Chang Chun ^a   Liang, Yue ^a   Li, Bing ^a   Chen, Yi Qiang ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Baicalein; Inflammatory cytokines; Pseudomonas aeruginosa; Quorum sensing; Signal transduction; Virulence

Indexed keywords

BAICALEIN; ELASTASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PROTEINASE; PYOCYANINE; RHAMNOLIPID; TUMOR NECROSIS FACTOR ALPHA; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CYTOKINE; FLAVANONE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BIOFILM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; MACROPHAGE; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; INFLAMMATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PSEUDOMONAS INFECTIONS; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CYTOKINES; DOWN-REGULATION; FLAVANONES; INFLAMMATION; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICROBIAL SENSITIVITY TESTS; NF-KAPPA B; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; VIRULENCE FACTORS;

EID: 84955130951     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S97221     Document Type: Article

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