An aqueous extract of Yunnan Baiyao inhibits the quorum-sensing-related virulence of Pseudomonas aeruginosa

Journal of Microbiology

Volumn 51, Issue 2, 2013, Pages 207-212

  Zhao, Zu Guo ^a   Yan, Shuang Shuang ^a   Yu, Yun Mei ^b   Mi, Na ^a   Zhang, La Xi ^b   Liu, Jun ^a   Li, Xiao Ling ^a   Liu, Fang ^a   Xu, Jun Fa ^a   Yang, Wei Qing ^a   Li, Guo Ming ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b The People's Liberation Army   (China)

Author keywords

motility; P. aeruginosa; quorum sensing; virulence; Yunnan Baiyao

Indexed keywords

PSEUDOMONAS AERUGINOSA;

EID: 84876820381     PISSN: 12258873     EISSN: 19763794     Source Type: Journal    
DOI: 10.1007/s12275-013-2595-x     Document Type: Article

References (39)

1. Adonizio, A., Kong, K. F., and Mathee, K. 2008. Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts. Antimicrob. Agents Chemother. 52, 198-203.
2. Antunes, L. C., Ferreira, R. B., Buckner, M. M., and Finlay, B. B. 2010. Quorum sensing in bacterial virulence. Microbiology156, 2271-2282.
3. Bala, A., Kumar, R., and Harjai, K. 2011. Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections. J. Med. Microbiol. 60, 300-306.
4. Balloy, V., Verma, A., Kuravi, S., Si-Tahar, M., Chignard, M., and Ramphal, R. 2007. The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa. J. Infect. Dis. 196, 289-296.
5. Beatson, S. A., Whitchurch, C. B., Sargent, J. L., Levesque, R. C., and Mattick, J. S. 2002. Differential regulation of twitching motility and elastase production by vfr in Pseudomonas aeruginosa. J. Bacteriol. 184, 3605-3613.
6. Bereket, W., Hemalatha, K., Getenet, B., Wondwossen, T., Solomon, A., Zeynudin, A., and Kannan, S. 2012. Update on bacterial nosocomial infections. Eur. Rev. Med. Pharmacol. Sci. 16, 1039-1044.
7. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
8. Bratu, S., Gupta, J., and Quale, J. 2006. Expression of the las and rhl quorum-sensing systems in clinical isolates of Pseudomonas aeruginosa does not correlate with efflux pump expression or antimicrobial resistance. J. Antimicrob. Chemother. 58, 1250-1253.
9. Cardona, P. J., Asensio, J. G., Arbues, A., Otal, I., Lafoz, C., Gil, O., Caceres, N., Ausina, V., Gicquel, B., and Martin, C. 2009. Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phop mutant. Vaccine27, 2499-2505.
10. Cataldi, T. R., Bianco, G., and Abate, S. 2009. Accurate mass analysis of N-acyl-homoserine-lactones and cognate lactone-opened compounds in bacterial isolates of Pseudomonas aeruginosa PAO1 by LC-ESI-LTQ-FTICR-MS. J. Mass Spectrom. 44, 182-192.
11. Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., and Greenberg, E. P. 1998. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science280, 295-298.
12. De Souza, J. T., Mazzola, M., and Raaijmakers, J. M. 2003. Conservation of the response regulator gene gacA in pseudomonas species. Environ. Microbiol. 5, 1328-1340.
13. Dekimpe, V. and Deziel, E. 2009. Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: The transcriptional regulator rhlR regulates lasR-specific factors. Microbiology155, 712-723.
14. Duan, K. and Surette, M. G. 2007. Environmental regulation of Pseudomonas aeruginosa PAO1 Las and Rhl quorum-sensing systems. J. Bacteriol. 189, 4827-4836.
15. Glessner, A., Smith, R. S., Iglewski, B. H., and Robinson, J. B. 1999. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of twitching motility. J. Bacteriol. 181, 1623-1629.
16. He, H., Ren, X., Wang, X., Shi, X., Ding, Z., Gao, P., and Xu, G. 2012. Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts. J. Pharm. Biomed. Anal. 59, 130-137.
17. Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Hoiby, N., andet al. 2002. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology148, 87-102.
18. Hentzer, M., Wu, H., Andersen, J. B., Riedel, K., Rasmussen, T. B., Bagge, N., Kumar, N., Schembri, M. A., Song, Z., Kristoffersen, P., andet al. 2003. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22, 3803-3815.
19. Jagani, S., Chelikani, R., and Kim, D. S. 2009. Effects of phenol and natural phenolic compounds on biofilm formation by Pseudomonas aeruginosa. Biofouling25, 321-324.
20. Jakobsen, T. H., van Gennip, M., Phipps, R. K., Shanmugham, M. S., Christensen, L. D., Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., andet al. 2012. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob. Agents Chemother. 56, 2314-2325.
21. Jia, J., Sun, Y., Yang, H., Wang, X., Liu, L., Zong, L., and Hu, H. 2012. Effect of human saliva on wound healing. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 26, 563-566.
22. Koh, K. H. and Tham, F. Y. 2011. Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. J. Microbiol. Immunol. Infect. 44, 144-148.
23. Kong, K. F., Jayawardena, S. R., Indulkar, S. D., Del Puerto, A., Koh, C. L., Hoiby, N., and Mathee, K. 2005. Pseudomonas aeruginosa Ampr is a global transcriptional factor that regulates expression of Ampc and Poxb beta-lactamases, proteases, quorum sensing, and other virulence factors. Antimicrob. Agents Chemother. 49, 4567-4575.
24. Li, R., Alex, P., Ye, M., Zhang, T., Liu, L., and Li, X. 2011. An old herbal medicine with a potentially new therapeutic application in inflammatory bowel disease. Int. J. Clin. Exp. Med. 4, 309-319.
25. Liang, H., Deng, X., Ji, Q., Sun, F., Shen, T., and He, C. 2012. The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J. Bacteriol. 194, 3098-3108.
26. Livak, K. J. and Schmittgen, T. D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods25, 402-408.
27. Patriquin, G. M., Banin, E., Gilmour, C., Tuchman, R., Greenberg, E. P., and Poole, K. 2008. Influence of quorum sensing and iron on twitching motility and biofilm formation in Pseudomonas aeruginosa. J. Bacteriol. 190, 662-671.
28. Rashid, M. H. and Kornberg, A. 2000. Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA97, 4885-4890.
29. Rasko, D. A. and Sperandio, V. 2010. Anti-virulence strategies to combat bacteria-mediated disease. Nat. Rev. Drug Discov. 9, 117-128.
30. Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Kote, M., Nielsen, J., Eberl, L., and Givskov, M. 2005. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J. Bacteriol. 187, 1799-1814.
31. Rice, S. A., McDougald, D., Kumar, N., and Kjelleberg, S. 2005. The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections. Curr. Opin. Investig. Drugs6, 178-184.
32. Song, Z., Kong, K. F., Wu, H., Maricic, N., Ramalingam, B., Priestap, H., Schneper, L., Quirke, J. M., Hoiby, N., and Mathee, K. 2010. Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. Phytomedicine17, 1040-1046.
33. Takaya, A., Tabuchi, F., Tsuchiya, H., Isogai, E., and Yamamoto, T. 2008. Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease. J. Bacteriol. 190, 4181-4188.
34. Tateda, K., Comte, R., Pechere, J. C., Kohler, T., Yamaguchi, K., and van Delden, C. 2001. Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 45, 1930-1933.
35. U. S. Food and Drug Administration. 2002. http://www. fda. gov/ohrms/DOCKETS/dailys/02/Sep02/091102/97s-0163-let0634-vol18. pdf.
36. Veesenmeyer, J. L., Hauser, A. R., Lisboa, T., and Rello, J. 2009. Pseudomonas aeruginosa virulence and therapy: Evolving translational strategies. Crit. Care Med. 37, 1777-1786.
37. Wu, T., Grassel, C., Levine, M. M., and Barry, E. M. 2011. Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin b subunit. Infect. Immun. 79, 4912-4922.
38. Wu, H., Song, Z., Hentzer, M., Andersen, J. B., Molin, S., Givskov, M., and Hoiby, N. 2004. Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J. Antimicrob. Chemother. 53, 1054-1061.
39. Yusof, N. M. and Halim, A. S. 2012. Outcomes of infected grade IIIB open tibial fractures. Singapore Med. J. 53, 591-594.