Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD

European Respiratory Journal

Volumn 23, Issue 5, 2004, Pages 685-691

  Banerjee, D ^a   Khair, O A ^a   Honeybourne, David ^a  

^a BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

Bacteria; Chronic obstructive pulmonary disease; Health status; Inflammation

Indexed keywords

FIBRINOGEN; INTERLEUKIN 8; LEUKOCYTE ELASTASE; LEUKOTRIENE B4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGE; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ISOLATE; BODY MASS; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FIBRINOGEN BLOOD LEVEL; HEALTH STATUS; HEALTH SURVEY; HUMAN; LUNG FUNCTION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; QUESTIONNAIRE; RESPIRATORY TRACT INFLAMMATION; SMOKING; SPUTUM ANALYSIS; SUPERNATANT;

AGED; BACTERIA; BLOOD VISCOSITY; BRONCHI; FIBRINOGEN; HEALTH STATUS; HUMANS; INFLAMMATION MEDIATORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX; SPUTUM;

EID: 2442533163     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.04.00056804     Document Type: Article

References (33)

1. Monso E, Ruiz J, Rosell A, Manterola J, Fiz J, Morera J. Bacterial infection in chronic obstructive pulmonary disease. A study of stable and exacerbated outpatients using the protected specimen brush. Am J Respir Crit Care Med 1995; 152: 1316-1320.
2. Monso E, Rosell A, Bonet G, Manterola J, Cardona PJ, Ruiz J. Risk factors for lower airway bacterial colonization in chronic bronchitis. Eur Respir J 1999; 13: 338-342.
3. Cabello H, Torres A, Celis R, El Ebiary M, Puig D, Xaubet A. Bacterial colonization of distal airways in healthy subjects and chronic lung disease: a bronchoscopic study. Eur Respir J 1997; 10: 1137-1144.
4. Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV. Simultaneous respiratory tract colonization by multiple strains of nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy. J Infect Dis 1999; 180: 404-409.
5. Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA. Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med 2000; 109: 288-295.
6. Soler N, Ewig S, Torres A, Filella X, Gonzalez J, Zaubet A. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur Respir J 1999; 14: 1015-1022.
7. Alessandri C, Basili S, Violi F, Ferroni P, Gazzaniga PP, Cordova C. Hypercoagulability state in patients with chronic obstructive pulmonary disease. Chronic Obstructive Bronchitis and Haemostasis Group. Thromb Haemost 1994; 72: 343-346.
8. Wedzicha JA, Seemungal TA, MacCallum PK, Paul EA, Donaldson GC, Bhowmik A. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost 2000; 84: 210-215.
9. Anon. BTS guidelines for the management of chronic obstructive pulmonary disease. The COPD Guidelines Group of the Standards of Care Committee of the BTS. Thorax 1997; 52: Suppl. 5, S1-S28.
10. Jarad NA, Wedzicha JA, Burge PS, Calverley PM. An observational study of inhaled corticosteroid withdrawal in stable chronic obstructive pulmonary disease. ISOLDE Study Group. Respir Med 1999; 93: 161-166.
11. Van der Valk P, Monninkhof E, Van der Palen J, Zielhuis G, van Herwaarden C. Effect of discontinuation of inhaled corticosteroids in patients with chronic obstructive pulmonary disease: the COPE study. Am J Respir Crit Care Med 2002; 166: 1358-1363.
12. Bhowmik A, Seemungal TA, Sapsford RJ, Devalia JL, Wedzicha JA. Comparison of spontaneous and induced sputum for investigation of airway inflammation in chronic obstructive pulmonary disease. Thorax 1998; 53: 953-956.
13. McGillivray DH, Burnett D, Afford SC, Stockley RA. An evaluation of four methods for the measurement of elastase activity. Clin Chim Acta 1981; 111: 289-294.
14. Stockley RA, Bayley DL. Validation of assays for inflammatory mediators in sputum. Eur Respir J 2000; 15: 778-781.
15. Falk W, Goodwin RH, Leonard EJ. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J Immunol Methods 1980; 33: 239-247.
16. Harvath L, Falk W, Leonard EJ. Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly. J Immunol Methods 1980; 37: 39-45.
17. Jepsen LV, Skottun T. A rapid one-step method for the isolation of human granulocytes from whole blood. Scand J Clin Lab Invest 1982; 42: 235-238.
18. Pye A, Stockley RA, Hill SL. Simple method for quantifying viable bacterial numbers in sputum. J Clin Pathol 1995; 48: 719-724.
19. Zalacain R, Sobradillo V, Amilibia J, Barron J, Achotegui V, Pijoan JI. Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease. Eur Respir J 1999; 13: 343-348.
20. Eller J, Ede A, Schaberg T. Infective exacerbations of chronic bronchitis. Chest 1998; 113: 1542-1548.
21. Wilson R. Bacteria, antibiotics and COPD. Eur Respir J 2001; 17: 995-1007.
22. Angrill J, Agusti C, De Celis R, et al. Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors. Thorax 2002; 57: 15-19.
23. Angrill J, Agusti C, De Celis R, et al. Bronchial inflammation and colonization in patients with clinically stable bronchiectasis. Am J Respir Crit Care Med 2001; 164: 1628-1632.
24. Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 1418-1422.
25. Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000; 55: 114-120.
26. Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57: 847-852.
27. Wilkinson TM, Patel IS, Wilks M, Donaldson GC, Wedzicha JA. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 167: 1090-1095.
28. Samet JM. Measuring the effectiveness of inhaled corticosteroids for COPD is not easy! Am J Respir Crit Care Med 2003; 168: 1-2.
29. Hattotuwa KL, Gizycki MJ, Ansari TW, Jeffery PK, Barnes NC. The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med 2002; 165: 1592-1596.
30. Keatings VM, Jatakanon A, Worsdell YM, Barnes PJ. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997; 155: 542-548.
31. Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, Barnes PJ. Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 1635-1639.
32. Llewellyn-Jones CG, Harris TA, Stockley RA. Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema. Am J Respir Crit Care Med 1996; 153: 616-621.
33. Patel IS, Roberts NJ, Lloyd-Owen SJ, Sapsford RJ, Wedzicha JA. Airway epithelial inflammatory responses and clinical parameters in COPD. Eur Respir J 2003; 22: 94-99.