Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 33, 2012, Pages 8171-8182

  Zhang, Zaijun ^a,b,c   Cui, Wei ^d   Li, Guohui ^e   Yuan, Shuai ^a,b   Xu, Daping ^a,b   Hoi, Maggie P M ^a,b   Lin, Zhixiu ^f   Dou, Juan ^g,h   Han, Yifan ^d   Lee, Simon M Y ^a,b  

^a China jack1987168 163com   (Macao)

^b University of Macau   (Macao)

^c JINAN UNIVERSITY   (China)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^g SUN YAT SEN UNIVERSITY   (China)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6-HYDROXYDOPAMINE (6-OHDA); ANTI-INFLAMMATORY ACTIVITY; ANTIOXIDANT RESPONSE ELEMENTS; BAICALEIN; CELLULAR DAMAGE; CONCENTRATION-DEPENDENT; CYTOPROTECTION; CYTOPROTECTIVE EFFECTS; EXPERIMENTAL MODELS; IN-VITRO; INDUCED DAMAGE; NEUROPROTECTIVE EFFECTS; NEUROTOXICITY; NUCLEAR TRANSLOCATIONS; OXIDATIVE DAMAGE; OXIDATIVE INJURY; OXYGENASES; PARKINSON'S DISEASE; PC12 CELLS; POST TREATMENT; PRE-TREATMENT; PROTEASOME INHIBITORS; PROTEIN EXPRESSIONS; PROTEIN PHOSPHORYLATION; SCUTELLARIA BAICALENSIS; SELECTIVE INHIBITORS; SIGNALING PATHWAYS; TRANSCRIPTIONAL ACTIVITY; TRANSCRIPTIONAL FACTORS; ZINC PROTOPORPHYRIN;

CELL DEATH; PHOSPHORYLATION; PIGMENTS; PROTEINS;

CHEMICAL COMPOUNDS;

ANTIOXIDANT; BAICALEIN; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; FLAVANONE DERIVATIVE; HEME OXYGENASE; HMOX1 PROTEIN, RAT; KEAP1 PROTEIN, RAT; LEUPEPTIN; NFE2L2 PROTEIN, RAT; OXIDOPAMINE; PROTEASOME INHIBITOR; PROTEIN; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTOPORPHYRIN; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROTECTION; DRUG EFFECT; METABOLISM; OXIDATIVE STRESS; PC12 CELL; PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; CYTOPROTECTION; FLAVANONES; HEME OXYGENASE (DECYCLIZING); LEUPEPTINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDOPAMINE; PC12 CELLS; PHOSPHORYLATION; PROTEASOME INHIBITORS; PROTEIN KINASE C-ALPHA; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTOPORPHYRINS; RATS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84865439362     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf301511m     Document Type: Article

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