Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis

Hepatology

Volumn 63, Issue 3, 2016, Pages 965-982

  Locatelli, Luigi ^a   Cadamuro, Massimiliano ^a,b   Spirlì, Carlo ^c   Fiorotto, Romina ^c   Lecchi, Silvia ^d   Morell, Carola Maria ^a   Popov, Yury ^e   Scirpo, Roberto ^a   De Matteis, Maria ^b   Amenduni, Mariangela ^c   Pietrobattista, Andrea ^f   Torre, Giuliano ^f   Schuppan, Detlef ^e,g   Fabris, Luca ^b,c   Strazzabosco, Mario ^a,c  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^c YALE UNIVERSITY   (United States)

^d PAPA GIOVANNI XXIII HOSPITAL   (Italy)

^e HARVARD MEDICAL SCHOOL   (United States)

^f BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^g JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAVBETA6 INTEGRIN; BETA CATENIN; CLODRONIC ACID; CXCL1 CHEMOKINE; FIBROCYSTIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA1; CELL SURFACE RECEPTOR; CHEMOKINE; COLLAGEN; INTEGRIN; PKHD1 PROTEIN, MOUSE; TGFB1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EPITHELIAL CELL; BONE MARROW DERIVED MACROPHAGE; CONGENITAL HEPATIC FIBROSIS; CONTROLLED STUDY; EPITHELIUM CELL; FIBROSIS; HUMAN; HUMAN TISSUE; LIVER CYST; LIVER FIBROSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PORTAL FIBROSIS; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN SECRETION; UPREGULATION; ANIMAL; DEFICIENCY; DISEASE MODEL; GENETIC DISORDER; IMMUNOLOGY; LIVER CIRRHOSIS; MACROPHAGE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; ANTIGENS, NEOPLASM; CHEMOKINES; CLODRONIC ACID; COLLAGEN; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENETIC DISEASES, INBORN; INTEGRINS; LIVER CIRRHOSIS; MACROPHAGES; MICE; MYOFIBROBLASTS; RECEPTORS, CELL SURFACE; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84955098530     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28382     Document Type: Article

References (32)

1. Ward CJ, Yuan D, Masyuk TV, Wang X, Punyashthiti R, Whelan S, et al. Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet 2003;12:2703-2710.
2. Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, et al. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci USA 2004;101:2311-2316.
3. Lazaridis KN, Strazzabosco M, Larusso NF. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 2004;127:1565-1577.
4. Nakanuma Y, Harada K, Sato Y, Ikeda H. Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia. Histol Histopathol 2010;25:223-235.
5. 675β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology 2013;58:1713-1723.
6. Anson M, Crain-Denoyelle AM, Baud V, Chereau F, Gougelet A, Terris B, et al. Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. J Clin Invest 2012;122:586-599.
7. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-435.
8. Nichols MT, Gidey E, Matzakos T, Dahl R, Stiegmann G, Shah RJ, et al. Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid. Hepatology 2004;40:836-846.
9. Fabris L, Cadamuro M, Fiorotto R, Roskams T, Spirlì C, Melero S, et al. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Hepatology 2006;43:1001-1012.
10. Gallagher AR, Esquivel EL, Briere TS, Tian X, Mitobe M, Menezes LF, et al. Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1. Am J Pathol 2008;172:417-429.
11. de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, et al. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. PLoS One 2010;5:e11256.
12. Sato A, Nakashima H, Nakashima M, Ikarashi M, Nishiyama K, Kinoshita M, et al. Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury. PLoS One 2014;9:e92515.
13. -/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol 2005;43:1045-1054.
14. Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, et al. Integrin αVβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 2008;48:453-464.
15. Teicher BA, Fricker SP. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010;16:2927-2931.
16. Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin αVβ6 on cholangiocytes blocks TGF-β activation and retards biliary fibrosis progression. Gastroenterology 2008;135:660-670.
17. O'Brien K, Font-Montgomery E, Lukose L, Bryant J, Piwnica-Worms K, Edwards H, et al. Congenital hepatic fibrosis and portal hypertension in autosomal dominant polycystic kidney disease. J Pediatr Gastroenterol Nutr 2012;54:83-89.
18. Dranoff JA, Wells RG. Portal fibroblasts: underappreciated mediators of biliary fibrosis. Hepatology 2010;51:1438-1444.
19. Fausther M, Lavoie EG, Dranoff JA. Contribution of myofibroblasts of different origins to liver fibrosis. Curr Pathobiol Rep 2013;1:225-230.
20. Antoniades CG, Quaglia A, Taams LS, Mitry RR, Hussain M, Abeles R, et al. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology 2012;56:735-746.
21. Sica A, Invernizzi P, Mantovani A. Macrophage plasticity and polarization in liver homeostasis and pathology. Hepatology 2014;59:2034-2042.
22. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012;122:787-795.
23. Morland CM, Fear J, McNab G, Joplin R, Adams DH. Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro. Proc Assoc Am Physicians 1997;109:372-382.
24. Hsieh CS, Huang CC, Wu JJ, Chaung HC, Wu CL, Chang NK, et al. Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. J Pediatr Surg 2001;36:1623-1628.
25. Lamireau T, Zoltowska M, Levy E, Yousef I, Rosenbaum J, Tuchweber B, et al. Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. Life Sci 2003;72:1401-1411.
26. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. The integrin αVβ6 binds and activates latent TGF-β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999;96:319-328.
27. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005;115:56-65.
28. Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature 2013;496:445-455.
29. Vieira SM, Lemos HP, Grespan R, Napimoga MH, Dal-Secco D, Freitas A, et al. A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5. Br J Pharmacol 2009;158:779-789.
30. Fabris L, Strazzabosco M. Epithelial-mesenchymal interactions in biliary diseases. Semin Liver Dis 2011;31:11-32.
31. Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells. Hepatology 1989;10:84-92.
32. Milani S, Herbst H, Schuppan D, Riecken EO, Stein H. Cellular localization of laminin gene transcripts in normal and fibrotic human liver. Am J Pathol 1989;134:1175-1182.