-
1
-
-
80053039210
-
Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis
-
Rivlin N, Brosh R, Oren M, Rotter V. Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes Cancer (2011) 2:466-74. doi: 10.1177/1947601911408889.
-
(2011)
Genes Cancer
, vol.2
, pp. 466-474
-
-
Rivlin, N.1
Brosh, R.2
Oren, M.3
Rotter, V.4
-
2
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, et al. Mutational landscape and significance across 12 major cancer types. Nature (2013) 502:333-9. doi:10.1038/nature12634.
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
-
3
-
-
70349443284
-
When mutants gain new powers: news from the mutant p53 field
-
Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 9:701-13. doi:10.1038/nrc2693.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 701-713
-
-
Brosh, R.1
Rotter, V.2
-
4
-
-
84862636275
-
Mutant p53: one name, many proteins
-
Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev (2012) 26:1268-86. doi:10.1101/gad.190678.112.
-
(2012)
Genes Dev
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
5
-
-
84868613148
-
The rebel angel: mutant p53 as the driving oncogene in breast cancer
-
Walerych D, Napoli M, Collavin L, Del Sal G. The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis (2012) 33:2007-17. doi:10.1093/carcin/bgs232.
-
(2012)
Carcinogenesis
, vol.33
, pp. 2007-2017
-
-
Walerych, D.1
Napoli, M.2
Collavin, L.3
Del Sal, G.4
-
6
-
-
84896098750
-
Mutant p53 in cancer: new functions and therapeutic opportunities
-
Muller PA, Vousden KH. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell (2014) 25:304-17. doi:10.1016/j.ccr.2014.01.021.
-
(2014)
Cancer Cell
, vol.25
, pp. 304-317
-
-
Muller, P.A.1
Vousden, K.H.2
-
7
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
-
Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat (2007) 28:622-9. doi:10.1002/humu.20495.
-
(2007)
Hum Mutat
, vol.28
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
Hainaut, P.6
-
8
-
-
79959428081
-
TP53 mutations in human cancer: database reassessment and prospects for the next decade
-
Soussi T. TP53 mutations in human cancer: database reassessment and prospects for the next decade. Adv Cancer Res (2011) 110:107-39. doi:10.1016/B978-0-12-386469-7.00005-0.
-
(2011)
Adv Cancer Res
, vol.110
, pp. 107-139
-
-
Soussi, T.1
-
9
-
-
80053022230
-
Li-Fraumeni syndrome
-
Malkin D. Li-Fraumeni syndrome. Genes Cancer (2011) 2:475-84. doi:10.1177/1947601911413466.
-
(2011)
Genes Cancer
, vol.2
, pp. 475-484
-
-
Malkin, D.1
-
10
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
-
Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science (1994) 265:346-55. doi:10.1126/science.8023157.
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
11
-
-
0034594995
-
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
-
Bullock AN, Henckel J, Fersht AR. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy. Oncogene (2000) 19:1245-56. doi:10.1038/sj.onc.1203434.
-
(2000)
Oncogene
, vol.19
, pp. 1245-1256
-
-
Bullock, A.N.1
Henckel, J.2
Fersht, A.R.3
-
12
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 119:847-60. doi:10.1016/j.cell.2004.11.004.
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
-
13
-
-
0031038701
-
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene
-
Varley JM, Thorncroft M, McGown G, Appleby J, Kelsey AM, Tricker KJ, et al. A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene. Oncogene (1997) 14:865-71. doi:10.1038/sj.onc.1201041.
-
(1997)
Oncogene
, vol.14
, pp. 865-871
-
-
Varley, J.M.1
Thorncroft, M.2
McGown, G.3
Appleby, J.4
Kelsey, A.M.5
Tricker, K.J.6
-
14
-
-
84932196346
-
A child with Li-Fraumeni syndrome: modes to inactivate the second allele of TP53 in three different malignancies
-
Schlegelberger B, Kreipe H, Lehmann U, Steinemann D, Ripperger T, Gohring G, et al. A child with Li-Fraumeni syndrome: modes to inactivate the second allele of TP53 in three different malignancies. Pediatr Blood Cancer (2015) 62:1481-4. doi:10.1002/pbc.25486.
-
(2015)
Pediatr Blood Cancer
, vol.62
, pp. 1481-1484
-
-
Schlegelberger, B.1
Kreipe, H.2
Lehmann, U.3
Steinemann, D.4
Ripperger, T.5
Gohring, G.6
-
15
-
-
84905900572
-
The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele
-
Shetzer Y, Kagan S, Koifman G, Sarig R, Kogan-Sakin I, Charni M, et al. The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele. Cell Death Differ (2014) 21:1419-31. doi:10.1038/cdd.2014.57.
-
(2014)
Cell Death Differ
, vol.21
, pp. 1419-1431
-
-
Shetzer, Y.1
Kagan, S.2
Koifman, G.3
Sarig, R.4
Kogan-Sakin, I.5
Charni, M.6
-
16
-
-
44149121239
-
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
-
Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, et al. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev (2008) 22:1337-44. doi:10.1101/gad.1662908.
-
(2008)
Genes Dev
, vol.22
, pp. 1337-1344
-
-
Terzian, T.1
Suh, Y.A.2
Iwakuma, T.3
Post, S.M.4
Neumann, M.5
Lang, G.A.6
-
17
-
-
82655181478
-
Multiple stress signals activate mutant p53 in vivo
-
Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, et al. Multiple stress signals activate mutant p53 in vivo. Cancer Res (2011) 71:7168-75. doi:10.1158/0008-5472.CAN-11-0459.
-
(2011)
Cancer Res
, vol.71
, pp. 7168-7175
-
-
Suh, Y.A.1
Post, S.M.2
Elizondo-Fraire, A.C.3
Maccio, D.R.4
Jackson, J.G.5
El-Naggar, A.K.6
-
18
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell (2004) 119:861-72. doi:10.1016/j.cell.2004.11.006.
-
(2004)
Cell
, vol.119
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.A.3
Liu, G.4
Rao, V.A.5
Parant, J.M.6
-
19
-
-
0025085667
-
Different tumor-derived p53 mutants exhibit distinct biological activities
-
Halevy O, Michalovitz D, Oren M. Different tumor-derived p53 mutants exhibit distinct biological activities. Science (1990) 250:113-6. doi:10.1126/science.2218501.
-
(1990)
Science
, vol.250
, pp. 113-116
-
-
Halevy, O.1
Michalovitz, D.2
Oren, M.3
-
20
-
-
0027210981
-
Gain of function mutations in p53
-
Dittmer D, Pati S, Zambetti G, Chu S, Teresky AK, Moore M, et al. Gain of function mutations in p53. Nat Genet (1993) 4:42-6. doi:10.1038/ng0593-42.
-
(1993)
Nat Genet
, vol.4
, pp. 42-46
-
-
Dittmer, D.1
Pati, S.2
Zambetti, G.3
Chu, S.4
Teresky, A.K.5
Moore, M.6
-
21
-
-
34247329362
-
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
-
Song H, Hollstein M, Xu Y. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol (2007) 9:573-80. doi:10.1038/ncb1571.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 573-580
-
-
Song, H.1
Hollstein, M.2
Xu, Y.3
-
22
-
-
84898614449
-
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling
-
Weissmueller S, Manchado E, Saborowski M, Morris JPT, Wagenblast E, Davis CA, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. Cell (2014) 157:382-94. doi:10.1016/j.cell.2014.01.066.
-
(2014)
Cell
, vol.157
, pp. 382-394
-
-
Weissmueller, S.1
Manchado, E.2
Saborowski, M.3
Morris, J.P.T.4
Wagenblast, E.5
Davis, C.A.6
-
23
-
-
84904985329
-
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53
-
Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, et al. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A (2014) 111:11145-50. doi:10.1073/pnas.1404139111.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 11145-11150
-
-
Xiong, S.1
Tu, H.2
Kollareddy, M.3
Pant, V.4
Li, Q.5
Zhang, Y.6
-
24
-
-
84870828710
-
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo
-
Lee MK, Teoh WW, Phang BH, Tong WM, Wang ZQ, Sabapathy K. Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo. Cancer Cell (2012) 22:751-64. doi:10.1016/j.ccr.2012.10.022.
-
(2012)
Cancer Cell
, vol.22
, pp. 751-764
-
-
Lee, M.K.1
Teoh, W.W.2
Phang, B.H.3
Tong, W.M.4
Wang, Z.Q.5
Sabapathy, K.6
-
25
-
-
77952005099
-
Characterization of functional domains necessary for mutant p53 gain of function
-
Yan W, Chen X. Characterization of functional domains necessary for mutant p53 gain of function. J Biol Chem (2010) 285:14229-38. doi:10.1074/jbc. M109.097253.
-
(2010)
J Biol Chem
, vol.285
, pp. 14229-14238
-
-
Yan, W.1
Chen, X.2
-
26
-
-
84935901131
-
Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
-
Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, et al. Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities. Nat Commun (2015) 6:7389. doi:10.1038/ncomms8389.
-
(2015)
Nat Commun
, vol.6
, pp. 7389
-
-
Kollareddy, M.1
Dimitrova, E.2
Vallabhaneni, K.C.3
Chan, A.4
Le, T.5
Chauhan, K.M.6
-
27
-
-
84941220446
-
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
-
Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature (2015) 525:206-11. doi:10.1038/nature15251.
-
(2015)
Nature
, vol.525
, pp. 206-211
-
-
Zhu, J.1
Sammons, M.A.2
Donahue, G.3
Dou, Z.4
Vedadi, M.5
Getlik, M.6
-
28
-
-
55849136479
-
The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs
-
Di Agostino S, Cortese G, Monti O, Dell'Orso S, Sacchi A, Eisenstein M, et al. The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs. Cell Cycle (2008) 7:3440-7. doi:10.4161/cc.7.21.6995.
-
(2008)
Cell Cycle
, vol.7
, pp. 3440-3447
-
-
Di Agostino, S.1
Cortese, G.2
Monti, O.3
Dell'Orso, S.4
Sacchi, A.5
Eisenstein, M.6
-
29
-
-
63049136592
-
A mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
-
Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, et al. A mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 137:87-98. doi:10.1016/j.cell.2009.01.039.
-
(2009)
Cell
, vol.137
, pp. 87-98
-
-
Adorno, M.1
Cordenonsi, M.2
Montagner, M.3
Dupont, S.4
Wong, C.5
Hann, B.6
-
30
-
-
33748211158
-
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
-
Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, et al. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell (2006) 10:191-202. doi:10.1016/j.ccr.2006.08.013.
-
(2006)
Cancer Cell
, vol.10
, pp. 191-202
-
-
Di Agostino, S.1
Strano, S.2
Emiliozzi, V.3
Zerbini, V.4
Mottolese, M.5
Sacchi, A.6
-
31
-
-
79960039752
-
A pin1/mutant p53 axis promotes aggressiveness in breast cancer
-
Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, et al. A pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell (2011) 20:79-91. doi:10.1016/j.ccr.2011.06.004.
-
(2011)
Cancer Cell
, vol.20
, pp. 79-91
-
-
Girardini, J.E.1
Napoli, M.2
Piazza, S.3
Rustighi, A.4
Marotta, C.5
Radaelli, E.6
-
32
-
-
77649298024
-
Modulation of the vitamin D3 response by cancer-associated mutant p53
-
Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, et al. Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell (2010) 17:273-85. doi:10.1016/j.ccr.2009.11.025.
-
(2010)
Cancer Cell
, vol.17
, pp. 273-285
-
-
Stambolsky, P.1
Tabach, Y.2
Fontemaggi, G.3
Weisz, L.4
Maor-Aloni, R.5
Siegfried, Z.6
-
33
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 148:244-58. doi:10.1016/j.cell.2011.12.017.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerod, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
-
34
-
-
70349791957
-
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
-
Fontemaggi G, Dell'Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol (2009) 16:1086-93. doi:10.1038/nsmb.1669.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1086-1093
-
-
Fontemaggi, G.1
Dell'Orso, S.2
Trisciuoglio, D.3
Shay, T.4
Melucci, E.5
Fazi, F.6
-
35
-
-
84859869155
-
Mutant p53 cooperates with ETS2 to promote etoposide resistance
-
Do PM, Varanasi L, Fan S, Li C, Kubacka I, Newman V, et al. Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes Dev (2012) 26:830-45. doi:10.1101/gad.181685.111.
-
(2012)
Genes Dev
, vol.26
, pp. 830-845
-
-
Do, P.M.1
Varanasi, L.2
Fan, S.3
Li, C.4
Kubacka, I.5
Newman, V.6
-
36
-
-
84919480782
-
Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP
-
Di Minin G, Bellazzo A, Dal Ferro M, Chiaruttini G, Nuzzo S, Bicciato S, et al. Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP. Mol Cell (2014) 56:617-29. doi:10.1016/j.molcel.2014.10.013.
-
(2014)
Mol Cell
, vol.56
, pp. 617-629
-
-
Di Minin, G.1
Bellazzo, A.2
Dal Ferro, M.3
Chiaruttini, G.4
Nuzzo, S.5
Bicciato, S.6
-
37
-
-
84863311924
-
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
-
Coffill CR, Muller PA, Oh HK, Neo SP, Hogue KA, Cheok CF, et al. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 13:638-44. doi:10.1038/embor.2012.74.
-
(2012)
EMBO Rep
, vol.13
, pp. 638-644
-
-
Coffill, C.R.1
Muller, P.A.2
Oh, H.K.3
Neo, S.P.4
Hogue, K.A.5
Cheok, C.F.6
-
38
-
-
84925247214
-
Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4
-
Polotskaia A, Xiao G, Reynoso K, Martin C, Qiu WG, Hendrickson RC, et al. Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. Proc Natl Acad Sci U S A (2015) 112(11):E1220-9. doi:10.1073/pnas.1416318112.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.11
, pp. E1220-E1229
-
-
Polotskaia, A.1
Xiao, G.2
Reynoso, K.3
Martin, C.4
Qiu, W.G.5
Hendrickson, R.C.6
-
39
-
-
72249100428
-
Mutant p53 drives invasion by promoting integrin recycling
-
Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, et al. Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 139:1327-41. doi:10.1016/j.cell.2009.11.026.
-
(2009)
Cell
, vol.139
, pp. 1327-1341
-
-
Muller, P.A.1
Caswell, P.T.2
Doyle, B.3
Iwanicki, M.P.4
Tan, E.H.5
Karim, S.6
-
40
-
-
27644529786
-
Tumor-derived p53 mutants induce NF-kappaB2 gene expression
-
Scian MJ, Stagliano KE, Anderson MA, Hassan S, Bowman M, Miles MF, et al. Tumor-derived p53 mutants induce NF-kappaB2 gene expression. Mol Cell Biol (2005) 25:10097-110. doi:10.1128/MCB.25.22.10097-10110.2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10097-10110
-
-
Scian, M.J.1
Stagliano, K.E.2
Anderson, M.A.3
Hassan, S.4
Bowman, M.5
Miles, M.F.6
-
41
-
-
84890695935
-
Tumour-associated mutant p53 drives the Warburg effect
-
Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 4:2935. doi:10.1038/ncomms3935.
-
(2013)
Nat Commun
, vol.4
, pp. 2935
-
-
Zhang, C.1
Liu, J.2
Liang, Y.3
Wu, R.4
Zhao, Y.5
Hong, X.6
-
42
-
-
84862864843
-
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
-
Neilsen PM, Noll JE, Suetani RJ, Schulz RB, Al-Ejeh F, Evdokiou A, et al. Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome. Oncotarget (2011) 2(12):1203-17. doi:10.18632/oncotarget.382.
-
(2011)
Oncotarget
, vol.2
, Issue.12
, pp. 1203-1217
-
-
Neilsen, P.M.1
Noll, J.E.2
Suetani, R.J.3
Schulz, R.B.4
Al-Ejeh, F.5
Evdokiou, A.6
-
43
-
-
83255185781
-
TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73
-
Liu K, Ling S, Lin WC. TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73. Mol Cell Biol (2011) 31:4464-81. doi:10.1128/MCB.05574-11.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4464-4481
-
-
Liu, K.1
Ling, S.2
Lin, W.C.3
-
44
-
-
84923295067
-
Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
-
Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun (2014) 5:5476. doi:10.1038/ncomms6476.
-
(2014)
Nat Commun
, vol.5
, pp. 5476
-
-
Chowdhury, P.1
Lin, G.E.2
Liu, K.3
Song, Y.4
Lin, F.T.5
Lin, W.C.6
-
45
-
-
84869121043
-
Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature
-
Solomon H, Buganim Y, Kogan-Sakin I, Pomeraniec L, Assia Y, Madar S, et al. Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci (2012) 125:3144-52. doi:10.1242/jcs.099663.
-
(2012)
J Cell Sci
, vol.125
, pp. 3144-3152
-
-
Solomon, H.1
Buganim, Y.2
Kogan-Sakin, I.3
Pomeraniec, L.4
Assia, Y.5
Madar, S.6
-
46
-
-
84897579255
-
Metabolic control of YAP and TAZ by the mevalonate pathway
-
Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol (2014) 16:357-66. doi:10.1038/ncb2936.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 357-366
-
-
Sorrentino, G.1
Ruggeri, N.2
Specchia, V.3
Cordenonsi, M.4
Mano, M.5
Dupont, S.6
-
47
-
-
84957440360
-
-
EMBO Rep
-
Di Agostino S, Sorrentino G, Ingallina E, Valenti F, Ferraiuolo M, Bicciato S, et al. YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins. EMBO Rep (2015).
-
(2015)
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins
-
-
Di Agostino, S.1
Sorrentino, G.2
Ingallina, E.3
Valenti, F.4
Ferraiuolo, M.5
Bicciato, S.6
-
48
-
-
79955532880
-
Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions
-
Zhang Y, Yan W, Chen X. Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. J Biol Chem (2011) 286:16218-28. doi:10.1074/jbc. M110.214585.
-
(2011)
J Biol Chem
, vol.286
, pp. 16218-16228
-
-
Zhang, Y.1
Yan, W.2
Chen, X.3
-
49
-
-
30544452870
-
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
-
Bossi G, Lapi E, Strano S, Rinaldo C, Blandino G, Sacchi A. Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression. Oncogene (2006) 25:304-9. doi:10.1038/sj.onc.1209026.
-
(2006)
Oncogene
, vol.25
, pp. 304-309
-
-
Bossi, G.1
Lapi, E.2
Strano, S.3
Rinaldo, C.4
Blandino, G.5
Sacchi, A.6
-
50
-
-
0029737509
-
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90
-
Blagosklonny MV, Toretsky J, Bohen S, Neckers L. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc Natl Acad Sci U S A (1996) 93:8379-83. doi:10.1073/pnas.93.16.8379.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8379-8383
-
-
Blagosklonny, M.V.1
Toretsky, J.2
Bohen, S.3
Neckers, L.4
-
51
-
-
0029145215
-
Geldanamycin selectively destabilizes and conformationally alters mutated p53
-
Blagosklonny MV, Toretsky J, Neckers L. Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene (1995) 11:933-9.
-
(1995)
Oncogene
, vol.11
, pp. 933-939
-
-
Blagosklonny, M.V.1
Toretsky, J.2
Neckers, L.3
-
52
-
-
0031586616
-
Geldanamycin prevents nuclear translocation of mutant p53
-
Dasgupta G, Momand J. Geldanamycin prevents nuclear translocation of mutant p53. Exp Cell Res (1997) 237:29-37. doi:10.1006/excr.1997.3766.
-
(1997)
Exp Cell Res
, vol.237
, pp. 29-37
-
-
Dasgupta, G.1
Momand, J.2
-
53
-
-
84937604711
-
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
-
Alexandrova EM, Yallowitz AR, Li D, Xu S, Schulz R, Proia DA, et al. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature (2015) 523:352-6. doi:10.1038/nature14430.
-
(2015)
Nature
, vol.523
, pp. 352-356
-
-
Alexandrova, E.M.1
Yallowitz, A.R.2
Li, D.3
Xu, S.4
Schulz, R.5
Proia, D.A.6
-
54
-
-
81155134638
-
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
-
Li D, Marchenko ND, Moll UM. SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 18(12):1904-13. doi:10.1038/cdd.2011.71.
-
(2011)
Cell Death Differ
, vol.18
, Issue.12
, pp. 1904-1913
-
-
Li, D.1
Marchenko, N.D.2
Moll, U.M.3
-
55
-
-
84875163565
-
Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
-
Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X. Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene (2013) 32:599-609. doi:10.1038/onc.2012.81.
-
(2013)
Oncogene
, vol.32
, pp. 599-609
-
-
Yan, W.1
Liu, S.2
Xu, E.3
Zhang, J.4
Zhang, Y.5
Chen, X.6
-
56
-
-
84937759226
-
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
-
Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, et al. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med (2015) 21:457-66. doi:10.1038/nm.3839.
-
(2015)
Nat Med
, vol.21
, pp. 457-466
-
-
Wei, S.1
Kozono, S.2
Kats, L.3
Nechama, M.4
Li, W.5
Guarnerio, J.6
-
57
-
-
0030961889
-
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
-
Selivanova G, Iotsova V, Okan I, Fritsche M, Strom M, Groner B, et al. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med (1997) 3:632-8. doi:10.1038/nm0697-632.
-
(1997)
Nat Med
, vol.3
, pp. 632-638
-
-
Selivanova, G.1
Iotsova, V.2
Okan, I.3
Fritsche, M.4
Strom, M.5
Groner, B.6
-
58
-
-
0037154149
-
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants
-
Friedler A, Hansson LO, Veprintsev DB, Freund SM, Rippin TM, Nikolova PV, et al. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U S A (2002) 99:937-42. doi:10.1073/pnas.241629998.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 937-942
-
-
Friedler, A.1
Hansson, L.O.2
Veprintsev, D.B.3
Freund, S.M.4
Rippin, T.M.5
Nikolova, P.V.6
-
59
-
-
53049108919
-
Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells
-
Guida E, Bisso A, Fenollar-Ferrer C, Napoli M, Anselmi C, Girardini JE, et al. Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells. Cancer Res (2008) 68:6550-8. doi:10.1158/0008-5472.CAN-08-0137.
-
(2008)
Cancer Res
, vol.68
, pp. 6550-6558
-
-
Guida, E.1
Bisso, A.2
Fenollar-Ferrer, C.3
Napoli, M.4
Anselmi, C.5
Girardini, J.E.6
-
60
-
-
0033601370
-
Pharmacological rescue of mutant p53 conformation and function
-
Foster BA, Coffey HA, Morin MJ, Rastinejad F. Pharmacological rescue of mutant p53 conformation and function. Science (1999) 286:2507-10. doi:10.1126/science.286.5449.2507.
-
(1999)
Science
, vol.286
, pp. 2507-2510
-
-
Foster, B.A.1
Coffey, H.A.2
Morin, M.J.3
Rastinejad, F.4
-
61
-
-
84930891710
-
CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo
-
He X, Kong X, Yan J, Zhang Y, Wu Q, Chang Y, et al. CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. Tumour Biol (2015) 36:1437-44. doi:10.1007/s13277-014-2389-8.
-
(2015)
Tumour Biol
, vol.36
, pp. 1437-1444
-
-
He, X.1
Kong, X.2
Yan, J.3
Zhang, Y.4
Wu, Q.5
Chang, Y.6
-
62
-
-
84940460460
-
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells
-
Li P, Zhao M, Parris AB, Feng X, Yang X. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochem Biophys Res Commun (2015) 464:1267-74. doi:10.1016/j.bbrc.2015.07.117.
-
(2015)
Biochem Biophys Res Commun
, vol.464
, pp. 1267-1274
-
-
Li, P.1
Zhao, M.2
Parris, A.B.3
Feng, X.4
Yang, X.5
-
63
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P, et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med (2002) 8:282-8. doi:10.1038/nm0302-282.
-
(2002)
Nat Med
, vol.8
, pp. 282-288
-
-
Bykov, V.J.1
Issaeva, N.2
Shilov, A.3
Hultcrantz, M.4
Pugacheva, E.5
Chumakov, P.6
-
64
-
-
84905124070
-
Mutant p53 reactivation by small molecules makes its way to the clinic
-
Bykov VJ, Wiman KG. Mutant p53 reactivation by small molecules makes its way to the clinic. FEBS Lett (2014) 588:2622-7. doi:10.1016/j.febslet.2014.04.017.
-
(2014)
FEBS Lett
, vol.588
, pp. 2622-2627
-
-
Bykov, V.J.1
Wiman, K.G.2
-
65
-
-
65449144050
-
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
-
Lambert JM, Gorzov P, Veprintsev DB, Soderqvist M, Segerback D, Bergman J, et al. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell (2009) 15:376-88. doi:10.1016/j.ccr.2009.03.003.
-
(2009)
Cancer Cell
, vol.15
, pp. 376-388
-
-
Lambert, J.M.1
Gorzov, P.2
Veprintsev, D.B.3
Soderqvist, M.4
Segerback, D.5
Bergman, J.6
-
66
-
-
52449087539
-
PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53
-
Zache N, Lambert JM, Wiman KG, Bykov VJ. PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53. Cell Oncol (2008) 30:411-8. doi:10.3233/CLO-2008-0440.
-
(2008)
Cell Oncol
, vol.30
, pp. 411-418
-
-
Zache, N.1
Lambert, J.M.2
Wiman, K.G.3
Bykov, V.J.4
-
67
-
-
77949267055
-
Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
-
Lambert JM, Moshfegh A, Hainaut P, Wiman KG, Bykov VJ. Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene (2010) 29:1329-38. doi:10.1038/onc.2009.425.
-
(2010)
Oncogene
, vol.29
, pp. 1329-1338
-
-
Lambert, J.M.1
Moshfegh, A.2
Hainaut, P.3
Wiman, K.G.4
Bykov, V.J.5
-
68
-
-
84861368058
-
Allele-specific p53 mutant reactivation
-
Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-specific p53 mutant reactivation. Cancer Cell (2012) 21:614-25. doi:10.1016/j.ccr.2012.03.042.
-
(2012)
Cancer Cell
, vol.21
, pp. 614-625
-
-
Yu, X.1
Vazquez, A.2
Levine, A.J.3
Carpizo, D.R.4
-
69
-
-
48749103325
-
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
-
Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 105:10360-5. doi:10.1073/pnas.0805326105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10360-10365
-
-
Boeckler, F.M.1
Joerger, A.C.2
Jaggi, G.3
Rutherford, T.J.4
Veprintsev, D.B.5
Fersht, A.R.6
-
70
-
-
84880234835
-
Small molecule induced reactivation of mutant p53 in cancer cells
-
Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J, et al. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res (2013) 41:6034-44. doi:10.1093/nar/gkt305.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 6034-6044
-
-
Liu, X.1
Wilcken, R.2
Joerger, A.C.3
Chuckowree, I.S.4
Amin, J.5
Spencer, J.6
-
71
-
-
84889674337
-
Disarming mutant p53 oncogenic function
-
Girardini JE, Marotta C, Del Sal G. Disarming mutant p53 oncogenic function. Pharmacol Res (2014) 79:75-87. doi:10.1016/j.phrs.2013.11.003.
-
(2014)
Pharmacol Res
, vol.79
, pp. 75-87
-
-
Girardini, J.E.1
Marotta, C.2
Del Sal, G.3
-
72
-
-
84867615093
-
Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
-
Lehmann S, Bykov VJ, Ali D, Andren O, Cherif H, Tidefelt U, et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J Clin Oncol (2012) 30:3633-9. doi:10.1200/JCO.2011.40.7783.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3633-3639
-
-
Lehmann, S.1
Bykov, V.J.2
Ali, D.3
Andren, O.4
Cherif, H.5
Tidefelt, U.6
-
73
-
-
84859726248
-
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
-
Ma CX, Cai S, Li S, Ryan CE, Guo Z, SchaiffWT, et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest (2012) 122:1541-52. doi:10.1172/JCI58765.
-
(2012)
J Clin Invest
, vol.122
, pp. 1541-1552
-
-
Ma, C.X.1
Cai, S.2
Li, S.3
Ryan, C.E.4
Guo, Z.5
Schaiff, W.T.6
-
74
-
-
84873411856
-
Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells
-
Origanti S, Cai SR, Munir AZ, White LS, Piwnica-Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene (2013) 32:577-88. doi:10.1038/onc.2012.84.
-
(2013)
Oncogene
, vol.32
, pp. 577-588
-
-
Origanti, S.1
Cai, S.R.2
Munir, A.Z.3
White, L.S.4
Piwnica-Worms, H.5
-
75
-
-
84877947967
-
A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer
-
Ma CX, Ellis MJ, Petroni GR, Guo Z, Cai SR, Ryan CE, et al. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat (2013) 137:483-92. doi:10.1007/s10549-012-2378-9.
-
(2013)
Breast Cancer Res Treat
, vol.137
, pp. 483-492
-
-
Ma, C.X.1
Ellis, M.J.2
Petroni, G.R.3
Guo, Z.4
Cai, S.R.5
Ryan, C.E.6
-
76
-
-
84888814077
-
The spectrum of statin therapy in cancer patients: is there a need for further investigation?
-
Gonyeau MJ. The spectrum of statin therapy in cancer patients: is there a need for further investigation? Curr Atheroscler Rep (2014) 16:383. doi:10.1007/s11883-013-0383-z.
-
(2014)
Curr Atheroscler Rep
, vol.16
, pp. 383
-
-
Gonyeau, M.J.1
-
77
-
-
84901257251
-
HSP90 inhibitors: current development and potential in cancer therapy
-
Sidera K, Patsavoudi E. HSP90 inhibitors: current development and potential in cancer therapy. Recent Pat Anticancer Drug Discov (2014) 9:1-20. doi:10.2174/15748928113089990031.
-
(2014)
Recent Pat Anticancer Drug Discov
, vol.9
, pp. 1-20
-
-
Sidera, K.1
Patsavoudi, E.2
-
78
-
-
84892942381
-
New and emerging HDAC inhibitors for cancer treatment
-
West AC, Johnstone RW. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest (2014) 124:30-9. doi:10.1172/JCI69738.
-
(2014)
J Clin Invest
, vol.124
, pp. 30-39
-
-
West, A.C.1
Johnstone, R.W.2
-
79
-
-
19444387176
-
PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis
-
Bykov VJ, Zache N, Stridh H, Westman J, Bergman J, Selivanova G, et al. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene (2005) 24:3484-91. doi:10.1038/sj.onc.1208419.
-
(2005)
Oncogene
, vol.24
, pp. 3484-3491
-
-
Bykov, V.J.1
Zache, N.2
Stridh, H.3
Westman, J.4
Bergman, J.5
Selivanova, G.6
-
80
-
-
84859103002
-
Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells
-
Messina RL, Sanfilippo M, Vella V, Pandini G, Vigneri P, Nicolosi ML, et al. Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells. Int J Cancer (2012) 130:2259-70. doi:10.1002/ijc.26228.
-
(2012)
Int J Cancer
, vol.130
, pp. 2259-2270
-
-
Messina, R.L.1
Sanfilippo, M.2
Vella, V.3
Pandini, G.4
Vigneri, P.5
Nicolosi, M.L.6
-
81
-
-
84872760450
-
PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation
-
Kobayashi N, Abedini M, Sakuragi N, Tsang BK. PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation. J Ovarian Res (2013) 6:7. doi:10.1186/1757-2215-6-7.
-
(2013)
J Ovarian Res
, vol.6
, pp. 7
-
-
Kobayashi, N.1
Abedini, M.2
Sakuragi, N.3
Tsang, B.K.4
|