Genetic factors in systemic lupus erythematosus: Contribution to disease phenotype

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Ceccarelli, Fulvia ^a   Perricone, Carlo ^a   Borgiani, Paola ^b   Ciccacci, Cinzia ^b   Rufini, Sara ^b   Cipriano, Enrica ^a   Alessandri, Cristiano ^a   Spinelli, Francesca Romana ^a   Sili Scavalli, Antonio ^a   Novelli, Giuseppe ^b   Valesini, Guido ^a   Conti, Fabrizio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTHRALGIA; GENETIC VARIABILITY; HEREDITY; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; META ANALYSIS (TOPIC); NEUROLOGIC DISEASE; ONSET AGE; PHENOTYPE; REVIEW; RHEUMATOID ARTHRITIS; SKIN MANIFESTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; DISEASE COURSE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; IMMUNOLOGY; LUPUS ERYTHEMATOSUS NEPHRITIS; RISK;

ANIMALS; DISEASE PROGRESSION; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; PHENOTYPE; POLYMORPHISM, GENETIC; RISK;

EID: 84954483802     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/745647     Document Type: Review

References (88)

1. G. C. Tsokos, "Systemic lupus erythematosus, "TheNew England Journal of Medicine, vol. 365, no. 22, pp. 2110-2121, 2011.
2. R. R. Graham, S. V. Kozyrev, E. C. Baechler et al. , "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus, " Nature Genetics, vol. 38, no. 5, pp. 550-555, 2006.
3. J. B. Harley, M. E. Alarcon-Riquelme, L. A. Criswell et al. , "Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci, " Nature Genetics, vol. 40, no. 2, pp. 204-210, 2008.
4. E. F. Remmers, R. M. Plenge, A. T. Lee et al. , "STAT4 andthe risk of rheumatoid arthritis and systemic lupus erythematosus, " The New England Journal of Medicine, vol. 357, no. 10, pp. 977-986, 2007.
5. V. Gateva, J. K. Sandling, G. Homet al. , "Alarge-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus, "NatureGenetics, vol. 41, no. 11, pp. 1228-1233, 2009.
6. O. J. Rullo and B. P. Tsao, "Recent insights into the genetic basis of systemic lupus erythematosus, " Annals of the Rheumatic Diseases, vol. 72, no. 2, pp. ii56-ii61, 2013.
7. Y. Ghodke-Puranik and T. B. Niewold, "Genetics of the type I interferon pathway in systemic lupus erythematosus, " International Journal of Clinical Rheumatology, vol. 8, no. 6, pp. 657-669, 2013.
8. J. B. Harley, J. A. Kelly, and K. M. Kaufman, "Unraveling the genetics of systemic lupus erythematosus, " Springer Seminars in Immunopathology, vol. 28, no. 2, pp. 119-130, 2006.
9. Avolcanic explosionof autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients, " Autoimmunity Reviews, vol. 14, no. 1, pp. 75-79, 2015.
10. R. Cervera, M. A. Khamashta, J. Font, G. D. Sebastiani, A. Gil, P. Lavilla et al. , "Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1, 000 patients. Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1, 000 patients. European Working Party on Systemic Lupus Erythematosus, " Medicine, vol. 78, no. 3, pp. 167-175, 1999.
11. Y. Li, X. Fang, and Q.-Z. Li, "Biomarker profiling for lupus nephritis, " Genomics, Proteomics and Bioinformatics, vol. 11, no. 3, pp. 158-165, 2013.
12. F. Conti, F. Ceccarelli, A. Gigante et al. , "Ultrasonographic evaluation of renal resistive index in patients with lupus nephritis: correlation with histologic findings, " Ultrasound in Medicine and Biology, vol. 40, no. 11, pp. 2573-2580, 2014.
13. Z. Niu, P. Zhang, and Y. Tong, "Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a metaanalysis, " International Journal of Rheumatic Diseases, vol. 18, no. 1, pp. 17-28, 2015.
14. U. S. Deshmukh, D. L. Sim, C. Dai et al. , "HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD, " Journal of Autoimmunity, vol. 37, no. 3, pp. 254-262, 2011.
15. S. A. Chung, E. E. Brown, A. H. Williams et al. , "Lupus nephritis susceptibility loci in women with systemic lupus erythematosus, " Journal of the American Society of Nephrology, vol. 25, no. 12, pp. 2859-2870, 2014.
16. K. E. Taylor, S. A. Chung, R. R. Graham et al. , "Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes, " PLoS Genetics, vol. 7, no. 2, Article ID e1001311, 2011.
17. K. Bolin, J. K. Sandling, A. Zickert et al. , "Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis, " PLoS ONE, vol. 8, no. 12, Article IDe84450, 2013.
18. K. E. Taylor, E. F. Remmers, A. T. Lee et al. , "Specificity of the STAT4 genetic association for severe diseasemanifestations of systemic lupus erythematosus, " PLoS Genetics, vol. 4, no. 5, Article ID e1000084, 2008.
19. A. Kawasaki, I. Ito, K. Hikami et al. , "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region, " Arthritis Research and Therapy, vol. 10, article R113, 2008.
20. P. Li, C. Cao, H. Luan et al. , "Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in aNorthernHan Chinese population, " Human Immunology, vol. 72, no. 3, pp. 249-255, 2011.
21. J. C. Crispin, M. Oukka, G. Bayliss et al. , "Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys, " The Journal of Immunology, vol. 181, no. 12, pp. 8761-8766, 2008.
22. S. Morimoto, S. Nakano, T. Watanabe et al. , "Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of (BAFF) in T cell-dependent B cell pathogenic autoantibody production, " Rheumatology, vol. 46, no. 7, pp. 1083-1086, 2007.
23. Y. Deng and B. P. Tsao, "Genetic susceptibility to systemic lupus erythematosus in the genomic era, " Nature Reviews Rheumatology, vol. 6, no. 12, pp. 683-692, 2010.
24. W. Yang, M. Zhao, N. Hirankarn et al. , "ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese andThai, " Human Molecular Genetics, vol. 18, no. 11, pp. 2063-2070, 2009.
25. T. M. Jarvinen, A. Hellquist, S. Koskenmies et al. , "Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus, " PLoS ONE, vol. 5, no. 12, Article ID e14212, 2010.
26. X. Kim-Howard, A. K. Maiti, J.-M. Anaya et al. , "ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry, " Annals of the Rheumatic Diseases, vol. 69, no. 7, pp. 1329-1332, 2010.
27. E. Sanchez, A. Nadig, B. C. Richardson et al. , "Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus, " Annals of the Rheumatic Diseases, vol. 70, no. 10, pp. 1752-1757, 2011.
28. S. C. Fagerholm, M. Macpherson, M. J. James, C. Sevier-Guy, and C. S. Lau, "The CD11b-integrin (ITGAM) and systemic lupus erythematosus, " Lupus, vol. 22, no. 7, pp. 657-663, 2013.
29. F. B. Karassa, T. A. Trikalinos, and J. P. A. Ioannidis, "The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: a meta-analysis, " Kidney International, vol. 63, no. 4, pp. 1475-1482, 2003.
30. G. S. Alarcon, G. McGwin Jr. , M. Petri et al. , "Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort, " PLoS Medicine, vol. 3, article e396, 2006.
31. R. Salloum and T. B. Niewold, "Interferon regulatory factors in human lupus pathogenesis, " Translational Research, vol. 157, no. 6, pp. 326-331, 2011.
32. S. G. Guerra, T. J. Vyse, and D. S. Cunninghame Graham, "The genetics of lupus: a functional perspective, " Arthritis Research and Therapy, vol. 14, article 211, 2012.
33. L. Qin, J. Lv, X. Zhou, P. Hou, H. Yang, and H. Zhang, "Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population, " Nephrology, vol. 15, no. 7, pp. 710-713, 2010.
34. P. Li, C. Cao, H. Luan et al. , "Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in aNorthernHan Chinese population, " Human Immunology, vol. 72, no. 3, pp. 249-255, 2011.
35. E. Stuber and W. Strober, "The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response, " The Journal of Experimental Medicine, vol. 183, no. 3, pp. 979-989, 1996.
36. J. Aten, A. Roos, N. Claessen, E. J. M. Schilder-Tol, I. J. M. Ten Berge, and J. J. Weening, "Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis, " Journal of the American Society of Nephrology, vol. 11, no. 8, pp. 1426-1438, 2000.
37. Y.-B. Zhou, R.-G. Ye, Y.-J. Li, and C.-M. Xie, "Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis, " Rheumatology International, vol. 29, no. 4, pp. 417-425, 2009.
38. M. N. Farres, D. S. Al-Zifzaf, A. A. Aly, and N. M. Abd Raboh, "OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis, " Annals of Saudi Medicine, vol. 31, no. 1, pp. 29-34, 2011.
39. D. Panneer, P. T. Antony, and V. S. Negi, "Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients, " Lupus, vol. 22, no. 10, pp. 996-1000, 2013.
40. A. Hakkim, B. G. Furnrohr, K. Amann et al. , "Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis, " Proceedings of theNational Academy of Sciences of the United States of America, vol. 107, no. 21, pp. 9813-9818, 2010.
41. Y. M. Mosaad, A. Hammad, Z. Fawzy et al. , "C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis, " Clinical and Experimental Immunology, vol. 182, no. 1, pp. 23-34, 2015.
42. M. Radanova, V. Vasilev, T. Dimitrov, B. Deliyska, V. Ikonomov, and D. Ivanova, "Association of rs172378 C1q gene cluster polymorphism with lupus nephritis in Bulgarian patients, " Lupus, vol. 24, no. 3, pp. 280-289, 2015.
43. H. Jeltsch-David and S. Muller, "Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers, " Nature Reviews Neurology, vol. 10, pp. 579-596, 2014.
44. M. Koga, A. Kawasaki, I. Ito et al. , "Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population, " Journal of Human Genetics, vol. 56, no. 7, pp. 503-507, 2011.
45. B. de Vries, G. M. Steup-Beekman, J. Haan et al. , "TREX1 gene variant in neuropsychiatric systemic lupus erythematosus, " Annals of the Rheumatic Diseases, vol. 69, no. 10, pp. 1886-1887, 2010.
46. M. A. Lee-Kirsch, M. Gong, D. Chowdhury et al. , "Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus, "NatureGenetics, vol. 39, no. 9, pp. 1065-1067, 2007.
47. B. Namjou, P. H. Kothari, J. A. Kelly et al. , "Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort, " Genes and Immunity, vol. 12, no. 4, pp. 270-279, 2011.
48. E. M. A. Ball and A. L. Bell, "Lupus arthritis-do we have a clinically useful classification?" Rheumatology, vol. 51, no. 5, Article ID ker381, pp. 771-779, 2012.
49. T. Warchol, M. Lianeri, J. K. Lacki, M. Olesinska, and P. P. Jagodzinski, "ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients fromasample of the polishpopulation, " DNA and Cell Biology, vol. 30, no. 1, pp. 33-38, 2011.
50. J. de Azevedo Silva, K. Monteiro Fernandes, J. A. Tres Pancotto et al. , "Vitamin D receptor (VDR) gene polymorphisms and susceptibility to systemic lupus erythematosus clinical manifestations, " Lupus, vol. 22, no. 11, pp. 1110-1117, 2013.
51. A. Singh and D. L. Kamen, "Potential benefits of vitamin D for patients with systemic lupus erythematosus, " Dermato-Endocrinology, vol. 4, no. 2, pp. 146-151, 2012.
52. M. Abbasi, Z. Rezaieyazdi, J. T. Afshari, M. Hatef, M. Sahebari, and N. Saadati, "Lack of association of vitamin D receptor gene BsmI polymorphisms in patients with systemic lupus erythematosus, " Rheumatology International, vol. 30, no. 11, pp. 1537-1539, 2010.
53. T. A. Briggs, G. I. Rice, S. Daly et al. , "Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature, " Nature Genetics, vol. 43, no. 2, pp. 127-131, 2011.
54. A. Jonsen, I. Gunnarsson, B. Gullstrand et al. , "Association between SLE nephritis and polymorphic variants of the CRP and FcγRIIIa genes, " Rheumatology, vol. 46, no. 9, pp. 1417-1421, 2007.
55. C. Ciccacci, C. Perricone, F. Ceccarelli et al. , "A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene, " PLoS ONE, vol. 9, no. 11, Article ID e111991, 2014.
56. J.-Y. Chen, C. M. Wang, C.-C. Ma et al. , "Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients, " Arthritis and Rheumatism, vol. 54, no. 12, pp. 3908-3917, 2006.
57. J. Y. Chen, C. M. Wang, S. W. Chang et al. , "Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients, " Arthritis and Rheumatology, vol. 66, pp. 3113-3121, 2014.
58. A. M. D. S. Fonseca, J. D. A. Silva, J. A. T. Pancotto et al. , "Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations, " Gene, vol. 527, no. 2, pp. 435-439, 2013.
59. C. Tanasescu, E. Balanescu, P. Balanescu et al. , "IL-17 in cutaneous lupus erythematosus, " European Journal of Internal Medicine, vol. 21, no. 3, pp. 202-207, 2010.
60. D. L. Damian, Y. J. Kim, K. M. Dixon, G. M. Halliday, A. Javeri, and R. S. Mason, "Topical calcitriol protects from UVinduced genetic damage but suppresses cutaneous immunity in humans, " Experimental Dermatology, vol. 19, no. 8, pp. 23-30, 2010.
61. D. Wang, R. Liu, H. Zhu, D. Zhou, Q. Mei, and G. Xu, "Vitamin D receptor Fok I polymorphism is associated with low bone mineral density in postmenopausal women: a meta-analysis focused on populations in Asian countries, " European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 169, no. 2, pp. 380-386, 2013.
62. Y. X. Cui, C. W. Fu, F. Jiang, L. X. Ye, and W. Meng, "Association of the interleukin-6 polymorphismswith systemic lupus erythematosus: a meta-analysis, " Lupus, vol. 24, no. 12, pp. 1308-1317, 2015.
63. C. Perricone, C. Ciccacci, F. Ceccarelli et al. , "TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development, " Immunogenetics, vol. 65, no. 10, pp. 703-709, 2013.
64. L. Wu, C. Wang, B. Boisson et al. , "The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling, " Journal of Immunology, vol. 193, no. 4, pp. 1590-1599, 2014.
65. X. Li, "Act1modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling, " Cytokine, vol. 41, no. 2, pp. 105-113, 2008.
66. A. Strange, F. Capon, C. C. Spencer, J. Knight, M. E. Weale, M. H. Allen et al. , "A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1, " Nature Genetics, vol. 42, no. 11, pp. 985-990, 2010.
67. L. Espino-Paisan, H. de la Calle, M. Fernandez-Arquero et al. , "A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes, " Immunogenetics, vol. 63, no. 4, pp. 255-258, 2011.
68. R. Spolski and W. J. Leonard, "The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer, " Current Opinion in Immunology, vol. 20, no. 3, pp. 295-301, 2008.
69. G. Monteleone, F. Pallone, and T. T. MacDonald, "Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses, " Trends in Immunology, vol. 29, no. 6, pp. 290-294, 2008.
70. I. Peluso, M. C. Fantini, D. Fina et al. , "IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes, " The Journal of Immunology, vol. 178, no. 2, pp. 732-739, 2007.
71. Y. Sherer, A. Gorstein, M. J. Fritzler, and Y. Shoenfeld, "Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients, " Seminars inArthritis and Rheumatism, vol. 34, no. 2, pp. 501-537, 2004.
72. C. Fabrizio, C. Fulvia, P. Carlo et al. , "Systemic lupus erythematosus with and without anti-dsDNA antibodies: analysis from a large monocentric cohort, " Mediators of Inflammation, vol. 2015, Article ID 328078, 6 pages, 2015.
73. M. R. Arbuckle, M. T. McClain, M. V. Rubertone et al. , "Development of autoantibodies before the clinical onset of systemic lupus erythematosus, " The New England Journal of Medicine, vol. 349, no. 16, pp. 1526-1533, 2003.
74. C. Perricone, N. Agmon-Levin, F. Ceccarelli, G. Valesini, J.-M. Anaya, and Y. Shoenfeld, "Genetics and autoantibodies, " Immunologic Research, vol. 56, no. 2-3, pp. 206-219, 2013.
75. T. A. Podrebarac, D. M. Boisert, and R. Goldstein, "Clinical correlates, serum autoantibodies and the role of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with SLE, " Lupus, vol. 7, no. 3, pp. 183-191, 1998.
76. C. Vasconcelos, C. Carvalho, B. Leal et al. , "HLA in Portuguese systemic lupus erythematosus patients and their relation to clinical features, " Annals of the New York Academy of Sciences, vol. 1173, pp. 575-580, 2009.
77. S. Sigurdsson, G. Nordmark, S. Garnier et al. , "A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5, " Human Molecular Genetics, vol. 17, no. 18, pp. 2868-2876, 2008.
78. S. A. Chung, K. E. Taylor, R. R. Graham et al. , "Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production, " PLoS Genetics, vol. 7, no. 3, Article ID e1001323, 2011.
79. E. Genin, M. Schumacher, J.-C. Rouaeau et al. , "Genomewide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe, " Orphanet Journal of Rare Diseases, vol. 6, article 52, 2011.
80. T. H. Karlsen, A. Franke, E. Melum et al. , "Genome-wide association analysis in primary sclerosing cholangitis, " Gastroenterology, vol. 138, no. 3, pp. 1102-1111, 2010.
81. R. M. Clancy, M. C. Marion, K. M. Kaufman et al. , "Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus, " Arthritis and Rheumatism, vol. 62, no. 11, pp. 3415-3424, 2010.
82. D. L. Morris, M. M. A. Fernando, K. E. Taylor et al. , "MHC associations with clinical and autoantibody manifestations in European SLE, " Genes and Immunity, vol. 15, no. 4, pp. 210-217, 2014.
83. T. B. Niewold, J. A. Kelly, S. N. Kariuki et al. , "IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus, " Annals of the Rheumatic Diseases, vol. 71, no. 3, pp. 463-468, 2012.
84. M. J. Walport and P. J. Lachmann, "Complement deficiencies and abnormalities of the complement system in systemic lupus erythematosus and related disorders, " Current Opinion in Rheumatology, vol. 2, no. 4, pp. 661-663, 1990.
85. R. F. van Vollenhoven, M. Mosca, G. Bertsias et al. , "Treat-totarget in systemic lupus erythematosus: recommendations from an international task force, " Annals of the Rheumatic Diseases, vol. 73, no. 6, pp. 958-967, 2014.
86. C. Carvalho, A. Marinho, B. Leal et al. , "Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients, " Lupus, vol. 24, no. 8, pp. 846-853, 2015.
87. D. Gladman, E. Ginzler, C. Goldsmith et al. , "The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus, " Arthritis and Rheumatism, vol. 39, no. 3, pp. 363-369, 1996.
88. A. C. Bonfa, L. P. C. Seguro, V. Caparbo, E. Bonfa, and R. M. R. Pereira, "RANKL and OPG gene polymorphisms: associations with vertebral fractures and bone mineral density in premenopausal systemic lupus erythematosus, " Osteoporosis International, vol. 26, no. 5, pp. 1563-1571, 2015.