The CD11b-integrin (ITGAM) and systemic lupus erythematosus

Lupus

Volumn 22, Issue 7, 2013, Pages 657-663

  Fagerholm, S C ^a,b   Macpherson, M ^a   James, M J ^a,c   Sevier Guy, C ^a,d   Lau, C S ^e  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d NHS TAYSIDE   (United Kingdom)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

integrin; ITGAM; Systemic lupus erythematosus

Indexed keywords

ARGININE; CD11B ANTIGEN; CD18 ANTIGEN; HISTIDINE; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

DISEASE COURSE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IMMUNITY; IMMUNOPATHOGENESIS; ITGAM GENE; PRIORITY JOURNAL; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

INTEGRIN; ITGAM; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD11B; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGE-1 ANTIGEN; RISK FACTORS;

EID: 84879231072     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203313491851     Document Type: Review

References (43)

1. Rhodes B, Vyse TJ. The genetics of SLE: An update in the light of genome-wide association studies. Rheumatology (Oxford). 2008 ; 47: 1603-1611
2. Hom G, Graham RR, Modrek B, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 ; 358: 900-909
3. Nath SK, Han S, Kim-Howard X, et al. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet. 2008 ; 40: 152-154
4. Harley JB, Alarcón-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008 ; 40: 204-210
5. Fan Y, Li LH, Pan HF, Tao JH, Sun ZQ, Ye DQ. Association of ITGAM polymorphism with systemic lupus erythematosus: A meta-analysis. J Eur Acad Dermatol Venereol. 2011 ; 25: 271-275
6. Han S, Kim-Howard X, Deshmukh H, et al. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet. 2009 ; 18: 1171-1180
7. Yang W, Zhao M, Hirankarn N, et al. ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai. Hum Mol Genet. 2009 ; 18: 2063-2070
8. Kim-Howard X, Maiti AK, Anaya JM, et al. ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry. Ann Rheum Dis. 2010 ; 69: 1329-1332
9. Hellquist A, Zucchelli M, Lindgren CM, et al. Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). PLoS One. 2009 ; 4: e8037 - e8037
10. Warchol T, Lianeri M, Lacki JK, Olesinska M, Jagodzinski PP. ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population. DNA Cell Biol. 2011 ; 30: 33-38
11. Kim K, Brown EE, Choi CB, et al. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis. 2012 ; 71: 1809-1814
12. Anaya JM, Kim-Howard X, Prahalad S, et al. Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev. 2012 ; 11: 276-280
13. Jarvinen TM, Hellquist A, Koskenmies S, et al. Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus. PLoS One. 2010 ; 5: e14212 - e14212
14. Suarez-Gestal M, Calaza M, Dieguez-Gonzalez R, et al. Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. Arthritis Rheum. 2009 ; 60: 2558-2564
15. Tan SM. The leucocyte β2 (CD18) integrins: The structure, functional regulation and signalling properties. Biosci Rep. 2012 ; 32: 241-269
16. Etzioni A. Genetic etiologies of leukocyte adhesion defects. Curr Opin Immunol. 2009 ; 21: 481-486
17. Gahmberg CG, Fagerholm SC, Nurmi SM, Chavakis T, Marchesan S, Gronholm M. Regulation of integrin activity and signalling. Biochim Biophys Acta. 2009 ; 1790: 431-444
18. Morelli AE, Larregina AT, Shufesky WJ, et al. Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: Dependence on complement receptors and effect on cytokine production. Blood. 2003 ; 101: 611-620
19. Phillipson M, Heit B, Colarusso P, Liu L, Ballantyne CM, Kubes P. Intraluminal crawling of neutrophils to emigration sites: A molecularly distinct process from adhesion in the recruitment cascade. J Exp Med. 2006 ; 203: 2569-2575
20. Fagerholm SC, Varis M, Stefanidakis M, Hilden TJ, Gahmberg CG. alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation. Blood. 2006 ; 108: 3379-3386
21. Podgrabinska S, Kamalu O, Mayer L, et al. Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J Immunol. 2009 ; 183: 1767-1779
22. Varga G, Balkow S, Wild MK, et al. Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation. Blood. 2007 ; 109: 661-669
23. Ehirchiou D, Xiong Y, Xu G, Chen W, Shi Y, Zhang L. CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J Exp Med. 2007 ; 204: 1519-1524
24. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol. 2010 ; 11: 734-742
25. Wang L, Gordon RA, Huynh L, et al. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity. 2010 ; 32: 518-530
26. Kevil CG, Hicks MJ, He X, et al. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am J Pathol. 2004 ; 165: 609-616
27. Yung R, Powers D, Johnson K, et al. Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest. 1996 ; 97: 2866-2871
28. MacPherson M, Lek HS, Prescott A, Fagerholm SC. A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis. J Biol Chem. 2011 ; 286: 17303-17310
29. Rhodes B, Fürnrohr BG, Roberts AL, et al. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. Ann Rheum Dis. 2012 ; 71: 2028-2034
30. Fossati-Jimack L, Ling GS, Cortini A, et al. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS One. 2013 ; 8: e57082 - e57082
31. Gaipl US, Voll RE, Sheriff A, Franz S, Kalden JR, Herrmann M. Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev. 2005 ; 4: 189-194
32. Ren Y, Tang J, Mok MY, Chan AW, Wu A, Lau CS. Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis Rheum. 2003 ; 48: 2888-2897
33. Chan VS, Nie YJ, Shen N, Yan S, Mok MY, Lau CS. Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus. Autoimmun Rev. 2012 ; 11: 890-897
34. Behrens EM, Ning Y, Muvarak N, Zoltick PW, Flake AW, Gallucci S. Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization. J Immunol. 2008 ; 181: 3018-3026
35. Mok MY, Wu HJ, Lo Y, Lau CS. The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus. J Rheumatol. 2010 ; 37: 2046-2052
36. van Spriel AB, Leusen JH, van Egmond M, et al. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood. 2001 ; 97: 2478-2486
37. Van Spriel AB, Leusen JH, Vile H, Van De Winkel JG. Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA. J Immunol. 2002 ; 169: 3831-3836
38. van Spriel AB, van Ojik HH, Bakker A, Jansen MJ, van de Winkel JG. Mac-1 (CD11b/CD18) is crucial for effective Fc receptor-mediated immunity to melanoma. Blood. 2003 ; 101: 253-258
39. Kelley JM, Edberg JC, Kimberly RP. Pathways: Strategies for susceptibility genes in SLE. Autoimmun Rev. 2010 ; 9: 473-476
40. Rosetti F, Tsuboi N, Chen K, et al. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 ; 189: 3714-3723
41. Björklund M, Aitio O, Stefanidakis M, et al. Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment. Biochemistry. 2006 ; 45: 2862-2871
42. Maiguel D, Faridi MH, Wei C, et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal. 2011 ; 4: ra57 - ra57
43. Reed JH, Jain M, Lee K, et al. Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: Implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins. J Biol Chem. 2013 ; 288: 9077-9083