Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model

Anatomical Record

Volumn 299, Issue 2, 2016, Pages 256-266

  Bai, Shi ^a,b   Hu, Zhiying ^c   Yang, Yang ^a   Yin, Yifei ^a   Li, Weiyun ^a   Wu, Lijuan ^b   Fang, Marong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TAIZHOU UNIVERSITY   (China)

^c Hangzhou Red Cross Hospital   (China)

Author keywords

Cerebral ischemia; COX 2; Neuroinflammation; NF B; Triptolide

Indexed keywords

ANTIINFLAMMATORY AGENT; CASPASE 3; CYCLOOXYGENASE 2; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; TRIPTOLIDE; ALKYLATING AGENT; DITERPENE; EPOXIDE; MESSENGER RNA; NITRIC OXIDE; PHENANTHRENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN INFARCTION VOLUME; BRAIN SIZE; BRAIN WATER; CELL ACTIVATION; CHINESE HERB; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; DRUG POTENCY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MALE; MORTALITY RATE; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NEUROLOGIC EXAMINATION; NEUROLOGICAL SEVERITY SCORE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT MODEL; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TRIPTERYGIUM WILFORDII; TUNEL ASSAY; UPREGULATION; WATER CONTENT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ENZYME IMMUNOASSAY; ENZYMOLOGY; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DITERPENES; EPOXY COMPOUNDS; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

EID: 84954402238     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.23293     Document Type: Article

References (33)

1. Chen LW, Wang YQ, Wei LC, Shi M, Chan YS. 2007. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets 6:273-281.
2. Dai YQ, Jin DZ, Zhu XZ, Lei DL. 2006. Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neurosci Res 55:154-160.
3. del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. 2000. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10:95-112.
4. Denes A, Thornton P, Rothwell NJ, Allan SM. 2010. Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav Immun 24:708-723.
5. Emsley HC, Tyrrell PJ. 2002. Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab 22:1399-1419.
6. Fang M, Huang JY, Wang J, Ling SC, Rudd JA, Hu ZY, Xu LH, Yuan ZG, Han S. 2011. Anti-neuroinflammatory and neurotrophic effects of combined therapy with annexin II and Reg-2 on injured spinal cord. Neurosignals 19:16-43.
7. Gao HM, Liu B, Zhang W, Hong JS. 2003. Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci 24:395-401.
8. Harari OA, Liao JK. 2010. NF-kappaB and innate immunity in ischemic stroke. Ann N Y Acad Sci 1207:32-40.
9. Ishrat T, Sayeed I, Atif F, Stein DG. 2009. Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 1257:94-101.
10. Jin XQ, Ye F, Zhang JJ, Zhao Y, Zhou XL. 2015. Triptolide attenuates cerebral ischemia and reperfusion injury in rats through the inhibition the nuclear factor kappa B signaling pathway. Neuropsychiatr Dis Treat 11:1395-1403.
11. Khan MM, Gandhi C, Chauhan N, Stevens JW, Motto DG, Lentz SR, Chauhan AK. 2012. Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice. Stroke 43:1376-1382.
12. Koistinaho J, Chan PH. 2000. Spreading depression-induced cyclooxygenase-2 expression in the cortex. Neurochem Res 25:645-651.
13. Liu Y, Chen HL, Yang G. 2010. Extract of Tripterygium wilfordii Hook F protect dopaminergic neurons against lipopolysaccharide-induced inflammatory damage. Am J Chin Med 38:801-814.
14. Maddahi A, Edvinsson L. 2010. Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway. J Neuroinflammation 7:14
15. Martinez-Murillo R, Fernandez AP, Serrano J, Rodrigo J, Salas E, Mourelle M, Martinez A. 2007. The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model. Neurosci Lett 415:149-153.
16. Mdzinarishvili A, Kiewert C, Kumar V, Hillert M, Klein J. 2007. Bilobalide prevents ischemia-induced edema formation in vitro and in vivo. Neuroscience 144:217-222.
17. Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N, Chan PH. 2010. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 1802:92-99.
18. Qiu D, Kao PN. 2003. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 4:1-18.
19. Sasaki T, Kitagawa K, Yamagata K, Takemiya T, Tanaka S, Omura-Matsuoka E, Sugiura S, Matsumoto M, Hori M. 2004. Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. J Cereb Blood Flow Metab 24:107-113.
20. Sieber MW, Claus RA, Witte OW, Frahm C. 2011. Attenuated inflammatory response in aged mice brains following stroke. PloS One 6:e26288
21. Su Z, Yuan Y, Cao L, Zhu Y, Gao L, Qiu Y, He C. 2010. Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation. Glia 58:901-915.
22. Sugimoto K, Iadecola C. 2003. Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. Brain Res960:273-276.
23. Tao X, Lipsky PE. 2000. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum Dis Clin North Am 26:29-50, viii.
24. Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. 2011. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol 7:182-188.
25. Tuttolomondo A, Di Sciacca R, Di Raimondo D, Renda C, Pinto A, Licata G. 2009. Inflammation as a therapeutic target in acute ischemic stroke treatment. Curr Top Med Chem 9:1240-1260.
26. Vaibhav K, Shrivastava P, Javed H, Khan A, Ahmed ME, Tabassum R, Khan MM, Khuwaja G, Islam F, Siddiqui MS, Safhi MM, Islam F. 2012. Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-kappaB in middle cerebral artery occlusion rat model. Mol Cell Biochem 367:73-84.
27. Wang X, Liang XB, Li FQ, Zhou HF, Liu XY, Wang JJ, Wang XM. 2008. Therapeutic strategies for Parkinson's disease: The ancient meets the future-traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells. Neurochem Res 33:1956-1963.
28. Xue B, Jiao J, Zhang L, Li KR, Gong YT, Xie JX, Wang XM. 2007. Triptolide upregulates NGF synthesis in rat astrocyte cultures. Neurochem Res 32:1113-1119.
29. Yang Y, Gao K, Hu Z, Li W, Davies H, Ling S, Rudd JA, Fang M. 2015. Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia. Mediators Inflamm 2015:120198
30. Yasuda Y, Shimoda T, Uno K, Tateishi N, Furuya S, Tsuchihashi Y, Kawai Y, Naruse S, Fujita S. 2011. Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats. J Neuroinflamm 8:70
31. Zhao G, Vaszar LT, Qiu D, Shi L, Kao PN. 2000. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 279:L958-L966.
32. Zhou HF, Liu XY, Niu DB, Li FQ, He QH, Wang XM. 2005. Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection. Neurobiol Dis 18:441-449.
33. Zhu N, Li H, Han M, Guo L, Chen L, Yun Y, Guo Z, Li G, Sang N. 2012. Environmental nitrogen dioxide (NO2) exposure influences development and progression of ischemic stroke. Toxicol Lett 214:120-130.