Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  Yang, Yang ^a   Gao, Keqiang ^a   Hu, Zhiying ^b   Li, Weiyun ^a   Davies, Henry ^a   Ling, Shucai ^a   Rudd, John A ^c   Fang, Marong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Hangzhou Red Cross Hospital   (China)

^c Prince of Wales Hospital   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 HYDROXYPYRIMIDINE; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN MCL 1; PYRIMIDINE DERIVATIVE; TRIPTOLIDE; UNCLASSIFIED DRUG; 5-DEHYDRO-3-DEOXY-D-ARABINO-HEPTULOSONIC ACID-7-PHOSPHATE; DITERPENE; EPOXIDE; PHENANTHRENE DERIVATIVE; SUGAR ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; IMMUNOBLOTTING; IMMUNOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; GENETICS; IMMUNOHISTOCHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUNEL ASSAY;

RATTUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; BRAIN ISCHEMIA; DITERPENES; EPOXY COMPOUNDS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SUGAR ACIDS;

EID: 84924086597     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/120198     Document Type: Article

References (36)

1. U. Dirnagl, C. Iadecola, and M. A. Moskowitz, "Pathobiology of ischaemic stroke: an integrated view," Trends in Neurosciences, vol. 22, no. 9, pp. 391-397, 1999.
2. C.-Y. Chen, Y.-B. Huang, and C. T.-C. Lee, "Epidemiology and disease burden of ischemic stroke in Taiwan," International Journal of Neuroscience, vol. 123, no. 10, pp. 724-731, 2013.
3. P. Zhang, W. Li, L. Li et al., "Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury," Neuroscience, vol. 201, pp. 297-306, 2012.
4. T. V. Arumugam, T. M. Phillips, A. Cheng, C. H. Morrell, M. P. Mattson, and R. Wan, "Age and energy intake interact to modify cell stress pathways and stroke outcome," Annals of Neurology, vol. 67, no. 1, pp. 41-52, 2010.
5. P. Wang,Y.-F. Guan,H. Du,Q.-W. Zhai,D.-F. Su, and C.-Y. Miao, "Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemic stroke," Autophagy, vol. 8, no. 1, pp. 77-87, 2012.
6. M. A. Moskowitz, E. H. Lo, and C. Iadecola, "The science of stroke:mechanisms in search of treatments," Neuron, vol. 67,no. 2, pp. 181-198, 2010.
7. S. Carloni, G. Buonocore, and W. Balduini, "Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury," Neurobiology of Disease, vol. 32, no. 3, pp. 329-339, 2008.
8. A. Rami, A. Langhagen, and S. Steiger, "Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death," Neurobiology of Disease, vol. 29, no. 1, pp. 132-141, 2008.
9. L. Liu, Y.-Q. Fang, Z.-F. Xue, Y.-P. He, R.-M. Fang, and L. Li, "Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1," European Journal of Pharmacology, vol. 680, no. 1-3, pp. 34-40, 2012.
10. S. Xing, Y. Zhang, J. Li et al., "Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction," Autophagy, vol. 8, no. 1, pp. 63-76, 2012.
11. A. Mdzinarishvili,C. Kiewert,v.Kumar,M. Hillert, and J. Klein, "Bilobalide prevents ischemia-induced edema formation in vitro and in vivo," Neuroscience, vol. 144, no. 1, pp. 217-222, 2007.
12. C. Xingyong, S. Xicui, S. Huanxing et al., "Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1- dependent autophagy in ischemic stroke in rats," BMC Neuroscience, vol. 14, article 56, 2013.
13. T. Wu,H. Wu, and J. Wang, "Expressionandcellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain," Journal of Neuroinflammation, vol. 8, article 22, 2011.
14. G. A. Kidd, H. Hong, A. Majid, D. I. Kaufman, and A. F. Chen, "Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke," Stroke, vol. 36, no. 12, pp. 2705-2711, 2005.
15. Y. Yao, H. Li, N. Dong et al., "The protective effects and its underlying mechanism of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats," Zhonghua Shao Shang Za Zhi, vol. 18, no. 2, pp. 84-87, 2002.
16. L.-W. Chen, Y.-Q. Wang, L.-C. Wei, M. Shi, and Y.-S. Chan, "Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease," CNS and Neurological Disorders: Drug Targets, vol. 6, no. 4, pp. 273-281, 2007.
17. Y. Liu, H.-L. Chen, and G. Yang, "Extract of Tripterygium wilfordii Hook F protect dopaminergic neurons against lipopolysaccharide-induced inflammatory damage," The American Journal of ChineseMedicine, vol. 38,no. 4, pp. 801-814, 2010.
18. M. Klawitter, L. Quero, J. Klasen et al., "Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells," European Spine Journal, vol. 21, supplement 6, pp. S850-S859, 2012.
19. Y. Lu, Y. Zhang, L. Li et al., "TAB1: a target of triptolide in macrophages," Chemistry and Biology, vol. 21, no. 2, pp. 246-256, 2014.
20. L. Li, N. H. Khatibi, Q. Hu et al., "Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats," Experimental Neurology, vol. 234, no. 1, pp. 181-190, 2012.
21. C. L. Luo, B. X. Li, Q. Q. Li et al., "Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice," Neuroscience, vol. 184, pp. 54-63, 2011.
22. G. A. Deuchar, D. Brennan, H. Griffiths, I. MacRae, and C. Santosh, "Perfluorocarbons enhance a T2∗-based MRI technique for identifying the penumbra in a rat model of acute ischemic stroke," Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 9, pp. 1422-1428, 2013.
23. L. Zhang, X. Hu, J. Luo et al., "Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats," BMC Neuroscience, vol. 14, article 46, 2013.
24. Y.-C. Wang, S. Zhang, T.-Y. Du, B. Wang, and X.-Q. Sun, "Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte," Brain Research, vol. 1323, pp. 149-151, 2010.
25. Y.-Q. Zheng, J.-X. Liu, X.-Z. Li, L. Xu, and Y.-G. Xu, "RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats," Acta Pharmacologica Sinica, vol. 30, no. 7, pp. 919-927, 2009.
26. W. Yan, H. Zhang, X. Bai, Y. Lu, H. Dong, and L. Xiong, "Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats," Brain Research, vol. 1402, pp. 109-121, 2011.
27. X. Zhang, S. Deguchi, K. Deguchi et al., "Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zuckermetabolic syndrome rats," Journal of Neuroscience Research, vol. 89, no. 8, pp. 1228-1234, 2011.
28. H.-K. Park, K. Chu, K.-H. Jung et al., "Autophagy is involved in the ischemic preconditioning," Neuroscience Letters, vol. 451, no. 1, pp. 16-19, 2009.
29. S. Sadasivan, W. A. Dunn Jr., R. L. Hayes, and K. K. W. Wang, "Changes in autophagy proteins in a ratmodel of controlled cortical impact induced brain injury," Biochemical and Biophysical Research Communications, vol. 373, no. 4, pp. 478-481, 2008.
30. M. Gaytán, C. Morales, J. E. Sánchez-Criado, and F. Gaytán, "Immunolocalization of beclin 1, a bcl-2-binding, autophagyrelated protein, in the human ovary: possible relation to life span of corpus luteum," Cell and Tissue Research, vol. 331, no. 2, pp. 509-517, 2008.
31. R. Kim, M. Emi, K. Matsuura, and K. Tanabe, "Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl- 2 as a chemosensitizer in cancer therapy," Cancer Gene Therapy, vol. 14, no. 1, pp. 1-11, 2007.
32. Z. Zhan, Q. Li, P. Wu et al., "Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1," Autophagy, vol. 8, no. 1, pp. 109-121, 2012.
33. C.M. Smith, Y. Chen, M. L. Sullivan, P. M. Kochanek, and R. S. B. Clark, "Autophagy in acute brain injury: feast, famine, or folly?" Neurobiology of Disease, vol. 43, no. 1, pp. 52-59, 2011.
34. S. Shen, O. Kepp, and G. Kroemer, "The end of autophagic cell death?" Autophagy, vol. 8, no. 1, pp. 1-3, 2012.
35. A. Bhardwaj, N. J. Alkayed, J. R. Kirsch, and P. D. Hurn, "Mechanisms of ischemic brain damage," Current Cardiology Reports, vol. 5, no. 2, pp. 160-167, 2003.
36. M. D. Ginsberg, "Neuroprotection for ischemic stroke: past, present and future," Neuropharmacology, vol. 55, no. 3, pp. 363-389, 2008.