Attenuated inflammatory response in aged mice brains following stroke

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Sieber, Matthias W ^a   Claus, Ralf A ^a   Witte, Otto W ^a   Frahm, Christiane ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; CHEMOKINE;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; CONTROLLED STUDY; ENCEPHALITIS; GENE EXPRESSION PROFILING; IMMUNOPATHOGENESIS; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REPERFUSION; STROKE; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; TIME;

ANIMALIA; MUS;

AGING; ANIMALS; BRAIN; CHEMOKINES; FEMALE; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; MICE; STROKE; TIME FACTORS;

EID: 80054766188     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026288     Document Type: Article

References (57)

1. Dilger RN, Johnson RW, (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84: 932-939.
2. Truelsen T, Piechowski-Jozwiak B, Bonita R, Mathers C, Bogousslavsky J, et al. (2006) Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol 13: 581-598.
3. Donnan GA, Fisher M, Macleod M, Davis SM, (2008) Stroke. Lancet 371: 1612-1623.
4. Saposnik G, Black SE, Hakim A, Fang J, Tu JV, et al. (2009) Age disparities in stroke quality of care and delivery of health services. Stroke 40: 3328-3335.
5. O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, et al. (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59: 467-477.
6. Buga AM, Sascau M, Pisoschi C, Herndon JG, Kessler C, et al. (2008) The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats. J Cell Mol Med 12: 2731-2753.
7. Campuzano O, Castillo-Ruiz MM, Acarin L, Castellano B, Gonzalez B, (2009) Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage. J Neurosci Res 87: 2484-2497.
8. Petcu EB, Sfredel V, Platt D, Herndon JG, Kessler C, et al. (2008) Cellular and molecular events underlying the dysregulated response of the aged brain to stroke: a mini-review. Gerontology 54: 6-17.
9. Sandhir R, Puri V, Klein RM, Berman NE, (2004) Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice. Neurosci Lett 369: 28-32.
10. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, et al. (2007) Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke 38: 770-773.
11. Feuerstein GZ, Wang X, (2001) Inflammation and stroke: benefits without harm? Arch Neurol 58: 672-674.
12. Whitaker JN, (2001) The potential for harm or benefit from inflammatory processes in stroke. Arch Neurol 58: 674.
13. Schroeter M, Jander S, Witte OW, Stoll G, (1994) Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J Neuroimmunol 55: 195-203.
14. Grubeck-Loebenstein B, Wick G, (2002) The aging of the immune system. Adv Immunol 80: 243-284.
15. Makinodan T, Kay MM, (1980) Age influence on the immune system. Adv Immunol 29: 287-330.
16. Rink L, Cakman I, Kirchner H, (1998) Altered cytokine production in the elderly. Mech Ageing Dev 102: 199-209.
17. Felzien LK, McDonald JT, Gleason SM, Berman NE, Klein RM, (2001) Increased chemokine gene expression during aging in the murine brain. Brain Res 890: 137-146.
18. Sheng JG, Mrak RE, Griffin WS, (1998) Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 95: 229-234.
19. Vexler ZS, Tang XN, Yenari MA, (2006) Inflammation in adult and neonatal stroke. Clin Neurosci Res 6: 293-313.
20. Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, et al. (2006) Inflammation following stroke. J Clin Neurosci 13: 1-8.
21. Barone FC, Kilgore KS, (2006) Role of inflammation and cellular stress in brain injury and central nervous system diseases. Clinical Neuroscience Research 6: 329-356.
22. del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, et al. (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10: 95-112.
23. Ginsberg MD, Busto R, (1989) Rodent models of cerebral ischemia. Stroke 20: 1627-1642.
24. Sieber MW, Guenther M, Kohl M, Witte OW, Claus RA, et al. (2010) Inter-age variability of bona fide unvaried transcripts Normalization of quantitative PCR data in ischemic stroke. Neurobiol Aging 31: 654-664.
25. Popp A, Jaenisch N, Witte OW, Frahm C, (2009) Identification of ischemic regions in a rat model of stroke. PLoS One 4: e4764.
26. Jaenisch N, Witte OW, Frahm C, (2009) Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia. Stroke 41: e151-159.
27. Sieber MW, Recknagel P, Glaser F, Witte OW, Bauer M, et al. (2010) Substantial performance discrepancies among commercially available kits for reverse transcription quantitative polymerase chain reaction: a systematic comparative investigator-driven approach. Anal Biochem 401: 303-311.
28. Popa-Wagner A, Schroder E, Walker LC, Kessler C, (1998) beta-Amyloid precursor protein and ss-amyloid peptide immunoreactivity in the rat brain after middle cerebral artery occlusion: effect of age. Stroke 29: 2196-2202.
29. Zhang L, Zhang RL, Wang Y, Zhang C, Zhang ZG, et al. (2005) Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 36: 847-852.
30. Zhao CS, Puurunen K, Schallert T, Sivenius J, Jolkkonen J, (2005) Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats. Behav Brain Res 156: 85-94.
31. Nakayama H, Jorgensen HS, Raaschou HO, Olsen TS, (1994) The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 25: 808-813.
32. Engelter ST, Provenzale JM, Petrella JR, DeLong DM, Alberts MJ, (2003) Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke. Cerebrovasc Dis 15: 188-191.
33. Davis M, Mendelow AD, Perry RH, Chambers IR, James OF, (1995) Experimental stroke and neuroprotection in the aging rat brain. Stroke 26: 1072-1078.
34. Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS, TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation 7: 62.
35. Popa-Wagner A, Badan I, Walker L, Groppa S, Patrana N, et al. (2007) Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats. Acta Neuropathol 113: 277-293.
36. Rosen CL, Dinapoli VA, Nagamine T, Crocco T, (2005) Influence of age on stroke outcome following transient focal ischemia. J Neurosurg 103: 687-694.
37. Dubal DB, Wise PM, (2001) Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 142: 43-48.
38. Neumann H, Takahashi K, (2007) Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J Neuroimmunol 184: 92-99.
39. Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K, (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55: 412-424.
40. Lee WH, Sonntag WE, Lee YW, (2010) Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neurosci Lett 476: 89-93.
41. Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA, (2001) Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol 119: 269-277.
42. Lee JC, Cho GS, Choi BO, Kim HC, Kim WK, (2009) Aging exacerbates intracerebral hemorrhage-induced brain injury. J Neurotrauma 26: 1567-1576.
43. Dinapoli VA, Benkovic SA, Li X, Kelly KA, Miller DB, et al. (2010) Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat. Neuroscience 170: 633-644.
44. Nawashiro H, Tasaki K, Ruetzler CA, Hallenbeck JM, (1997) TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 17: 483-490.
45. Ohtsuki T, Ruetzler CA, Tasaki K, Hallenbeck JM, (1996) Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons. J Cereb Blood Flow Metab 16: 1137-1142.
46. Sawada M, Suzumura A, Marunouchi T, (1992) TNF alpha induces IL-6 production by astrocytes but not by microglia. Brain Res 583: 296-299.
47. Tuttolomondo A, Di Raimondo D, di Sciacca R, Pinto A, Licata G, (2008) Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des 14: 3574-3589.
48. Che X, Ye W, Panga L, Wu DC, Yang GY, (2001) Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res 902: 171-177.
49. Cartier L, Hartley O, Dubois-Dauphin M, Krause KH, (2005) Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev 48: 16-42.
50. Barone FC, Arvin B, White RF, Miller A, Webb CL, et al. (1997) Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 28: 1233-1244.
51. Suzuki S, Tanaka K, Suzuki N, (2009) Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab 29: 464-479.
52. Planas AM, Gorina R, Chamorro A, (2006) Signalling pathways mediating inflammatory responses in brain ischaemia. Biochem Soc Trans 34: 1267-1270.
53. Kaltschmidt B, Widera D, Kaltschmidt C, (2005) Signaling via NF-kappaB in the nervous system. Biochim Biophys Acta 1745: 287-299.
54. Vallabhapurapu S, Karin M, (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
55. Ziebell JM, Morganti-Kossmann MC, (2010) Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 7: 22-30.
56. Takami S, Minami M, Nagata I, Namura S, Satoh M, (2001) Chemokine receptor antagonist peptide, viral MIP-II, protects the brain against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21: 1430-1435.
57. Terao S, Yilmaz G, Stokes KY, Russell J, Ishikawa M, et al. (2008) Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion. Stroke 39: 2560-2570.