Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats

Biopharmaceutics and Drug Disposition

Volumn 33, Issue 6, 2012, Pages 292-303

  Lee, Soo Hyun ^a   An, Ji Hye ^a,b   Lee, Hwa Jeong ^b   Jung, Byung Hwa ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

acetaminophen; gut microflora; LC MS MS; metabolism; pharmacokinetics; pseudo germ free rats

Indexed keywords

BACITRACIN; DRUG METABOLITE; GLUTATHIONE; NEOMYCIN; PARACETAMOL; STREPTOMYCIN; SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG METABOLISM; DRUG TRANSFORMATION; GERMFREE ANIMAL; INTESTINE FLORA; LIQUID CHROMATOGRAPHY; NONHUMAN; PSEUDO GERMFREE RAT; RAT; SEROLOGY; TANDEM MASS SPECTROMETRY;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BACITRACIN; BACTERIA; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; HALF-LIFE; HOST-PATHOGEN INTERACTIONS; INTESTINES; LIVER; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; NEOMYCIN; RATS; RATS, SPRAGUE-DAWLEY; STREPTOMYCIN; SULFATES; TANDEM MASS SPECTROMETRY;

EID: 84866262534     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1799     Document Type: Article

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