The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity

Liver International

Volumn 35, Issue 3, 2015, Pages 764-773

  Possamai, Lucia A ^a   Mcphail, Mark Jw ^a   Khamri, Wafa ^a   Wu, Bishan ^b   Concas, Danilo ^b   Harrison, Mark ^b   Williams, Roger ^c   Cox, Roger D ^b   Cox, I Jane ^c   Anstee, Quentin M ^d   Thursz, Mark R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^c INSTITUTE OF HEPATOLOGY   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Acetaminophen; Acute liver failure; Germ free; Metabonomics; Microbiota

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN; CREATININE; CYTOCHROME P450 2E1; GLUCOSE; GLUCURONIDE; GLUTATHIONE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PARACETAMOL; SULFATE; TOLL LIKE RECEPTOR 4; CYTOKINE;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; BIOCHEMISTRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG INDUCED DISEASE; DRUG METABOLISM; DRUG URINE LEVEL; GENE EXPRESSION; GERMFREE MOUSE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; INTESTINE FLORA; LIVER CELL DAMAGE; LIVER LEVEL; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RISK FACTOR; SIGNAL TRANSDUCTION; URINALYSIS; ANIMAL; BLOOD; C3H MOUSE; DISEASE MODEL; INTESTINE; LIVER; MICROBIOLOGY; MICROFLORA; PATHOLOGY; PATHOPHYSIOLOGY; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; INTESTINES; LIVER; MALE; MICE; MICE, INBRED C3H; MICROBIOTA; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84922746074     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12689     Document Type: Article

References (29)

1. Bernal W, Auzinger G, Wendon J. Prognostic utility of the bilirubin lactate and etiology score. Clin Gastroenterol Hepatol 2009; 7: 249 author reply 49.
2. Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J 1966; 2: 497-9.
3. Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42: 1364-72.
4. Schmidt LE, Dalhoff K, Poulsen HE. Acute vs. chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 2002; 35: 876-82.
5. Gregory B, Larson AM, Reisch J, Lee WM. Acetaminophen dose does not predict outcome in acetaminophen-induced acute liver failure. J Investing Med 2010; 58: 707-10.
6. Harrill AH, Watkins PB, SU S, et al. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res 2009; 19: 1507-15.
7. Watkins PB. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA: The Journal of the American Medical Association 2006; 296: 87-93.
8. Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology 2012; 143: 1158-72.
9. Wilson ID. Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring. Proc Natl Acad Sci USA 2009; 106: 14187-8.
10. Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA 2009; 106: 14728-33.
11. Toda T, Ohi K, Kudo T, et al. Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora. Drug Metab Pharmacokinet 2009; 24: 201-8.
12. Toda T, Saito N, Ikarashi N, et al. Intestinal flora induces the expression pf Cyp3a in the mouse liver. Xenobiotica 2009; 39: 323-34.
13. Smith GE, Griffiths LA. Metabolism of a biliary metabolite of phenacetin and other acetanilides by the intestinal microflora. Experientia 1976; 32: 1556-7.
14. Watari N, Iwai M, Kaneniwa N. Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats. J Pharmacokinet Biopharm 1983; 11: 245-72.
15. Su GL, Hoesel LM, Bayliss J, Hemmila MR, Wang SC. Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 2010; 299: G1319-25.
16. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-8.
17. Wishart DS, Tzur D, Knox C, et al. HMDB: the human metabolome database. Nucleic Acids Res 2007; 35: D521-6.
18. Claus SP, Tsang TM, Wang Y, et al. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol 2008; 4: 219.
19. Waterfield CJ, Turton JA, Scales MD, Timbrell JA. The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage. Toxicology 1993; 2: 1-5.
20. Mikov M, Caldwell J, Dolphin CT, Smith RL. The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol Studies in neomycin-pretreated and germ-free mice. Biochem Pharmacol 1988; 37: 1445-9.
21. Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011; 29: 139-62.
22. Antoine DJ, Jenkins RE, Dear JW, et al. Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol 2012; 56: 1070-9.
23. Antoine DJ, Williams DP, Kipar A, et al. High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Toxicol Sci 2009; 112: 521-31.
24. Shah N, Montes De Oca M, Jover-Cobos M, et al. Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure. Liver Transpl 2013; 19: 751-61.
25. Ben-Ari Z, Avlas O, Fallach R, et al. Ischemia and reperfusion liver injury is reduced in the absence of Toll-like receptor 4. Cell Physiol Biochem 2012; 30: 489-98.
26. Yohe HC, O'hara KA, Hunt JA, et al. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1269-79.
27. Kitazawa T, Tsujimoto T, Kawaratani H, Fukui H. Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury. J Gastroenterol Hepatol 2009; 24: 1089-94.
28. Heading RC, Nimmo J, Prescott LF, Tothill P. The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol 1973; 47: 415-21.
29. Josting D, Winne D, Bock KW. Glucuronidation of paracetamol, morphine and 1-naphthol in the rat intestinal loop. Biochem Pharmacol 1976; 25: 613-6.