Anti-pruritic effect of baicalin and its metabolites, baicalein and oroxylin A, in mice

Acta Pharmacologica Sinica

Volumn 31, Issue 6, 2010, Pages 718-724

  Trinh, Hien Trung ^a   Joh, Eun Ha ^a   Kwak, Ho Young ^a   Baek, Nam In ^a   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Baicalein; Baicalin; Histamine; Metabolism; Oroxylin A; Scratching behavior; Scutellaria baicalensis

Indexed keywords

AZELASTINE; BAICALEIN; BAICALIN; COMPOUND 48-80; HISTAMINE; OROXYLIN A; STREPTOMYCIN; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG ISOLATION; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; GUINEA PIG; HISTOPATHOLOGY; HUMAN; ILEUM; INTESTINE FLORA; MALE; MOUSE; NONHUMAN; RHIZOME; SCRATCHING; SCUTELLARIA BAICALENSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPRURITICS; FECES; FLAVANONES; FLAVONOIDS; GUINEA PIGS; HISTAMINE; HISTAMINE ANTAGONISTS; INTESTINES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; PHYTOTHERAPY; PRURITUS; SCUTELLARIA BAICALENSIS; STREPTOMYCIN; TETRACYCLINE;

EID: 77953236227     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.42     Document Type: Article

References (30)

1. Hagermark O. Itch mediators. Semin Dermatol 1955; 14: 271-276
2. Lerner EA. "Itch: mechanisms and management of pruritis," Berhard J, editor. New York: McGraw-Hill, 1944. p 23-25
3. Schmeiz M, Schmidt R, Bickel A, Handerker HO, Torebjork HE. Specific C-receptors for itch in human skin. J Neurosci 1997; 17: 8003-8008
4. Raiford DS. Pruritus of chronic chlestasis. QJM 1995; 88: 603-607
5. Kuraishi Y, Nagasawa T, Hayashi K, Satoh M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 1995; 275: 229-233
6. Zhu YP. "Chinese Materia Medica." Australia: Harwood academic publichers; 1998. p127-35.
7. Wu S, Sun A, Liu R. Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography. J Chromatogr A 2005; 1066: 243-247 (Pubitemid 40283571)
8. Chou TC, Chang LP, Li CY, Wong CS, Yang SP. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Anesth Analq 2003; 17: 1724-1729
9. Jang SI, Kim HJ, Hwang KM, Jekal SJ, Pae HO, Choi BM, et al. Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice. Immunopharmacol Immunotoxicol 2003; 25: 585-594
10. Kim DH, Cho KH, Moon SK, Kim YS, Kim DH, Choi JS, et al. Cytoprotective mechanism of baicalin against endothelial cell damage by peroxynitrite. J Pharm Pharmacol 2005; 57: 1581-1590
11. Akao T, Kawabata K, Yanagisawa E. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol 2000; 52: 1563-1568
12. Yim JS, Kim YS, Moon SK, Cho KH, Bae HS, Kim JJ, et al. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull 2004; 27: 1580-1583
13. Abe K, Inoue O, Yumioka E. Biliary excretion of metabolites of baicalin and baicalein in rats. Chem Pharm Bull 1990; 38: 209-211
14. Akao T, Dakashita Y, Hanada M, Goto H, Shimada Y, Terasawa K. Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2. Pharm Res 2004; 21: 2120-2126
15. Lu T, Song J, Huang F, Deng Y, Xie L, Wang G, et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol 2007; 110: 412-418
16. Xing J, Chen XY, Zhong DF. Absorption and enterohepatic circulation of baicalin in rats. Life Sci 2005; 78: 140-146
17. Xing J, Chen XY, Sun YM, Luan Y, Zhong DF. Interaction of baicalin and baicalein with antibiotics in the gastrointestinal tract. J Pharm Pharmacol 2005; 57: 743-750
18. Takido M, Aimi M, Takahashi S, Yamamouchi S, Torii H, Dohi S. Studies on the constituents in the water extracts of crude drugs. I. On the roots of Scutellaria baicalensis Georgi (W?gon) (1). Yakugaku Zasshi 1975; 95: 108-113
19. Tomimori T, Miyaichi Y, Kizu H. On the flavonoid constituents from the roots of Scutellaria baicalensis Georgi. I. Yakugaku Zasshi 1982; 102: 388-391
20. Lee DK, Kim YS, Ko CN, Cho KH, Bae HS, Lee KS, et al. Fecal metabolic activities of herbal components to bioactive compounds. Arch Pharm Res 2003; 25: 165-169
21. Sugimoto Y, Umakoshi K, Nojiri N, Kamei C. Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur J Pharmacol 1998; 351: 1-5.
22. Choo MK, Park EK, Han MJ, Kim DH. Antiallergic activity of ginseng and its ginsenosides. Planta Med 2003; 69: 518-522
23. Liaw J, Gau YY, Chao YC. Effect of baicalin on tracheal permeability in ovalbumin (OA)-sensitized guinea pigs. Pharm Res 1999; 16: 1653-1657
24. Koda A, Nagai H, Wada H. Pharmacological actions of baicalin and baicalein. 2. On passive anaphylaxis. Nippon Yakurigaku Zasshi 1970; 66: 237-247
25. Taniguchi C, Homma M, Takano O, Hirano T, Oka K, Aoyagi Y, et al. Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction. Planta Med 2000; 66: 607-611.
26. Kobashi K, Akao T. Relation of intestinal bacteria to pharmacological effects of glycosides. Bioscience Microflora 1997; 16: 1-7.
27. Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1998; 50: 1155-1160 (Pubitemid 28488135)
28. Inagaki N, Nagao M, Kawasaki H, Kim JF, Nagai H. Scratching behavior in various strains of mice. Skin Pharmacol Appl Skin Physiol. 2001; 14: 87-96.
29. Ui H, Andoh T, Lee JB, Nojima H, Kuraishi Y. Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in antipruritic effect of nafamostat mesilate in mice. Eur J Pharmacol 2006; 530: 172-178
30. Inagaki N, Igeta K, Kim JF, Nagao M, Shiraishi N, Nakamura N, et al. Involvement of unique mechanisms in the induction of scratching behavior in BALB/c mice by compound 48/80. Eur J Pharmacol 2002; 448: 175-183