메뉴 건너뛰기




Volumn 9, Issue 4, 2015, Pages 265-276

Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis

Author keywords

Cancer stem cells CSCs; Clonal evolution; Epithelial mesenchymal transition (EMT); Intratumoral heterogeneity; Metastasis; Non cell autonomous; Tumor microenvironment

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; WNT1 PROTEIN;

EID: 84954201325     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/19336918.2014.972761     Document Type: Article
Times cited : (54)

References (129)
  • 1
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • PMID: 959840
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23-8; PMID: 959840; http: //dx. doi. org/10. 1126/science. 959840
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 2
    • 0017105982 scopus 로고
    • Clonal origin of human tumors
    • PMID: 1067873
    • Fialkow PJ. Clonal origin of human tumors. Biochim Biophys Acta 1976; 458: 283-321; PMID: 1067873
    • (1976) Biochim Biophys Acta , vol.458 , pp. 283-321
    • Fialkow, P.J.1
  • 3
    • 47549090260 scopus 로고    scopus 로고
    • Clonal diversity in carcinomas: Its implications for tumour progression and the contribution made to it by epithelial-mesenchymal transitions
    • PMID: 18071912
    • Lyons JG, Lobo E, Martorana AM, Myerscough MR. Clonal diversity in carcinomas: its implications for tumour progression and the contribution made to it by epithelial-mesenchymal transitions. Clin Exp Metastasis 2008; 25: 665-77; PMID: 18071912; http: //dx. doi. org/10. 1007/s10585-007-9134-2
    • (2008) Clin Exp Metastasis , vol.25 , pp. 665-677
    • Lyons, J.G.1    Lobo, E.2    Martorana, A.M.3    Myerscough, M.R.4
  • 4
    • 79952147724 scopus 로고    scopus 로고
    • Monoclonal tumor origin is an underlying misconception of the RESIC approach
    • PMID: 21239682; author reply E6
    • Parsons BL. Monoclonal tumor origin is an underlying misconception of the RESIC approach. Proc Natl Acad Sci U S A 2011; 108: E15; author reply E6; PMID: 21239682; http: //dx. doi. org/10. 1073/pnas. 1017998108
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Parsons, B.L.1
  • 5
    • 50049087526 scopus 로고    scopus 로고
    • Many different tumor types have polyclonal tumor origin: Evidence and implications
    • PMID: 18614394
    • Parsons BL. Many different tumor types have polyclonal tumor origin: evidence and implications. Mutat Res 2008; 659: 232-47; PMID: 18614394; http: //dx. doi. org/10. 1016/j. mrrev. 2008. 05. 004
    • (2008) Mutat Res , vol.659 , pp. 232-247
    • Parsons, B.L.1
  • 9
    • 0018141482 scopus 로고
    • Tumor heterogeneity and the biology of cancer invasion and metastasis
    • PMID: 354778
    • Fidler IJ. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 1978; 38: 2651-60; PMID: 354778
    • (1978) Cancer Res , vol.38 , pp. 2651-2660
    • Fidler, I.J.1
  • 10
    • 84872008395 scopus 로고    scopus 로고
    • Cell plasticity and heterogeneity in cancer
    • PMID: 23220226
    • Marjanovic ND, Weinberg RA, Chaffer CL. Cell plasticity and heterogeneity in cancer. Clin Chem 2013; 59: 168-79; PMID: 23220226; http: //dx. doi. org/10. 1373/clinchem. 2012. 184655
    • (2013) Clin Chem , vol.59 , pp. 168-179
    • Marjanovic, N.D.1    Weinberg, R.A.2    Chaffer, C.L.3
  • 11
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • PMID: 19737509
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009; 138: 822-9; PMID: 19737509; http: //dx. doi. org/10. 1016/j. cell. 2009. 08. 017
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 12
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • PMID: 22513401
    • Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 2012; 12: 323-34; PMID: 22513401; http: //dx. doi. org/10. 1038/nrc3261
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • PMID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell; 144: 646-74; PMID: 21376230; http: //dx. doi. org/10. 1016/j. cell. 2011. 02. 013
    • Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 15
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • PMID: 24048066
    • Burrell RA, McGranahan N, Bartek J, Swanton C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013; 501: 338-45; PMID: 24048066; http: //dx. doi. org/10. 1038/nature 12625
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 18
    • 0018420201 scopus 로고
    • The pathology of tumors, part III: Grading, staging & classification
    • PMID: 219944
    • Rosai J, Ackerman LV. The pathology of tumors, part III: grading, staging & classification. CA: Cancer J Clin 1979; 29: 66-77; PMID: 219944; http: //dx. doi. org/10. 1017/S0009838800035175
    • (1979) CA: Cancer J Clin , vol.29 , pp. 66-77
    • Rosai, J.1    Ackerman, L.V.2
  • 19
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • PMID: 22323597
    • Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, Ozawa T, Holland EC, Huse JT, Jhanwar S, et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci U S A 2012; 109: 3041-6; PMID: 22323597; http: //dx. doi. org/10. 1073/pnas. 1114033109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3    Azim, M.4    McGuire, J.5    Fang, Y.6    Ozawa, T.7    Holland, E.C.8    Huse, J.T.9    Jhanwar, S.10
  • 20
    • 0018075053 scopus 로고
    • Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor
    • PMID: 698935
    • HeppnerGH, Dexter DL, DeNucci T, Miller FR, Calabresi P. Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res 1978; 38: 3758-63; PMID: 698935
    • (1978) Cancer Res , vol.38 , pp. 3758-3763
    • Heppner, G.H.1    Dexter, D.L.2    DeNucci, T.3    Miller, F.R.4    Calabresi, P.5
  • 21
    • 84873084388 scopus 로고    scopus 로고
    • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer
    • PMID: 23239622
    • Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, et al. Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science 2013; 339: 543-8; PMID: 23239622; http: //dx. doi. org/10. 1126/science. 1227670
    • (2013) Science , vol.339 , pp. 543-548
    • Kreso, A.1    O'Brien, C.A.2    van Galen, P.3    Gan, O.I.4    Notta, F.5    Brown, A.M.6    Ng, K.7    Ma, J.8    Wienholds, E.9    Dunant, C.10
  • 23
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • PMID: 1540948
    • Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992; 52: 1399-405; PMID: 1540948
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 25
    • 84893810104 scopus 로고    scopus 로고
    • Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
    • PMID: 23817176
    • Walker BA, Wardell CP, Melchor L, Brioli A, Johnson DC, Kaiser MF, Mirabella F, Lopez-Corral L, Humphray S, Murray L, et al. Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms. Leukemia 2014; 28: 384-90; PMID: 23817176; http: //dx. doi. org/10. 1038/leu. 2013. 199
    • (2014) Leukemia , vol.28 , pp. 384-390
    • Walker, B.A.1    Wardell, C.P.2    Melchor, L.3    Brioli, A.4    Johnson, D.C.5    Kaiser, M.F.6    Mirabella, F.7    Lopez-Corral, L.8    Humphray, S.9    Murray, L.10
  • 26
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • PMID: 24048065
    • Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature 2013; 501: 328-37; PMID: 24048065; http: //dx. doi. org/10. 1038/nature 12624
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 27
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • PMID: 22258609
    • Greaves M, Maley CC. Clonal evolution in cancer. Nature 2012; 481: 306-13; PMID: 22258609; http: // dx. doi. org/10. 1038/nature10762
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 28
    • 84890294470 scopus 로고    scopus 로고
    • Implications of intratumour heterogeneity for treatment stratification
    • PMID: 24115146
    • Crockford A, Jamal-Hanjani M, Hicks J, Swanton C. Implications of intratumour heterogeneity for treatment stratification. J Pathol 2014; 232: 264-73; PMID: 24115146; http: //dx. doi. org/ 10. 1002/path. 4270
    • (2014) J Pathol , vol.232 , pp. 264-273
    • Crockford, A.1    Jamal-Hanjani, M.2    Hicks, J.3    Swanton, C.4
  • 29
    • 0020616225 scopus 로고
    • Human tumor cell heterogeneity and metastasis
    • PMID: 6366142
    • Spremulli EN, Dexter DL. Human tumor cell heterogeneity and metastasis. J Clin Oncol 1983; 1: 496-509; PMID: 6366142
    • (1983) J Clin Oncol , vol.1 , pp. 496-509
    • Spremulli, E.N.1    Dexter, D.L.2
  • 30
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour microenvironment heterogeneity on therapeutic response
    • PMID: 24048067
    • Junttila MR, de Sauvage FJ. Influence of tumour microenvironment heterogeneity on therapeutic response. Nature 2013; 501: 346-54; PMID: 24048067; http: //dx. doi. org/10. 1038/nature12626
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 31
    • 84873314642 scopus 로고    scopus 로고
    • Cancer. Cancer cell phenotypes, in fifty shades of grey
    • PMID: 23372002
    • Marusyk A, Polyak K. Cancer. Cancer cell phenotypes, in fifty shades of grey. Science 2013; 339: 528-9; PMID: 23372002; http: //dx. doi. org/10. 1126/ science. 1234415
    • (2013) Science , vol.339 , pp. 528-529
    • Marusyk, A.1    Polyak, K.2
  • 32
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • PMID: 9931353
    • Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2010; 1805: 105-17; PMID: 9931353
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 33
    • 75349091751 scopus 로고    scopus 로고
    • Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    • PMID: 20144787
    • Charles N, Ozawa T, SquatritoM, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010; 6: 141-52; PMID: 20144787; http: //dx. doi. org/10. 1016/j. stem. 2010. 01. 001
    • (2010) Cell Stem Cell , vol.6 , pp. 141-152
    • Charles, N.1    Ozawa, T.2    Squatrito, M.3    Bleau, A.M.4    Brennan, C.W.5    Hambardzumyan, D.6    Holland, E.C.7
  • 35
    • 80053401068 scopus 로고    scopus 로고
    • Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    • PMID: 21965337
    • Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 2011; 121: 3804-9; PMID: 21965337; http: //dx. doi. org/10. 1172/JCI57099
    • (2011) J Clin Invest , vol.121 , pp. 3804-3809
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 36
    • 84871666795 scopus 로고    scopus 로고
    • The hitchhikers guide to cancer stem cell theory: Markers, pathways and therapy
    • PMID: 22997049
    • Fabian A, Vereb G, Szollosi J. The hitchhikers guide to cancer stem cell theory: markers, pathways and therapy. Cytometry A 2013; 83: 62-71; PMID: 22997049; http: //dx. doi. org/10. 1002/cyto. a. 22206
    • (2013) Cytometry A , vol.83 , pp. 62-71
    • Fabian, A.1    Vereb, G.2    Szollosi, J.3
  • 37
    • 84877057303 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance in cancer stem cells
    • PMID: 23369605
    • Abdullah LN, Chow EK. Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med 2013; 2: 3; PMID: 23369605; http: //dx. doi. org/10. 1186/2001-1326-2-3
    • (2013) Clin Transl Med , vol.2 , pp. 3
    • Abdullah, L.N.1    Chow, E.K.2
  • 38
    • 84896912505 scopus 로고    scopus 로고
    • Investigating molecular profiles of ovarian cancer: An update on cancer stem cells
    • PMID: 24723972
    • Tomao F, Papa A, Strudel M, Rossi L, Lo Russo G, Benedetti Panici P, Ciabatta FR, Tomao S. Investigating molecular profiles of ovarian cancer: an update on cancer stem cells. J Cancer 2014; 5: 301-10; PMID: 24723972; http: //dx. doi. org/10. 7150/jca. 8610
    • (2014) J Cancer , vol.5 , pp. 301-310
    • Tomao, F.1    Papa, A.2    Strudel, M.3    Rossi, L.4    Lo Russo, G.5    Benedetti Panici, P.6    Ciabatta, F.R.7    Tomao, S.8
  • 39
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • PMID: 18485877
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15; PMID: 18485877; http: //dx. doi. org/ 10. 1016/j. cell. 2008. 03. 027
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6    Brooks, M.7    Reinhard, F.8    Zhang, C.C.9    Shipitsin, M.10
  • 40
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • PMID: 22869594
    • Baccelli I, Trumpp A. The evolving concept of cancer and metastasis stem cells. J Cell Biol 2012; 198: 281-93; PMID: 22869594; http: //dx. doi. org/10. 1083/ jcb. 201202014
    • (2012) J Cell Biol , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 41
    • 70449732774 scopus 로고    scopus 로고
    • Analysis of cancer stem cell metastasis in xenograft animal models
    • PMID: 19582418
    • Kang Y. Analysis of cancer stem cell metastasis in xenograft animal models. Methods Mol Biol 2009; 568: 7-19; PMID: 19582418; http: //dx. doi. org/ 10. 1007/978-1-59745-280-9_2
    • (2009) Methods Mol Biol , vol.568 , pp. 7-19
    • Kang, Y.1
  • 42
    • 34848853915 scopus 로고    scopus 로고
    • Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
    • PMID: 17851532
    • Cobaleda C, Jochum W, Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 2007; 449: 473-7; PMID: 17851532; http: //dx. doi. org/10. 1038/nature 06159
    • (2007) Nature , vol.449 , pp. 473-477
    • Cobaleda, C.1    Jochum, W.2    Busslinger, M.3
  • 43
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • PMID: 18682804
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008; 3: e2888; PMID: 18682804; http: //dx. doi. org/ 10. 1371/journal. pone. 0002888
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 45
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • PMID: 21220315
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A 2011; 108: 1397-402; PMID: 21220315; http: //dx. doi. org/ 10. 1073/pnas. 1018898108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 46
    • 78349295300 scopus 로고    scopus 로고
    • Bmi-1 regulates snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells
    • 2011: pii: 609259; PMID: 20936121
    • Yu CC, Lo WL, Chen YW, Huang PI, Hsu HS, Tseng LM, Hung SC, Kao SY, Chang CJ, Chiou SH. Bmi-1 regulates snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells. J oOcol 2011; 2011: pii: 609259; PMID: 20936121
    • (2011) J oOcol
    • Yu, C.C.1    Lo, W.L.2    Chen, Y.W.3    Huang, P.I.4    Hsu, H.S.5    Tseng, L.M.6    Hung, S.C.7    Kao, S.Y.8    Chang, C.J.9    Chiou, S.H.10
  • 47
    • 84873537569 scopus 로고    scopus 로고
    • Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
    • PMID: 23333246
    • Kim SY, Kang JW, Song X, Kim BK, Yoo YD, Kwon YT, Lee YJ. Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal 2013; 25: 961-9; PMID: 23333246; http: //dx. doi. org/10. 1016/j. cellsig. 2013. 01. 007
    • (2013) Cell Signal , vol.25 , pp. 961-969
    • Kim, S.Y.1    Kang, J.W.2    Song, X.3    Kim, B.K.4    Yoo, Y.D.5    Kwon, Y.T.6    Lee, Y.J.7
  • 51
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression
    • PMID: 21392411
    • May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res 2011; 13: 202; PMID: 21392411; http: //dx. doi. org/10. 1186/bcr2789
    • (2011) Breast Cancer Res , vol.13 , pp. 202
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 52
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • PMID: 23201163
    • Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A, Nieto MA. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012; 22: 709-24; PMID: 23201163; http: //dx. doi. org/10. 1016/j. ccr. 2012. 10. 012
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3    Moreno-Bueno, G.4    Acloque, H.5    Vega, S.6    Barrallo-Gimeno, A.7    Cano, A.8    Nieto, M.A.9
  • 53
    • 79952499030 scopus 로고    scopus 로고
    • Twist1-induced invadopodia formation promotes tumor metastasis
    • PMID: 21397860
    • Eckert MA, Lwin TM, Chang AT, Kim J, Danis E, Ohno-Machado L, Yang J. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011; 19: 372-86; PMID: 21397860; http: //dx. doi. org/10. 1016/j. ccr. 2011. 01. 036
    • (2011) Cancer Cell , vol.19 , pp. 372-386
    • Eckert, M.A.1    Lwin, T.M.2    Chang, A.T.3    Kim, J.4    Danis, E.5    Ohno-Machado, L.6    Yang, J.7
  • 54
    • 84876457158 scopus 로고    scopus 로고
    • WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells
    • PMID: 23615002
    • Kanzawa M, Semba S, Hara S, Itoh T, Yokozaki H. WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells. Pathobiology 2013; 80: 235-44; PMID: 23615002; http: //dx. doi. org/ 10. 1159/000346843
    • (2013) Pathobiology , vol.80 , pp. 235-244
    • Kanzawa, M.1    Semba, S.2    Hara, S.3    Itoh, T.4    Yokozaki, H.5
  • 55
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • PMID: 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90; PMID: 19945376; http: //dx. doi. org/10. 1016/j. cell. 2009. 11. 007
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 57
    • 79959921981 scopus 로고    scopus 로고
    • Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    • PMID: 21754979
    • Fomchenko EI, Dougherty JD, Helmy KY, Katz AM, Pietras A, Brennan C, Huse JT, Milosevic A, Holland EC. Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. PloS one 2011; 6: e20605; PMID: 21754979; http: //dx. doi. org/10. 1371/journal. pone. 0020605
    • (2011) PloS one , vol.6
    • Fomchenko, E.I.1    Dougherty, J.D.2    Helmy, K.Y.3    Katz, A.M.4    Pietras, A.5    Brennan, C.6    Huse, J.T.7    Milosevic, A.8    Holland, E.C.9
  • 58
    • 84897482887 scopus 로고    scopus 로고
    • Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
    • PMID: 24695311
    • Cleary AS, Leonard TL, Gestl SA, Gunther EJ. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers. Nature 2014; 508: 113-7; PMID: 24695311; http: //dx. doi. org/10. 1038/nature13187
    • (2014) Nature , vol.508 , pp. 113-117
    • Cleary, A.S.1    Leonard, T.L.2    Gestl, S.A.3    Gunther, E.J.4
  • 59
    • 81955167415 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells
    • PMID: 22045189
    • Bose D, Zimmerman LJ, Pierobon M, Petricoin E, Tozzi F, Parikh A, Fan F, Dallas N, Xia L, Gaur P, et al. Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells. British journal of cancer 2011; 105: 1759-67; PMID: 22045189; http: //dx. doi. org/ 10. 1038/bjc. 2011. 449
    • (2011) British journal of cancer , vol.105 , pp. 1759-1767
    • Bose, D.1    Zimmerman, L.J.2    Pierobon, M.3    Petricoin, E.4    Tozzi, F.5    Parikh, A.6    Fan, F.7    Dallas, N.8    Xia, L.9    Gaur, P.10
  • 60
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • PMID: 19931353
    • Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2010; 1805: 105-17; PMID: 19931353
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 61
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • PMID: 16723991
    • Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer 2006; 6: 449-58; PMID: 16723991; http: //dx. doi. org/10. 1038/nrc1886
    • (2006) Nat Rev Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 62
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • PMID: 12154349
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2: 563-72; PMID: 12154349; http: //dx. doi. org/10. 1038/nrc865
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 63
    • 23144442644 scopus 로고    scopus 로고
    • Breast cancer metastasis: Markers and models
    • PMID: 16056258
    • Weigelt B, Peterse JL, van 't Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer 2005; 5: 591-602; PMID: 16056258; http: //dx. doi. org/10. 1038/nrc1670
    • (2005) Nat Rev Cancer , vol.5 , pp. 591-602
    • Weigelt, B.1    Peterse, J.L.2    van 't Veer, L.J.3
  • 65
    • 0036850146 scopus 로고    scopus 로고
    • Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: Mutations occur early and persist throughout tumor progression
    • PMID: 12429636
    • Omholt K, Karsberg S, Platz A, Kanter L, Ringborg U, Hansson J. Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res 2002; 8: 3468-74; PMID: 12429636
    • (2002) Clin Cancer Res , vol.8 , pp. 3468-3474
    • Omholt, K.1    Karsberg, S.2    Platz, A.3    Kanter, L.4    Ringborg, U.5    Hansson, J.6
  • 66
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • PMID: 12192390
    • Bernards R, Weinberg RA. A progression puzzle. Nature 2002; 418: 823; PMID: 12192390; http: //dx. doi. org/10. 1038/418823a
    • (2002) Nature , vol.418 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 67
    • 0020683142 scopus 로고
    • Do metastases arise from pre-existing subpopulations of cancer cells?
    • PMID: 6571784
    • Weiss L, Holmes JC, Ward PM. Do metastases arise from pre-existing subpopulations of cancer cells? Br J Cancer 1983; 47: 81-9; PMID: 6571784; http: //dx. doi. org/10. 1038/bjc. 1983. 10
    • (1983) Br J Cancer , vol.47 , pp. 81-89
    • Weiss, L.1    Holmes, J.C.2    Ward, P.M.3
  • 68
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • PMID: 887927
    • Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977; 197: 893-5; PMID: 887927; http: //dx. doi. org/ 10. 1126/science. 887927
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 70
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • PMID: 12469122
    • Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet 2003; 33: 49-54; PMID: 12469122; http: //dx. doi. org/10. 1038/ng1060
    • (2003) Nat Genet , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 71
    • 0026639108 scopus 로고
    • Prognostic factors and treatment decisions in axillary-node-negative breast cancer
    • PMID: 1594018
    • McGuire WL, Clark GM. Prognostic factors and treatment decisions in axillary-node-negative breast cancer. N Engl J Med 1992; 326: 1756-61; PMID: 1594018; http: //dx. doi. org/10. 1056/NEJM199206253262607
    • (1992) N Engl J Med , vol.326 , pp. 1756-1761
    • McGuire, W.L.1    Clark, G.M.2
  • 72
    • 84896689570 scopus 로고    scopus 로고
    • Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets
    • PMID: 24356096
    • Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sanchez V, et al. Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov 2014; 4: 232-45; PMID: 24356096; http: //dx. doi. org/10. 1158/2159-8290. CD-13-0286
    • (2014) Cancer Discov , vol.4 , pp. 232-245
    • Balko, J.M.1    Giltnane, J.M.2    Wang, K.3    Schwarz, L.J.4    Young, C.D.5    Cook, R.S.6    Owens, P.7    Sanders, M.E.8    Kuba, M.G.9    Sanchez, V.10
  • 73
    • 73449133770 scopus 로고    scopus 로고
    • Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis
    • PMID: 19795462
    • StoeckleinNH, Klein CA. Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. Int J Cancer 2010; 126: 589-98; PMID: 19795462; http: //dx. doi. org/10. 1002/ijc. 24916
    • (2010) Int J Cancer , vol.126 , pp. 589-598
    • Stoecklein, N.H.1    Klein, C.A.2
  • 74
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • PMID: 24202395
    • Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med 2013; 19: 1423-37; PMID: 24202395; http: //dx. doi. org/ 10. 1038/nm. 3394
    • (2013) Nat Med , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 77
    • 0021070441 scopus 로고
    • Tumor subpopulation interactions in metastasis
    • PMID: 6677628
    • Miller FR. Tumor subpopulation interactions in metastasis. Invasion Metastasis 1983; 3: 234-42; PMID: 6677628
    • (1983) Invasion Metastasis , vol.3 , pp. 234-242
    • Miller, F.R.1
  • 78
    • 0025324197 scopus 로고
    • Cellular interactions in metastasis
    • PMID: 2208566
    • Miller FR, Heppner GH. Cellular interactions in metastasis. Cancer Metastasis Rev 1990; 9: 21-34; PMID: 2208566; http: //dx. doi. org/10. 1007/BF000 47586
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 21-34
    • Miller, F.R.1    Heppner, G.H.2
  • 79
    • 0018957497 scopus 로고
    • Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor
    • PMID: 7471048
    • Miller BE, Miller FR, Leith J, Heppner GH. Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor. Cancer Res 1980; 40: 3977-81; PMID: 7471048
    • (1980) Cancer Res , vol.40 , pp. 3977-3981
    • Miller, B.E.1    Miller, F.R.2    Leith, J.3    Heppner, G.H.4
  • 80
    • 0023750023 scopus 로고
    • Dominance of a tumor subpopulation line in mixed heterogeneous mouse mammary tumors
    • PMID: 3167832
    • Miller BE, Miller FR, Wilburn D, Heppner GH. Dominance of a tumor subpopulation line in mixed heterogeneous mouse mammary tumors. Cancer Res 1988; 48: 5747-53; PMID: 3167832
    • (1988) Cancer Res , vol.48 , pp. 5747-5753
    • Miller, B.E.1    Miller, F.R.2    Wilburn, D.3    Heppner, G.H.4
  • 81
    • 0019807159 scopus 로고
    • Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells
    • PMID: 6947225
    • Poste G, Doll J, Fidler IJ. Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci U S A 1981; 78: 6226-30; PMID: 6947225; http: //dx. doi. org/10. 1073/pnas. 78. 10. 6226
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6226-6230
    • Poste, G.1    Doll, J.2    Fidler, I.J.3
  • 82
    • 0027168649 scopus 로고
    • Studies on relationships between metastatic and nonmetastatic tumor cell populations using lineages labeled with dominant selectable genetic markers
    • PMID: 8507566
    • Baban D, Matsumura Y, Kocialkowski S, Tarin D. Studies on relationships between metastatic and nonmetastatic tumor cell populations using lineages labeled with dominant selectable genetic markers. Int J Dev Biol 1993; 37: 237-43; PMID: 8507566
    • (1993) Int J Dev Biol , vol.37 , pp. 237-243
    • Baban, D.1    Matsumura, Y.2    Kocialkowski, S.3    Tarin, D.4
  • 83
    • 33746548361 scopus 로고    scopus 로고
    • Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cellreleased exosomes
    • PMID: 16837903
    • Hao S, Ye Z, Li F, Meng Q, Qureshi M, Yang J, Xiang J. Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cellreleased exosomes. Exp Oncol 2006; 28: 126-31; PMID: 16837903
    • (2006) Exp Oncol , vol.28 , pp. 126-131
    • Hao, S.1    Ye, Z.2    Li, F.3    Meng, Q.4    Qureshi, M.5    Yang, J.6    Xiang, J.7
  • 84
    • 79751511326 scopus 로고    scopus 로고
    • A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer
    • PMID: 21316603
    • Calbo J, van Montfort E, Proost N, van Drunen E, Beverloo HB, Meuwissen R, Berns A. A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer. Cancer Cell 2011; 19: 244-56; PMID: 21316603; http: //dx. doi. org/10. 1016/j. ccr. 2010. 12. 021
    • (2011) Cancer Cell , vol.19 , pp. 244-256
    • Calbo, J.1    van Montfort, E.2    Proost, N.3    van Drunen, E.4    Beverloo, H.B.5    Meuwissen, R.6    Berns, A.7
  • 85
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • PMID: 19487818
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-8; PMID: 19487818; http: //dx. doi. org/10. 1172/JCI39104
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 86
    • 80755173296 scopus 로고    scopus 로고
    • Breast cancer epithelial-to-mesenchymal transition: Examining the functional consequences of plasticity
    • PMID: 22078097
    • Drasin DJ, Robin TP, Ford HL. Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res 2011; 13: 226; PMID: 22078097; http: //dx. doi. org/ 10. 1186/bcr3037
    • (2011) Breast Cancer Res , vol.13 , pp. 226
    • Drasin, D.J.1    Robin, T.P.2    Ford, H.L.3
  • 87
    • 0029157019 scopus 로고
    • Transformations between epithelium and mesenchyme: Normal, pathological, and experimentally induced
    • PMID: 7573028
    • Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Dis 1995; 26: 678-90; PMID: 7573028; http: //dx. doi. org/10. 1016/0272-6386(95)90610-X
    • (1995) Am J Kidney Dis , vol.26 , pp. 678-690
    • Hay, E.D.1    Zuk, A.2
  • 88
    • 0242413065 scopus 로고    scopus 로고
    • Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development
    • PMID: 14623443
    • Shook D, Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mechanisms Dev 2003; 120: 1351-83; PMID: 14623443; http: //dx. doi. org/10. 1016/j. mod. 2003. 06. 005
    • (2003) Mechanisms Dev , vol.120 , pp. 1351-1383
    • Shook, D.1    Keller, R.2
  • 89
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • PMID: 23201165
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22: 725-36; PMID: 23201165; http: //dx. doi. org/10. 1016/j. ccr. 2012. 09. 022
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 90
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
    • PMID: 17145872
    • Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res 2006; 66: 11271-8; PMID: 17145872; http: //dx. doi. org/ 10. 1158/0008-5472. CAN-06-2044
    • (2006) Cancer Res , vol.66 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 91
    • 34250749646 scopus 로고    scopus 로고
    • Mesenchymal to epithelial transition in development and disease
    • PMID: 17587803
    • Chaffer CL, Thompson EW, Williams ED. Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 2007; 185: 7-19; PMID: 17587803; http: //dx. doi. org/10. 1159/ 000101298
    • (2007) Cells Tissues Organs , vol.185 , pp. 7-19
    • Chaffer, C.L.1    Thompson, E.W.2    Williams, E.D.3
  • 92
    • 77954865521 scopus 로고    scopus 로고
    • Mammary gland studies as important contributors to the cause of epithelial mesenchymal plasticity in malignancy
    • PMID: 20544376
    • Ford HL, Thompson EW. Mammary gland studies as important contributors to the cause of epithelial mesenchymal plasticity in malignancy. J Mammary Gland Biol Neoplasia 2010; 15: 113-5; PMID: 20544376; http: //dx. doi. org/10. 1007/s10911-010-9182-0
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 113-115
    • Ford, H.L.1    Thompson, E.W.2
  • 93
    • 77954860342 scopus 로고    scopus 로고
    • Epithelialmesenchymal transition in cancer: Parallels between normal development and tumor progression
    • PMID: 20490631
    • Micalizzi DS, Farabaugh SM, Ford HL. Epithelialmesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15: 117-34; PMID: 20490631; http: //dx. doi. org/10. 1007/s10911-010-9178-9
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 94
    • 67650711156 scopus 로고    scopus 로고
    • MicroRNAs in Cancer
    • PMID: 19630570
    • Garzon R, Calin GA, Croce CM. MicroRNAs in Cancer. Annu Rev Med 2009; 60: 167-79; PMID: 19630570; http: //dx. doi. org/10. 1146/annurev. med. 59. 053006. 104707
    • (2009) Annu Rev Med , vol.60 , pp. 167-179
    • Garzon, R.1    Calin, G.A.2    Croce, C.M.3
  • 95
    • 84896789930 scopus 로고    scopus 로고
    • MicroRNAs: History, Biogenesis, and Their Evolving Role in Animal Development and Disease
    • PMID: 24045890
    • Bhaskaran M, Mohan M. MicroRNAs: History, Biogenesis, and Their Evolving Role in Animal Development and Disease. Vet Path 2013; 51: 759-774; PMID: 24045890
    • (2013) Vet Path , vol.51 , pp. 759-774
    • Bhaskaran, M.1    Mohan, M.2
  • 96
    • 33749435799 scopus 로고    scopus 로고
    • The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart
    • PMID: 16860783
    • Brade T, Manner J, Kuhl M. The role of Wnt signalling in cardiac development and tissue remodelling in the mature heart. Cardiovasc Res 2006; 72: 198-209; PMID: 16860783; http: //dx. doi. org/ 10. 1016/j. cardiores. 2006. 06. 025
    • (2006) Cardiovasc Res , vol.72 , pp. 198-209
    • Brade, T.1    Manner, J.2    Kuhl, M.3
  • 97
    • 52449115337 scopus 로고    scopus 로고
    • MicroRNAs in development and disease
    • PMID: 18713256
    • Erson AE, Petty EM. MicroRNAs in development and disease. Clin Genet 2008; 74: 296-306; PMID: 18713256; http: //dx. doi. org/10. 1111/j. 1399-0004. 2008. 01076. x
    • (2008) Clin Genet , vol.74 , pp. 296-306
    • Erson, A.E.1    Petty, E.M.2
  • 98
    • 79960104144 scopus 로고    scopus 로고
    • MicroRNAs in development and disease
    • PMID: 21742789
    • Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev 2011; 91: 827-87; PMID: 21742789; http: //dx. doi. org/10. 1152/physrev. 00006. 2010
    • (2011) Physiol Rev , vol.91 , pp. 827-887
    • Sayed, D.1    Abdellatif, M.2
  • 99
    • 84984765621 scopus 로고    scopus 로고
    • Canalization of development by microRNAs
    • PMID: 16736020
    • Hornstein E, Shomron N. Canalization of development by microRNAs. Nat Genet 2006; 38 Suppl: S20-4; PMID: 16736020; http: //dx. doi. org/10. 1038/ ng1803
    • (2006) Nat Genet , vol.38 , pp. S20-S24
    • Hornstein, E.1    Shomron, N.2
  • 101
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • PMID: 17011485
    • Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-50; PMID: 17011485; http: // dx. doi. org/10. 1016/j. devcel. 2006. 09. 009
    • (2006) Dev Cell , vol.11 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.2
  • 102
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • PMID: 15105502
    • Yekta S, Shih IH, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Science 2004; 304: 594-6; PMID: 15105502; http: //dx. doi. org/10. 1126/ science. 1097434
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 103
    • 84884853106 scopus 로고    scopus 로고
    • MicroRNAs in kidney fibrosis and diabetic nephropathy: Roles on EMT and EndMT
    • PMID: 24089659
    • Srivastava SP, Koya D, Kanasaki K. MicroRNAs in kidney fibrosis and diabetic nephropathy: roles on EMT and EndMT. BioMed Res Int 2013; 2013: 125469; PMID: 24089659; http: //dx. doi. org/ 10. 1155/2013/125469
    • (2013) BioMed Res Int , vol.2013 , pp. 125469
    • Srivastava, S.P.1    Koya, D.2    Kanasaki, K.3
  • 104
    • 84890831249 scopus 로고    scopus 로고
    • MicroRNAs as critical regulators involved in regulating epithelial-mesenchymal transition
    • PMID: 24168189
    • Zhao X, Lu Y, Nie Y, Fan D. MicroRNAs as critical regulators involved in regulating epithelial-mesenchymal transition. Curr Cancer Drug Targets 2013; 13: 935-44; PMID: 24168189; http: //dx. doi. org/ 10. 2174/15680096113136660099
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 935-944
    • Zhao, X.1    Lu, Y.2    Nie, Y.3    Fan, D.4
  • 105
    • 84902548716 scopus 로고    scopus 로고
    • MicroRNA control of epithelial-mesenchymal transition in cancer stem cells
    • PMID: 24500893
    • Hao J, Zhang Y, Deng M, Ye R, Zhao S, Wang Y, Li J, Zhao Z. MicroRNA control of epithelial-mesenchymal transition in cancer stem cells. Int J Cancer 2014; 135: 1019-27; PMID: 24500893
    • (2014) Int J Cancer , vol.135 , pp. 1019-1027
    • Hao, J.1    Zhang, Y.2    Deng, M.3    Ye, R.4    Zhao, S.5    Wang, Y.6    Li, J.7    Zhao, Z.8
  • 106
    • 61749097816 scopus 로고    scopus 로고
    • Tgf-beta superfamily signaling in embryonic development and homeostasis
    • PMID: 19289080
    • Wu MY, Hill CS. Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev Cell 2009; 16: 329-43; PMID: 19289080; http: //dx. doi. org/10. 1016/j. devcel. 2009. 02. 012
    • (2009) Dev Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 107
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • PMID: 15473860
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781-810; PMID: 15473860; http: //dx. doi. org/10. 1146/annurev. cellbio. 20. 010403. 113126
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 108
    • 56849100883 scopus 로고    scopus 로고
    • The six family of homeobox genes in development and cancer
    • PMID: 19055944
    • Christensen KL, Patrick AN, McCoy EL, Ford HL. The six family of homeobox genes in development and cancer. Adv Cancer Res 2008; 101: 93-126; PMID: 19055944; http: //dx. doi. org/10. 1016/S0065-230X(08)00405-3
    • (2008) Adv Cancer Res , vol.101 , pp. 93-126
    • Christensen, K.L.1    Patrick, A.N.2    McCoy, E.L.3    Ford, H.L.4
  • 109
    • 77957262381 scopus 로고    scopus 로고
    • Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    • PMID: 20713713
    • Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A 2010; 107: 15449-54; PMID: 20713713; http: //dx. doi. org/ 10. 1073/pnas. 1004900107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15449-15454
    • Taube, J.H.1    Herschkowitz, J.I.2    Komurov, K.3    Zhou, A.Y.4    Gupta, S.5    Yang, J.6    Hartwell, K.7    Onder, T.T.8    Gupta, P.B.9    Evans, K.W.10
  • 110
    • 84900449511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer
    • PMID: 24179606
    • Garg M. Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer. World J Stem Cells 2013; 5: 188-95; PMID: 24179606; http: //dx. doi. org/10. 4252/wjsc. v5. i4. 188
    • (2013) World J Stem Cells , vol.5 , pp. 188-195
    • Garg, M.1
  • 113
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • PMID: 18589210
    • Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008; 110: 13-21; PMID: 18589210; http: //dx. doi. org/10. 1016/j. ygyno. 2008. 04. 033
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 115
    • 77957262381 scopus 로고    scopus 로고
    • Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    • PMID: 20713713
    • Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A 2010; 107: 15449-54; PMID: 20713713; http: //dx. doi. org/ 10. 1073/pnas. 1004900107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15449-15454
    • Taube, J.H.1    Herschkowitz, J.I.2    Komurov, K.3    Zhou, A.Y.4    Gupta, S.5    Yang, J.6    Hartwell, K.7    Onder, T.T.8    Gupta, P.B.9    Evans, K.W.10
  • 116
    • 80054784515 scopus 로고    scopus 로고
    • The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    • PMID: 22028892
    • Dhasarathy A, Phadke D, Mav D, Shah RR, Wade PA. The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PloS One 2011; 6: e26514; PMID: 22028892; http: //dx. doi. org/10. 1371/journal. pone. 0026514
    • (2011) PloS One , vol.6
    • Dhasarathy, A.1    Phadke, D.2    Mav, D.3    Shah, R.R.4    Wade, P.A.5
  • 117
    • 59649128301 scopus 로고    scopus 로고
    • A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition
    • PMID: 18978814
    • Smith AP, Verrecchia A, Faga G, Doni M, Perna D, Martinato F, Guccione E, Amati B. A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene 2009; 28: 422-30; PMID: 18978814; http: //dx. doi. org/ 10. 1038/onc. 2008. 395
    • (2009) Oncogene , vol.28 , pp. 422-430
    • Smith, A.P.1    Verrecchia, A.2    Faga, G.3    Doni, M.4    Perna, D.5    Martinato, F.6    Guccione, E.7    Amati, B.8
  • 118
    • 84885915873 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity in carcinoma metastasis
    • PMID: 24142872
    • Tsai JH, Yang J. Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev 2013; 27: 2192-206; PMID: 24142872; http: //dx. doi. org/10. 1101/gad. 225334. 113
    • (2013) Genes Dev , vol.27 , pp. 2192-2206
    • Tsai, J.H.1    Yang, J.2
  • 119
    • 84858288644 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transition in tumor microenvironment
    • PMID: 21880137
    • Jing Y, Han Z, Zhang S, Liu Y, Wei L. Epithelial-Mesenchymal Transition in tumor microenvironment. Cell Biosci 2011; 1: 29; PMID: 21880137; http: //dx. doi. org/10. 1186/2045-3701-1-29
    • (2011) Cell Biosci , vol.1 , pp. 29
    • Jing, Y.1    Han, Z.2    Zhang, S.3    Liu, Y.4    Wei, L.5
  • 120
    • 84867115486 scopus 로고    scopus 로고
    • Microenvironmental regulation of epithelial-mesenchymal transitions in cancer
    • PMID: 23002209
    • Gao D, Vahdat LT, Wong S, Chang JC, Mittal V. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res 2012; 72: 4883-9; PMID: 23002209; http: //dx. doi. org/ 10. 1158/0008-5472. CAN-12-1223
    • (2012) Cancer Res , vol.72 , pp. 4883-4889
    • Gao, D.1    Vahdat, L.T.2    Wong, S.3    Chang, J.C.4    Mittal, V.5
  • 121
    • 84897121604 scopus 로고    scopus 로고
    • Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events
    • PMID: 24027434
    • Junk DJ, Cipriano R, Bryson BL, Gilmore HL, Jackson MW. Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events. Neoplasia 2013; 15: 1100-9; PMID: 24027434
    • (2013) Neoplasia , vol.15 , pp. 1100-1109
    • Junk, D.J.1    Cipriano, R.2    Bryson, B.L.3    Gilmore, H.L.4    Jackson, M.W.5
  • 122
    • 0032211308 scopus 로고    scopus 로고
    • Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition
    • PMID: 9810007
    • Martorana AM, Zheng G, Crowe TC, O'Grady RL, Lyons JG. Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition. Cancer Res 1998; 58: 4970-9; PMID: 9810007
    • (1998) Cancer Res , vol.58 , pp. 4970-4979
    • Martorana, A.M.1    Zheng, G.2    Crowe, T.C.3    O'Grady, R.L.4    Lyons, J.G.5
  • 123
    • 0036071107 scopus 로고    scopus 로고
    • Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene
    • PMID: 12139252
    • Zheng G, Lyons JG. Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene. BioTechniques 2002; 33: 32, 34, 36; PMID: 12139252
    • (2002) BioTechniques , vol.33
    • Zheng, G.1    Lyons, J.G.2
  • 124
    • 0024599725 scopus 로고
    • Cellular interactions determining the production of collagenase by a rat mammary carcinoma cell line
    • PMID: 2536004
    • Lyons JG, Siew K, O'Grady RL. Cellular interactions determining the production of collagenase by a rat mammary carcinoma cell line. Int J Cancer 1989; 43: 119-25; PMID: 2536004; http: //dx. doi. org/ 10. 1002/ijc. 2910430123
    • (1989) Int J Cancer , vol.43 , pp. 119-125
    • Lyons, J.G.1    Siew, K.2    O'Grady, R.L.3
  • 125
    • 57749092869 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth
    • PMID: 19074907
    • Tsuji T, Ibaragi S, Shima K, Hu MG, Katsurano M, Sasaki A, Hu GF. Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res 2008; 68: 10377-86; PMID: 19074907; http: //dx. doi. org/10. 1158/0008-5472. CAN-08-1444
    • (2008) Cancer Res , vol.68 , pp. 10377-10386
    • Tsuji, T.1    Ibaragi, S.2    Shima, K.3    Hu, M.G.4    Katsurano, M.5    Sasaki, A.6    Hu, G.F.7
  • 127
    • 33748601601 scopus 로고    scopus 로고
    • Evolution of cooperation among tumor cells
    • PMID: 16938860
    • Axelrod R, Axelrod DE, Pienta KJ. Evolution of cooperation among tumor cells. Proc Natl Acad Sci U S A 2006; 103: 13474-9; PMID: 16938860; http: //dx. doi. org/10. 1073/pnas. 0606053103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13474-13479
    • Axelrod, R.1    Axelrod, D.E.2    Pienta, K.J.3
  • 128
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • PMID: 17957189
    • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007; 7: 834-46; PMID: 17957189; http: //dx. doi. org/ 10. 1038/nrc2256
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.