메뉴 건너뛰기




Volumn 135, Issue 5, 2014, Pages 1019-1027

MicroRNA control of epithelial-mesenchymal transition in cancer stem cells

Author keywords

cancer stem cells; cancer therapy; epithelial mesenchymal transition; microRNA

Indexed keywords

MICRORNA;

EID: 84902548716     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28761     Document Type: Review
Times cited : (63)

References (130)
  • 1
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • Visvader JE, Lindeman GJ,. Cancer stem cells: current status and evolving complexities. Cell Stem Cell 2012; 10: 717-28.
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 2
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ,. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 5
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLOS ONE 2008; 3: e2888.
    • (2008) PLOS ONE , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3
  • 6
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 7
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA,. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 8
    • 84871952125 scopus 로고    scopus 로고
    • Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential
    • Yin G, Alvero AB, Craveiro V, et al. Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential. Oncogene 2013; 32: 39-49.
    • (2013) Oncogene , vol.32 , pp. 39-49
    • Yin, G.1    Alvero, A.B.2    Craveiro, V.3
  • 9
    • 33751163757 scopus 로고    scopus 로고
    • MicroRNA expression and function in cancer
    • Garzon R, Fabbri M, Cimmino A, et al. MicroRNA expression and function in cancer. Trends Mol Med 2006; 12: 580-7.
    • (2006) Trends Mol Med , vol.12 , pp. 580-587
    • Garzon, R.1    Fabbri, M.2    Cimmino, A.3
  • 10
    • 77749254611 scopus 로고    scopus 로고
    • MicroRNA, cell cycle, and human breast cancer
    • Yu Z, Baserga R, Chen L, et al. microRNA, cell cycle, and human breast cancer. Am J Pathol 2010; 176: 1058-64.
    • (2010) Am J Pathol , vol.176 , pp. 1058-1064
    • Yu, Z.1    Baserga, R.2    Chen, L.3
  • 11
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834-8.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 12
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Bert AG, et al. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008; 7: 3112-8.
    • (2008) Cell Cycle , vol.7 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3
  • 13
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-8.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 14
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100: 3983-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3
  • 15
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63: 5821-8.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 16
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ,. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 2012; 21: 283-96.
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 17
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012; 488: 522-6.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3
  • 18
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • Driessens G, Beck B, Caauwe A, et al. Defining the mode of tumour growth by clonal analysis. Nature 2012; 488: 527-30.
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3
  • 19
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • Schepers AG, Snippert HJ, Stange DE, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012; 337: 730-5.
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1    Snippert, H.J.2    Stange, D.E.3
  • 20
    • 84882861470 scopus 로고    scopus 로고
    • MicroRNAs and cancer stem cells: Therapeutic approaches and future perspectives
    • Leal JA, Lleonart ME,. MicroRNAs and cancer stem cells: therapeutic approaches and future perspectives. Cancer Lett 2012.
    • (2012) Cancer Lett
    • Leal, J.A.1    Lleonart, M.E.2
  • 21
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1: 555-67.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 22
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells
    • Scheel C, Weinberg RA,. Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells. Int J Cancer 2011; 129: 2310-4.
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 23
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer B, Valles AM, Edme N,. Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 2000; 60: 1091-9.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 24
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3
  • 25
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117: 927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 26
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008; 14: 79-89.
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3
  • 27
    • 37149040456 scopus 로고    scopus 로고
    • Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition
    • Lien HC, Hsiao YH, Lin YS, et al. Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 2007; 26: 7859-71.
    • (2007) Oncogene , vol.26 , pp. 7859-7871
    • Lien, H.C.1    Hsiao, Y.H.2    Lin, Y.S.3
  • 28
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP,. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764-74.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 29
    • 84870806564 scopus 로고    scopus 로고
    • EMT and MET in metastasis: Where are the cancer stem cells
    • Brabletz T,. EMT and MET in metastasis: where are the cancer stem cells. Cancer Cell 2012; 22: 699-701.
    • (2012) Cancer Cell , vol.22 , pp. 699-701
    • Brabletz, T.1
  • 30
    • 84880570961 scopus 로고    scopus 로고
    • MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
    • Song SJ, Poliseno L, Song MS, et al. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 2013; 154: 311-24.
    • (2013) Cell , vol.154 , pp. 311-324
    • Song, S.J.1    Poliseno, L.2    Song, M.S.3
  • 31
    • 84892942187 scopus 로고    scopus 로고
    • Emerging Role of MicroRNAs in Cancer and Cancer Stem Cells
    • (4)
    • Hao J, Zhao S, Zhang Y, Zhao Z, Ye R, Wen J, Li J,. Emerging Role of MicroRNAs in Cancer and Cancer Stem Cells. J Cell Biochem 2014; 115 (4): 605-10.
    • (2014) J Cell Biochem , vol.115 , pp. 605-610
    • Hao, J.1    Zhao, S.2    Zhang, Y.3    Zhao, Z.4    Ye, R.5    Wen, J.6    Li, J.7
  • 32
    • 84865169224 scopus 로고    scopus 로고
    • Epigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transition
    • Wu CY, Tsai YP, Wu MZ, et al. Epigenetic reprogramming and post-transcriptional regulation during the epithelial-mesenchymal transition. Trends Genet 2012; 28: 454-63.
    • (2012) Trends Genet , vol.28 , pp. 454-463
    • Wu, C.Y.1    Tsai, Y.P.2    Wu, M.Z.3
  • 33
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G,. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 2013; 13: 97-110.
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 34
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008; 9: 582-9.
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3
  • 35
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3
  • 36
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, et al. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008; 283: 14910-4.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3
  • 37
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894-907.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3
  • 38
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens H, Jackstadt R, Hunten S, et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011; 10: 4256-71.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3
  • 39
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop - A motor of cellular plasticity in development and cancer
    • Brabletz S, Brabletz T,. The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer. EMBO Rep 2010; 11: 670-7.
    • (2010) EMBO Rep , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 40
    • 84862645250 scopus 로고    scopus 로고
    • MiRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling
    • Ru P, Steele R, Newhall P, et al. miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling. Mol Cancer Ther 2012; 11: 1166-73.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1166-1173
    • Ru, P.1    Steele, R.2    Newhall, P.3
  • 41
    • 84855999432 scopus 로고    scopus 로고
    • MiR-30 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1
    • Zhang J, Zhang H, Liu J, et al. miR-30 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1. Biochem Biophys Res Commun 2012; 417: 1100-5.
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 1100-1105
    • Zhang, J.1    Zhang, H.2    Liu, J.3
  • 42
    • 84890730778 scopus 로고    scopus 로고
    • MiR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts
    • Gandellini P, Giannoni E, Casamichele A, et al. miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts. Antioxidant Redox Signal 2013.
    • (2013) Antioxidant Redox Signal
    • Gandellini, P.1    Giannoni, E.2    Casamichele, A.3
  • 43
    • 80054884390 scopus 로고    scopus 로고
    • MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines
    • Liu X, Wang C, Chen Z, Jin Y, et al. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J 2011; 440: 23-31.
    • (2011) Biochem J , vol.440 , pp. 23-31
    • Liu, X.1    Wang, C.2    Chen, Z.3    Jin, Y.4
  • 44
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • Kim NH, Kim HS, Li XY, et al. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 2011; 195: 417-33.
    • (2011) J Cell Biol , vol.195 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.Y.3
  • 45
    • 84859720222 scopus 로고    scopus 로고
    • A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition
    • Moes M, Le BA, Crespo I, et al. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLOS ONE 2012; 7: e35440.
    • (2012) PLOS ONE , vol.7
    • Moes, M.1    Le, B.A.2    Crespo, I.3
  • 46
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong W, Yang H, He L, et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008; 28: 6773-84.
    • (2008) Mol Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3
  • 47
    • 77649275464 scopus 로고    scopus 로고
    • MiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    • Ma L, Young J, Prabhala H, et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Natl Cell Biol 2010; 12: 247-56.
    • (2010) Natl Cell Biol , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3
  • 48
    • 78649588750 scopus 로고    scopus 로고
    • MiR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice
    • Meng Z, Fu X, Chen X, et al. miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology 2010; 52: 2148-57.
    • (2010) Hepatology , vol.52 , pp. 2148-2157
    • Meng, Z.1    Fu, X.2    Chen, X.3
  • 49
    • 84865036180 scopus 로고    scopus 로고
    • Inverse association between miR-194 expression and tumor invasion in gastric cancer
    • Song Y, Zhao F, Wang Z, et al. Inverse association between miR-194 expression and tumor invasion in gastric cancer. Ann Surg Oncol 2012; 19 Suppl 3: S509-17.
    • (2012) Ann Surg Oncol , vol.19 , Issue.SUPPL. 3
    • Song, Y.1    Zhao, F.2    Wang, Z.3
  • 50
    • 77955466130 scopus 로고    scopus 로고
    • MiR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers
    • Vetter G, Saumet A, Moes M, et al. miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers. Oncogene 2010; 29: 4436-48.
    • (2010) Oncogene , vol.29 , pp. 4436-4448
    • Vetter, G.1    Saumet, A.2    Moes, M.3
  • 51
    • 78650038626 scopus 로고    scopus 로고
    • TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells
    • Zhou Q, Fan J, Ding X, et al. TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells. J Biol Chem 2010; 285: 40019-27.
    • (2010) J Biol Chem , vol.285 , pp. 40019-40027
    • Zhou, Q.1    Fan, J.2    Ding, X.3
  • 52
    • 84874212546 scopus 로고    scopus 로고
    • MiR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin
    • Hamada S, Satoh K, Miura S, et al. miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol 2013; 228: 1255-63.
    • (2013) J Cell Physiol , vol.228 , pp. 1255-1263
    • Hamada, S.1    Satoh, K.2    Miura, S.3
  • 53
    • 11144223157 scopus 로고    scopus 로고
    • Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
    • Rao M,. Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Dev Biol 2004; 275: 269-86.
    • (2004) Dev Biol , vol.275 , pp. 269-286
    • Rao, M.1
  • 54
    • 84881263135 scopus 로고    scopus 로고
    • Targeting deregulated epigenetic control in cancer
    • Zaidi SK, Van Wijnen AJ, Lian JB, et al. Targeting deregulated epigenetic control in cancer. J Cell Physiol 2013; 228: 2103-8.
    • (2013) J Cell Physiol , vol.228 , pp. 2103-2108
    • Zaidi, S.K.1    Van Wijnen, A.J.2    Lian, J.B.3
  • 55
    • 80055092259 scopus 로고    scopus 로고
    • MicroRNAs, an active and versatile group in cancers
    • Liu J, Zheng M, Tang YL, et al. MicroRNAs, an active and versatile group in cancers. Int J Oral Sci 2011; 3: 165-75.
    • (2011) Int J Oral Sci , vol.3 , pp. 165-175
    • Liu, J.1    Zheng, M.2    Tang, Y.L.3
  • 56
    • 84872975055 scopus 로고    scopus 로고
    • MicroRNAs, stem cells and cancer stem cells
    • Garg M,. MicroRNAs, stem cells and cancer stem cells. World J Stem Cells 2012; 4: 62-70.
    • (2012) World J Stem Cells , vol.4 , pp. 62-70
    • Garg, M.1
  • 57
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLOS ONE 2009; 4: e6816.
    • (2009) PLOS ONE , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 58
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131: 1109-23.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3
  • 59
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y, Zabala M, Cho RW, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009; 138: 592-603.
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3
  • 60
    • 77956547097 scopus 로고    scopus 로고
    • Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • Iliopoulos D, Lindahl-Allen M, Polytarchou C, et al. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell 2010; 39: 761-72.
    • (2010) Mol Cell , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3
  • 61
    • 59449100501 scopus 로고    scopus 로고
    • The miR-302-367 cluster as a potential stemness regulator in ESCs
    • Barroso-del JA, Lucena-Aguilar G, Menendez P,. The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle 2009; 8: 394-8.
    • (2009) Cell Cycle , vol.8 , pp. 394-398
    • Barroso-Del, J.A.1    Lucena-Aguilar, G.2    Menendez, P.3
  • 62
    • 55449089454 scopus 로고    scopus 로고
    • Embryonic stem cell-specific miR302-367 cluster: Human gene structure and functional characterization of its core promoter
    • Barroso-delJesus A, Romero-Lopez C, Lucena-Aguilar G, et al. Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol 2008; 28: 6609-19.
    • (2008) Mol Cell Biol , vol.28 , pp. 6609-6619
    • Barroso-Deljesus, A.1    Romero-Lopez, C.2    Lucena-Aguilar, G.3
  • 63
    • 84863577404 scopus 로고    scopus 로고
    • Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7
    • Liu C, Kelnar K, Vlassov AV, et al. Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7. Cancer Res 2012; 72: 3393-404.
    • (2012) Cancer Res , vol.72 , pp. 3393-3404
    • Liu, C.1    Kelnar, K.2    Vlassov, A.V.3
  • 64
    • 84855221069 scopus 로고    scopus 로고
    • A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer
    • Wang L, Zhang D, Zhang C, et al. A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncol Lett 2012; 3: 119-24.
    • (2012) Oncol Lett , vol.3 , pp. 119-124
    • Wang, L.1    Zhang, D.2    Zhang, C.3
  • 65
    • 84874324849 scopus 로고    scopus 로고
    • MiR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4
    • Okuda H, Xing F, Pandey PR, et al. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res 2013; 73: 1434-44.
    • (2013) Cancer Res , vol.73 , pp. 1434-1444
    • Okuda, H.1    Xing, F.2    Pandey, P.R.3
  • 66
    • 77951757309 scopus 로고    scopus 로고
    • The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression
    • Wong P, Iwasaki M, Somervaille TC, et al. The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res 2010; 70: 3833-42.
    • (2010) Cancer Res , vol.70 , pp. 3833-3842
    • Wong, P.1    Iwasaki, M.2    Somervaille, T.C.3
  • 67
    • 84860752172 scopus 로고    scopus 로고
    • Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145
    • Jia Y, Liu H, Zhuang Q, Xu S, et al. Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol Rep 2012; 27: 1865-72.
    • (2012) Oncol Rep , vol.27 , pp. 1865-1872
    • Jia, Y.1    Liu, H.2    Zhuang, Q.3    Xu, S.4
  • 68
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI
    • Yang YP, Chien Y, Chiou GY, et al. Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 2012; 33: 1462-76.
    • (2012) Biomaterials , vol.33 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3
  • 69
    • 82555204537 scopus 로고    scopus 로고
    • MiR-93 suppresses proliferation and colony formation of human colon cancer stem cells
    • Yu XF, Zou J, Bao ZJ, et al. miR-93 suppresses proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol 2011; 17: 4711-7.
    • (2011) World J Gastroenterol , vol.17 , pp. 4711-4717
    • Yu, X.F.1    Zou, J.2    Bao, Z.J.3
  • 70
    • 80052632447 scopus 로고    scopus 로고
    • MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    • de Antonellis P, Medaglia C, Cusanelli E, et al. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLOS ONE 2011; 6: e24584.
    • (2011) PLOS ONE , vol.6
    • De Antonellis, P.1    Medaglia, C.2    Cusanelli, E.3
  • 72
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tang SN, Rodova M, et al. Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLOS ONE 2011; 6: e24099.
    • (2011) PLOS ONE , vol.6
    • Nalls, D.1    Tang, S.N.2    Rodova, M.3
  • 73
    • 84855279252 scopus 로고    scopus 로고
    • MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells
    • Yu F, Jiao Y, Zhu Y, et al. MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem 2012; 287: 465-73.
    • (2012) J Biol Chem , vol.287 , pp. 465-473
    • Yu, F.1    Jiao, Y.2    Zhu, Y.3
  • 74
    • 84855389885 scopus 로고    scopus 로고
    • MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells
    • Yu Y, Kanwar SS, Patel BB, et al. MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. Carcinogenesis 2012; 33: 68-76.
    • (2012) Carcinogenesis , vol.33 , pp. 68-76
    • Yu, Y.1    Kanwar, S.S.2    Patel, B.B.3
  • 75
    • 84880958993 scopus 로고    scopus 로고
    • MicroRNA-21 promotes ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro
    • Chung WM, Chang WC, Chen L, et al. MicroRNA-21 promotes ovarian teratocarcinoma PA1 cell line by sustaining cancer stem/progenitor populations in vitro. Stem Cell Res Ther 2013; 4: 88.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 88
    • Chung, W.M.1    Chang, W.C.2    Chen, L.3
  • 76
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu F, Deng H, Yao H, et al. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010; 29: 4194-204.
    • (2010) Oncogene , vol.29 , pp. 4194-4204
    • Yu, F.1    Deng, H.2    Yao, H.3
  • 77
    • 84863124163 scopus 로고    scopus 로고
    • MicroRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb
    • Zhang J, Luo N, Luo Y, et al. microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. Int J Oncol 2012; 40: 747-56.
    • (2012) Int J Oncol , vol.40 , pp. 747-756
    • Zhang, J.1    Luo, N.2    Luo, Y.3
  • 78
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski J, Nowicki MO, Bronisz A, et al. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 2008; 68: 9125-30.
    • (2008) Cancer Res , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3
  • 79
    • 81255138201 scopus 로고    scopus 로고
    • Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5
    • Zhu Y, Yu F, Jiao Y, et al. Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin Cancer Res 2011; 17: 7105-15.
    • (2011) Clin Cancer Res , vol.17 , pp. 7105-7115
    • Zhu, Y.1    Yu, F.2    Jiao, Y.3
  • 80
    • 84873250716 scopus 로고    scopus 로고
    • Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression
    • Fan X, Chen X, Deng W, et al. Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression. BMC Cancer 2013; 13: 61.
    • (2013) BMC Cancer , vol.13 , pp. 61
    • Fan, X.1    Chen, X.2    Deng, W.3
  • 81
    • 52049096593 scopus 로고    scopus 로고
    • MIR-451 and imatinib mesylate inhibit tumor growth of glioblastoma stem cells
    • Gal H, Pandi G, Kanner AA, Ram Z, et al. MIR-451 and imatinib mesylate inhibit tumor growth of glioblastoma stem cells. Biochem Biophys Res Commun 2008; 376: 86-90.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 86-90
    • Gal, H.1    Pandi, G.2    Kanner, A.A.3    Ram, Z.4
  • 82
    • 80054924979 scopus 로고    scopus 로고
    • MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells
    • Bitarte N, Bandres E, Boni V, et al. MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. Stem Cells 2011; 29: 1661-71.
    • (2011) Stem Cells , vol.29 , pp. 1661-1671
    • Bitarte, N.1    Bandres, E.2    Boni, V.3
  • 83
    • 73649147994 scopus 로고    scopus 로고
    • MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation
    • Shi L, Zhang J, Pan T, et al. MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation. Brain Res 2010; 1312: 120-6.
    • (2010) Brain Res , vol.1312 , pp. 120-126
    • Shi, L.1    Zhang, J.2    Pan, T.3
  • 84
    • 84455194000 scopus 로고    scopus 로고
    • MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis
    • Shi L, Zhang S, Feng K, et al. MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis. Int J Oncol 2012; 40: 119-29.
    • (2012) Int J Oncol , vol.40 , pp. 119-129
    • Shi, L.1    Zhang, S.2    Feng, K.3
  • 85
    • 79551511687 scopus 로고    scopus 로고
    • MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis
    • Otsubo T, Akiyama Y, Hashimoto Y, et al. MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLOS ONE 2011; 6: e16617.
    • (2011) PLOS ONE , vol.6
    • Otsubo, T.1    Akiyama, Y.2    Hashimoto, Y.3
  • 86
    • 84880168463 scopus 로고    scopus 로고
    • NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rgamma null mice by regulating Bmi-1 and microRNA-128
    • Nanta R, Kumar D, Meeker D, et al. NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rgamma null mice by regulating Bmi-1 and microRNA-128. Oncogenesis 2013; 2: e42.
    • (2013) Oncogenesis , vol.2
    • Nanta, R.1    Kumar, D.2    Meeker, D.3
  • 87
    • 84883189850 scopus 로고    scopus 로고
    • MicroRNA-128 coordinately targets polycomb repressor complexes in glioma stem cells
    • Peruzzi P, Bronisz A, Nowicki MO, et al. MicroRNA-128 coordinately targets polycomb repressor complexes in glioma stem cells. Neuro Oncol 2013.
    • (2013) Neuro Oncol
    • Peruzzi, P.1    Bronisz, A.2    Nowicki, M.O.3
  • 88
    • 79955501601 scopus 로고    scopus 로고
    • ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9-mediated suppression of SOX2
    • Jeon HM, Sohn YW, Oh SY, et al. ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9-mediated suppression of SOX2. Cancer Res 2011; 71: 3410-21.
    • (2011) Cancer Res , vol.71 , pp. 3410-3421
    • Jeon, H.M.1    Sohn, Y.W.2    Oh, S.Y.3
  • 89
    • 80054937128 scopus 로고    scopus 로고
    • CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells
    • Schraivogel D, Weinmann L, Beier D, et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J 2011; 30: 4309-22.
    • (2011) EMBO J , vol.30 , pp. 4309-4322
    • Schraivogel, D.1    Weinmann, L.2    Beier, D.3
  • 90
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Natl Cell Biol 2009; 11: 1487-95.
    • (2009) Natl Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 91
    • 72949119530 scopus 로고    scopus 로고
    • MiR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion
    • Xia H, Ng SS, Jiang S, et al. miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun 2010; 391: 535-41.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 535-541
    • Xia, H.1    Ng, S.S.2    Jiang, S.3
  • 92
    • 79551708071 scopus 로고    scopus 로고
    • MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells
    • Lo WL, Yu CC, Chiou GY, et al. MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol 2011; 223: 482-95.
    • (2011) J Pathol , vol.223 , pp. 482-495
    • Lo, W.L.1    Yu, C.C.2    Chiou, G.Y.3
  • 93
    • 79954576652 scopus 로고    scopus 로고
    • EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells
    • Tellez CS, Juri DE, Do K, et al. EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res 2011; 71: 3087-97.
    • (2011) Cancer Res , vol.71 , pp. 3087-3097
    • Tellez, C.S.1    Juri, D.E.2    Do, K.3
  • 94
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, Yamashita T, Budhu A, et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009; 50: 472-80.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3
  • 95
    • 79953043006 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
    • Wang Y, Yu Y, Tsuyada A, Ren X, et al. Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene 2011; 30: 1470-80.
    • (2011) Oncogene , vol.30 , pp. 1470-1480
    • Wang, Y.1    Yu, Y.2    Tsuyada, A.3    Ren, X.4
  • 96
    • 84855176010 scopus 로고    scopus 로고
    • Functional analysis of microRNAs in human hepatocellular cancer stem cells
    • Meng F, Glaser SS, Francis H, et al. Functional analysis of microRNAs in human hepatocellular cancer stem cells. J Cell Mol Med 2012; 16: 160-73.
    • (2012) J Cell Mol Med , vol.16 , pp. 160-173
    • Meng, F.1    Glaser, S.S.2    Francis, H.3
  • 97
    • 78549261109 scopus 로고    scopus 로고
    • Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
    • Yang X, Lin X, Zhong X, Kaur S, et al. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res 2010; 70: 9463-72.
    • (2010) Cancer Res , vol.70 , pp. 9463-9472
    • Yang, X.1    Lin, X.2    Zhong, X.3    Kaur, S.4
  • 98
    • 79957613439 scopus 로고    scopus 로고
    • MiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1
    • Hwang-Verslues WW, Chang PH, Wei PC, et al. miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene 2011; 30: 2463-74.
    • (2011) Oncogene , vol.30 , pp. 2463-2474
    • Hwang-Verslues, W.W.1    Chang, P.H.2    Wei, P.C.3
  • 99
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S, Tang KH, Chan YP, et al. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010; 7: 694-707.
    • (2010) Cell Stem Cell , vol.7 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3
  • 100
    • 84878011791 scopus 로고    scopus 로고
    • Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells
    • Babashah S, Sadeghizadeh M, Hajifathali A, et al. Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells. Int J Cancer 2013; 133: 579-89.
    • (2013) Int J Cancer , vol.133 , pp. 579-589
    • Babashah, S.1    Sadeghizadeh, M.2    Hajifathali, A.3
  • 101
    • 78049303163 scopus 로고    scopus 로고
    • Downregulation of ABCG2 expression in glioblastoma cancer stem cells with miRNA-328 may decrease their chemoresistance
    • Li WQ, Li YM, Tao BB, et al. Downregulation of ABCG2 expression in glioblastoma cancer stem cells with miRNA-328 may decrease their chemoresistance. Med Sci Monit 2010; 16: HY27-30.
    • (2010) Med Sci Monit , vol.16
    • Li, W.Q.1    Li, Y.M.2    Tao, B.B.3
  • 102
    • 63449135077 scopus 로고    scopus 로고
    • MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma
    • Garzia L, Andolfo I, Cusanelli E, et al. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLOS ONE 2009; 4: e4998.
    • (2009) PLOS ONE , vol.4
    • Garzia, L.1    Andolfo, I.2    Cusanelli, E.3
  • 103
    • 48949116262 scopus 로고    scopus 로고
    • MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • Silber J, Lim DA, Petritsch C, et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008; 6: 14.
    • (2008) BMC Med , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3
  • 105
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer CL, Brueckmann I, Scheel C, et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci USA 2011; 108: 7950-5.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7950-7955
    • Chaffer, C.L.1    Brueckmann, I.2    Scheel, C.3
  • 106
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011; 146: 633-44.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3
  • 107
    • 84860230610 scopus 로고    scopus 로고
    • Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations
    • Yang G, Quan Y, Wang W, et al. Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations. Br J Cancer 2012; 106: 1512-9.
    • (2012) Br J Cancer , vol.106 , pp. 1512-1519
    • Yang, G.1    Quan, Y.2    Wang, W.3
  • 108
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Smith E, et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011; 22: 1686-98.
    • (2011) Mol Biol Cell , vol.22 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Smith, E.3
  • 109
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • Chaffer CL, Marjanovic ND, Lee T, et al. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 2013; 154: 61-74.
    • (2013) Cell , vol.154 , pp. 61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3
  • 110
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
    • Yang MH, Hsu DS, Wang HW, et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 2010; 12: 982-92.
    • (2010) Nat Cell Biol , vol.12 , pp. 982-992
    • Yang, M.H.1    Hsu, D.S.2    Wang, H.W.3
  • 111
    • 77957902732 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    • Kong D, Banerjee S, Ahmad A, et al. Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLOS ONE 2010; 5: e12445.
    • (2010) PLOS ONE , vol.5
    • Kong, D.1    Banerjee, S.2    Ahmad, A.3
  • 112
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang CJ, Chao CH, Xia W, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 2011; 13: 317-23.
    • (2011) Nat Cell Biol , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3
  • 113
    • 84879996033 scopus 로고    scopus 로고
    • MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition
    • Chen D, Zhang Y, Wang J, et al. MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition. J Ovarian Res 2013; 6: 50.
    • (2013) J Ovarian Res , vol.6 , pp. 50
    • Chen, D.1    Zhang, Y.2    Wang, J.3
  • 114
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    • Han M, Liu M, Wang Y, et al. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN. PLOS ONE 2012; 7: e39520.
    • (2012) PLOS ONE , vol.7
    • Han, M.1    Liu, M.2    Wang, Y.3
  • 115
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani P, Golipour A, David L, et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010; 7: 64-77.
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1    Golipour, A.2    David, L.3
  • 116
    • 84860578009 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celia-Terrassa T, Meca-Cortes O, Mateo F, et al. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest 2012; 122: 1849-68.
    • (2012) J Clin Invest , vol.122 , pp. 1849-1868
    • Celia-Terrassa, T.1    Meca-Cortes, O.2    Mateo, F.3
  • 117
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH, Corcoles R, Fabra A, et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012; 22: 709-24.
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3
  • 118
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, et al. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22: 725-36.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3
  • 119
    • 79960799901 scopus 로고    scopus 로고
    • Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer
    • Chang CJ, Hsu CC, Chang CH, et al. Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer. Oncol Rep 2011; 26: 1003-10.
    • (2011) Oncol Rep , vol.26 , pp. 1003-1010
    • Chang, C.J.1    Hsu, C.C.2    Chang, C.H.3
  • 120
    • 84860390076 scopus 로고    scopus 로고
    • Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, et al. Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. J Cell Biochem 2011; 112: 2296-306.
    • (2011) J Cell Biochem , vol.112 , pp. 2296-2306
    • Bao, B.1    Wang, Z.2    Ali, S.3
  • 121
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, et al. Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 2011; 307: 26-36.
    • (2011) Cancer Lett , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3
  • 122
    • 84861686487 scopus 로고    scopus 로고
    • MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1alpha expression in third-sphere forming breast cancer stem cell-like cells
    • Han M, Wang Y, Liu M, et al. MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1alpha expression in third-sphere forming breast cancer stem cell-like cells. Cancer Sci 2012; 103: 1058-64.
    • (2012) Cancer Sci , vol.103 , pp. 1058-1064
    • Han, M.1    Wang, Y.2    Liu, M.3
  • 123
    • 84856369168 scopus 로고    scopus 로고
    • MIR-99a and MIR-99b modulate TGF-beta induced epithelial to mesenchymal plasticity in normal murine mammary gland cells
    • Turcatel G, Rubin N, El-Hashash A, et al. MIR-99a and MIR-99b modulate TGF-beta induced epithelial to mesenchymal plasticity in normal murine mammary gland cells. PLOS ONE 2012; 7: e31032.
    • (2012) PLOS ONE , vol.7
    • Turcatel, G.1    Rubin, N.2    El-Hashash, A.3
  • 124
    • 84871246002 scopus 로고    scopus 로고
    • The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
    • Smith AL, Iwanaga R, Drasin DJ, et al. The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 2012; 31: 5162-71.
    • (2012) Oncogene , vol.31 , pp. 5162-5171
    • Smith, A.L.1    Iwanaga, R.2    Drasin, D.J.3
  • 125
    • 80051793013 scopus 로고    scopus 로고
    • MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
    • Dong P, Kaneuchi M, Watari H, et al. MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1. Mol Cancer 2011; 10: 99.
    • (2011) Mol Cancer , vol.10 , pp. 99
    • Dong, P.1    Kaneuchi, M.2    Watari, H.3
  • 126
    • 78449255989 scopus 로고    scopus 로고
    • MiR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling
    • Xia H, Cheung WK, Sze J, et al. miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling. J Biol Chem 2010; 285: 36995-7004.
    • (2010) J Biol Chem , vol.285 , pp. 36995-37004
    • Xia, H.1    Cheung, W.K.2    Sze, J.3
  • 127
    • 73349099030 scopus 로고    scopus 로고
    • MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
    • Iliopoulos D, Polytarchou C, Hatziapostolou M, et al. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2009; 2: ra62.
    • (2009) Sci Signal , vol.2
    • Iliopoulos, D.1    Polytarchou, C.2    Hatziapostolou, M.3
  • 128
    • 84857919158 scopus 로고    scopus 로고
    • Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs
    • Guttilla IK, Phoenix KN, Hong X, et al. Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs. Breast Cancer Res Treat 2012; 132: 75-85.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 75-85
    • Guttilla, I.K.1    Phoenix, K.N.2    Hong, X.3
  • 129
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh A, Settleman J,. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29: 4741-51.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 130
    • 84861194016 scopus 로고    scopus 로고
    • EMT as the ultimate survival mechanism of cancer cells
    • Tiwari N, Gheldof A, Tatari M, et al. EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol 2012; 22: 194-207.
    • (2012) Semin Cancer Biol , vol.22 , pp. 194-207
    • Tiwari, N.1    Gheldof, A.2    Tatari, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.