메뉴 건너뛰기




Volumn 12, Issue 1, 2016, Pages 14-24

Interleukin-1 function and role in rheumatic disease

Author keywords

[No Author keywords available]

Indexed keywords

CANAKINUMAB; GEVOKIZUMAB; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1BETA; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

EID: 84954198098     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.166     Document Type: Review
Times cited : (225)

References (147)
  • 1
    • 0001471024 scopus 로고
    • Human leukocytic pyrogen: Purification and development of a radioimmunoassay
    • Dinarello, C. A., Renfer, L. & Wolff, S. M. Human leukocytic pyrogen: purification and development of a radioimmunoassay. Proc. Natl Acad. Sci. USA 74, 4624-4627 (1977).
    • (1977) Proc. Natl Acad. Sci. USA , vol.74 , pp. 4624-4627
    • Dinarello, C.A.1    Renfer, L.2    Wolff, S.M.3
  • 2
    • 0021745716 scopus 로고
    • Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
    • Lomedico, P. T. et al. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature. 312, 458-462 (1984).
    • (1984) Nature , vol.312 , pp. 458-462
    • Lomedico, P.T.1
  • 3
    • 0000814155 scopus 로고
    • Nucleotide sequence of human monocyte interleukin 1 precursor cDNA
    • Auron, P. E. et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl Acad. Sci. USA 81, 7907-7911 (1984).
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 7907-7911
    • Auron, P.E.1
  • 4
    • 0015365707 scopus 로고
    • Potentiation of the T-lymphocyte response to mitogens
    • Gery, I. & Waksman, B. H. Potentiation of the T-lymphocyte response to mitogens. J. Exp. Med. 136,143-155 (1972).
    • (1972) J. Exp. Med. , vol.136 , pp. 143-155
    • Gery, I.1    Waksman, B.H.2
  • 5
    • 0016191801 scopus 로고
    • Demonstration and characterization of two distinct human leukocytic pyrogens
    • Dinarello, C. A., Goldin, N. P. & Wolff, S, M. Demonstration and characterization of two distinct human leukocytic pyrogens. J. Exp. Med. 139, 1269-1281 (1974).
    • (1974) J. Exp. Med. , vol.139 , pp. 1269-1281
    • Dinarello, C.A.1    Goldin, N.P.2    Wolff, S.M.3
  • 6
    • 0019863205 scopus 로고
    • Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro
    • Dinarello, C. A. & Bernheim, H. A. Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J. Neurochem. 37, 702-708 (1981).
    • (1981) J. Neurochem. , vol.37 , pp. 702-708
    • Dinarello, C.A.1    Bernheim, H.A.2
  • 7
    • 0017687558 scopus 로고
    • Prostaglandin production by rheumatoid synovial cells: Stimulation by a factor from human mononuclear cells
    • Dayer, J. M., Robinson, D. R & Krane, S. M. Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear cells. J. Exp. Med. 145, 1399-1404 (1977).
    • (1977) J. Exp. Med. , vol.145 , pp. 1399-1404
    • Dayer, J.M.1    Robinson, D.R.2    Krane, S.M.3
  • 8
    • 0015400563 scopus 로고
    • Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
    • Horton, J. E. et al. Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science 177, 793-795 (1972).
    • (1972) Science , vol.177 , pp. 793-795
    • Horton, J.E.1
  • 9
    • 0017325645 scopus 로고
    • Collagenase production by rheumatoid synovial cells: Stimulation by a human lymphocyte factor
    • Dayer, J. M., Graham, R., Russell, G. & Krane, S. M. Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science 195, 181-183 (1977).
    • (1977) Science , vol.195 , pp. 181-183
    • Dayer, J.M.1    Graham, R.2    Russell, G.3    Krane, S.M.4
  • 10
    • 0019137699 scopus 로고
    • Identification of catabolin, a protein from synovium which induces degradation of cartilage in organ culture
    • Saklatvala, J. & Dingle, J. T. Identification of catabolin, a protein from synovium which induces degradation of cartilage in organ culture. Biochem. Biophys. Res. Commun. 16, 1225-1231 (1980).
    • (1980) Biochem. Biophys. Res. Commun. , vol.16 , pp. 1225-1231
    • Saklatvala, J.1    Dingle, J.T.2
  • 11
    • 0345214235 scopus 로고
    • Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1
    • Mizel, S. B, Dayer, J.-M., Krane, S. M. & Mergenhagen, S. E. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1). Proc. Natl Acad. Sci. USA 78, 2474-2477 (1981).
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 2474-2477
    • Mizel, S.B.1    Dayer, J.-M.2    Krane, S.M.3    Mergenhagen, S.E.4
  • 12
    • 0020678196 scopus 로고
    • Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1)-a mechanism for the increased degradation of muscle proteins during fever
    • Baracos, V., Rodemann, H. P., Dinarello, C. A. & Goldberg, A. L. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1)-a mechanism for the increased degradation of muscle proteins during fever. N. Engl. J. Med. 10, 553-558 (1983).
    • (1983) N. Engl. J. Med. , vol.10 , pp. 553-558
    • Baracos, V.1    Rodemann, H.P.2    Dinarello, C.A.3    Goldberg, A.L.4
  • 13
    • 0018753864 scopus 로고
    • Revised nomenclature for antigen nonspecific T cell proliferation and helper factors
    • Aarden, L. A. et al. Revised nomenclature for antigen nonspecific T cell proliferation and helper factors. J. Immunol. 123, 2928-2929 (1979).
    • (1979) J. Immunol. , vol.123 , pp. 2928-2929
    • Aarden, L.A.1
  • 15
    • 77958118283 scopus 로고    scopus 로고
    • IL-1 family nomenclature
    • Dinnarello, C. et al. IL-1 family nomenclature. Nat. Immunol. 11, 973 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 973
    • Dinnarello, C.1
  • 16
    • 84890235827 scopus 로고    scopus 로고
    • The interleukin-1 family: Back to the future
    • Garlanda, C., Dinarello, C. A. & Mantovani, A. The interleukin-1 family: back to the future. Immunity 39, 1003-1018 (2013).
    • (2013) Immunity , vol.39 , pp. 1003-1018
    • Garlanda, C.1    Dinarello, C.A.2    Mantovani, A.3
  • 17
    • 84857397087 scopus 로고    scopus 로고
    • IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
    • van de Veerdonk, F. L. et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl Acad. Sci. USA 109, 3001-3005 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 3001-3005
    • Van De Veerdonk, F.L.1
  • 18
    • 84948419437 scopus 로고    scopus 로고
    • Interleukin 38 exerts anti-inflammatory functions and is associated with disease activity in systemic lupus erythematosus
    • Rudloff, I. et al. Interleukin 38 exerts anti-inflammatory functions and is associated with disease activity in systemic lupus erythematosus. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.39328 (2015).
    • (2015) Arthritis Rheumatol.
    • Rudloff, I.1
  • 19
    • 0028170376 scopus 로고
    • Structure and mechanism of interleukin-1 converting enzyme
    • Wilson, K. P. et al. Structure and mechanism of interleukin-1 converting enzyme. Nature 370, 270-275 (1994).
    • (1994) Nature , vol.370 , pp. 270-275
    • Wilson, K.P.1
  • 20
    • 0026507126 scopus 로고
    • A novel heterodimeric cysteine protease is required for interleukin-1 processing in monocytes
    • Thornberry, N. A. et al. A novel heterodimeric cysteine protease is required for interleukin-1 processing in monocytes. Nature 356, 768-774 (1992).
    • (1992) Nature , vol.356 , pp. 768-774
    • Thornberry, N.A.1
  • 21
    • 34447116244 scopus 로고    scopus 로고
    • Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    • Chen, C. J. et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 13, 851-856 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 851-856
    • Chen, C.J.1
  • 22
    • 84937605509 scopus 로고    scopus 로고
    • Proteolytic processing of Interleukin-1 family cytokines: Variations on a common theme
    • Afonina, I. S., Mller, C., Martin, S. J. & Beyaert, R. Proteolytic processing of Interleukin-1 family cytokines: variations on a common theme. Immunity 42, 991-1004 (2015).
    • (2015) Immunity , vol.42 , pp. 991-1004
    • Afonina, I.S.1    Mller, C.2    Martin, S.J.3    Beyaert, R.4
  • 23
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: A sensor for metabolic danger
    • Schroder, K., Zhou, R. & Tschopp, J. The NLRP3 inflammasome: a sensor for metabolic danger Science 327, 296-300 (2010).
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 24
    • 64049084303 scopus 로고    scopus 로고
    • Differential requirement for the activation of the inflammasome for processing and release of IL-1 in monocytes and macrophages
    • Netea, M. G. et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1 in monocytes and macrophages. Blood 113, 2324-2335 (2009).
    • (2009) Blood , vol.113 , pp. 2324-2335
    • Netea, M.G.1
  • 25
    • 33646072818 scopus 로고    scopus 로고
    • The P2X7 receptor: A key player in IL-1 processing and release
    • Ferrari, D. et al. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 176, 3877-3883 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 3877-3883
    • Ferrari, D.1
  • 26
    • 1842581655 scopus 로고    scopus 로고
    • A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 processing and release
    • Elssner, A. et al. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 processing and release. J. Immunol. 172, 4987-4994 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4987-4994
    • Elssner, A.1
  • 27
    • 84922553500 scopus 로고    scopus 로고
    • Neutrophil IL-1 processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux
    • Karmakar, M. et al. Neutrophil IL-1 processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J. Immunol.194, 1763-1775 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 1763-1775
    • Karmakar, M.1
  • 28
    • 84904792729 scopus 로고    scopus 로고
    • The neutrophil NLRC4 inflammasome selectively promotes IL-1 maturation without pyroptosis during acute Salmonella challenge
    • Chen, K. W. et al. The neutrophil NLRC4 inflammasome selectively promotes IL-1 maturation without pyroptosis during acute Salmonella challenge. Cell Rep. 8, 570-582 (2014).
    • (2014) Cell Rep , vol.8 , pp. 570-582
    • Chen, K.W.1
  • 29
    • 0032989434 scopus 로고    scopus 로고
    • Converting enzyme-independent release of tumor necrosis factor and IL-1 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
    • Coeshott, C. et al. Converting enzyme-independent release of tumor necrosis factor and IL-1 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc. Natl Acad. Sci. USA 96, 6261-6266 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 6261-6266
    • Coeshott, C.1
  • 30
    • 0035575705 scopus 로고    scopus 로고
    • Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells
    • Sugawara, S. et al. Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J. Immunol. 167, 6568-6575 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6568-6575
    • Sugawara, S.1
  • 31
    • 0028988261 scopus 로고
    • Granzyme A is an interleukin 1-converting enzyme
    • Irmler, M. et al. Granzyme A is an interleukin 1-converting enzyme. J. Exp. Med. 181, 1917-1922 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1917-1922
    • Irmler, M.1
  • 32
    • 58949101292 scopus 로고    scopus 로고
    • Meprin A and meprin generate biologically functional IL-1 from pro-IL-1
    • Herzog, C. et al. Meprin A and meprin generate biologically functional IL-1 from pro-IL-1. Biochem. Biophys. Res. Commun. 379, 904-908 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 904-908
    • Herzog, C.1
  • 33
    • 84902968079 scopus 로고    scopus 로고
    • Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines
    • Schauer, C. et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat. Med. 20, 511-517 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 511-517
    • Schauer, C.1
  • 34
    • 80555133279 scopus 로고    scopus 로고
    • IL-1 and IL-1 recruit different myeloid cells and promote different stages of sterile inflammation
    • Rider, P. et al. IL-1 and IL-1 recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol. 187, 4835-4843 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 4835-4843
    • Rider, P.1
  • 35
    • 77249085646 scopus 로고    scopus 로고
    • Differential release of chromatin-bound IL-1 discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
    • Cohen, I. et al. Differential release of chromatin-bound IL-1 discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc. Natl Acad. Sci. USA 107, 2574-2579 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2574-2579
    • Cohen, I.1
  • 36
    • 0023266696 scopus 로고
    • A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha
    • Seckinger, P. et al. A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha. J. Immunol. 139, 1541-1545 (1987).
    • (1987) J. Immunol. , vol.139 , pp. 1541-1545
    • Seckinger, P.1
  • 37
    • 0034618862 scopus 로고    scopus 로고
    • The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1
    • Dinarello, C. A. The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N. Engl. J. Med. 343, 732-734 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 732-734
    • Dinarello, C.A.1
  • 38
    • 34249730581 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis of the interleukin-1 receptor II by-, and-secretase
    • Kuhn, P. H. et al. Regulated intramembrane proteolysis of the interleukin-1 receptor II by-,-, and-secretase. J. Biol. Chem. 282, 11982-11995 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 11982-11995
    • Kuhn, P.H.1
  • 39
    • 0029924136 scopus 로고    scopus 로고
    • Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: A surface 'receptor' with anti-interleukin-1 function
    • Re, F. et al. Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface 'receptor' with anti-interleukin-1 function. J. Exp. Med. 183, 1841-1850 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1841-1850
    • Re, F.1
  • 40
    • 0027181936 scopus 로고
    • Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4
    • Colotta, F. et al. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261, 472-475 (1993).
    • (1993) Science , vol.261 , pp. 472-475
    • Colotta, F.1
  • 41
    • 0029145145 scopus 로고
    • The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type i interleukin-1 soluble receptor
    • Burger, D., Chicheportiche, R., Giri, J. G. & Dayer, J. M. The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor. J. Clin. Invest. 96, 38-41 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 38-41
    • Burger, D.1    Chicheportiche, R.2    Giri, J.G.3    Dayer, J.M.4
  • 42
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-a proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 145-149
    • Spits, H.1
  • 43
    • 84891889644 scopus 로고    scopus 로고
    • Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
    • Kim, H. Y. et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat. Med. 20, 54-61 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 54-61
    • Kim, H.Y.1
  • 44
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton, C. et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1685-1691
    • Sutton, C.1
  • 45
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung, Y. et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576-587 (2009).
    • (2009) Immunity , vol.30 , pp. 576-587
    • Chung, Y.1
  • 46
    • 34548125305 scopus 로고    scopus 로고
    • Interleukin 1 and 6 but not transforming growth factor-are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V. et al. Interleukin 1 and 6 but not transforming growth factor-are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8, 942-949 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1
  • 47
    • 84860241847 scopus 로고    scopus 로고
    • Pathogen-induced human TH17 cells produce IFN-or IL-10 and are regulated by IL-1
    • Zielinski, C. E. et al. Pathogen-induced human TH17 cells produce IFN-or IL-10 and are regulated by IL-1. Nature 484, 514-518 (2012).
    • (2012) Nature , vol.484 , pp. 514-518
    • Zielinski, C.E.1
  • 48
    • 55749116154 scopus 로고    scopus 로고
    • Prostaglandin E2 (PGE2) synergistically with interleukin-23 (IL-23) favors human TH17 expansion
    • Chizzolini, C. et al. Prostaglandin E2 (PGE2) synergistically with interleukin-23 (IL-23) favors human TH17 expansion. Blood 112, 3696-3703 (2008).
    • (2008) Blood , vol.112 , pp. 3696-3703
    • Chizzolini, C.1
  • 50
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from T cells, amplifying Th17 responses and autoimmunity
    • Sutton, C. E. et al. Interleukin-1 and IL-23 induce innate IL-17 production from T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331-341 (2009).
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1
  • 51
    • 49249135394 scopus 로고    scopus 로고
    • Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    • Cosmi, L. et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 205, 1903-1916 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1903-1916
    • Cosmi, L.1
  • 52
    • 77956124982 scopus 로고    scopus 로고
    • CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
    • Maggi, L. et al. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur. J. Immunol. 40, 2174-2181 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2174-2181
    • Maggi, L.1
  • 53
    • 0028574382 scopus 로고
    • Interleukin-1 tumor necrosis factor and their specific inhibitors
    • Dayer, J. M. & Burger, D. Interleukin-1, tumor necrosis factor and their specific inhibitors. Eur. Cytokine Netw. 5, 563-571 (1994).
    • (1994) Eur. Cytokine Netw. , vol.5 , pp. 563-571
    • Dayer, J.M.1    Burger, D.2
  • 54
    • 34547436716 scopus 로고    scopus 로고
    • TNF-induced structural joint damage is mediated by IL-1
    • Zwerina, J. et al. TNF-induced structural joint damage is mediated by IL-1. Proc. Natl Acad. Sci. USA 104, 11742-11747 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 11742-11747
    • Zwerina, J.1
  • 55
    • 1542316309 scopus 로고    scopus 로고
    • The process of identifying and understanding cytokines: From basic studies to treating rheumatic diseases
    • Dayer, J. M. The process of identifying and understanding cytokines: from basic studies to treating rheumatic diseases. Best Pract. Res. Clin. Rheumatol. 18, 31-45 (2004).
    • (2004) Best Pract. Res. Clin. Rheumatol. , vol.18 , pp. 31-45
    • Dayer, J.M.1
  • 56
    • 0021069905 scopus 로고
    • An interleukin 1 like factor stimulates bone resorption in vitro
    • Gowen, M., Wood, D. D., Ihrie, E. J., McGuire, M. K. & Russell, R. G. An interleukin 1 like factor stimulates bone resorption in vitro. Nature 306, 378-380 (1983).
    • (1983) Nature , vol.306 , pp. 378-380
    • Gowen, M.1    Wood, D.D.2    Ihrie, E.J.3    McGuire, M.K.4    Russell, R.G.5
  • 58
    • 0023679882 scopus 로고
    • Interleukin-1 as a potent hyperalgesic agent antagonized by a tripeptide analogue
    • Ferreira, S. H., Lorenzetti, B. B., Bristow, A. F. & Poole, S. Interleukin-1 as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334, 698-700 (1988).
    • (1988) Nature , vol.334 , pp. 698-700
    • Ferreira, S.H.1    Lorenzetti, B.B.2    Bristow, A.F.3    Poole, S.4
  • 59
    • 35748940015 scopus 로고    scopus 로고
    • Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation
    • Blumberg, H. et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 204, 2603-2614 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2603-2614
    • Blumberg, H.1
  • 60
    • 0025036102 scopus 로고
    • Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1
    • Kullberg, B. J., van 't Wout, J. W. & van Furth, R. Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1. Infect. Immun. 58, 3319-3324 (1990).
    • (1990) Infect. Immun. , vol.58 , pp. 3319-3324
    • Kullberg, B.J.1    Van 'T Wout, J.W.2    Van Furth, R.3
  • 61
    • 33646017449 scopus 로고    scopus 로고
    • Distinct roles of TLR2 and the adaptor ASC in IL-1/IL-18 secretion in response to Listeria monocytogenes
    • Ozren, N. et al. Distinct roles of TLR2 and the adaptor ASC in IL-1/IL-18 secretion in response to Listeria monocytogenes. J. Immunol. 176, 4337-4342 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 4337-4342
    • Ozren, N.1
  • 62
    • 47249095738 scopus 로고    scopus 로고
    • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection
    • Warren, S. E., Mao, D. P., Rodriguez, A. E., Miao, E. A. & Aderem, A. Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J. Immunol. 180, 7558-7564 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 7558-7564
    • Warren, S.E.1    Mao, D.P.2    Rodriguez, A.E.3    Miao, E.A.4    Aderem, A.5
  • 63
    • 33745012076 scopus 로고    scopus 로고
    • Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    • Lara-Tejero, M. et al. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J. Exp. Med. 203, 1407-1412 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1407-1412
    • Lara-Tejero, M.1
  • 64
    • 0033823682 scopus 로고    scopus 로고
    • Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis
    • Juffermans, N. P. et al. Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis. J. Infect. Dis. 182, 902-908 (2000).
    • (2000) J. Infect. Dis. , vol.182 , pp. 902-908
    • Juffermans, N.P.1
  • 65
    • 0036845130 scopus 로고    scopus 로고
    • Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial
    • Nuki, G. et al. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 46, 2838-2846 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 2838-2846
    • Nuki, G.1
  • 66
    • 0028239555 scopus 로고
    • Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome
    • Fisher, C. J. Jr et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. JAMA 271, 1836-1843 (1994).
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fisher, C.J.1
  • 67
    • 84983132688 scopus 로고    scopus 로고
    • Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies
    • Cavalli, G. & Dinarello, C. A. Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatology (Oxford) 12, 2134-2144 (2015).
    • (2015) Rheumatology (Oxford) , vol.12 , pp. 2134-2144
    • Cavalli, G.1    Dinarello, C.A.2
  • 68
    • 0022195205 scopus 로고
    • T cell activation: Differences required for IL 2 production by nonactivated and activated T cells
    • Manger, B., Weiss, A., Weyand, C., Goronzy, J. & Stobo, J. D. T cell activation: differences required for IL 2 production by nonactivated and activated T cells. J. Immunol. 135, 3669-3673 (1985).
    • (1985) J. Immunol. , vol.135 , pp. 3669-3673
    • Manger, B.1    Weiss, A.2    Weyand, C.3    Goronzy, J.4    Stobo, J.D.5
  • 69
    • 27344448749 scopus 로고    scopus 로고
    • Familial autoinflammatory diseases: Genetics, pathogenesis and treatment
    • Stojanov, S. & Kastner, D. L. Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr. Opin. Rheumatol. 17, 586-599 (2005).
    • (2005) Curr. Opin. Rheumatol. , vol.17 , pp. 586-599
    • Stojanov, S.1    Kastner, D.L.2
  • 70
    • 33645125321 scopus 로고    scopus 로고
    • Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism
    • Rynne, M., Maclean, C., Bybee, A., McDermott, M. F. & Emery, P. Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism. Ann. Rheum. Dis. 65, 533-534 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 533-534
    • Rynne, M.1    MacLean, C.2    Bybee, A.3    McDermott, M.F.4    Emery, P.5
  • 71
    • 17244381937 scopus 로고    scopus 로고
    • Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease
    • Lovell, D. J., Bowyer, S. L. & Solinger, A. M. Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease. Arthritis Rheum. 52, 1283-1286 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1283-1286
    • Lovell, D.J.1    Bowyer, S.L.2    Solinger, A.M.3
  • 72
    • 33746876396 scopus 로고    scopus 로고
    • Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 inhibition
    • Goldbach-Mansky, R. et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 inhibition. N. Engl. J. Med. 355, 581-592 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 581-592
    • Goldbach-Mansky, R.1
  • 73
    • 1042290321 scopus 로고    scopus 로고
    • Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
    • Hawkins, P. N., Lachmann, H. J., Aganna, E. & McDermott, M. F. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum. 50, 607-612 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 607-612
    • Hawkins, P.N.1    Lachmann, H.J.2    Aganna, E.3    McDermott, M.F.4
  • 74
    • 35648971662 scopus 로고    scopus 로고
    • Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra
    • Kuijk, L. M., Govers, A. M., Frenkel, J. & Hofhuis, W. J. Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra. Ann. Rheum. Dis. 66, 1545-1546 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 1545-1546
    • Kuijk, L.M.1    Govers, A.M.2    Frenkel, J.3    Hofhuis, W.J.4
  • 75
    • 0030804743 scopus 로고    scopus 로고
    • A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome
    • Lindor, N. M., Arsenault, T. M., Solomon, H., Seidman, C. E. & McEvoy, M. T. A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. Mayo Clin. Proc. 72, 611-615 (1997).
    • (1997) Mayo Clin. Proc. , vol.72 , pp. 611-615
    • Lindor, N.M.1    Arsenault, T.M.2    Solomon, H.3    Seidman, C.E.4    McEvoy, M.T.5
  • 76
    • 71149085612 scopus 로고    scopus 로고
    • Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra
    • Brenner, M., Ruzicka, T., Plewig, G., Thomas, P. & Herzer, P. Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br. J. Dermatol. 161, 1199-1201 (2009).
    • (2009) Br. J. Dermatol. , vol.161 , pp. 1199-1201
    • Brenner, M.1    Ruzicka, T.2    Plewig, G.3    Thomas, P.4    Herzer, P.5
  • 77
    • 66649121678 scopus 로고    scopus 로고
    • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    • Aksentijevich, I. et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N. Engl. J. Med. 360, 2426-2437 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2426-2437
    • Aksentijevich, I.1
  • 78
    • 43949128071 scopus 로고    scopus 로고
    • Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome
    • Gattorno, M. et al. Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum. 58, 1516-1520 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 1516-1520
    • Gattorno, M.1
  • 79
    • 33845807104 scopus 로고    scopus 로고
    • Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis
    • Cailliez, M. et al. Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J. Inherit Metab. Dis. 29, 763 (2006).
    • (2006) J. Inherit Metab. Dis. , vol.29 , pp. 763
    • Cailliez, M.1
  • 80
    • 78650926948 scopus 로고    scopus 로고
    • Sodium overload and water influx activate the NALP3 inflammasome
    • Schorn, C. et al. Sodium overload and water influx activate the NALP3 inflammasome. J. Biol. Chem. 286, 35-41 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 35-41
    • Schorn, C.1
  • 81
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon, F., Ptrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006).
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Ptrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 82
    • 0036272522 scopus 로고    scopus 로고
    • Monosodium urate monohydrate crystal-induced inflammation in vivo: Quantitative histomorphometric analysis of cellular events
    • Schiltz, C. et al. Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events. Arthritis Rheum. 46, 1643-1650 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 1643-1650
    • Schiltz, C.1
  • 83
    • 78249286865 scopus 로고    scopus 로고
    • Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1 production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    • Joosten, L. A. et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1 production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 62, 3237-3248 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 3237-3248
    • Joosten, L.A.1
  • 84
    • 34047174085 scopus 로고    scopus 로고
    • A pilot study of IL-1 inhibition by anakinra in acute gout
    • So, A., De Smedt, T., Revaz, S. & Tschopp, J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res. Ther. 9, R28 (2007).
    • (2007) Arthritis Res. Ther. , vol.9 , pp. R28
    • So, A.1    De Smedt, T.2    Revaz, S.3    Tschopp, J.4
  • 85
    • 84881334136 scopus 로고    scopus 로고
    • Treatment of acute gouty arthritis in complex hospitalized patients with anakinra
    • Ghosh, P., Cho, M., Rawat, G., Simkin, P. A. & Gardner, G. C. Treatment of acute gouty arthritis in complex hospitalized patients with anakinra. Arthritis Care Res. (Hoboken) 65, 1381-1384 (2013).
    • (2013) Arthritis Care Res. (Hoboken) , vol.65 , pp. 1381-1384
    • Ghosh, P.1    Cho, M.2    Rawat, G.3    Simkin, P.A.4    Gardner, G.C.5
  • 86
    • 84891378160 scopus 로고    scopus 로고
    • Efficacy of anakinra in gouty arthritis: A retrospective study of 40 cases
    • Ottaviani, S. et al. Efficacy of anakinra in gouty arthritis: a retrospective study of 40 cases. Arthritis Res. Ther. 15, R123 (2013).
    • (2013) Arthritis Res. Ther. , vol.15 , pp. R123
    • Ottaviani, S.1
  • 87
    • 84864335117 scopus 로고    scopus 로고
    • Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: Results from a Phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study
    • Schumacher, H. R. Jr et al. Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a Phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study. Arthritis Care Res. (Hoboken) 64, 1462-1470 (2012).
    • (2012) Arthritis Care Res. (Hoboken) , vol.64 , pp. 1462-1470
    • Schumacher, H.R.1
  • 88
    • 84879816861 scopus 로고    scopus 로고
    • Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: Results from the PRESURGE-2 international, Phase 3, randomized, placebo-controlled trial
    • Mitha, E. et al. Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, Phase 3, randomized, placebo-controlled trial. Rheumatology (Oxford) 52, 1285-1292 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 1285-1292
    • Mitha, E.1
  • 89
    • 84867405545 scopus 로고    scopus 로고
    • Canakinumab for acute gouty arthritis in patients with limited treatment options: Results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions
    • Schlesinger, N. et al. Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions. Ann. Rheum. Dis. 71, 1839-1848 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1839-1848
    • Schlesinger, N.1
  • 90
    • 84860595927 scopus 로고    scopus 로고
    • Efficacy of anakinra in articular chondrocalcinosis: Report of three cases
    • Couderc, M., Mathieu, S., Glace, B. & Soubrier, M. Efficacy of anakinra in articular chondrocalcinosis: report of three cases. Joint Bone Spine 79, 330-331 (2012).
    • (2012) Joint Bone Spine , vol.79 , pp. 330-331
    • Couderc, M.1    Mathieu, S.2    Glace, B.3    Soubrier, M.4
  • 91
    • 84873742291 scopus 로고    scopus 로고
    • A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder
    • Zufferey, P. & So, A. A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder. Ann. Rheum. Dis. 72, 465-467 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 465-467
    • Zufferey, P.1    So, A.2
  • 92
    • 0023241974 scopus 로고
    • Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis
    • Prieur, A. M., Kaufmann, M. T., Griscelli, C. & Dayer, J. M. Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis. Lancet 2, 1240-1242 (1987).
    • (1987) Lancet , vol.2 , pp. 1240-1242
    • Prieur, A.M.1    Kaufmann, M.T.2    Griscelli, C.3    Dayer, J.M.4
  • 93
    • 18644370644 scopus 로고    scopus 로고
    • Rapid responses to anakinra in patients with refractory adult-onset Still's disease
    • Fitzgerald, A. A., Leclercq, S. A., Yan, A., Homik, J. E. & Dinarello, C. A. Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum. 52, 1794-1803 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1794-1803
    • Fitzgerald, A.A.1    Leclercq, S.A.2    Yan, A.3    Homik, J.E.4    Dinarello, C.A.5
  • 95
    • 84943195545 scopus 로고    scopus 로고
    • Efficacy of anakinra in refractory adult-onset Still's disease: Multicenter study of 41 patients and literature review
    • Ortiz-Sanjuán, F. et al. Efficacy of anakinra in refractory adult-onset Still's disease: multicenter study of 41 patients and literature review. Medicine (Baltimore). 94, e1554 (2015).
    • (2015) Medicine (Baltimore , vol.1554
    • Ortiz-Sanjuán, F.1
  • 96
    • 39549109506 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: Preliminary experience in France
    • Lequerré, T. et al. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann. Rheum. Dis. 67, 302-308 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 302-308
    • Lequerré, T.1
  • 97
    • 43949116263 scopus 로고    scopus 로고
    • The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    • Gattorno, M. et al. The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 58, 1505-1515 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 1505-1515
    • Gattorno, M.1
  • 98
    • 43049158200 scopus 로고    scopus 로고
    • Anakinra treatment for systemic onset juvenile idiopathic arthritis (SOJIA
    • Ohlsson, V. et al. Anakinra treatment for systemic onset juvenile idiopathic arthritis (SOJIA). Rheumatology (Oxford) 47, 555-556 (2008).
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 555-556
    • Ohlsson, V.1
  • 99
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai, R. et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191, 313-320 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 313-320
    • Horai, R.1
  • 100
    • 0020627050 scopus 로고
    • Isolation of an interleukin-1-like factor from human joint effusions
    • Wood, D. D., Ihrie, E. J., Dinarello, C. A. & Cohen, P. L. Isolation of an interleukin-1-like factor from human joint effusions. Arthritis Rheum. 26, 975-983 (1983).
    • (1983) Arthritis Rheum , vol.26 , pp. 975-983
    • Wood, D.D.1    Ihrie, E.J.2    Dinarello, C.A.3    Cohen, P.L.4
  • 101
    • 0026731856 scopus 로고
    • Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages
    • Koch, A. E. et al. Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages. Clin. Immunol. Immunopathol. 65, 23-29 (1992).
    • (1992) Clin. Immunol. Immunopathol. , vol.65 , pp. 23-29
    • Koch, A.E.1
  • 102
    • 0026721695 scopus 로고
    • IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium
    • Firestein, G. S. et al. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J. Immunol. 149, 1054-1062 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 1054-1062
    • Firestein, G.S.1
  • 103
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNF, anti-IL-1/, and IL-1Ra
    • Joosten, L. A., Helsen, M. M., van de Loo, F. A. & van den Berg, W. B. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNF, anti-IL-1/, and IL-1Ra. Arthritis Rheum. 39, 797-809 (1996).
    • (1996) Arthritis Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.1    Helsen, M.M.2    Van De Loo, F.A.3    Vanden Berg, W.B.4
  • 104
    • 9144261181 scopus 로고    scopus 로고
    • Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction
    • Zwerina, J. et al. Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum. 50, 277-290 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 277-290
    • Zwerina, J.1
  • 105
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan, B. et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. 41, 2196-2204 (1998).
    • (1998) Arthritis Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1
  • 106
    • 3442885115 scopus 로고    scopus 로고
    • A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate
    • Cohen, S. B. et al. A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate. Ann. Rheum. Dis. 63, 1062-1068 (2004).
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 1062-1068
    • Cohen, S.B.1
  • 107
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: Results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
    • Cohen, S. et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 46, 614-624 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 614-624
    • Cohen, S.1
  • 108
    • 0035022796 scopus 로고    scopus 로고
    • Anti-interleukin-1 therapy in rheumatic diseases
    • Dayer, J. M. et al. Anti-interleukin-1 therapy in rheumatic diseases. Curr. Opin. Rheumatol. 13, 170-176 (2001).
    • (2001) Curr. Opin. Rheumatol. , vol.13 , pp. 170-176
    • Dayer, J.M.1
  • 109
    • 0034083128 scopus 로고    scopus 로고
    • A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: Radiologic progression and correlation of Genant and Larsen scores
    • Jiang, Y. et al. A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum. 43, 1001-1009 (2000).
    • (2000) Arthritis Rheum , vol.43 , pp. 1001-1009
    • Jiang, Y.1
  • 110
    • 0037870458 scopus 로고    scopus 로고
    • Erosion healing in rheumatoid arthritis after anakinra treatment
    • Rau, R., Sander, O. & Wassenberg, S. Erosion healing in rheumatoid arthritis after anakinra treatment. Ann. Rheum. Dis. 62, 671-673 (2003).
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 671-673
    • Rau, R.1    Sander, O.2    Wassenberg, S.3
  • 111
    • 0035303568 scopus 로고    scopus 로고
    • The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis
    • Bresnihan, B. The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 30, 17-20 (2001).
    • (2001) Semin. Arthritis Rheum. , vol.30 , pp. 17-20
    • Bresnihan, B.1
  • 112
    • 80052189130 scopus 로고    scopus 로고
    • Efficacy and safety of the human anti-IL-1 monoclonal antibody canakinumab in rheumatoid arthritis: Results of a 12-week, Phase II, dose-finding study
    • Alten, R. et al. Efficacy and safety of the human anti-IL-1 monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study. BMC Musculoskelet. Disord.12, 153 (2011).
    • (2011) BMC Musculoskelet. Disord , vol.12 , pp. 153
    • Alten, R.1
  • 113
    • 0033851463 scopus 로고    scopus 로고
    • Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase and nuclear factor B: Differential regulation of collagenase 1 and collagenase 3
    • Mengshol, J. A. et al. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase and nuclear factor B: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 43, 801-811 (2000).
    • (2000) Arthritis Rheum , vol.43 , pp. 801-811
    • Mengshol, J.A.1
  • 114
    • 0031738172 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinases (MMP-2,-3,-9, and-13) by interleukin-1 and interleukin-6 in mouse calvaria: Association of MMP induction with bone resorption
    • Kusano, K. et al. Regulation of matrix metalloproteinases (MMP-2,-3,-9, and-13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology 139, 1338-1345 (1998).
    • (1998) Endocrinology , vol.139 , pp. 1338-1345
    • Kusano, K.1
  • 115
    • 0028172988 scopus 로고
    • Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes
    • Goldring, M. B. et al. Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest. 94, 2307-2316 (1994).
    • (1994) J. Clin. Invest. , vol.94 , pp. 2307-2316
    • Goldring, M.B.1
  • 116
    • 0021858830 scopus 로고
    • Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules
    • Tyler, J. A. Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules. Biochem. J. 227, 869-878 (1985).
    • (1985) Biochem. J. , vol.227 , pp. 869-878
    • Tyler, J.A.1
  • 117
    • 0025991299 scopus 로고
    • Influence of human recombinant interleukin-1 beta on human articular cartilage. Mitotic activity and proteoglycan metabolism
    • Verbruggen, G. et al. Influence of human recombinant interleukin-1 beta on human articular cartilage. Mitotic activity and proteoglycan metabolism. Clin. Exp. Rheumatol. 9, 481-488 (1991).
    • (1991) Clin. Exp. Rheumatol. , vol.9 , pp. 481-488
    • Verbruggen, G.1
  • 118
    • 0029043151 scopus 로고
    • IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2
    • Blanco, F. J. & Lotz, M. IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2. Exp. Cell Res. 218, 319-325 (1995).
    • (1995) Exp. Cell Res. , vol.218 , pp. 319-325
    • Blanco, F.J.1    Lotz, M.2
  • 119
    • 0031965384 scopus 로고    scopus 로고
    • Autocrine production of IL-1 by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8
    • Attur, M. G. et al. Autocrine production of IL-1 by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc. Assoc. Am. Physicians 110, 65-72 (1998).
    • (1998) Proc. Assoc. Am. Physicians , vol.110 , pp. 65-72
    • Attur, M.G.1
  • 120
    • 0030961873 scopus 로고    scopus 로고
    • In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
    • Pelletier, J. P. et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum. 40, 1012-1019 (1997).
    • (1997) Arthritis Rheum , vol.40 , pp. 1012-1019
    • Pelletier, J.P.1
  • 121
    • 0032924502 scopus 로고    scopus 로고
    • In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: Prevention of osteoarthritis progression
    • Fernandes, J. et al. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am. J. Pathol. 154, 1159-1169 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 1159-1169
    • Fernandes, J.1
  • 122
    • 62549104691 scopus 로고    scopus 로고
    • Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study
    • Chevalier, X. et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 61, 344-352 (2009).
    • (2009) Arthritis Rheum , vol.61 , pp. 344-352
    • Chevalier, X.1
  • 123
    • 79960862976 scopus 로고    scopus 로고
    • A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
    • Cohen, S. B. et al. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res. Ther. 13, R125 (2011).
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R125
    • Cohen, S.B.1
  • 124
    • 77951590246 scopus 로고    scopus 로고
    • Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    • Attur, M. et al. Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Ann. Rheum. Dis. 69, 856-861 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 856-861
    • Attur, M.1
  • 125
    • 79951858462 scopus 로고    scopus 로고
    • Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis
    • Kerkhof, H. J. et al. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthr. Cartil. 19, 265-271 (2011).
    • (2011) Osteoarthr. Cartil. , vol.19 , pp. 265-271
    • Kerkhof, H.J.1
  • 126
    • 77953717433 scopus 로고    scopus 로고
    • Synovial immunopathology in haemochromatosis arthropathy
    • Heiland, G. R. et al. Synovial immunopathology in haemochromatosis arthropathy. Ann. Rheum. Dis. 69, 1214-1219 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1214-1219
    • Heiland, G.R.1
  • 127
    • 84875922144 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands
    • Latourte, A., Frazier, A., Brire, C., Ea, H. K. & Richette, P. Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands. Ann. Rheum. Dis. 72, 783-784 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 783-784
    • Latourte, A.1    Frazier, A.2    Brire, C.3    Ea, H.K.4    Richette, P.5
  • 128
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1 in type 2 diabetes
    • Masters, S. L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1 in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 897-904
    • Masters, S.L.1
  • 129
    • 84887618957 scopus 로고    scopus 로고
    • Impact of interleukin-1 antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial
    • Hensen, J., Howard, C. P., Walter, V. & Thuren, T. Impact of interleukin-1 antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: results of secondary endpoints from a randomized, placebo-controlled trial. Diabetes Metab. 39, 524-531 (2013).
    • (2013) Diabetes Metab , vol.39 , pp. 524-531
    • Hensen, J.1    Howard, C.P.2    Walter, V.3    Thuren, T.4
  • 130
    • 84870619337 scopus 로고    scopus 로고
    • Effects of interleukin-1 inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: A h IIb randomized, placebo-controlled trial
    • Ridker, P. M. et al. Effects of interleukin-1 inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a h IIb randomized, placebo-controlled trial. Circulation 126, 2739-2748 (2012).
    • (2012) Circulation , vol.126 , pp. 2739-2748
    • Ridker, P.M.1
  • 132
    • 84907085562 scopus 로고    scopus 로고
    • The interleukin-1 modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model
    • Roubille, F. et al. The interleukin-1 modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model. Atherosclerosis 236, 277-285 (2014).
    • (2014) Atherosclerosis , vol.236 , pp. 277-285
    • Roubille, F.1
  • 133
    • 84862010053 scopus 로고    scopus 로고
    • Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: An open-label study
    • Krause, K. et al. Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study. Allergy 67, 943-950 (2012).
    • (2012) Allergy , vol.67 , pp. 943-950
    • Krause, K.1
  • 134
    • 84883790466 scopus 로고    scopus 로고
    • Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome
    • De Koning, H. D. et al. Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome. Ann. Rheum. Dis. 72, 1634-1638 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 1634-1638
    • De Koning, H.D.1
  • 135
    • 61449122079 scopus 로고    scopus 로고
    • Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1-induced interleukin-6 production and the myeloma proliferative component
    • Lust, J. A. et al. Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1-induced interleukin-6 production and the myeloma proliferative component. Mayo Clin. Proc. 84, 114-122 (2009).
    • (2009) Mayo Clin. Proc. , vol.84 , pp. 114-122
    • Lust, J.A.1
  • 136
    • 84857922054 scopus 로고    scopus 로고
    • Interleukin-1-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: An open-label pilot study
    • Gl, A. et al. Interleukin-1-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study. Ann. Rheum. Dis. 71, 563-566 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 563-566
    • Gl, A.1
  • 137
    • 84948711592 scopus 로고    scopus 로고
    • Treatment of two patients with generalized pustular psoriasis with the interleukin-1 inhibitor gevokizumab
    • Mansouri, B., Richards, L. & Menter, A. Treatment of two patients with generalized pustular psoriasis with the interleukin-1 inhibitor gevokizumab. Br. J. Dermatol. 173, 239-241 (2015).
    • (2015) Br. J. Dermatol. , vol.173 , pp. 239-241
    • Mansouri, B.1    Richards, L.2    Menter, A.3
  • 138
    • 84867802417 scopus 로고    scopus 로고
    • An overview of interleukin-1 receptor antagonist, anakinra, in the treatment of cutaneous diseases
    • Pazyar, N., Feily, A. & Yaghoobi, R. An overview of interleukin-1 receptor antagonist, anakinra, in the treatment of cutaneous diseases. Curr. Clin. Pharmacol. 7, 271-275 (2012).
    • (2012) Curr. Clin. Pharmacol. , vol.7 , pp. 271-275
    • Pazyar, N.1    Feily, A.2    Yaghoobi, R.3
  • 139
    • 84860919264 scopus 로고    scopus 로고
    • Anakinra treatment of SAPHO syndrome: Short-term results of an open study
    • Wendling, D., Prati, C. & Aubin, F. Anakinra treatment of SAPHO syndrome: short-term results of an open study. Ann. Rheum. Dis. 71, 1098-1100 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1098-1100
    • Wendling, D.1    Prati, C.2    Aubin, F.3
  • 140
    • 84863879273 scopus 로고    scopus 로고
    • Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: A hitherto undescribed manifestation of autoinflammation
    • Rech, J. et al. Adult-onset Still's disease and chronic recurrent multifocal osteomyelitis: a hitherto undescribed manifestation of autoinflammation. Rheumatol. Int. 32, 1827-1829 (2012).
    • (2012) Rheumatol. Int. , vol.32 , pp. 1827-1829
    • Rech, J.1
  • 141
    • 84892839044 scopus 로고    scopus 로고
    • Treating inflammation by blocking interleukin-1 in humans
    • Dinarello, C. A. & van der Meer, J. W. Treating inflammation by blocking interleukin-1 in humans. Semin. Immunol. 15, 469-484 (2013).
    • (2013) Semin. Immunol. , vol.15 , pp. 469-484
    • Dinarello, C.A.1    Van Der Meer, J.W.2
  • 142
    • 84929670705 scopus 로고    scopus 로고
    • Open-label trial of MABp1, a true human monoclonal antibody targeting interleukin 1, for the treatment of psoriasis
    • Coleman, K. M. et al. Open-label trial of MABp1, a true human monoclonal antibody targeting interleukin 1, for the treatment of psoriasis. JAMA Dermatol. 151, 555-556 (2015).
    • (2015) JAMA Dermatol , vol.151 , pp. 555-556
    • Coleman, K.M.1
  • 143
    • 0025321201 scopus 로고
    • Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
    • Carter, D. B. et al. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344, 633-638 (1990).
    • (1990) Nature , vol.344 , pp. 633-638
    • Carter, D.B.1
  • 144
    • 49449094179 scopus 로고    scopus 로고
    • Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndroms: Results from two sequential placebo-controlled studies
    • Hoffman, H. M. et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndroms: results from two sequential placebo-controlled studies. Arthritis Rheum. 58, 2443-2452 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 2443-2452
    • Hoffman, H.M.1
  • 145
    • 58049194057 scopus 로고    scopus 로고
    • Rilonacept in cryopyrin-associated periodic syndroms: The beginning of longer-acting interleukin-1 antagonism
    • Church, L. D. & McDermott, M. F. Rilonacept in cryopyrin-associated periodic syndroms: the beginning of longer-acting interleukin-1 antagonism. Nat. Clin. Pract. Rheumatol. 5, 14-15 (2009).
    • (2009) Nat. Clin. Pract. Rheumatol. , vol.5 , pp. 14-15
    • Church, L.D.1    McDermott, M.F.2
  • 146
    • 84860426838 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1 monoclonal antibody
    • Chakraborty, A. et al. Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1 monoclonal antibody. Clin. Pharmacokinet. 51, e1-e18 (2012).
    • (2012) Clin. Pharmacokinet. , vol.51 , pp. e1-e18
    • Chakraborty, A.1
  • 147
    • 78651389288 scopus 로고    scopus 로고
    • XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1-mediated diseases
    • Owyang, A. M. et al. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1-mediated diseases. MAbs 3, 49-60 (2011).
    • (2011) MAbs , vol.3 , pp. 49-60
    • Owyang, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.