Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

Journal of Experimental Medicine

Volumn 204, Issue 11, 2007, Pages 2603-2614

  Blumberg, Hal ^a   Dinh, Huyen ^a   Trueblood, Esther S ^a   Pretorius, James ^b   Kugler, David ^a   Weng, Ning ^a   Kanaly, Suzanne T ^a,d   Towne, Jennifer E ^a   Willis, Cynthia R ^a   Kuechle, Melanie K ^c   Sims, John E ^a   Peschon, Jacques J ^a,e  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d ALLERGAN INC   (United States)

^e INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1;

ACANTHOSIS; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUMAN; HYPERKERATOSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFLAMMATION;

ANIMALS; HUMANS; INFLAMMATION; INTERLEUKIN-1; LIGANDS; MICE; MICE, TRANSGENIC; POLYSACCHARIDES, BACTERIAL; PROMOTER REGIONS (GENETICS); SKIN; SKIN DISEASES;

EID: 35748940015     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20070157     Document Type: Article

References (37)

1. Sims, J.E., M.J. Nicklin, J.F. Bazan, J.L. Barton, S.J. Busfield, J.E. Ford, R.A. Kastelein, S. Kumar, H. Lin, J.J. Mulero, et al. 2001. A new nomenclature for IL-1-family genes. Trends Immunol. 22:536-537.
2. Sims, J.E. 2002. IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol. 14:117-122.
3. Greenfeder, S.A., P. Nunes, L. Kwee, M. Labow, R.A. Chizzonite, and G. Ju. 1995. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 270:13757-13765.
4. Eisenberg, S.P., M.T. Brewer, E. Verderber, P. Heimdal, B.J. Brandhuber, and R.C. Thompson. 1991. Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc. Natl. Acad. Sci. USA. 88:5232-5236.
5. Re, F., M. Sironi, M. Muzio, C. Matteucci, M. Introna, S. Orlando, G. Penton-Rol, S.K. Dower, J.E. Sims, F. Colotta, et al. 1996. Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface "receptor" with anti-interleukin-1 function. J. Exp. Med. 183:1841-1850.
6. Smith, D.E., R. Hanna, D. Friend, H. Moore, H. Chen, A.M. Farese, T.J. Mac Vittie, G.D. Virca, and J.E. Sims. 2003. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity. 18:87-96.
7. Dinarello, C.A. 1999. IL-18: A Th1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol. 103:11-24.
8. Akira, S. 2000. The role of IL-18 in innate immunity. Curr. Opin. Immunol. 12:59-63.
9. Born, T.L., E. Thomassen, T.A. Bird, and J.E. Sims. 1998. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273:29445-29450.
10. Novick, D., S.H. Kim, G. Fantuzzi, L.L. Reznikov, C.A. Dinarello, and M. Rubinstein. 1999. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 10:127-136.
11. Groves, R.W., H. Mizutani, J.D. Kieffer, and T.S. Kupper. 1995. Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc. Natl. Acad. Sci. USA. 92:11874-11878.
12. Kawase, Y., T. Hoshino, K. Yokota, A. Kuzuhara, Y. Kirii, E. Nishiwaki, Y. Maeda, J. Takeda, M. Okamoto, S. Kato, et al. 2003. Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin. J. Invest. Dermatol. 121:502-509.
13. Shepherd, J., M.C. Little, and M.J.H. Nicklin. 2004. Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. J. Invest. Dermatol. 122:665-669.
14. Labow, M., D. Shuster, M. Zetterstrom, P. Nunes, R. Terry, E.B. Cullinan, T. Bartfai, C. Solorzano, L.L. Moldawer, R. Chizzonite, et al. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159:2452-2461.
15. Glaccum, M.B., K.L. Stocking, K. Charrier, J.L. Smith, C.R. Willis, C. Maliszewski, D.J. Livingston, J.J. Peschon, and P.J. Morrissey. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J. Immunol. 159:3364-3371.
16. Cullinan, E.B., L. Kwee, P. Nunes, D.J. Shuster, G. Ju, K.W. McIntyre, R.A. Chizzonite, and M.A. Labow. 1998. IL-1 receptor accessory protein is an essential component of the IL-1 receptor. J. Immunol. 161:5614-5620.
17. Hoshino, K., H. Tsutsui, T. Kawai, K. Takeda, K. Nakanishi, Y. Takeda, and S. Akira. 1999. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162:5041-5044.
18. Cheung, H., N.J. Chen, Z. Cao, N. Ono, P.S. Ohashi, and W.C. Yeh. 2005. Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174:5351-5357.
19. Mulero, J.J., A.M. Pace, S.T. Nelken, D.B. Loeb, T.R. Correa, R. Drmanac, and J.E. Ford. 1999. IL1HY1: A novel interleukin-1 receptor antagonist gene. Biochem. Biophys. Res. Commun. 263:702-706.
20. Lin, H., A.S. Ho, D. Haley-Vicente, J. Zhang, J. Bernal-Fussell, A.M. Pace, D. Hansen, K. Schweighofer, N.K. Mize, and J.E. Ford. 2001. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J. Biol. Chem. 276:20597-20602.
21. Smith, D.E., B.R. Renshaw, R.R. Ketchem, M. Kubin, K.E. Garka, and J.E. Sims. 2000. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 275:1169-1175.
22. Kumar, S., P.C. McDonnell, R. Lehr, L. Tierney, M.N. Tzimas, D.E. Griswold, E.A. Capper, R. Tal-Singer, G.I. Wells, M.L. Doyle, et al. 2000. Identification and initial characterization of four novel members of the interleukin-1 family. J. Biol. Chem. 275:10308-10314.
23. Dunn, E., J.E. Sims, M.J.H. Nicklin, and L.A.J. O ' Neill. 2001. Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Trends Immunol. 22:533-536.
24. Taylor, S.L., B.R. Renshaw, K.E. Garka, D.E. Smith, and J.E. Sims. 2002. Genomic organization of the interleukin-1 locus. Genomics. 79:726-733.
25. Nicklin, M.J.H., J.L. Barton, M. Nguyen, M.G. FitzGerald, G.W. Duff, and K. Kornman. 2002. A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics. 79:718-725.
26. Lovenberg, T.W., P.D. Crowe, C. Liu, D.T. Chalmers, X.J. Liu, C. Liaw, W. Clevenger, T. Oltersdorf, E.B. De Souza, and R.A. Maki. 1996. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). J. Neuroimmunol. 70:113-122.
27. Debets, R., J.C. Timans, B. Homey, S. Zurawski, T.R. Sana, S. Lo, J. Wagner, G. Edwards, T. Clifford, S. Menon, et al. 2001. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 167:1440-1446.
28. Towne, J.E., K.E. Garka, B.R. Renshaw, G.D. Virca, and J.E. Sims. 2004. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RacP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 279:13677-13688.
29. Victor, F.C., A.B. Gottlieb, and A. Menter. 2003. Changing paradigms in dermatology: tumor necrosis factor alpha (TNF-alpha) blockade in psoriasis and psoriatic arthritis. Clin. Dermatol. 21:392-397.
30. Sheehan, K.C., N.H. Ruddle, and R.D. Schreiber. 1989. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J. Immunol. 142:3884-3893.
31. Schon, M., D. Denzer, R.C. Kubitza, T. Ruzicka, and M.P. Schon. 2000. Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice. J. Invest. Dermatol. 114:976-983.
32. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
33. Hardman, M.J., P. Sisi, D.N. Banbury, and C. Byrne. 1998. Patterned acquisition of skin barrier function during development. Development. 125:1541-1552.
34. Schmitz, J., A. Owyang, E. Oldham, Y. Song, E. Murphy, T.K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, X. Li, et al. 2005. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 23:479-490.
35. Ribalta, T., I.E. McCutcheon, K.D. Aldape, J.M. Bruner, and G.N. Fuller. 2004. The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria. Am. J. Surg. Pathol. 28:1532-1536.
36. Sil, A.K., S. Maeda, Y. Sano, D.R. Roop, and M. Karin. 2004. IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 428:660-664.
37. Munz, B., H. Smola, F. Engelhardt, K. Bleuel, M. Brauchle, I. Lein, L.W. Evans, D. Huylebroeck, R. Balling, and S. Werner. 1999. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 18:5205-5215.