Uracil-DNA glycosylase UNG promotes tet-mediated DNA demethylation

Journal of Biological Chemistry

Volumn 291, Issue 2, 2016, Pages 731-738

  Xue, Jian Huang ^a   Xu, Gui Fang ^a,b   Gu, Tian Peng ^a   Chen, Guo Dong ^a   Han, Bin Bin ^a   Xu, Zhi Mei ^a   Bjørås, Magnar ^c   Krokan, Hans E ^d   Xu, Guo Liang ^a,e   Du, Ya Rui ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b FUDAN UNIVERSITY   (China)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e SHANGHAITECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AROMATIC COMPOUNDS; CELLS; CHEMICAL REACTIONS; CYTOLOGY; MAMMALS; METHYLATION; STEM CELLS; TRANSCRIPTION;

DNA DEMETHYLATION; DNA GLYCOSYLASE; EMBRYONIC STEM CELLS; FUNCTIONAL GENOMICS; INDUCED PLURIPOTENT STEM CELLS; LUCIFERASE REPORTER ASSAYS; TRANSFECTED CELLS; URACIL-DNA GLYCOSYLASE;

DNA;

CELL PROTEIN; GENOMIC DNA; TET PROTEIN; TET2 PROTEIN; UNCLASSIFIED DRUG; UNG PROTEIN; UNG2 PROTEIN; URACIL; URACIL DNA GLYCOSIDASE; 5-CARBOXYLCYTOSINE; CYTOSINE; DNA; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; FEMALE; FUNCTIONAL GENOMICS; GENE SILENCING; GENETIC TRANSFECTION; HEK293 CELL LINE; MALE; MAMMAL CELL; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION INITIATION; UNG GENE; ZYGOTE; ANALOGS AND DERIVATIVES; ANIMAL; DEFICIENCY; GENE LOCUS; HUMAN; HUMAN GENOME; METABOLISM;

ANIMALS; CYTOSINE; DNA; DNA METHYLATION; DNA-BINDING PROTEINS; GENES, REPORTER; GENETIC LOCI; GENOME, HUMAN; HEK293 CELLS; HUMANS; MICE; PLASMIDS; PROTO-ONCOGENE PROTEINS; TRANSFECTION; URACIL; URACIL-DNA GLYCOSIDASE; ZYGOTE;

EID: 84954133230     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.693861     Document Type: Article

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