Long chain fatty acids and dietary fats in fetal nutrition

Journal of Physiology

Volumn 587, Issue 14, 2009, Pages 3441-3451

  Cetin, Irene ^a   Alvino, Gioia ^b   Cardellicchio, Manuela ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; LINOLEIC ACID; LONG CHAIN FATTY ACID; POLYUNSATURATED FATTY ACID; CHOLESTEROL; CHOLESTEROL ESTER; DOCOSAHEXAENOIC ACID; ENDOTHELIAL LIPASE; ESSENTIAL FATTY ACID; GLYCEROL; HYDROCORTISONE; ICOSAPENTAENOIC ACID; KETONE BODY; LEPTIN; LIPOPROTEIN LIPASE; OMEGA 3 FATTY ACID; OMEGA 3 PROSTANOID; OMEGA 6 PROSTANOID; PHOSPHOLIPID; PROGESTERONE; PROSTANOID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

CONFERENCE PAPER; FAT INTAKE; FATTY ACID METABOLISM; HUMAN; INTRAUTERINE GROWTH RETARDATION; MATERNAL NUTRITION; NUTRIENT AVAILABILITY; PLACENTAL TRANSFER; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREGNANCY DISORDER; PRIORITY JOURNAL; ADIPOSE TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN GROWTH; CALORIC INTAKE; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FETAL NUTRITION; FETUS; FETUS MALFORMATION; GLUCOSE TOLERANCE; GLYCEROL BLOOD LEVEL; HIGH RISK PATIENT; HORMONAL REGULATION; HYPERPHAGIA; HYPERTRIGLYCERIDEMIA; INCIDENCE; INSULIN SENSITIVITY; LACTATION; LIPID BILAYER; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; NERVE CELL DIFFERENTIATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITION; OBESITY; PATHOGENESIS; PREECLAMPSIA; PUERPERAL DEPRESSION;

DIETARY FATS; FATTY ACIDS; FEMALE; FETAL GROWTH RETARDATION; HUMANS; MATERNAL-FETAL EXCHANGE; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PLACENTA; PLACENTA DISEASES; PREGNANCY;

EID: 67651100910     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.173062     Document Type: Conference Paper

References (82)

1. Ahmad A, Moriguchi T & Salem N (2002). Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatr Neurol 26, 210-218.
2. Alvarez JJ, Montelongo A, Iglesias A, Lasunciòn MA & Herrera E (1996). Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and post heparin lipases during gestation in women. J Lipid Res 37, 299-308.
3. Alvino G, Cozzi V, Radaelli T, Ortega H, Herrera E & Cetin I (2008). Maternal and fetal fatty acid profile in normal and intrauterine growth restriction pregnancies with and without preeclampsia. Pediatr Res 64, 615-620.
4. 14C-tripalmitate administration in the late pregnant rat. Metabolism 38, 104-108.
5. Benassayag C, Rigourd V, Mignot TM, Hassid J, Leroy MJ, Robert B, Civel C, Grangé G, Dallot E, Tanguy J, Nunez EA & Ferré F (1999). Does high polyunsaturated free fatty acid level at the feto-maternal interface alter steroid hormone message during pregnancy? Prostaglandins Leukot Essent Fatty Acids 60, 393-399.
6. Bézard J, Blond JP & Bernard A (1994). The metabolism and availability of essential fatty acids in animal and human tissues. Reprod Nutr Dev 34, 539-568.
7. Brenner RR, Bernasconi AM & Garda HA (2000). Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes. Prostaglandins Leukot Essent Fatty Acids 63, 167-176.
8. Burdge GC & Calder PC (2005). Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 45, 581-597.
9. Campbell FM, Bush PG, Veerkamp JH & Duttaroy AK (1998a). Detection and cellular localization of plasma membraneassociated and cytoplasmic fatty acid binding proteins in human placenta. Placenta 19, 409-415.
10. Campbell FM, Gordon MJ & Dutta-Roy AK (1998b). Placental membrane fatty acid binding protein preferentially binds arachidonic and docosahexaenoic acids. Life Sci 63, 235-240.
11. Carlson SE, Werkman SH & Tolley EA (1996). Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Am J Clin Nutr 63, 687-697.
12. Carpenter MW (2007). Gestational diabetes, pregnancy hypertension, and late vascular disease. Diabetes Care 30 Suppl. 2, S246-250.
13. Catalano PM, Thomas A, Huston-Presley L & Amini SB (2007). Phenotype of infants of mothers with gestational diabetes. Diabetes Care 30 Suppl. 2, S156-160.
14. Catov JM, Patrick TE, Powers RW, Ness RB, Harger G & Roberts JM (2007). Maternal leptin across pregnancy in women with small-for-gestational-age infants. Am J Obstet Gynecol 196, 558.e1-8.
15. Cetin I & Alvino G (2009). Intrauterine growth restriction: implications for placental metabolism and transport. A review. Placenta; DOI 10.1016/J.placenta.2008.12.006.
16. Cetin I, Alvino G, Radaelli T & Pardi G (2005). Fetal nutrition: A review. Acta Paediatr Suppl 94, 7-13.
17. Cetin I, Giovannini N, Alvino G, Agostoni C, Riva E & Giovannini M (2002). Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. Pediatr Res 52, 750-755.
18. Chechi K & Cheema SK (2006). Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Exp Clin Cardiol 11, 129-135.
19. Chechi K, McGuire JJ & Cheema SK (2009). Developmental programming of lipid metabolism and aortic vascular function in C57Bl/6 mice: A novel study suggesting an involvement of LDL-receptor. Am J Physiol Regul Integr Comp Physiol 296, 1029-1040.
20. Cheruku SR, Montgomery-Downs HE, Farkas SL, Thoman EB & Lammi-Keefe CJ (2002). Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning. Am J Clin Nutr 76, 608-613.
21. Clandinin MT, Chappell JE, Heim T, Swyer PR & Chance GW (1981). Fatty acid utilization in perinatal de novo synthesis of tissue. Early Hum Dev 5, 355-366.
22. Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR & Chance GW (1980). Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 4, 121-129.
23. Cousins L (1991). Insulin sensitivity in pregnancy. Diabetes 40, 39-43.
24. Crawford MA, Hassan AG, Williams G & Whitehouse WL (1976). Essential fatty acids and fetal brain growth. Lancet 1, 452-453.
25. De Rooij SR, Painter RC, Holleman F, Bossuyt PM & Roseboom TJ (2007). The metabolic syndrome in adults prenatally exposed to the Dutch famine. Am J Clin Nutr 86, 1219-1224.
26. De Vriese SR, Christophe AB & Maes M (2003). Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression. Life Sci 73, 3181-3187.
27. DuttaRoy AK (2000). Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 71, 315S-322S.
28. Duttaroy AK (2008). Transport of fatty acids across the human placenta: A review. Prog Lipid Res 48, 52-61.
29. Enke U, Seyfarth L, Schleussner E & Markert UR (2008). Impact of PUFA on early immune and fetal development. Br J Nutr 100, 1158-1168.
30. Felig P & Lynch V (1970). Starvation in human pregnancy: hypoglycemia, hypoinsulinemia and hyperketonemia. Science 170, 990-992.
31. Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M & Gelenberg AJ (2006). Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand 113, 31-35.
32. Gale CR, Robinson SM, Godfrey KM, Law CM, Schlotz W & O'Callaghan FJ (2008). Oily fish intake during pregnancy-association with lower hyperactivity but not with higher full-scale IQ in offspring. J Child Psychol Psychiatry 49, 1061-1068.
33. Gauster M, Hiden U, Blaschitz A, Frank S, Lang U, Alvino G, Cetin I, Desoye G & Wadsack C (2007). Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 92, 2256-2263.
34. Grandjean P & Weihe P (2003). Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure. Am J Clin Nutr 77, 715-719.
35. Haggarty P, Ashton J, Joynson M, Abramovich DR & Page K (1999). Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. Biol Neonate 75, 350-359.
36. Harder T, Rodekamp E, Schellong K, Dudenhausen J & Plagemann A (2007). Birth weight and subsequent risk of type 2 diabetes: A meta-analysis. Am J Epidemiol 165, 849-857.
37. Helland IB, Smith L, Saarem K, Saugstad OD & Drevon CA (2003). Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 111, 39-44.
38. Herrera E (2002). Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development - a review. Placenta 23, Suppl. A, S9-S19.
39. Herrera E, Amusquivar E, Lopez-Soldado I & Ortega H (2006). Maternal lipid metabolism and placental lipid transfer. Horm Res 65 (Suppl. 3), 59-64.
40. Herrera E, Ortega H, Alvino G, Giovannini N, Amusquivar E & Cetin I (2004). Relationship between plasma fatty acid profile and antioxidant vitamins during normal pregnancy. EJCN 58, 1231-1238.
41. Hibbeln JR (2002). Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: A cross-national, ecological analysis. J Affect Disord 69, 15-29.
42. Hoggard N, Haggarty P, Thomas L & Lea RG (2001). Leptin expression in placental and fetal tissues: Does leptin have a functional role? Biochem Soc Trans 29, 57-63.
43. Hollingsworth DR & Grundy SM (1982). Pregnancy-associated hypertriglyceridemia in normal and diabetic women. Differences in insulin-dependent, noninsulin-dependent, and gestational diabetes. Diabetes 31, 1092-1097.
44. Horvath, Koletzko B & Szajewska H (2007). Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: A meta-analysis of randomized controlled trials. Br J Nutr 98, 253-259.
45. Innis SM (2003). Perinatal biochemistry and physiology of long chain polyunsaturated fatty acids. J Pediatr 143, (2 suppl. 1) S1-8.
46. Innis SM (2005). Essential fatty acid transfer and fetal development. Placenta 26 Suppl. A, S70-75.
47. Innis SM (2007a). Dietary (n 3) fatty acids and brain development. J Nutr 137, 855-859.
48. Innis SM (2007b). Fatty acids and early human development. Early Hum Dev 83, 761-766.
49. Jansson T, Cetin I, Powell TL, Desoye G, Radaelli T, Ericsson A & Sibley CP (2006). Placental transport and metabolism in fetal overgrowth - a workshop report. Placenta 27, Suppl. A, S109-113.
50. Jeffrey BG & Neuringer M (2009). Age-related decline in rod phototransduction sensitivity in rhesus monkeys fed an n-3 fatty acid deficient diet. Invest Ophthalmol Vis Sci; DOI 10.1167/iovs.09-3640.
51. Khan IY, Dekou V, Douglas G, Jensen R, Hanson MA, Poston L & Taylor PD (2005). A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 288, R127-R133.
52. King JC (2006). Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr 26, 271-291.
53. Koletzko B, Cetin I & Brenna JT; Perinatal Lipid Intake Working Group; Child Health Foundation; Diabetic Pregnancy Study Group; European Association of Perinatal Medicine; European Society for Clinical Nutrition and Metabolism; European Society for Paediatric Gastroenterology, Hepatology and Nutrition, Committee on Nutrition; International Federation of Placenta Associations; International Society for the Study of Fatty Acids and Lipids. (2007). Dietary fat intakes for pregnant and lactating women. Br J Nutr 98, 873-877.
54. Koletzko B, Lien E, Agostoni C, Böhles H, Campoy C, Cetin I, Decsi T, Dudenhausen JW, Dupont C, Forsyth S, Hoesli I, Holzgreve W, Lapillonne A, Putet G, Secher NJ, Symonds M, Szajewska H, Willatts P & Uauy R (2008). The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: Review of current knowledge and consensus recommendations. World Association of Perinatal Medicine Dietary Guidelines Working Group. J Perinat Med 36, 5-14.
55. 13 C-labeled fatty acids in humans. J Lipid Res 44, 49-55.
56. Llanos A, Li Y, Mena P & Salem N (2005). Infants with intra uterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: A stable isotope study. Pediatric Res 58, 735-740.
57. Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC & Heird WC (2003). Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol 188, 1348-1353.
58. Magnusson AL, Waterman IJ, Wennergren M, Jansson T & Powell TL (2004). Triglyceride hydrolase activities and expression of fatty acid binding proteins in the human placenta in pregnancies complicated by intrauterine growth restriction and diabetes. J Clin Endocrinol Metab 89, 4607-4614.
59. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T & Nakao K (1997). Non adipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nat Med 3, 1029-1033.
60. Montelongo A, Lasunción MA, Pallardo LF & Herrera E (1992). Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 41, 1651-1659.
61. Olsen SF (2004). Is supplementation with marine omega-3 fatty acids during pregnancy a useful tool in the prevention of preterm birth? Clin Obstet Gynecol 47, 768-774.
62. Olsen SF, Østerdal ML, Salvig JD, Weber T, Tabor A, Secher NJ (2007). Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: A randomised clinical trial with fish oil. Eur J Clin Nutr 61, 976-985.
63. Ortega-Senovilla H, Alvino G, Taricco E, Cetin I, Herrera E (2009). Gestational diabetes mellitus upsets the proportion of fatty acids in umbilical arterial but not venous plasma. Diabetes Care 32, 120-122.
64. Pardi G, Marconi AM & Cetin I (2002). Placental-fetal interrelationship in IUGR fetuses - a review. Placenta 23 Suppl. A, S136-141.
65. Prentice AM & Golberg R (2000). Energy adaptations in human pregnancy: Limits and long term consequences. Am J Clin Nutr 71, 1226S-1232S.
66. Rees AM, Austin MP, Owen C & Parker G (2009). Omega-3 deficiency associated with perinatal depression: Case control study. Psychiatry Res 166, 254-259.
67. Reisbick S, Neuringer M, Hasnain R & Connor WE (1990). Polydipsia in rhesus monkeys deficient in omega 3 fatty acids. Physiol Behav 47, 315-323.
68. Ruyle M, Connor WE, Anderson GJ & Lowensohn RI (1990). Placental transfer of essential fatty acids in humans: Venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. Proc Natl Acad Sci U S A 87, 7902-7906.
69. Schaefer-Graf UM, Pawliczek J, Passow D, Hartmann R, Rossi R, Bührer C, Harder T, Plagemann A, Vetter K & Kordonouri O (2005). Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes. Diabetes Care 28, 1745-1750.
70. Sibley CP, Turner MA, Cetin I, Ayuk P, Boyd CA & D'Souza SW (2005). Placental phenotypes of intrauterine growth. Pediatr Res 58, 827-832.
71. Siemelink M, Verhoef A, Dormans JA, Span PN & Piersma AH (2002). Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring. Diabetologia 45, 1397-1403.
72. Smithers LG, Gibson RA, McPhee A & Makrides M (2008). Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: Results of a randomized controlled trial. Am J Clin Nutr 88, 1049-1056.
73. Smuts CM, Borod E, Peeples JM & Carlson SE (2003). High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. Lipids 38, 407-414.
74. Szajewska H, Horvath A & Koletzko B (2006). Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: A meta-analysis of randomized controlled trials. Am J Clin Nutr 83, 1337-1344.
75. 13C-labeled linoleic acid in newborn infants during the first week of life. Pediatr Res 45, 669-673.
76. Tabano S, Alvino G, Antonazzo P, Grati FR, Miozzo M & Cetin I (2006). Placental LPL gene expression is increased in severe intrauterine growth-restricted pregnancies. Pediatr Res 59, 250-253.
77. Taricco E, Radaelli T, Nobile de Santis MS & Cetin I (2003). Foetal and placental weights in relation to maternal characteristics in gestational diabetes. Placenta 24, 343-347.
78. Thomas B, Ghebremeskel K, Lowy C, Min Y & Crawford MA (2004). Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women. Eur J Clin Nutr 58, 1492-1497.
79. Weisinger HS, Armitage JA, Sinclair AJ, Vingrys AJ, Burns PL & Weisinger RS (2001). Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7, 258-259.
80. Wijendran V, Bendel RB, Couch SC, Philipson EH, Thomsen K, Zhang X & Lammi-Keefe CJ (1999). Maternal plasma phospholipid polyunsaturated fatty acids in pregnancy with and without gestational diabetes mellitus: relations with maternal factors. Am J Clin Nutr 70, 53-61.
81. Wittmaack FM, Gafvels ME, Bronner M, Matsuo H, McCrae KR, Tomaszewski JE, Robinson SL, Strickland DK & Strauss JF (1995). Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: Trophoblast expression predicts a role for the receptor in placental lipid transport. Endocrinology 136, 340-348.
82. Zorzano A, Lasunción MA & Herrera E (1986). Role of the availability of substrates on hepatic and renal gluconeogenesis in the fasted late pregnant rat. Metabolism 35, 297-303.