Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

World Journal of Gastroenterology

Volumn 22, Issue 1, 2016, Pages 176-187

  Wu, Shan Ying ^a   Lan, Sheng Hui ^a   Liu, Hsiao Sheng ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Autophagy; Hepatitis B virus; Hepatocellular carcinoma; MicroRNA; Viral replication

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; MEMBRANE PROTEIN; MICRORNA; RIBONUCLEASE; VIRUS ENVELOPE PROTEIN;

AUTOPHAGY; DNA REPLICATION; GENE TARGETING; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; RNA STABILITY; RNA SYNTHESIS; RNA TRANSCRIPTION; VIRUS ENVELOPE; VIRUS GENE; VIRUS REPLICATION; CARCINOMA, HEPATOCELLULAR; CHRONIC HEPATITIS B; COMPLICATION; GENETICS; HOST PATHOGEN INTERACTION; LIVER NEOPLASMS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER NEOPLASMS; MICRORNAS; VIRUS REPLICATION;

EID: 84953385504     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v22.i1.176     Document Type: Review

References (84)

1. Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ. Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem 2008; 283: 4766-4777 [PMID: 18073215 DOI: 10.1074/jbc.M706666200]
2. Ponpuak M, Mandell MA, Kimura T, Chauhan S, Cleyrat C, Deretic V. Secretory autophagy. Curr Opin Cell Biol 2015; 35: 106-116 [PMID: 25988755 DOI: 10.1016/j.ceb.2015.04.016]
3. Bhattacharya A, Prakash YS, Eissa NT. Secretory function of autophagy in innate immune cells. Cell Microbiol 2014; 16: 1637-1645 [PMID: 25237740 DOI: 10.1111/cmi.12365]
4. Jiang S, Dupont N, Castillo EF, Deretic V. Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators. J Innate Immun 2013; 5: 471-479 [PMID: 23445716 DOI: 10.1159/000346707]
5. Sakai Y, Oku M, van der Klei IJ, Kiel JA. Pexophagy: autophagic degradation of peroxisomes. Biochim Biophys Acta 2006; 1763: 1767-1775 [PMID: 17005271 DOI: 10.1016/j.bbamcr.2006.08.023]
6. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21: 1367-1381 [PMID: 17510285 DOI: 10.1101/gad.1545107]
7. Eisenberg-Lerner A, Kimchi A. The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 2009; 14: 376-391 [PMID: 19172397 DOI: 10.1007/s10495-008-0307-5]
8. Yousefi S, Simon HU. Autophagy in cancer and chemotherapy. Results Probl Cell Differ 2009; 49: 183-190 [PMID: 19142622 DOI: 10.1007/400-2008-25]
9. Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 2010; 6: 322-329 [PMID: 20224296]
10. Jin S, White E. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 2008; 4: 563-566 [PMID: 18326941]
11. Deretic V, Kimura T, Timmins G, Moseley P, Chauhan S, Mandell M. Immunologic manifestations of autophagy. J Clin Invest 2015; 125: 75-84 [PMID: 25654553 DOI: 10.1172/JCI73945]
12. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol 2013; 13: 722-737 [PMID: 24064518 DOI: 10.1038/nri3532]
13. Mostowy S, Cossart P. Bacterial autophagy: restriction or promotion of bacterial replication? Trends Cell Biol 2012; 22: 283-291 [PMID: 22555009 DOI: 10.1016/j.tcb.2012.03.006]
14. Lee YR, Hu HY, Kuo SH, Lei HY, Lin YS, Yeh TM, Liu CC, Liu HS. Dengue virus infection induces autophagy: an in vivo study. J Biomed Sci 2013; 20: 65 [PMID: 24011333 DOI: 10.1186/1423-0127-20-65]
15. Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005; 6: 376-385 [PMID: 15852042 DOI: 10.1038/nrm1644]
16. Couzin J. MicroRNAs make big impression in disease after disease. Science 2008; 319: 1782-1784 [PMID: 18369134 DOI: 10.1126/science.319.5871.1782]
17. Gish RG, Given BD, Lai CL, Locarnini SA, Lau JY, Lewis DL, Schluep T. Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities. Antiviral Res 2015; 121: 47-58 [PMID: 26092643 DOI: 10.1016/j.antiviral.2015.06.008]
18. Nassal M. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Gut 2015; 64: 1972-1984 [PMID: 26048673 DOI: 10.1136/gutjnl-2015-309809]
19. Wang J, Shi Y, Yang H. [Infection with hepatitis B virus enhances basal autophagy]. Weishengwu Xuebao 2010; 50: 1651-1656 [PMID: 21365919]
20. Tang H, Da L, Mao Y, Li Y, Li D, Xu Z, Li F, Wang Y, Tiollais P, Li T, Zhao M. Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology 2009; 49: 60-71 [PMID: 19065679 DOI: 10.1002/hep.22581]
21. Sir D, Tian Y, Chen WL, Ann DK, Yen TS, Ou JH. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci USA 2010; 107: 4383-4388 [PMID: 20142477 DOI: 10.1073/pnas.0911373107]
22. Xia Y, Zeng D, Yu F, He J, Zhou Z, Tu W, Deng H, Tian DA, Liu M. Role of autophagy in monokine induced by interferon ? (Mig) production during adenovirus-hepatitis B virus infection. Hepatogastroenterology 2012; 59: 1245-1250 [PMID: 22580676 DOI: 10.5754/hge12089]
23. Zhang HT, Chen GG, Hu BG, Zhang ZY, Yun JP, He ML, Lai PB. Hepatitis B virus x protein induces autophagy via activating deathassociated protein kinase. J Viral Hepat 2014; 21: 642-649 [PMID: 24188325 DOI: 10.1111/jvh.12191]
24. Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-580 [PMID: 21311563 DOI: 10.1038/cdd.2010.191]
25. Wirth M, Joachim J, Tooze SA. Autophagosome formation-the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Semin Cancer Biol 2013; 23: 301-309 [PMID: 23727157 DOI: 10.1016/j.semcancer.2013.05.007]
26. Levin-Salomon V, Bialik S, Kimchi A. DAP-kinase and autophagy. Apoptosis 2014; 19: 346-356 [PMID: 24264886 DOI: 10.1007/s10495-013-0918-3]
27. Zhang H, Chen GG, Zhang Z, Chun S, Leung BC, Lai PB. Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK. Apoptosis 2012; 17: 325-334 [PMID: 22170404 DOI: 10.1007/s10495-011-0685-y]
28. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R, Kimchi A. DAPkinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009; 10: 285-292 [PMID: 19180116 DOI: 10.1038/embor.2008.246]
29. Li J, Liu Y, Wang Z, Liu K, Wang Y, Liu J, Ding H, Yuan Z. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J Virol 2011; 85: 6319-6333 [PMID: 21507968 DOI: 10.1128/JVI.02627-10]
30. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5: 215-229 [PMID: 15738952 DOI: 10.1038/nri1573]
31. Lee YR, Lei HY, Liu MT, Wang JR, Chen SH, Jiang-Shieh YF, Lin YS, Yeh TM, Liu CC, Liu HS. Autophagic machinery activated by dengue virus enhances virus replication. Virology 2008; 374: 240-248 [PMID: 18353420 DOI: 10.1016/j.virol.2008.02.016]
32. Taylor MP, Kirkegaard K. Modification of cellular autophagy protein LC3 by poliovirus. J Virol 2007; 81: 12543-12553 [PMID: 17804493 DOI: 10.1128/JVI.00755-07]
33. Tian Y, Sir D, Kuo CF, Ann DK, Ou JH. Autophagy required for hepatitis B virus replication in transgenic mice. J Virol 2011; 85: 13453-13456 [PMID: 21957292 DOI: 10.1128/JVI.06064-11]
34. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol 2015; 185: 1800-1808 [PMID: 25956028 DOI: 10.1016/j.ajpath.2015.03.009]
35. Liu W, Cao Y, Wang T, Xiang G, Lu J, Zhang J, Hou P. The N-Glycosylation Modification of LHBs (Large Surface Proteins of HBV) Effects on Endoplasmic Reticulum Stress, Cell Proliferation and its Secretion. Hepat Mon 2013; 13: e12280 [PMID: 24282423 DOI: 10.5812/hepatmon.12280]
36. Li B, Gao B, Ye L, Han X, Wang W, Kong L, Fang X, Zeng Y, Zheng H, Li S, Wu Z, Ye L. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res 2007; 124: 44-49 [PMID: 17092596 DOI: 10.1016/j.virusres.2006.09.011]
37. Hirao K, Natsuka Y, Tamura T, Wada I, Morito D, Natsuka S, Romero P, Sleno B, Tremblay LO, Herscovics A, Nagata K, Hosokawa N. EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-Associated degradation and mannose trimming. J Biol Chem 2006; 281: 9650-9658 [PMID: 16431915 DOI: 10.1074/jbc.M512191200]
38. Lazar C, Macovei A, Petrescu S, Branza-Nichita N. Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle production. PLoS One 2012; 7: e34169 [PMID: 22461906 DOI: 10.1371/journal.pone.0034169]
39. Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, Dai Z, Shi GM, Wang XY, Ke AW, Wu B, Fan J. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008; 68: 9167-9175 [PMID: 19010888 DOI: 10.1158/0008-5472.CAN-08-1573]
40. Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011; 25: 795-800 [PMID: 21498569 DOI: 10.1101/gad.2016211]
41. Tian Y, Kuo CF, Sir D, Wang L, Govindarajan S, Petrovic LM, Ou JH. Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Differ 2015; 22: 1025-1034 [PMID: 25526090 DOI: 10.1038/cdd.2014.201]
42. Lan SH, Wu SY, Zuchini R, Lin XZ, Su IJ, Tsai TF, Lin YJ, Wu CT, Liu HS. Autophagy suppresses tumorigenesis of hepatitis B virus-Associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology 2014; 59: 505-517 [PMID: 23913306 DOI: 10.1002/hep.26659]
43. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-1820 [PMID: 14638851 DOI: 10.1172/JCI20039]
44. Kotsafti A, Farinati F, Cardin R, Cillo U, Nitti D, Bortolami M. Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC Gastroenterol 2012; 12: 118 [PMID: 22928777 DOI: 10.1186/1471-230X-12-118]
45. Green DR, Galluzzi L, Kroemer G. Cell biology. Metabolic control of cell death. Science 2014; 345: 1250256 [PMID: 25237106 DOI: 10.1126/science.1250256]
46. Su CL, Chen FN, Won SJ. Involvement of apoptosis and autophagy in reducing mouse hepatoma ML-1 cell growth in inbred BALB/c mice by bacterial fermented soybean products. Food Chem Toxicol 2011; 49: 17-24 [PMID: 20732379 DOI: 10.1016/j.fct.2010.08.017]
47. Zhang J, Fu LL, Tian M, Liu HQ, Li JJ, Li Y, He J, Huang J, Ouyang L, Gao HY, Wang JH. Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy. Bioorg Med Chem 2015; 23: 976-984 [PMID: 25650312 DOI: 10.1016/j.bmc.2015.01.020]
48. Li Y, Cheng P, Wen Y, Chen P, Yang L, Zhao X, Lv H, Quan Q, Wu Y, Yang H, Liu J, Wen X, Liu N, Kang Z, Luo S, Wang L, Wei Y. T lymphocyte responses against hepatitis B virus-related hepatocellular carcinoma induced by adenovirus vaccine encoding HBx. Int J Mol Med 2010; 26: 869-876 [PMID: 21042781]
49. Wang YJ, Hou Y, Huang H, Liu GR, White AP, Liu SL. Two oral HBx vaccines delivered by live attenuated Salmonella: both eliciting effective anti-tumor immunity. Cancer Lett 2008; 263: 67-76 [PMID: 18226855 DOI: 10.1016/j.canlet.2007.12.022]
50. Wang C, Yang W, Yan HX, Luo T, Zhang J, Tang L, Wu FQ, Zhang HL, Yu LX, Zheng LY, Li YQ, Dong W, He YQ, Liu Q, Zou SS, Lin Y, Hu L, Li Z, Wu MC, Wang HY. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology 2012; 55: 108-120 [PMID: 21932402 DOI: 10.1002/hep.24675]
51. Zhang XD, Wang Y, Ye LH. Hepatitis B virus X protein accelerates the development of hepatoma. Cancer Biol Med 2014; 11: 182-190 [PMID: 25364579 DOI: 10.7497/j.issn.2095-3941.2014.03.004]
52. Yan Y, Liu N, Lu L, Zang CM, Shao B, Li Y, Wen Y, Wei Y, Cheng P. Autophagy enhances antitumor immune responses induced by irradiated hepatocellular carcinoma cells engineered to express hepatitis B virus X protein. Oncol Rep 2013; 30: 993-999 [PMID: 23754319 DOI: 10.3892/or.2013.2531]
53. Rogov V, Dötsch V, Johansen T, Kirkin V. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol Cell 2014; 53: 167-178 [PMID: 24462201 DOI: 10.1016/j.molcel.2013.12.014]
54. Lu H, Li G, Liu L, Feng L, Wang X, Jin H. Regulation and function of mitophagy in development and cancer. Autophagy 2013; 9: 1720-1736 [PMID: 24091872 DOI: 10.4161/auto.26550]
55. Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev 2015; 87: 3-14 [PMID: 25979468 DOI: 10.1016/j.addr.2015.05.001]
56. Staedel C, Darfeuille F. MicroRNAs and bacterial infection. Cell Microbiol 2013; 15: 1496-1507 [PMID: 23795564 DOI: 10.1111/cmi.12159]
57. Guo YE, Steitz JA. Virus meets host microRNA: the destroyer, the booster, the hijacker. Mol Cell Biol 2014; 34: 3780-3787 [PMID: 25047834 DOI: 10.1128/MCB.00871-14]
58. Wu FL, Jin WB, Li JH, Guo AG. Targets for human encoded microRNAs in HBV genes. Virus Genes 2011; 42: 157-161 [PMID: 21113793 DOI: 10.1007/s11262-010-0555-7]
59. Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K. Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA. J Viral Hepat 2014; 21: e89-e97 [PMID: 24835118 DOI: 10.1111/jvh.12240]
60. Zhang GL, Li YX, Zheng SQ, Liu M, Li X, Tang H. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 2010; 88: 169-175 [PMID: 20728471 DOI: 10.1016/j.antiviral.2010.08.008]
61. Potenza N, Papa U, Mosca N, Zerbini F, Nobile V, Russo A. Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen. Nucleic Acids Res 2011; 39: 5157-5163 [PMID: 21317190 DOI: 10.1093/nar/gkr067]
62. Jin WB, Wu FL, Kong D, Guo AG. HBV-encoded microRNA candidate and its target. Comput Biol Chem 2007; 31: 124-126 [PMID: 17350341 DOI: 10.1016/j.compbiolchem.2007.01.005]
63. Guo H, Liu H, Mitchelson K, Rao H, Luo M, Xie L, Sun Y, Zhang L, Lu Y, Liu R, Ren A, Liu S, Zhou S, Zhu J, Zhou Y, Huang A, Wei L, Guo Y, Cheng J. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology 2011; 54: 808-819 [PMID: 21608007 DOI: 10.1002/hep.24441]
64. Jin J, Tang S, Xia L, Du R, Xie H, Song J, Fan R, Bi Q, Chen Z, Yang G, Liu J, Shi Y, Fan D. MicroRNA-501 promotes HBV replication by targeting HBXIP. Biochem Biophys Res Commun 2013; 430: 1228-1233 [PMID: 23266610 DOI: 10.1016/j.bbrc.2012.12.071]
65. Zhang X, Zhang E, Ma Z, Pei R, Jiang M, Schlaak JF, Roggendorf M, Lu M. Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1. Hepatology 2011; 53: 1476-1485 [PMID: 21520166 DOI: 10.1002/hep.24195]
66. Hu W, Wang X, Ding X, Li Y, Zhang X, Xie P, Yang J, Wang S. MicroRNA-141 represses HBV replication by targeting PPARA. PLoS One 2012; 7: e34165 [PMID: 22479552 DOI: 10.1371/journal. pone.0034165]
67. Dai X, Zhang W, Zhang H, Sun S, Yu H, Guo Y, Kou Z, Zhao G, Du L, Jiang S, Zhang J, Li J, Zhou Y. Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1?. Nucleic Acids Res 2014; 42: 6578-6590 [PMID: 24705650 DOI: 10.1093/nar/gku260]
68. Qiu L, Fan H, Jin W, Zhao B, Wang Y, Ju Y, Chen L, Chen Y, Duan Z, Meng S. miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Biochem Biophys Res Commun 2010; 398: 771-777 [PMID: 20633528 DOI: 10.1016/j.bbrc.2010.07.021]
69. Ji F, Yang B, Peng X, Ding H, You H, Tien P. Circulating microRNAs in hepatitis B virus-infected patients. J Viral Hepat 2011; 18: e242-e251 [PMID: 21692939 DOI: 10.1111/j.1365-2893.2011.01443.x]
70. Hu J, Xu Y, Hao J, Wang S, Li C, Meng S. MiR-122 in hepatic function and liver diseases. Protein Cell 2012; 3: 364-371 [PMID: 22610888 DOI: 10.1007/s13238-012-2036-3]
71. Chang J, Guo JT, Jiang D, Guo H, Taylor JM, Block TM. Liverspecific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol 2008; 82: 8215-8223 [PMID: 18550664 DOI: 10.1128/JVI.02575-07]
72. Wang S, Qiu L, Yan X, Jin W, Wang Y, Chen L, Wu E, Ye X, Gao GF, Wang F, Chen Y, Duan Z, Meng S. Loss of microRNA expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1)-modulated P53 activity. Hepatology 2012; 55: 730-741 [PMID: 22105316 DOI: 10.1002/hep.24809]
73. Song K, Han C, Zhang J, Lu D, Dash S, Feitelson M, Lim K, Wu T. Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells. Hepatology 2013; 58: 1681-1692 [PMID: 23703729 DOI: 10.1002/hep.26514]
74. D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep 2012; 2: 1537-1545 [PMID: 23200856 DOI: 10.1016/j.celrep.2012.10.023]
75. Peng F, Xiao X, Jiang Y, Luo K, Tian Y, Peng M, Zhang M, Xu Y, Gong G. HBx down-regulated Gld2 plays a critical role in HBVrelated dysregulation of miR-122. PLoS One 2014; 9: e92998 [PMID: 24667324 DOI: 10.1371/journal.pone.0092998]
76. Li C, Wang Y, Wang S, Wu B, Hao J, Fan H, Ju Y, Ding Y, Chen L, Chu X, Liu W, Ye X, Meng S. Hepatitis B virus mRNAmediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion. J Virol 2013; 87: 2193-2205 [PMID: 23221562 DOI: 10.1128/JVI.02831-12]
77. Liu Y, Zhao JJ, Wang CM, Li MY, Han P, Wang L, Cheng YQ, Zoulim F, Ma X, Xu DP. Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line. Chin Med J (Engl) 2009; 122: 10-14 [PMID: 19187610]
78. Ren M, Qin D, Li K, Qu J, Wang L, Wang Z, Huang A, Tang H. Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressing HBV. Antiviral Res 2012; 94: 225-231 [PMID: 22554933 DOI: 10.1016/j.antiviral.2012.04.004]
79. Shan X, Ren M, Chen K, Huang A, Tang H. Regulation of the microRNA processor DGCR8 by hepatitis B virus proteins via the transcription factor YY1. Arch Virol 2015; 160: 795-803 [PMID: 25427980 DOI: 10.1007/s00705-014-2286-x]
80. Lund E, Güttinger S, Calado A, Dahlberg JE, Kutay U. Nuclear export of microRNA precursors. Science 2004; 303: 95-98 [PMID: 14631048 DOI: 10.1126/science.1090599]
81. Liu L, An J, Liu J, Wen J, Zhai X, Liu Y, Pan S, Jiang J, Wen Y, Liu Z, Zhang Y, Chen J, Xing J, Ji G, Shen H, Hu Z, Fan Z. Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma. Mol Carcinog 2013; 52 Suppl 1: E148-E154 [PMID: 23868705 DOI: 10.1002/mc.22062]
82. Wang K, Wu ZB, Ye YN, Liu J, Zhang GL, Su YJ, He HL, Zheng YB, Gao ZL. Plasma Interleukin-10: A Likely Predictive Marker for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure. Hepat Mon 2014; 14: e19370 [PMID: 25147572 DOI: 10.5812/hepatmon.19370]
83. Duan XZ, Hu JH, Li C, Liu FF, Liu XY, Tong JJ, Xin SJ. Relation between serum levels of high mobility group box 1 and hepatitis B virus-related acute-on-chronic liver failure. Zhonghua Ganzangbing Zazhi 2013; 21: 434-437 [PMID: 24034844 DOI: 10.3760/cma.j.issn.1007-3418.2013.06.012]
84. Wu DL, Xu GH, Lu SM, Ma BL, Miao NZ, Liu XB, Cheng YP, Feng JH, Liu ZG, Feng-Ding WQ, Zhao YR. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Hum Immunol 2013; 74: 514-521 [PMID: 23376086 DOI: 10.1016/j.humimm.2013.01.022]