Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 5, 2015, Pages 976-984

  Zhang, Jin ^a   Fu, Lei Lei ^b   Tian, Mao ^b   Liu, Hao Qiu ^b   Li, Jing Jing ^b   Li, Yan ^a   He, Jun ^b   Huang, Jian ^a   Ouyang, Liang ^b   Gao, Hui Yuan ^a   Wang, Jin Hui ^a,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Anti HBV drug candidate; Autophagy; Hepatitis B virus (HBV); Sodium taurocholate cotransporting polypeptide (NTCP)

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; APOLIPOPROTEIN A1; BECLIN 1; HEPATITIS B VIRUS X PROTEIN; METHYL[5 (4 HYDROXY 3 METHOXYBENZOYL) 1H IMIDAZO(4,5 B)PYRIDIN 2 YL]CARBAMATE; SODIUM BILE ACID COTRANSPORTER; UNCLASSIFIED DRUG; APOLIPOPROTEIN B; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; COTRANSPORTER; MEMBRANE PROTEIN; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TRANSACTIVATOR PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS B; HEPATITIS B VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; POLYMERASE CHAIN REACTION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; SYNTHESIS; TUMOR CELL LINE;

HEPATITIS B VIRUS;

ANTIVIRAL AGENTS; APOLIPOPROTEINS B; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; HEPATITIS B; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SYMPORTERS; TRANS-ACTIVATORS;

EID: 84923106330     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.01.020     Document Type: Article

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