Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy

Biomaterials

Volumn 81, Issue , 2016, Pages 1-13

  Chen, Pengfei ^a,b   Xia, Chen ^a,b   Mei, Sheng ^a,b   Wang, Jiying ^a,b   Shan, Zhi ^a,b   Lin, Xianfeng ^a,b   Fan, Shunwu ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b Key Laboratory of Biotherapy of Zhejiang Province   (China)

Author keywords

Autophagy; Hydrogel; Osteoarthritis; Sinomenium

Indexed keywords

BODY FLUIDS; CARTILAGE; CHITIN; CHITOSAN; MAMMALS; MICROSPHERES; PATIENT TREATMENT;

AUTOPHAGY; CHITOSAN MICROSPHERES; CROSS-LINKED GELATINS; OSTEOARTHRITIS; PATHOLOGICAL CHANGES; SINOMENIUM; SURGICALLY-INDUCED OSTEOARTHRITIS; THERAPEUTIC EFFECTS;

HYDROGELS;

AGGRECAN; AGGRECANASE 2; ALKALOID; CHITOSAN; COL2A1 PROTEIN; COLLAGENASE 3; GELATIN; INTERLEUKIN 1BETA; MESSENGER RNA; METHACRYLIC ACID; MICROSPHERE; PROTEIN; PROTEOGLYCAN; SINOMENIUM (DRUG); UNCLASSIFIED DRUG; CROSS LINKING REAGENT; HYDROGEL; LIGHT CHAIN 3, HUMAN; MAP1LC3 PROTEIN, MOUSE; METHACRYLIC ACID DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS LINKING; ENCAPSULATION; EX VIVO STUDY; EXPLANT; HUMAN; HUMAN TISSUE; HYDROGEL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOARTHRITIS; POROSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; THERAPY EFFECT; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CARTILAGE; CHEMISTRY; CHONDROCYTE; DRUG EFFECTS; EXTRACELLULAR MATRIX; INTRAARTICULAR DRUG ADMINISTRATION; LIGHT; METABOLISM; PATHOLOGY; PIG; SINOMENIUM; SYNTHESIS;

ANIMALS; AUTOPHAGY; CARTILAGE; CHITOSAN; CHONDROCYTES; CROSS-LINKING REAGENTS; EXTRACELLULAR MATRIX; GELATIN; HUMANS; HYDROGEL; INJECTIONS, INTRA-ARTICULAR; LIGHT; METHACRYLATES; MICE, INBRED C57BL; MICROSPHERES; MICROTUBULE-ASSOCIATED PROTEINS; OSTEOARTHRITIS; PLANT EXTRACTS; SINOMENIUM; SUS SCROFA;

EID: 84953254259     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.12.006     Document Type: Article

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