Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits

Biomedical Chromatography

Volumn 29, Issue 6, 2015, Pages 883-889

  Yan, Huan ^a,b   Yan, Miao ^a   Li, Huan De ^a   Jiang, Pei ^a   Deng, Yang ^a   Cai, Hua Lin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Electroporation; Microdialysis; Pharmacokinetics; Sinomenine; Synovial fluid penetration

Indexed keywords

BODY FLUIDS; DIALYSIS; DISEASES;

ARTHRITIS DRUGS; ELECTROPORATION; FLUID PENETRATION; HPLC-MS-MS; MICRO-DIALYSIS; RHEUMATOID ARTHRITIS; SINOMENINE; SYNOVIAL FLUID; SYNOVIAL FLUID PENETRATION; SYSTEMIC ADMINISTRATION;

PHARMACOKINETICS;

SINOMENINE; STRYCHNINE; MORPHINAN DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG ELIMINATION; DRUG PENETRATION; ELECTROPORATION; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; LINEAR REGRESSION ANALYSIS; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICRODIALYSIS; NEW ZEALAND RABBIT; NONHUMAN; PLASMA; SYNOVIAL FLUID; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; CHEMISTRY; INTRADERMAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; METABOLISM; RABBIT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ORYCTOLAGUS CUNICULUS; SINOMENIUM ACUTUM;

ADMINISTRATION, CUTANEOUS; ANIMALS; ELECTROPORATION; INJECTIONS, INTRAMUSCULAR; LINEAR MODELS; MICRODIALYSIS; MORPHINANS; RABBITS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID;

EID: 84929439476     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3369     Document Type: Article

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