Chondroprotection and the prevention of osteoarthritis progression of the knee: A systematic review of treatment agents

American Journal of Sports Medicine

Volumn 43, Issue 3, 2015, Pages 734-744

  Gallagher, Brian ^a   Tjoumakaris, Fotios P ^a   Harwood, Marc I ^a   Good, Robert P ^a   Ciccotti, Michael G ^a   Freedman, Kevin B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

articular cartilage; chondroprotection; knee; nutraceutical

Indexed keywords

CHONDROITIN; GLUCOSAMINE; HYALURONIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; VISCOSUPPLEMENT; VITAMIN;

ARTHRALGIA; ARTICULAR CARTILAGE; DIET SUPPLEMENTATION; DISEASE COURSE; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; OSTEOARTHRITIS, KNEE; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADMINISTRATION, ORAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRALGIA; CARTILAGE, ARTICULAR; CHONDROITIN; DIETARY SUPPLEMENTS; DISEASE PROGRESSION; GLUCOSAMINE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; OSTEOARTHRITIS, KNEE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VISCOSUPPLEMENTS; VITAMINS;

EID: 84924911826     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546514533777     Document Type: Review

References (46)

1. Als-Nielsen B, Chen W, Gluud C, Kjaergard LL. Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events?. JAMA. 2003 ; 290 (7). 921-928
2. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986 ; 29 (8). 1039-1049
3. Amin S, LaValley MP, Guermazi A, et al. The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis. Arthritis Rheum. 2005 ; 52 (10). 3152-3159
4. Bergink AP, Uitterlinden AG, Van Leeuwen JP, et al. Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: the Rotterdam Study. J Clin Rheumatol. 2009 ; 15 (5). 230-237
5. Buckland-Wright C. Review of the anatomical and radiological differences between fluoroscopic and non-fluoroscopic positioning of osteoarthritic knees. Osteoarthritis Cartilage. 2006 ; 14: A19 - A31
6. Buckland-Wright JC, MacFarlane DG, Lynch JA, Jasani MK. Quantitative microfocal radiography detects changes in OA knee joint space width in patients in placebo controlled trial of NSAID therapy. J Rheumatol. 1995 ; 22 (5). 937-943
7. Canter PH, Wider B, Ernst E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology (Oxford). 2007 ; 46 (8). 1223-1233
8. Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008 ; 16 (4). 399-408
9. Cole BJ, Seroyer ST, Filardo G, Bajaj S, Fortier LA. Platelet-rich plasma: where are we now and where are we going?. Sports Health. 2010 ; 2 (3). 203-210
10. Dieppe P, Cushnaghan J, Jasani MK, McCrae F, Watt I. A two-year, placebo-controlled trial of non-steroidal anti-inflammatory therapy in osteoarthritis of the knee joint. Br J Rheumatol. 1993 ; 32 (7). 595-600
11. Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013 ; 31 (1). 16-25
12. Fam H, Kontopoulou M, Bryant JT. Effect of concentration and molecular weight on the rheology of hyaluronic acid/bovine calf serum solutions. Biorheology. 2009 ; 46 (1). 31-43
13. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis. 2008 ; 67: iii75 - iii82
14. Heidari B, Heidari P, Hajian-Tilaki K. Association between serum vitamin D deficiency and knee osteoarthritis. Int Orthop. 2011 ; 35 (11). 1627-1631
15. Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage. 2010 ; 18: S28 - S31
16. Jackson CG, Plaas AH, Sandy JD, et al. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis Cartilage. 2010 ; 18 (3). 297-302
17. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996 ; 17 (1). 1-12
18. Jevsevar DS, Brown GA, Jones DL, et al Treatment of Osteoarthritis of the Knee: Evidence Based Guideline. 2 nd ed.Rosemont, Illinois: American Academy of Orthopaedic Surgeons; 2013. Rosemont, Illinois: American Academy of Orthopaedic Surgeons ; 2013
19. Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2009 ; 60 (2). 524-533
20. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 ; 16 (4). 494-502
21. Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis Rheum. 2009 ; 60 (12). 3546-3553
22. Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheum. 2008 ; 58 (1). 26-35
23. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int. 2010 ; 30 (3). 357-363
24. Listrat V, Ayral X, Patarnello F, et al. Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee. Osteoarthritis Cartilage. 1997 ; 5 (3). 153-160
25. Lopez HL. Nutritional interventions to prevent and treat osteoarthritis, part I: focus on fatty acids and macronutrients. PM R. 2012 ; 4: S145 - S154
26. Lopez HL. Nutritional interventions to prevent and treat osteoarthritis, part II: focus on micronutrients and supportive nutraceuticals. PM R. 2012 ; 4: S155 - S168
27. Lotz M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res. 2001 ;: S108 - S115
28. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 2008 ; 22 (2). 351-384
29. Mazzuca SA, Brandt KD, Katz BP, Lane KA, Buckwalter KA. Comparison of quantitative and semiquantitative indicators of joint space narrowing in subjects with knee osteoarthritis. Ann Rheum Dis. 2006 ; 65 (1). 64-68
30. McAlindon T, LaValley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013 ; 309 (2). 155-162
31. Michel BA, Stucki G, Frey D, et al. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Arthritis Rheum. 2005 ; 52 (3). 779-786
32. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 ; 162 (18). 2113-2123
33. Pelletier JP, Raynauld JP, Berthiaume MJ, et al. Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study. Arthritis Res Ther. 2007 ; 9 (4). R74
34. Pham T, Le Henanff A, Ravaud P, Dieppe P, Paolozzi L, Dougados M. Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis. Ann Rheum Dis. 2004 ; 63 (12). 1611-1617
35. Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother. 2005 ; 39 (6). 1080-1087
36. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001 ; 357 (9252). 251-256
37. Rutjes AW, Juni P, da Costa BR, Trelle S, Nuesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012 ; 157 (3). 180-191
38. Saklatvala J. Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets. 2007 ; 8 (2). 305-313
39. Sawitzke AD, Shi H, Finco MF, et al. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis. 2010 ; 69 (8). 1459-1464
40. Uebelhart D, Malaise M, Marcolongo R, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage. 2004 ; 12 (4). 269-276
41. van den Berg WB. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage. 2011 ; 19 (4). 338-341
42. Vlad SC, LaValley MP, McAlindon TE, Felson DT. Glucosamine for pain in osteoarthritis: why do trial results differ?. Arthritis Rheum. 2007 ; 56 (7). 2267-2277
43. Wang Y, Hall S, Hanna F, et al. Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial. BMC Musculoskelet Disord. 2011 ; 12: 195
44. Wluka AE, Stuckey S, Brand C, Cicuttini FM. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol. 2002 ; 29 (12). 2585-2591
45. Wluka AE, Wolfe R, Stuckey S, Cicuttini FM. How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis?. Ann Rheum Dis. 2004 ; 63 (3). 264-268
46. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis, part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010 ; 18 (4). 476-499