Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates Osteoarthritis development in vivo

Annals of the Rheumatic Diseases

Volumn 74, Issue 1, 2015, Pages 285-293

  Zhu, Shouan ^a   Lu, Ping ^a   Liu, Huanhuan ^a   Chen, Pengfei ^a   Wu, Yan ^a   Wang, Yanyan ^a   Sun, Heng ^a   Zhang, Xiaolei ^a,b   Xia, Qingqing ^a   Heng, Boon Chin ^c   Zhou, Yiting ^a   Ouyang, Hong Wei ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; AGGRECANASE 2; BETA CATENIN; CHITOSAN DERIVATIVE; CHITOSAN MICROSPHERE; COLLAGEN TYPE 10; COLLAGENASE 3; GREEN FLUORESCENT PROTEIN; HYALURONIC ACID; INTERLEUKIN 1BETA; MICROSPHERE; RAC1 PROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; AMINOQUINOLINE DERIVATIVE; CHITOSAN; DELAYED RELEASE FORMULATION; MESSENGER RNA; MMP13 PROTEIN, HUMAN; NEUROPEPTIDE; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE; RUNX2 PROTEIN, HUMAN;

ADAMTS 5 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CARTILAGE INJURY; COLX GENE; CONTROLLED DRUG RELEASE; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROENCAPSULATION; MMP13 GENE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; RUNX2 GENE; TREATMENT OUTCOME; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; ARTICULAR CARTILAGE; CALCINOSIS; DELAYED RELEASE FORMULATION; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; HYPERTROPHY; METABOLISM; OSTEOARTHRITIS, KNEE; PATHOLOGY;

ADAM PROTEINS; AMINOQUINOLINES; ANIMALS; ARTHRITIS, EXPERIMENTAL; CALCINOSIS; CARTILAGE, ARTICULAR; CHITOSAN; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DELAYED-ACTION PREPARATIONS; GENE EXPRESSION PROFILING; HUMANS; HYPERTROPHY; MATRIX METALLOPROTEINASE 13; MICE; MICROSPHERES; NEUROPEPTIDES; OSTEOARTHRITIS, KNEE; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RNA, MESSENGER;

EID: 84918558388     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203901     Document Type: Article

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