Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the β-reaction by α-site ligands

Biochemistry

Volumn 46, Issue 26, 2007, Pages 7740-7753

  Ngo, Huu ^a   Kimmich, Novelle ^a   Harris, Rodney ^a   Niks, Dimitri ^a   Blumenstein, Lars ^b   Kulik, Victor ^b   Barends, Thomas Reinier ^b   Schlichting, Ilme ^b   Dunn, Michael F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC EFFECTORS; INDOLE; TRYPTOPHAN SYNTHASE;

BINDING SITES; COMPLEXATION; ISOTOPES; LIGANDS; NITROGEN COMPOUNDS;

ENZYMES;

ALDIMINE; DEHYDROALANINE; GLYCERALDEHYDE 3 PHOSPHATE; IMINE; INDOLE; NATURAL PRODUCT; PYRIDOXAL 5 PHOSPHATE; SERINE; TRYPTOPHAN SYNTHASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; KINETICS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; REGULATORY MECHANISM; SALMONELLA TYPHIMURIUM; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BINDING SITES; CATALYSIS; CRYSTALLIZATION; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; SALMONELLA TYPHIMURIUM; SERINE; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPTOPHAN SYNTHASE;

EID: 34347366323     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7003872     Document Type: Article

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