Crystal structures of a mutant (βK87T) tryptophan synthase α2β2 complex with ligands bound to the active sites of the α- and β-subunits reveal ligand-induced conformational changes

Biochemistry

Volumn 36, Issue 25, 1997, Pages 7664-7680

  Rhee, Sangkee ^a   Parris, Kevin D ^a,b   Hyde, C Craig ^c   Ahmed, S Ashraf ^a   Miles, Edith Wilson ^a   Davies, David R ^a,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b PFIZER INC   (United States)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; COENZYME A; GLYCEROPHOSPHATE; INDOLEPROPIONIC ACID; LIGAND; MUTANT PROTEIN; PROTEIN SUBUNIT; PYRIDOXAL 5 PHOSPHATE; SERINE; TRYPTOPHAN; TRYPTOPHAN SYNTHASE;

ALLOSTERISM; ALPHA CHAIN; ARTICLE; BETA CHAIN; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SALMONELLA TYPHIMURIUM; TRYPTOPHAN METABOLISM;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM; TRYPTOPHAN SYNTHASE;

BACTERIA (MICROORGANISMS); SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS PHAGE 187; TYPHIMURIUM;

EID: 0030800147     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9700429     Document Type: Article

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