The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease

Progress in Cardiovascular Diseases

Volumn 58, Issue 5, 2016, Pages 464-472

  DiNicolantonio, James J ^a   Lucan, Sean C ^b   O'Keefe, James H ^a  

^a SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiovascular disease; Cholesterol; Coronary heart disease; Fatty acids; Fructose; Lipids; Lipoproteins; Saturated fat; Sucrose; Sugar

Indexed keywords

CHOLESTEROL; FRUCTOSE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; SATURATED FATTY ACID; SUCROSE; SUGAR; TRIACYLGLYCEROL; URIC ACID; FAT INTAKE; SUGAR INTAKE;

CARBOHYDRATE INTAKE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY ATHEROSCLEROSIS; FAT INTAKE; GLUCOSE BLOOD LEVEL; HEART PROTECTION; HORMONE RESISTANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LOW CARBOHYDRATE DIET; MORTALITY; NONALCOHOLIC FATTY LIVER; REVIEW; SUGAR INTAKE; THROMBOCYTE DYSFUNCTION; URIC ACID BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; CORONARY DISEASE; DIETARY REFERENCE INTAKE; FEEDING BEHAVIOR; HEALTHY DIET; LIFESTYLE; LOW FAT DIET; NUTRITIONAL STATUS; NUTRITIONAL VALUE; PATHOPHYSIOLOGY; PREVENTIVE HEALTH SERVICE; PROCEDURES; PROGNOSIS; RISK FACTOR; RISK REDUCTION;

ANIMALS; CORONARY DISEASE; DIET, CARBOHYDRATE-RESTRICTED; DIET, FAT-RESTRICTED; DIETARY FATS; DIETARY SUCROSE; FEEDING BEHAVIOR; HEALTHY DIET; HUMANS; LIFE STYLE; NUTRITIONAL STATUS; NUTRITIVE VALUE; PREVENTIVE HEALTH SERVICES; PROGNOSIS; RECOMMENDED DIETARY ALLOWANCES; RISK FACTORS; RISK REDUCTION BEHAVIOR;

EID: 84953232932     PISSN: 00330620     EISSN: 18731740     Source Type: Journal    
DOI: 10.1016/j.pcad.2015.11.006     Document Type: Review

References (145)

1. Roger V.L., Go A.S., Lloyd-Jones D.M., et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012, 125:e2-e220.
2. Johnson T. Reducing the prevalence and costs of heart disease. NCSL Legisbrief 2015, 23:1-2.
3. Ahrens R.A. Sucrose, hypertension, and heart disease an historical perspective. Am J Clin Nutr 1974, 27:403-422.
4. Stehbens W.E. Anitschkow and the cholesterol over-fed rabbit. Cardiovasc Pathol 1999, 8:177-178.
5. Buja L.M., Nikolai N. Anitschkow and the lipid hypothesis of atherosclerosis. Cardiovasc Pathol 2014, 23:183-184.
6. Bailey C.H. Atheroma and other lesions produced in rabbits by cholesterol feeding. J Exp Med 1916, 23:69-84.
7. Scientific Report of the 2015 Dietary Guidelines Advisory Committee. Office of Disease Prevention and Health Promotion http://health.gov/dietaryguidelines/2015-scientific-report/.
8. Dietary fat and its relation to heart attacks and strokes. Report by the Central Committee for Medical and Community Program of the American Heart Association. JAMA 1961, 175:389-391.
9. http://zerodisease.com/archive/Dietary_Goals_For_The_United_States.pdf.
10. Yudkin J. Dietary fat and dietary sugar in relation to ischaemic heart-disease and diabetes. Lancet 1964, 2:4-5.
11. Ravnskov U. Is saturated fat bad?. Nutr Health 2010, part 2:109-119. F. De Meester, S. Zibadi, R.R. Watson (Eds.).
12. Robinson F., Hackett A.F., Billington D., et al. Changing from a mixed to self-selected vegetarian diet-influence on blood lipids. J Hum Nutr Diet 2002, 15:323-329.
13. Mensink R.P., Zock P.L., Kester A.D., et al. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003, 77:1146-1155.
14. Clarke R., Frost C., Collins R., et al. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ 1997, 314:112-117.
15. Frantz I.D., Dawson E.A., Ashman P.L., et al. Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey. Arteriosclerosis 1989, 9:129-135.
16. Chait A., Brunzell J.D., Denke M.A., et al. Rationale of the diet-heart statement of the American Heart Association. Report of the Nutrition Committee. Circulation 1993, 88:3008-3029.
17. Ravnskov U. A hypothesis out-of-date. The diet-heart idea. J Clin Epidemiol 2002, 55:1057-1063.
18. Weinberg S.L. The diet-heart hypothesis: a critique. J Am Coll Cardiol 2004, 43:731-733.
19. Anderson K.M., Castelli W.P., Levy D. Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA 1987, 257:2176-2180.
20. Tribble D.L., Holl L.G., Wood P.D., et al. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis 1992, 93:189-199.
21. Verhoye E., Langlois M.R. Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?. Clin Chem Lab Med 2009, 47:128-137.
22. Henriksen T., Mahoney E.M., Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis 1983, 3:149-159.
23. Weidtmann A., Scheithe R., Hrboticky N., et al. Mildly oxidized LDL induces platelet aggregation through activation of phospholipase A2. Arterioscler Thromb Vasc Biol 1995, 15:1131-1138.
24. Korporaal S.J., Van Eck M., Adelmeijer J., et al. Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A. Arterioscler Thromb Vasc Biol 2007, 27:2476-2483.
25. Wraith K.S., Magwenzi S., Aburima A., et al. Oxidized low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase-signaling pathways. Blood 2013, 122:580-589.
26. Ferretti G., Rabini R.A., Bacchetti T., et al. Glycated low density lipoproteins modify platelet properties: a compositional and functional study. J Clin Endocrinol Metab 2002, 87:2180-2184.
27. Daub K., Seizer P., Stellos K., et al. Oxidized LDL-activated platelets induce vascular inflammation. Semin Thromb Hemost 2010, 36:146-156.
28. Fernandez M.L. Rethinking dietary cholesterol. Curr Opin Clin Nutr Metab Care 2012, 15:117-121.
29. Griffin B.A., Freeman D.J., Tait G.W., et al. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 1994, 106:241-253.
30. Lamarche B., Tchernof A., Moorjani S., et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 1997, 95:69-75.
31. Dreon D.M., Fernstrom H.A., Campos H., et al. Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr 1998, 67:828-836.
32. Campos H., Moye L.A., Glasser S.P., et al. Low-density lipoprotein size, pravastatin treatment, and coronary events. JAMA 2001, 286:1468-1474.
33. Mora S., Szklo M., Otvos J.D., et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2007, 192:211-217.
34. Ramsden C.E., Faurot K.R., Carrera-Bastos P., et al. Dietary fat quality and coronary heart disease prevention: a unified theory based on evolutionary, historical, global, and modern perspectives. Curr Treat Options Cardiovasc Med 2009, 11:289-301.
35. Kitamura A., Iso H., Naito Y., et al. High-density lipoprotein cholesterol and premature coronary heart disease in urban Japanese men. Circulation 1994, 89:2533-2539.
36. Stein O., Stein Y. Atheroprotective mechanisms of HDL. Atherosclerosis 1999, 144:285-301.
37. Plump A.S., Scott C.J., Breslow J.L. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A 1994, 91:9607-9611.
38. Vega G.L., Grundy S.M. Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease. Curr Opin Lipidol 1996, 7:209-216.
39. Kinosian B., Glick H., Preiss L., et al. Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. J Investig Med 1995, 43:443-450.
40. Stampfer M.J., Sacks F.M., Salvini S., et al. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med 1991, 325:373-381.
41. Akinyanju P.A., Qureshi R.U., Salter A.J., et al. Effect of an "atherogenic" diet containing starch or sucrose on the blood lipids of young men. Nature 1968, 218:975-977.
42. Naismith D.J., Stock A.L., Yudkin J. Effect of changes in the proportions of the dietary carbohydrates and in energy intake on the plasma lipid concentrations in healthy young men. Nutr Metab 1974, 16:295-304.
43. Vorster H.H., Kruger A., Wentzel-Viljoen E., et al. Added sugar intake in South Africa: findings from the Adult Prospective Urban and Rural Epidemiology cohort study. Am J Clin Nutr 2014, 99:1479-1486.
44. Yudkin J., Kang S.S., Bruckdorfer K.R. Effects of high dietary sugar. Br Med J 1980, 281:1396.
45. Hokanson J.E., Austin M.A. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 1996, 3:213-219.
46. Taubes G. Good calories, bad calories. New York City, Knopf 2007.
47. Albrink M.J., Meigs J.W., Man E.B. Serum lipids, hypertension and coronary artery disease. Am J Med 1961, 31:4-23.
48. Szanto S., Yudkin J. The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers. Postgrad Med J 1969, 45:602-607.
49. Szanto S., Yudkin J. Dietary sucrose and platelet behaviour. Nature 1970, 225:467-468.
50. Te Morenga L.A., Howatson A.J., Jones R.M., et al. Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Am J Clin Nutr 2014, 100(1):65-79.
51. Yudkin J. Dietary prevention of atherosclerosis. Lancet 1970, 1:418.
52. Hite A.H., Feinman R.D., Guzman G.E., et al. In the face of contradictory evidence: report of the Dietary Guidelines for Americans Committee. Nutrition 2010, 26:915-924.
53. Yudkin J., Kakkar V.V., Szanto S. Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease. Postgrad Med J 1969, 45:608-611.
54. Bruckdorfer K.R., Worcester N.A., Yudkin J. Influence of diet on rat platelet aggregation. Nutr Metab 1977, 21(Suppl. 1):196-198.
55. Szanto S., Yudkin J. Plasma lipids, glucose tolerance, insulin levels and body-weight in men after diets rich in sucrose. Proc Nutr Soc 1969, 28:11a-12a.
56. Reiser S., Handler H.B., Gardner L.B., et al. Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blood insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load. Am J Clin Nutr 1979, 32:2206-2216.
57. Stout R.W., Bierman E.L., Ross R. Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells. Circ Res 1975, 36:319-327.
58. Pfeifle B., Ditschuneit H.H., Ditschuneit H. Insulin as a cellular growth regulator of rat arterial smooth muscle cells in vitro. Horm Metab Res 1980, 12:381-385.
59. Pfeifle B., Ditschuneit H. Effect of insulin on growth of cultured human arterial smooth muscle cells. Diabetologia 1981, 20:155-158.
60. Kersten S. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2001, 2:282-286.
61. Waddell W.R., Geyer R.P., Hurley N., et al. Abnormal carbohydrate metabolism in patients with hypercholesterolemia and hyperlipemia. Metabolism 1958, 7:707-716.
62. Lustig R.H. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 2010, 110:1307-1321.
63. Barua R.S., Ambrose J.A. Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol 2013, 33:1460-1467.
64. Bhatt S.P., Dransfield M.T. Chronic obstructive pulmonary disease and cardiovascular disease. Transl Res 2013, 162:237-251.
65. Reiser S., Michaelis OEt, Cataland S., et al. Effect of isocaloric exchange of dietary starch and sucrose in humans on the gastric inhibitory polypeptide response to a sucrose load. Am J Clin Nutr 1980, 33:1907-1911.
66. DiNicolantonio J.J., O'Keefe J.H., Lucan S.C. Added fructose: a principal driver of type 2 diabetes mellitus and its consequences. Mayo Clin Proc 2015, 90:372-381.
67. Beck-Nielsen H., Pedersen O., Lindskov H.O. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr 1980, 33:273-278.
68. Gutman R.A., Basilico M.Z., Bernal C.A., et al. Long-term hypertriglyceridemia and glucose intolerance in rats fed chronically an isocaloric sucrose-rich diet. Metabolism 1987, 36:1013-1020.
69. Pagliassotti M.J., Shahrokhi K.A., Moscarello M. Involvement of liver and skeletal muscle in sucrose-induced insulin resistance: dose-response studies. Am J Physiol 1994, 266:R1637-R1644.
70. Vrana A.S.Z., Kazdova L., Fabry P. Insulin sensitivity of adipose tissue on serum insulin concentrations in rats fed sucrose and starch diets. Nutr Rep 1971, 31-37.
71. Bruckdorfer K.R., Kang S.S., Yudkin J. Insulin sensitivity of adipose tissue of rats fed with various carbohydrates. Proc Nutr Soc 1974, 33:4a-5a.
72. Dunnigan M.G., Fyfe T., McKiddie M.T., et al. The effects of isocaloric exchange of dietary starch and sucrose on glucose tolerance, plasma insulin and serum lipids in man. Clin Sci 1970, 38:1-9.
73. Cohen A.M., Teitelbaum A. Effect of dietary sucrose and starch on oral glucose tolerance and insulin-like activity. Am J Physiol 1964, 206:105-108.
74. Hutter N., Baena M., Sanguesa G., et al. Liquid fructose supplementation in LDL-R-/- mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption. IJC Metab Endocr 2015, 9:12-21.
75. Stanhope K.L., Schwarz J.M., Keim N.L., et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009, 119:1322-1334.
76. Jenkins A.J., Best J.D., Klein R.L., et al. Lipoproteins, glycoxidation and diabetic angiopathy. Diabetes Metab Res Rev 2004, 20:349-368.
77. Ahmed N., Furth A.J. Failure of common glycation assays to detect glycation by fructose. Clin Chem 1992, 38:1301-1303.
78. Bunn H.F., Higgins P.J. Reaction of monosaccharides with proteins: possible evolutionary significance. Science 1981, 213:222-224.
79. Seneff S., Wainwright G., Mascitelli L. Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?. Arch Med Sci 2011, 7:8-20.
80. Lopes A., Vilela T.C., Taschetto L., et al. Evaluation of the effects of fructose on oxidative stress and inflammatory parameters in rat brain. Mol Neurobiol 2014, 50:1124-1130.
81. Delbosc S., Paizanis E., Magous R., et al. Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis 2005, 179:43-49.
82. Lanter B.B., Sauer K., Davies D.G. Bacteria present in carotid arterial plaques are found as biofilm deposits which may contribute to enhanced risk of plaque rupture. mBio 2014, 5:e01206-e01214.
83. Vasselli J.R., Scarpace P.J., Harris R.B., et al. Dietary components in the development of leptin resistance. Adv Nutr 2013, 4:164-175.
84. Lucan S.C., DiNicolantonio J.J. How calorie-focused thinking about obesity and related diseases may mislead and harm public health. An alternative. Public Health Nutr 2014, 18(4):571-581.
85. Stubbs A., Kotfila C., Xu H., et al. Identifying risk factors for heart disease over time: overview of 2014 i2b2/UTHealth shared task Track 2. J Biomed Inform 2015, [pii: S1532-0464(15)00140-9].
86. Chhabra R., O'Keefe J.H., Patil H., et al. Association of coronary artery calcification with hepatic steatosis in asymptomatic individuals. Mayo Clin Proc 2013, 88:1259-1265.
87. Lim J.S., Mietus-Snyder M., Valente A., et al. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol 2010, 7:251-264.
88. Schwarz J.M., Noworolski S.M., Wen M.J., et al. Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat. J Clin Endocrinol Metab 2015, 100:2434-2442.
89. Schwarz J.-M., Noworolski S.M., Wen M.J., et al. Isocaloric fructose restriction for 10 days reduces hepatic de novo lipogenesis and liver fat in obese Latino and African American children. Poster presented at: ENDO 2015; March 5, 2015; San Diego, California 2015, [Endocrine Society website. https://endo.confex.com/endo/2015endo/webprogram/Paper19571.html. Accessed May 12, 2015.].
90. Brown C.M., Dulloo A.G., Yepuri G., et al. Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol 2008, 294:R730-R737.
91. Young J.B., Landsberg L. Stimulation of the sympathetic nervous system during sucrose feeding. Nature 1977, 269:615-617.
92. Bruckdorfer K.R., Khan I.H., Yudkin J. The lipid content of the aortas of rats given sucrose. Proc Nutr Soc 1972, 31:9a-10a.
93. Yudkin J., Szanto S. Hyperinsulinism and atherogenesis. Br Med J 1971, 1:349.
94. Leosdottir M., Nilsson P.M., Nilsson J.A., et al. Dietary fat intake and early mortality patterns-data from The Malmo Diet and Cancer Study. J Intern Med 2005, 258:153-165.
95. Ravnskov U. The questionable role of saturated and polyunsaturated fatty acids in cardiovascular disease. J Clin Epidemiol 1998, 51:443-460.
96. Siri-Tarino P.W., Sun Q., Hu F.B., et al. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010, 91:535-546.
97. Hooper L., Summerbell C.D., Higgins J.P., et al. Dietary fat intake and prevention of cardiovascular disease: systematic review. BMJ 2001, 322:757-763.
98. Harcombe Z., Baker J.S., Cooper S.M., et al. Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis. Open Heart 2015, 2:e000196.
99. Harcombe Z., Davies B., Baker J.S., Sculthorpe N., DiNicolantonio J.J., Grace F. Evidence from randomized controlled trials does not support current dietary fat guidelines:. A systematic review and meta-analysis 2016, (unpublished).
100. Hooper L., Martin N., Abdelhamid A., et al. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev 2015, 6:Cd011737.
101. de Souza R.J., Mente A., Maroleanu A., et al. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ 2015, 351:h3978.
102. Puaschitz N.G., Strand E., Norekval T.M., et al. Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease. J Nutr 2015, 145:299-305.
103. de Oliveira Otto M.C., Mozaffarian D., Kromhout D., et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 2012, 96:397-404.
104. O'Sullivan T.A., Hafekost K., Mitrou F., et al. Food sources of saturated fat and the association with mortality: a meta-analysis. Am J Public Health 2013, 103:e31-e42.
105. Ramsden C.E., Hibbeln J.R., Majchrzak S.F., et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 2010, 104:1586-1600.
106. Woodhill J.M., Palmer A.J., Leelarthaepin B., et al. Low fat, low cholesterol diet in secondary prevention of coronary heart disease. Adv Exp Med Biol 1978, 109:317-330.
107. Ramsden C.E., Zamora D., Leelarthaepin B., et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ 2013, 346:e8707.
108. Li Y., Hruby A., Bernstein A.M., et al. Saturated fats compared with unsaturated fats and sources of carbohydrates in relation to risk of coronary heart disease: a prospective cohort study. J Am Coll Cardiol 2015, 66:1538-1548.
109. Jakobsen M.U., O'Reilly E.J., Heitmann B.L., et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009, 89:1425-1432.
110. Liu S., Willett W.C., Stampfer M.J., et al. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 2000, 71:1455-1461.
111. Hu F.B. Are refined carbohydrates worse than saturated fat?. Am J Clin Nutr 2010, 91:1541-1542.
112. Maegawa H., Kobayashi M., Ishibashi O., et al. Effect of diet change on insulin action: difference between muscles and adipocytes. Am J Physiol 1986, 251:E616-E623.
113. Hallfrisch J., Ellwood K.C., Michaelis OEt, et al. Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr 1983, 113:1819-1826.
114. Reiser S., Bohn E., Hallfrisch J., et al. Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am J Clin Nutr 1981, 34:2348-2358.
115. Basu S., Yoffe P., Hills N., et al. The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS One 2013, 8:e57873.
116. Goran M.I., Ulijaszek S.J., Ventura E.E. High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 2013, 8:55-64.
117. Gross L.S., Li L., Ford E.S., et al. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 2004, 79:774-779.
118. Robertson W.B., Strong J.P. Atherosclerosis in persons with hypertension and diabetes mellitus. Lab Invest 1968, 18:538-551.
119. Vigorita V.J., Moore G.W., Hutchins G.M. Absence of correlation between coronary arterial atherosclerosis and severity or duration of diabetes mellitus of adult onset. Am J Cardiol 1980, 46:535-542.
120. Elkeles R.S. Insulin and atheroma. Lancet 1969, 1:1211.
121. Waller B.F., Palumbo P.J., Lie J.T., et al. Status of the coronary arteries at necropsy in diabetes mellitus with onset after age 30 years. Analysis of 229 diabetic patients with and without clinical evidence of coronary heart disease and comparison to 183 control subjects. Am J Med 1980, 69:498-506.
122. Soler N.G., Pentecost B.L., Bennett M.A., et al. Coronary care for myocardial infarction in diabetics. Lancet 1974, 1:475-477.
123. Lapidus L., Bengtsson C., Blohme G., et al. Blood glucose, glucose tolerance and manifest diabetes in relation to cardiovascular disease and death in women. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. Acta Med Scand 1985, 218:455-462.
124. Garcia M.J., McNamara P.M., Gordon T., et al. Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes 1974, 23:105-111.
125. Stout R.W. Blood glucose and atherosclerosis. Arteriosclerosis 1981, 1:227-234.
126. Venkataraman K., Khoo C.M., Leow M.K., et al. New measure of insulin sensitivity predicts cardiovascular disease better than HOMA estimated insulin resistance. PLoS One 2013, 8:e74410.
127. Gast K.B., Tjeerdema N., Stijnen T., et al. Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One 2012, 7:e52036.
128. Opie L.H., Stubbs W.A. Carbohydrate metabolism in cardiovascular disease. Clin Endocrinol Metab 1976, 5:703-729.
129. Stout R.W. The relationship of abnormal circulating insulin levels to atherosclerosis. Atherosclerosis 1977, 27:1-13.
130. Stout R.W. Diabetes and atherosclerosis-the role of insulin. Diabetologia 1979, 16:141-150.
131. Welborn T.A., Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 1979, 2:154-160.
132. Pyorala K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 1979, 2:131-141.
133. Ducimetiere P., Eschwege E., Papoz L., et al. Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia 1980, 19:205-210.
134. Alajbegovic S., Metelko Z., Alajbegovic A., et al. Hyperglycemia and acute myocardial infarction in a nondiabetic population. Diabetol Croat 2003, 32:169-174.
135. Fuller J.H., Shipley M.J., Rose G., et al. Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study. Lancet 1980, 1:1373-1376.
136. Yang Q., Zhang Z., Gregg E.W., et al. Added sugar intake and cardiovascular diseases mortality among US adults. JAMA Intern Med 2014, 174:516-524.
137. Pure J.Y. White and deadly. Penguin Books 2012.
138. Yudkin J. Dietary carbohydrate and ischemic heart disease. Am Heart J 1963, 66:835-836.
139. Yudkin J. Dietetic aspects of atherosclerosis. Angiology 1966, 17:127-133.
140. Bray G.A., Popkin B.M. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes Care 2014, 37:950-956.
141. http://www.ers.usda.gov/AmberWaves/April03/Indicators/behinddata.htm. http://webarchives.cdlib.org/sw1tx36512/.
142. Hansen L., Dragsted L.O., Olsen A., et al. Fruit and vegetable intake and risk of acute coronary syndrome. Br J Nutr 2010, 104:248-255.
143. Wang X., Ouyang Y., Liu J., et al. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 2014, 349:g4490.
144. Ng S.W., Slining M.M., Popkin B.M. Use of caloric and noncaloric sweeteners in US consumer packaged foods, 2005-2009. J Acad Nutr Diet 2012, 112:1828-1834.e1-6.
145. Zampelas A. Still questioning the association between egg consumption and the risk of cardiovascular diseases. Atherosclerosis 2012, 224:318-319.