Matrix metalloproteinase inhibitors for chronic obstructive pulmonary disease

Drugs of the Future

Volumn 37, Issue 7, 2012, Pages 523-529

  Antoniu, Sabina Antonela ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Chronic obstructive pulmonary disease; Matrix metalloproteinase inhibitors; MMP 12; MMP 9; Smoking

Indexed keywords

ALPHA 1 ANTITRYPSIN; AS 111793; AS 112108; AZ 11557272; AZD 1236; BRONCHODILATING AGENT; BUDESONIDE; CORTICOSTEROID; DEXAMETHASONE; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ILOMASTAT; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; ROFLUMILAST; UNCLASSIFIED DRUG;

ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; DRUG EFFICACY; EMPHYSEMA; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; REVIEW; TREATMENT OUTCOME;

EID: 84952987100     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2012.037.07.1789352     Document Type: Review

References (61)

1. Tetley, T.D. Macrophages and the pathogenesis of COPD. Chest 2002, 121(5, Suppl.): 156S-9S. (Pubitemid 34497334)
2. Churg, A., Zhou, S., Wright, J.L. Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in COPD. Eur Respir J 2012, 39(1): 197-209.
3. Wilhelm, S.M., Collier, I.E., Marmer, B.L., Eisen, A.Z., Grant, G.A., Goldberg, G.I. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 1989, 264(29): 17213-21. (Pubitemid 19255553)
4. Atkinson, J.J., Senior, R.M. Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 2003, 28(1): 12-24. (Pubitemid 36017046)
5. Opdenakker, G., Van den Steen, P.E., Dubois, B. et al. Gelatinase b functions as regulator and effector in leukocyte biology. J Leukocyte Biol 2001, 69(6): 851-9. (Pubitemid 32577883)
6. Shapiro, S.D., Kobayashi, D.K., Ley, T.J. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem 1993, 268(32): 23824-9. (Pubitemid 23335353)
7. Gronski, T.J. Jr., Martin. R.L., Kobayashi. D-.K. et al. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J Biol Chem 1997, 272(18): 12189-94.
8. Parks, W., Shapiro, S. Matrix metalloproteinases in lung biology. Respir Res 2001, 2: 10-9. (Pubitemid 34187902)
9. Xie, S., Issa, R., Sukkar, M.B. et al. Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir Res 2005, 6: 148.
10. Finlay, G.A, O'Driscoll, L.R., Russell, K.J. et al. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am J Respir Crit Care Med 1997, 156(1): 240-7. (Pubitemid 27293196)
11. Finlay, G.A., Russell, K.J., McMahon, K.J., D'Arcy, E.M., Masterson, J.B., FitzGerald, M.X., O'Connor, C.M. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997, 52(6): 502-6. (Pubitemid 27298499)
12. Betsauyaku, T, Nishimura, M., Takeyabu, K., Tanino, M., Venge, P., Xu, S., Kawakami, Y. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med 1999, 159(6): 1985-91. (Pubitemid 29275073)
13. Boschetto, P., Quintavalle, S., Zeni, E. et al. Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax 2006, 61(12): 1037-42. (Pubitemid 44852020)
14. Vernooy, J.H.J., Lindeman, J.H.N., Jacobs, J.A., Hanemaaijer, R., Wouters, E.F.M. Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest 2004, 126(6): 1802-10. (Pubitemid 39643983)
15. Kang, M.J., Oh, Y.M., Lee, J.C. et al. Lung matrix metalloproteinase-9 correlates with cigarette smoking and obstruction of airflow. J Korean Med Sci 2003, 18(6): 821-7. (Pubitemid 38072932)
16. Foronjy, R., Nkyimbeng, T., Wallace, A., Thankachen, J., Okada, Y., Lemaitre, V., D'Armiento, J. Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin. Am J Physiol Lung Cell Mol Physiol 2008, 294(6): L1149-57.
17. Lim, S., Roche, N., Oliver, B.G., Mattos, W., Barnes, P.J., Fan Chung, K. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Am J Respir Crit Care Med 2000, 162(4, Pt. 1): 1355-60.
18. Russell, R.E., Culpitt, S.V., DeMatos, C., Donnelly, L., Smith, M., Wiggins, J., Barnes, P.J. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2002, 26(5): 602-9. (Pubitemid 34315869)
19. Wallace, A.M., Sandford, A.J. Genetic polymorphisms of matrix metalloproteinases: Functional importance in the development of chronic obstructive pulmonary disease? Am J Pharmacogenomics 2002, 2(3): 167-75. (Pubitemid 35167863)
20. Lee, S.Y., Kim, M.J., Kang, H.G. et al. Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. Respiration 2010, 80(2): 133-8.
21. Atkinson, J.J., Lutey, B.A., Suzuki, Y.The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am J Respir Crit Care Med 2011, 183(7): 876-84.
22. Nénan, S., Lagente, V., Planquois, J.-M., Hitier, S., Berna, P., Bertrand, C.P., Boichot, E. Metalloelastase (MMP-12) induced inflammatory response in mice airways: Effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol 2007, 559(1): 75-81.
23. Nénan, S., Boichot, E., Planquois, J.-M. et al. Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways. Eur J Pharmacol 2008, 579(1-3): 374-81.
24. Churg, A., Wang, R.D., Tai, H. et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-a? release. Am J Respir Crit Care Med 2003, 167(8): 1083-9. (Pubitemid 36459653)
25. Wright, J.L., Tai, H., Wang, R., Wang, X., Churg, A. Cigarette smoke upregulates pulmonary vascular matrix metalloproteinases via TNF-α signaling. Am J Physiol Lung Cell Mol Physiol 2007, 292(1): L125-33. (Pubitemid 46103438)
26. Lavigne, M.C., Eppihimer, M.J. Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia. Biochem Biophys Res Commun 2005, 330(1): 194-203. (Pubitemid 40394952)
27. Lavigne, M.C., Thakker, P., Gunn, J. et al. Human bronchial epithelial cells express and secrete MMP-12. Biochem Biophys Res Commun 2004, 324(2): 534-46. (Pubitemid 39345550)
28. Demedts, I.K., Morel-Montero, A., Lebecque, S. et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006, 61(3): 196-201.
29. Chaudhuri, R., McSharry, C., Brady, J. et al. Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity. J Allergy Clin Immunol 2012, 129(3): 655-63.
30. Molet, S., Belleguic, C., Lena, H. et al. Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res 2005, 54(1): 31-6. (Pubitemid 40385338)
31. Babusyte, A., Stravinskaite, K., Jeroch, J., Lotvall, J., Sakalauskas, R., Sitkauskiene, B. Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir Res 2007, 8: 81.
32. Haq, I., Chappell, S., Johnson, S. et al. Association of MMP-12 polymorphisms with severe and very severe COPD: A case control study of MMPs-1, 9 and 12 in a European population. BMC Med Genet 2010, 11: 7.
33. Haq, I., Lowrey, G.E., Kalsheker, N., Johnson, S.R. Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD. Thorax 2011, 66(11): 970-6.
34. Hautamaki, R.D., Kobayashi, D.K., Senior, R.M., Shapiro, S.D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997, 277(5334): 2002-4. (Pubitemid 27449144)
35. Wallace, A.M., Sandford, A.J., English, J.C. et al. Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema. COPD 2008, 5(1): 13-23. (Pubitemid 351225520)
36. Hunninghake, G.M., Cho, M.H., Tesfaigzi, Y. et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009, 361(27): 2599-608.
37. Vliagoftis, H., Schwingshackl, A., Milne, C.D. et al. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. J Allergy Clin Immunol 2000, 106(3): 537-45. (Pubitemid 32037707)
38. Culpitt, S.V., Maziak, W., Loukidis, S., Nightingale J.A., Mathhews, J.L., Barnex, P.J. Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999, 160(5, Pt. 1): 1635-9.
39. Omachi, T., Eisner, M., Rames, A., Markovtsova, L., Blanc, P. Matrix metalloproteinase-9 predicts pulmonary status declines in alpha1-antitrypsin deficiency. Respir Res 2011, 12: 35.
40. Churg, A., Wang, X., Wang, R.D., Meixner, S.C., Pryzdial, E.L.G., Wright, J.L. α1-antitrypsin suppresses TNF-α and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol2007, 37(2): 144-51.
41. Kim, S.E., Thanh Thuy, T.T., Lee, J.H. et al. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. Exp Mol Med 2009, 41(4): 277-87.
42. Kamio, K., Liu, X.D., Sugiura, H. et al. Statins inhibit matrix metalloproteinase release from human lung fibroblasts. Eur Respir J 2010, 35(3): 637-46.
43. Antoniu, S.A. New therapeutic options in the management of COPD - Focus on roflumilast. Int J Chron Obstruct Dis 2011, 6: 147-55.
44. Wang, Y.-J., Jiang, Y.-l., Tang, H.-F., Zhao, C.-Z., Chen, J,-Q. Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model. Int Immunopharmacol 2010, 10(2): 252-8.
45. Selman, M., Cisneros-Lira, J., Gaxiola, M., Ramírez, R., Kudlacz, E.M., Mitchell, P.G., Pardo, A. Matrix metalloproteinase inhibition attenuates tobacco smoke-induced emphysema in guinea pigs. Chest 2003, 123(5): 1633-41. (Pubitemid 36549786)
46. Morris, A., Kinnear, G., Wan, W.-Y.H., Wyss, D., Bahra, P., Stevenson, C.S. Comparison of cigarette smoke-induced acute inflammation in multiple strains of mice and the effect of a matrix metalloproteinase inhibitor on these responses. J Pharmacol Exp Ther 2008, 327(3): 851-62.
47. Churg, A., Dai, J., Zay, K. et al. Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, rs113456, have similar acute anti-inflammatory effects. Lab Invest 2001, 81(8): 1119-31. (Pubitemid 32772072)
48. Pemberton, P.A., Cantwell, J.S., Kim, K.M. et al. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 2005, 2(3): 303-10. (Pubitemid 43879446)
49. Churg, A., Dai, J., Zay, K. et al. Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, rs113456, have similar acute anti-inflammatory effects. Lab Invest 2001, 81(8): 1119-31. (Pubitemid 32772072)
50. Brass, D.M., Hollingsworth, J.W., Cinque, M. et al. Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. Am J Respir Cell Mol Biol 2008,39(5): 584-90.
51. Le Quément, C., Guénon, I., Gillon, J.Y., Valença, S., Cayron-Elizondo, V., Lagente, V., Boichot, E. The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke. Br J Pharmacol 2008, 154(6): 1206-15.
52. Oshitari, T., Okuyama, Y., Miyata, Y., Kosano, H., Takahashi, H., Natsugari, H. Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production. Bioorg Med Chem Lett 2011, 21(15): 4540-4.
53. Periasamy, S., Hsu, D.-Z., Chen, S.-Y., Yang, S.-S., Chandrasekaran, V., Liu, M.-Y. Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9. Cell Biochem Biophys 2011, 61(2): 327-36.
54. Li, W., Li, J., Wu, Y. et al. A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): Discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfon- amido)-3-methylbutanoic acid (MMP408). J Med Chem 2009, 52(7): 1799-802.
55. Wu, Y., Li, J., Wu, J. et al. Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett 2012, 22(1): 138-43.
56. Nuti, E., Panelli, L., Casalini, F. et al. Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors. J Med Chem 2009, 52(20): 6347-61.
57. Garbacki, N., Di Valentin, E., Piette, J., Cataldo, D., Crahay, C., Colige, A. Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling? Pulm Pharmacol Ther 2009, 22(4): 267-78.
58. Churg, A., Wang, R., Wang, X., Onnervik, P.-O., Thim, K., Wright, J.L. Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax 2007, 62(8): 706-13. (Pubitemid 47235016)
59. Lagente, V., Boichot, E., Le Quément, C., Guenon, I., Muzio, V., Gillon, J.Y. Antiinflammatory properties of MMP inhibitors in experimental models of chronic obstructive pulmonary disease and lung inflammation. In: Matrix Metalloproteinases in Tissue Remodelling and Inflammation. V. Lagente, E. Boithoc (Eds.). Birkhauser: Basel, 2008, 57-69.
60. Magnussen, H., Watz, H., Kirsten, A., Wang, M., Wray, H., Samuelsson, V., Mo, J., Kay, R. Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: A randomised controlled 6-week trial. Pulm Pharmacol Ther 2011, 24(5): 563-70
61. Dahl, R., Titlestad, I., Lindqvist, A. et al. Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: A randomised controlled trial. Pulm Pharmacol Ther 2012, 25(2): 169-77.