The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke

British Journal of Pharmacology

Volumn 154, Issue 6, 2008, Pages 1206-1215

  Le Quement C ^a   Guenon I ^a   Gillon, J Y ^b   Valenca S ^a   Cayron Elizondo, V ^b,c   Lagente, V ^a   Boichot, E ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b MERCK SERONO S A   (Switzerland)

^c PregLem SA   (Switzerland)

Author keywords

Cigarette smoke; COPD; Inflammation; LPS; Lung; MMP 12

Indexed keywords

2 HYDROXY 3 [1 (THIOPHENYLOXADIAZOLYL) 2,2 DIMETHYL PROPYLCARBAMOYL]METHYLHEXANOHYDROXAMIC ACID; CIGARETTE SMOKE; CXCL1 CHEMOKINE; CXCL11 CHEMOKINE; ELASTASE INHIBITOR; FRACTALKINE; GELATINASE B; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INHIBITION; LUNG LAVAGE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

AMINOPYRIDINES; ANIMALS; BENZAMIDES; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL1; CYCLOPROPANES; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MATRIX METALLOPROTEINASE 12; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTEASE INHIBITORS; RESPIRATORY SYSTEM; SMOKING;

EID: 47249112549     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.180     Document Type: Article

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