Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD

Thorax

Volumn 66, Issue 11, 2011, Pages 970-976

  Haq, Imran ^a   Lowrey, Gillian E ^a   Kalsheker, Noor ^a   Johnson, Simon R ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MACROPHAGE ELASTASE;

ADULT; AGED; ARTICLE; CELL COUNT; CELL INFILTRATION; CELL MIGRATION; CELL VIABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; SPUTUM CULTURE;

EID: 80054106572     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2011.159087     Document Type: Article

References (27)

1. 1-antitrypsin deficiency. Scand J Clin Lab Invest 1963;15:132-40.
2. Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361:2599-608.
3. Hautamaki RD, Kobayashi DK, Senior RM, et al. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997;277:2002-4. (Pubitemid 27449144)
4. Molet S, Belleguic C, Lena H, et al. Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res 2005;54:31-6. (Pubitemid 40385338)
5. Demedts IK, Morel-Montero A, Lebecque S, et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006;61:196-201.
6. Babusyte A, Stravinskaite K, Jeroch J, et al. Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir Res 2007;8:81.
7. Haq I, Chappell S, Johnson S, et al. Association of MMP-12 polymorphisms with severe and very severe COPD: a case control study of MMPs 1, 9 and 12 in a European population. BMC Med Genet 2010;11:7.
8. Jormsjo S, Ye S, Moritz J, et al. Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease. Circ Res 2000;86:998-1003. (Pubitemid 30324313)
9. Belvisi MG, Bottomley KM. The role of matrix metalloproteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs? Inflamm Res 2003;52:95-100. (Pubitemid 36470068)
10. Lowrey GE, Henderson N, Blakey JD, et al. MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD. Respir Med 2008;102:845-51.
11. Vestbo J, Anderson W, Coxson HO, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J 2008;31:869-73.
12. Henderson N, Markwick LJ, Elshaw SR, et al. Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration. Am J Physiol Lung Cell Mol Physiol 2007;292:L1030-8. (Pubitemid 46608250)
13. Ceresa CC, Knox AJ, Johnson SR. Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling. Am J Physiol Lung Cell Mol Physiol 2009;296:L1059-66.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
15. Shipley JM, Wesselschmidt RL, Kobayashi DK, et al. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A 1996;93:3942-6. (Pubitemid 26144227)
16. Nénan S, Boichot E, Lagente V, et al. Macrophage elastase (MMP-12): a proinflammatory mediator? Mem Inst Oswaldo Cruz 2005;100:167-72. (Pubitemid 40685458)
17. International HapMap Consortium. The International HapMap Project. Nature 2003;426:789-96.
18. Shapiro SD, Kobayashi DK, Ley TJ. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem 1993;268:23824-9. (Pubitemid 23335353)
19. Bertini I, Calderone V, Fragai M, et al. Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12. J Am Chem Soc 2008;130:7011-21. (Pubitemid 351770143)
20. Banda MJ, Clark EJ, Werb Z. Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor. J Exp Med 1980;152:1563-70. (Pubitemid 11210337)
21. Fletcher C, Peto R. The natural history of chronic airflow obstruction. BMJ 1977;1:1645-8. (Pubitemid 8124466)
22. Houghton AM, Grisolano JL, Baumann ML, et al. Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res 2006;66:6149-55.
23. Su L, Zhou W, Asomaning K, et al. Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis 2006;27:1024-9.
24. Heist RS, Marshall AL, Liu G, et al. Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer. Clin Cancer Res 2006;12:5448-53. (Pubitemid 44497260)
25. Churg A, Wang RD, Tai H, et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 2003;167:1083-9. (Pubitemid 36459653)
26. Churg A, Wang RD, Tai H, et al. Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2004;170:492-8. (Pubitemid 39209129)
27. Gronski TJ Jr, Martin RL, Kobayashi DK, et al. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J Biol Chem 1997;272:12189-94. (Pubitemid 27202803)