Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

Genome Biology

Volumn 16, Issue 1, 2015, Pages

  Busche, Stephan ^a   Shao, Xiaojian ^a   Caron, Maxime ^a   Kwan, Tony ^a   Allum, Fiona ^a   Cheung, Warren A ^a   Ge, Bing ^a   Westfall, Susan ^a   Simon, Marie Michelle ^a   Barrett, Amy ^b   Bell, Jordana T ^c   McCarthy, Mark I ^b,d,e   Deloukas, Panos ^f,g   Blanchette, Mathieu ^a   Bourque, Guillaume ^a   Spector, Timothy D ^c   Lathrop, Mark ^a   Pastinen, Tomi ^a   Grundberg, Elin ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e CHURCHILL HOSPITAL   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Adipose; Blood; CpH methylation; Differentially methylated region (DMR); DNA methylation; Enhancer; Environment; Population; Twins; Whole genome bisulfite sequencing (WGBS)

Indexed keywords

BISULFITE;

ADIPOSE TISSUE; ARTICLE; BLOOD SAMPLING; CELL COUNT; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DIZYGOTIC TWINS; DNA METHYLATION; ENHANCER REGION; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; MALE; MONOZYGOTIC TWINS; POPULATION DYNAMICS; POPULATION GENETICS; POPULATION RESEARCH; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TISSUE SPECIFICITY; BLOOD; GENETIC VARIATION; GENETICS; METABOLISM; TWINS;

ADIPOSE TISSUE; BLOOD; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC VARIATION; GENOME, HUMAN; HUMANS; SMOKING; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 84952975366     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-015-0856-1     Document Type: Article

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