Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

Oncotarget

Volumn 6, Issue 41, 2015, Pages 43182-43201

  Duffy, David J ^a,e   Krstic, Aleksandar ^a   Halasz, Melinda ^a   Schwarzl, Thomas ^a,f   Fey, Dirk ^a   Iljin, Kristiina ^d   Mehta, Jai Prakash ^a   Killick, Kate ^a   Whilde, Jenny ^a   Turriziani, Benedetta ^a   Haapa Paananen, Saija ^d   Fey, Vidal ^d   Fischer, Matthias ^c   Westermann, Frank ^b   Henrich, Kai Oliver ^b   Bannert, Steffen ^b   Higgins, Desmond G ^a   Kolch, Walter ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^e UNIVERSITY OF FLORIDA   (United States)

^f EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

4sU seq; MRNA sequencing (mRNA seq); MYC (c MYC); Neuroblastoma; Transcriptional regulation

Indexed keywords

ESTRADIOL; MESSENGER RNA; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; SMALL INTERFERING RNA; MYCN PROTEIN, HUMAN; N MYC PROTO ONCOGENE PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE FUNCTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MYCN GENE; NEUROBLASTOMA; ONCOGENE; PROTEIN INTERACTION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; WESTERN BLOTTING; BIOLOGY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; ONCOGENE MYC; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROCEDURES; PROTEIN PROTEIN INTERACTION;

BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; N-MYC PROTO-ONCOGENE PROTEIN; NEUROBLASTOMA; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS; POLYMERASE CHAIN REACTION; PROTEIN INTERACTION MAPS; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 84952936951     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6568     Document Type: Article

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