Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages

Journal of Biological Chemistry

Volumn 291, Issue 1, 2016, Pages 413-424

  Snodgrass, Ryan G ^a   Boß, Marcel ^a   Zezina, Ekaterina ^a   Weigert, Andreas ^a   Dehne, Nathalie ^a   Fleming, Ingrid ^a   Brüne, Bernhard ^a   Namgaladze, Dmitry ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELL MEMBRANES; CELL SIGNALING; CHEMICAL ACTIVATION; FATTY ACIDS; GENE EXPRESSION; IMMUNOLOGY; MACROPHAGES; PATHOLOGY; PROTEINS; SATURATED FATTY ACIDS; TISSUE; TRANSCRIPTION;

ENDOPLASMIC RETICULUM STRESS; HUMAN MONOCYTE-DERIVED MACROPHAGES; INDUCED TRANSCRIPTION; INFLAMMATORY RESPONSE; NUCLEAR FACTOR KAPPAB; P38 MITOGEN-ACTIVATED PROTEIN KINASE; PRO-INFLAMMATORY CYTOKINES; REACTIVE OXYGEN SPECIES;

PALMITIC ACID;

DUAL SPECIFICITY PHOSPHATASE 16; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PALMITIC ACID; PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; ACETYLCYSTEINE; AUTACOID; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CONDITIONED MEDIUM; CYTOKINE; DUAL SPECIFICITY PHOSPHATASE; DUSP16 PROTEIN, HUMAN; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOTEMPO; ORGANOPHOSPHORUS COMPOUND; OXYGEN; PALMITIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IL 1BETA GENE; IL 6 GENE; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CONDITIONED MEDIUM; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; PHARMACOLOGY; PHOSPHORYLATION;

ACETYLCYSTEINE; ADIPOCYTES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DUAL-SPECIFICITY PHOSPHATASES; ENDOPLASMIC RETICULUM STRESS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGES; MICE, INBRED C57BL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; ORGANOPHOSPHORUS COMPOUNDS; OXYGEN; PALMITATES; PHOSPHORYLATION; PIPERIDINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84952924397     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.686709     Document Type: Article

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