PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

Molecular Cell

Volumn 60, Issue 5, 2015, Pages 755-768

  Dawicki McKenna, Jennine M ^a   Langelier, Marie France ^b,c   DeNizio, Jamie E ^a   Riccio, Amanda A ^b,c   Cao, Connie D ^a   Karch, Kelly R ^a   McCauley, Michael ^b   Steffen, Jamin D ^b   Black, Ben E ^a   Pascal, John M ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PARP2 PROTEIN, HUMAN;

ARTICLE; CRYSTALLOGRAPHY; DEUTERIUM HYDROGEN EXCHANGE; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME BINDING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN UNFOLDING; CHEMISTRY; DNA REPAIR; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; DNA; DNA BREAKS; DNA REPAIR; HUMANS; MODELS, MOLECULAR; MUTATION; NAD; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING;

EID: 84952876742     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.10.013     Document Type: Article

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